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2012

Proton transfer in ba 3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Ädelroth, P., Gennis, R. B. & Brzezinski, P., Apr 1 2012, In : Biochimica et Biophysica Acta - Bioenergetics. 1817, 4, p. 650-657 8 p.

Research output: Contribution to journalReview article

Thermus thermophilus
Proton transfer
Electron Transport Complex IV
Protons
Oxidoreductases
2015

The two transmembrane helices of CcoP are sufficient for assembly of the cbb3-type heme-copper oxygen reductase from Vibrio cholerae

Ahn, Y. O., Lee, H. J., Kaluka, D., Yeh, S. R., Rousseau, D. L., Ädelroth, P. & Gennis, R. B., Jul 13 2015, In : Biochimica et Biophysica Acta - Bioenergetics. 1847, 10, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Heme
Copper
Oxidoreductases
Oxygen
2010

The diheme cytochrome c 4 from Vibrio cholerae is a natural electron donor to the respiratory cbb 3 oxygen reductase

Chang, H. Y., Ahn, Y., Pace, L. A., Lin, M. T., Lin, Y. H. & Gennis, R. B., Sep 7 2010, In : Biochemistry. 49, 35, p. 7494-7503 10 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Oxidoreductases
Electrons
Oxygen
Proteobacteria
2013

Characterization of the Type III sulfide:quinone oxidoreductase from Caldivirga maquilingensis and its membrane binding

Lencina, A. M., Ding, Z., Schurig-Briccio, L. A. & Gennis, R. B., Mar 1 2013, In : Biochimica et Biophysica Acta - Bioenergetics. 1827, 3, p. 266-275 10 p.

Research output: Contribution to journalArticle

sulfide quinone reductase
Membranes
Sulfides
Enzymes
Electrons
2015

Division of labor in transhydrogenase by alternating proton translocation and hydride transfer

Leung, J. H., Schurig-Briccio, L. A., Yamaguchi, M., Moeller, A., Speir, J. A., Gennis, R. B. & Stout, C. D., Jan 9 2015, In : Science. 347, 6218, p. 178-181 4 p.

Research output: Contribution to journalArticle

NADP
Protons
NADP Transhydrogenases
Thermus thermophilus
Proton-Motive Force
2010
Rhodobacter sphaeroides
Electron Transport Complex IV
Heme
Electrons
Protons
2011

High-resolution membrane protein structure by joint calculations with solid-state NMR and X-ray experimental data

Tang, M., Sperling, L. J., Berthold, D. A., Schwieters, C. D., Nesbitt, A. E., Nieuwkoop, A. J., Gennis, R. B. & Rienstra, C. M., Nov 1 2011, In : Journal of Biomolecular NMR. 51, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance spectroscopy
Membrane Proteins
Magnetic Resonance Spectroscopy
Joints
X-Rays
2013

Characterization of the nitric oxide reductase from Thermus thermophilus

Schurig-Briccio, L. A., Venkatakrishnan, P., Hemp, J., Bricio, C., Berenguer, J. & Gennis, R. B., Jul 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. 12613-12618 6 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Heme
Catalytic Domain
Oxidoreductases
Enzymes
2012

Interactions of intermediate semiquinone with surrounding protein residues at the QH site of wild-type and D75H mutant cytochrome bo 3 from Escherichia coli

Lin, M. T., Baldansuren, A., Hart, R., Samoilova, R. I., Narasimhulu, K. V., Yap, L. L., Choi, S. K., O'Malley, P. J., Gennis, R. B. & Dikanov, S. A., May 8 2012, In : Biochemistry. 51, 18, p. 3827-3838 12 p.

Research output: Contribution to journalArticle

Cytochromes
Labeling
Escherichia coli
Nitrogen
Proteins
2010

Functional interactions between membrane-bound transporters and membranes

Öjemyr, L. N., Lee, H. J., Gennis, R. B. & Brzezinski, P., Sep 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 36, p. 15763-15767 5 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Membranes
Protons
Membrane Proteins
Respiratory Transport
2012

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer

Näsvik Öjemyr, L., Von Ballmoos, C., Gennis, R. B., Sligar, S. & Brzezinski, P., Mar 9 2012, In : FEBS Letters. 586, 5, p. 640-645 6 p.

Research output: Contribution to journalReview article

Liposomes
Protons
Oxidoreductases
Electrons
Membranes
2010

A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O2-reduction activity

Namslauer, I., Lee, H. J., Gennis, R. B. & Brzezinski, P., May 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 5, p. 550-556 7 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Proton transfer
Protons
Mutation
Substitution reactions

Functional role of Thr-312 and Thr-315 in the proton-transfer pathway in ba 3 cytochrome c oxidase from thermus thermophilus

Smirnova, I., Reimann, J., Von Ballmoos, C., Chang, H. Y., Gennis, R. B., Fee, J. A., Brzezinski, P. & Ädelroth, P., Aug 24 2010, In : Biochemistry. 49, 33, p. 7033-7039 7 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Proton transfer
Electron Transport Complex IV
Protons
Oxidoreductases
2010

Nitroxide spin labels as EPR reporters of the relaxation and magnetic properties of the heme-copper site in cytochrome bo 3, E. coli

Oganesyan, V. S., White, G. F., Field, S., Marritt, S., Gennis, R. B., Yap, L. L. & Thomson, A. J., Nov 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 8, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

Spin Labels
Heme
Relaxation time
Paramagnetic resonance
Copper
2013

Proton uptake and pKa changes in the uncoupled Asn139Cys variant of cytochrome c oxidase

Johansson, A. L., Carlsson, J., Högbom, M., Hosler, J. P., Gennis, R. B. & Brzezinski, P., Feb 5 2013, In : Biochemistry. 52, 5, p. 827-836 10 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Protons
Membrane Proteins
Membranes
Proton Pumps
2012

Cell-free synthesis of cytochrome bo 3 ubiquinol oxidase in artificial membranes

Yildiz, A. A., Knoll, W., Gennis, R. B. & Sinner, E. K., Apr 1 2012, In : Analytical Biochemistry. 423, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

Artificial Membranes
Cytochromes
Membranes
Membrane Proteins
Proteins
2015

Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase: Swivelling the dIII component may gate the proton channel

Jackson, J. B., Leung, J. H., Stout, C. D., Schurig-Briccio, L. A. & Gennis, R. B., Jul 20 2015, In : FEBS Letters. 589, 16, p. 2027-2033 7 p.

Research output: Contribution to journalReview article

NADP
Protons
Thermus thermophilus
Mitochondria
Enzymes
2018

Unpaired Electron Spin Density Distribution across Reduced [2Fe-2S] Cluster Ligands by 13Cβ-Cysteine Labeling

Taguchi, A. T., Miyajima-Nakano, Y., Fukazawa, R., Lin, M. T., Baldansuren, A., Gennis, R. B., Hasegawa, K., Kumasaka, T., Dikanov, S. & Iwasaki, T., Jan 16 2018, In : Inorganic Chemistry. 57, 2, p. 741-746 6 p.

Research output: Contribution to journalArticle

cysteine
electron spin
Labeling
marking
Cysteine
2016

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

Binding sites
Copper
Binding Sites
electron spin resonance
copper
2019
Vitamin K 2
Cytochromes
Escherichia coli
Binding Sites
coenzyme Q10
2018

Mechanism of proton transfer through the KC proton pathway in the Vibrio cholerae cbb3 terminal oxidase

Ahn, Y. O., Albertsson, I., Gennis, R. B. & Ädelroth, P., Nov 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 11, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

Proton transfer
Vibrio cholerae
Protons
Oxidoreductases
Oxygen
2013

Role of aspartate 132 at the orifice of a proton pathway in cytochrome c oxidase

Johansson, A. L., Högbom, M., Carlsson, J., Gennis, R. B. & Brzezinski, P., May 28 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 22, p. 8912-8917 6 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Aspartic Acid
Protons
Biological Phenomena
Membranes
2018

Type 2 NADH dehydrogenase is the only point of entry for electrons into the Streptococcus agalactiae respiratory chain and is a potential drug target

Lencina, A. M., Franza, T., Sullivan, M. J., Ulett, G. C., Ipe, D. S., Gaudu, P., Gennis, R. B. & Schurig-Briccio, L. A., Jul 1 2018, In : mBio. 9, 4, e01034-18.

Research output: Contribution to journalArticle

Open Access
NADH Dehydrogenase
Streptococcus agalactiae
Electron Transport
Electrons
Oxidoreductases
2014

Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase

Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S. R., Arjona, D., Rousseau, D. L., Tajkhorshid, E., Ädelroth, P. & Gennis, R. B., Oct 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 42, p. E4419-E4428

Research output: Contribution to journalArticle

Vibrio cholerae
Catalytic Domain
Oxidoreductases
Oxygen
Protons
2016
Thermus thermophilus
Lipid bilayers
Lipid Bilayers
Catalytic Domain
Tunnels
2012

Structure changes upon deprotonation of the proton release group in the bacteriorhodopsin photocycle

Morgan, J. E., Vakkasoglu, A. S., Lanyi, J. K., Lugtenburg, J., Gennis, R. B. & Maeda, A., Aug 8 2012, In : Biophysical journal. 103, 3, p. 444-452 9 p.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Protons
Water
Fourier Analysis
2017

Dynamics of the KB Proton Pathway in Cytochrome ba3 from Thermus thermophilus

von Ballmoos, C., Smirnova, I., Poiana, F., Gonska, N., Chang, H. Y., Gennis, R. B., Brzezinski, P. & Ädelroth, P., May 1 2017, In : Israel Journal of Chemistry. 57, 5, p. 424-436 13 p.

Research output: Contribution to journalArticle

Protons
Oxidoreductases
Proton transfer
Pumps
Proton Pumps
2010

The quinone-binding sites of the cytochrome bo3 ubiquinol oxidase from Escherichia coli

Yap, L. L., Lin, M. T., Ouyang, H., Samoilova, R. I., Dikanov, S. A. & Gennis, R. B., Dec 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 12, p. 1924-1932 9 p.

Research output: Contribution to journalArticle

Cytochromes
coenzyme Q10
Escherichia coli
Binding Sites
Enzymes
2014

Subunit CydX of Escherichia coli cytochrome bd ubiquinol oxidase is essential for assembly and stability of the di-heme active site

Hoeser, J., Hong, S., Gehmann, G., Gennis, R. B. & Friedrich, T., May 2 2014, In : FEBS Letters. 588, 9, p. 1537-1541 5 p.

Research output: Contribution to journalArticle

Cytochromes
Heme
Escherichia coli
Catalytic Domain
Technology
2012

Timing of electron and proton transfer in the ba3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Jun 5 2012, In : Biochemistry. 51, 22, p. 4507-4517 11 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Proton transfer
Electron Transport Complex IV
Protons
Electrons

Dissection of hydrogen bond interaction network around an iron-sulfur cluster by site-specific isotope labeling of hyperthermophilic archaeal rieske-type ferredoxin

Iwasaki, T., Fukazawa, R., Miyajima-Nakano, Y., Baldansuren, A., Matsushita, S., Lin, M. T., Gennis, R. B., Hasegawa, K., Kumasaka, T. & Dikanov, S., Dec 5 2012, In : Journal of the American Chemical Society. 134, 48, p. 19731-19738 8 p.

Research output: Contribution to journalArticle

Isotope Labeling
Ferredoxins
Dissection
dissection
Sulfur
2014

Evidence for distinct electron transfer processes in terminal oxidases from different origin by means of protein film voltammetry

Meyer, T., Melin, F., Xie, H., Von Der Hocht, I., Choi, S. K., Noor, M. R., Michel, H., Gennis, R. B., Soulimane, T. & Hellwig, P., Aug 6 2014, In : Journal of the American Chemical Society. 136, 31, p. 10854-10857 4 p.

Research output: Contribution to journalArticle

Voltammetry
Oxidoreductases
Enzymes
Electrons
enzyme
2013

Direct electrochemistry of cytochrome bo3 oxidase at a series of gold nanoparticles-modified electrodes

Melin, F., Meyer, T., Lankiang, S., Choi, S. K., Gennis, R. B., Blanck, C., Schmutz, M. & Hellwig, P., Jan 1 2013, In : Electrochemistry Communications. 26, 1, p. 105-108 4 p.

Research output: Contribution to journalArticle

Electrochemistry
Gold
Nanoparticles
Proteins
Immobilized Enzymes
2014

Proton pumping by an inactive structural variant of cytochrome c oxidase

Svahn, E., Faxén, K., Gennis, R. B. & Brzezinski, P., Nov 2014, In : Journal of Inorganic Biochemistry. 140, p. 6-11 6 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Protons
Catalytic Domain
Paracoccus denitrificans
Proton transfer

Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines

Schurig-Briccio, L. A., Yano, T., Rubin, H. & Gennis, R. B., Jul 2014, In : Biochimica et Biophysica Acta - Bioenergetics. 1837, 7, p. 954-963 10 p.

Research output: Contribution to journalArticle

Phenothiazines
Vitamin K 2
NAD
Staphylococcus aureus
Oxidoreductases
2011

Oriented immobilization and electron transfer to the cytochrome c oxidase

Nowak, C., Schach, D., Gebert, J., Grosserueschkamp, M., Gennis, R. B., Ferguson-Miller, S., Knoll, W., Walz, D. & Naumann, R. L. C., Jan 1 2011, In : Journal of Solid State Electrochemistry. 15, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

oxidase
cytochromes
Electron Transport Complex IV
immobilization
Chelating Agents
2010

Modeling direct electron transfer to a multi-redox center protein: Cytochrome c Oxidase

Schach, D., Nowak, C., Gennis, R. B., Ferguson-Miller, S., Knoll, W., Walz, D. & Naumann, R. L. C., Nov 15 2010, In : Journal of Electroanalytical Chemistry. 649, 1-2, p. 268-276 9 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Proteins
Electrons
Lipid bilayers
Enzymes
2015

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

Proton-Motive Force
Mycobacterium tuberculosis
undecaprenyl pyrophosphate synthetase
Membranes
Staphylococcus aureus
2014

The KC channel in the cbb3-type respiratory oxygen reductase from Rhodobacter capsulatus is required for both chemical and pumped protons

Yildiz, G. G., Gennis, R. B., Daldal, F. & Öztürk, M., 2014, In : Journal of bacteriology. 196, 10, p. 1825-1832 8 p.

Research output: Contribution to journalArticle

Rhodobacter capsulatus
Protons
Oxidoreductases
Oxygen
Heme
2017

Location of the Substrate Binding Site of the Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli

Choi, S. K., Schurig-Briccio, L., Ding, Z., Hong, S., Sun, C. & Gennis, R. B., Jun 21 2017, In : Journal of the American Chemical Society. 139, 24, p. 8346-8354 9 p.

Research output: Contribution to journalArticle

Binding sites
Cytochromes
Escherichia coli
cytochrome
coenzyme Q10
2016

The unusual redox properties of C-type oxidases

Melin, F., Xie, H., Meyer, T., Ahn, Y. O., Gennis, R. B., Michel, H. & Hellwig, P., Dec 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 12, p. 1892-1899 8 p.

Research output: Contribution to journalArticle

Heme
Oxidation-Reduction
Oxidoreductases
Protons
Pseudomonas stutzeri
2018

Role of the tightly bound quinone for the oxygen reaction of cytochrome bo3 oxidase from Escherichia coli

Melin, F., Sabuncu, S., Choi, S. K., Leprince, A., Gennis, R. B. & Hellwig, P., Oct 2018, In : FEBS Letters. 592, 20, p. 3380-3387 8 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Escherichia coli
Oxygen
Quinones
Ubiquinone
2012
Rhodobacter capsulatus
Rhodobacter sphaeroides
Bacterial Proteins
Electron Transport Complex IV
Protons
2011

Entrance of the proton pathway in cbb 3-type heme-copper oxidases

Lee, H. J., Gennis, R. B. & Ädelroth, P., Oct 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17661-17666 6 p.

Research output: Contribution to journalArticle

Heme
Protons
Rhodobacter sphaeroides
Proton-Motive Force
Membranes
2018

The electron distribution in the "activated" state of cytochrome c oxidase

Vilhjálmsdóttir, J., Gennis, R. B. & Brzezinski, P., Dec 1 2018, In : Scientific reports. 8, 1, 7502.

Research output: Contribution to journalArticle

Open Access
Electron Transport Complex IV
Electrons
Protons
Free energy
Membranes
2012
Rhodobacter sphaeroides
Electron Transport Complex IV
Cytochromes c
Horses
His-His-His-His-His-His
2014

The semiquinone at the Qisite of the bc 1complex explored using HYSCORE spectroscopy and specific isotopic labeling of ubiquinone in rhodobacter sphaeroides via 13c methionine and construction of a methionine auxotroph

Hong, S., De Almeida, W. B., Taguchi, A. T., Samoilova, R. I., Gennis, R. B., O'Malley, P. J., Dikanov, S. & Crofts, A. R., Sep 30 2014, In : Biochemistry. 53, 38, p. 6022-6031 10 p.

Research output: Contribution to journalArticle

Rhodobacter sphaeroides
Ubiquinone
Methionine
Labeling
Spectrum Analysis
2010

Catalase activity of cytochrome c oxidase assayed with hydrogen peroxide-sensitive electrode microsensor

Bolshakov, I. A., Vygodina, T. V., Gennis, R. B., Karyakin, A. A. & Konstantinov, A. A., Nov 1 2010, In : Biochemistry (Moscow). 75, 11, p. 1352-1360 9 p.

Research output: Contribution to journalArticle

Microsensors
Electron Transport Complex IV
Catalase
Hydrogen Peroxide
Electrodes
2015

Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site

Von Ballmoos, C., Gonska, N., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Mar 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 11, p. 3397-3402 6 p.

Research output: Contribution to journalArticle

Protons
Oxidoreductases
Mutation
Electron Transport Complex IV
Electrons