Find Research outputs

Search results

• 2011

  Estrogen receptor β ligands: Recent advances and biomedical applications

  Minutolo, F., Macchia, M., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., May 2011, In: Medicinal Research Reviews. 31, 3, p. 364-442 79 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Ligands
  • Non-Steroidal Estrogens
  • Endometriosis
  • Cytoplasmic and Nuclear Receptors

• Estrogen-regulated prohibitin is required for mouse uterine development and adult function

  He, B., Kim, T. H., Kommagani, R., Feng, Q., Lanz, R. B., Jeong, J. W., DeMayo, F. J., Katzenellenbogen, B. S., Lydon, J. P. & O'Malley, B. W., Mar 2011, In: Endocrinology. 152, 3, p. 1047-1056 10 p.

  Research output: Contribution to journal › Article › peer-review

  • prohibitin
  • Estrogens
  • Estrogen Receptors
  • Uterus
  • Steroid Receptors

• Genomic collaboration of estrogen receptor α and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs

  Madak-Erdogan, Z., Lupien, M., Stossi, F., Brown, M. & Katzenellenbogen, B. S., Jan 2011, In: Molecular and cellular biology. 31, 1, p. 226-236 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase 1
  • Estrogen Receptors
  • Genes
  • Cytoplasmic and Nuclear Receptors
  • Mitogen-Activated Protein Kinases

• Repressor of Estrogen Receptor Activity (REA) is essential for mammary gland morphogenesis and functional activities: Studies in conditional knockout mice

  Park, S., Zhao, Y., Yoon, S., Xu, J., Liao, L., Lydon, J., DeMayo, F., O'Malley, B. W. & Katzenellenbogen, B. S., Nov 2011, In: Endocrinology. 152, 11, p. 4336-4349 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Mammary Glands
  • Morphogenesis
  • Estrogen Receptors
  • Knockout Mice
  • Breast

• Reversal of endocrine resistance in breast cancer: Interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis

  Bergamaschi, A., Christensen, B. L. & Katzenellenbogen, B. S., Jun 29 2011, In: Breast Cancer Research. 13, 3, R70.

  Research output: Contribution to journal › Article › peer-review

  • Mitosis
  • Breast Neoplasms
  • Estrogen Receptors
  • Genes
  • Aurora Kinase B

• The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells

  Stender, J. D., Stossi, F., Funk, C. C., Charn, T. H., Barnett, D. H. & Katzenellenbogen, B. S., Oct 1 2011, In: Molecular Endocrinology. 25, 10, p. 1699-1709 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Estrogen Receptors
  • Estrogens
  • Transcription Factors
  • Breast Neoplasms
• 2013

  14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers

  Bergamaschi, A., Frasor, J., Borgen, K., Stanculescu, A., Johnson, P., Rowland, K., Wiley, E. L. & Katzenellenbogen, B. S., Feb 2013, In: Breast Cancer Research and Treatment. 137, 3, p. 689-696 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hormones
  • Breast Neoplasms
  • Neoplasm Metastasis
  • Recurrence
  • Estrogen Receptors

• A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-α and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties

  Kim, K., Madak-Erdogan, Z., Ventrella, R. & Katzenellenbogen, B. S., Apr 2013, In: Hormones and Cancer. 4, 2, p. 78-91 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase 1
  • Estrogen Receptors
  • Breast Neoplasms
  • MicroRNAs
  • Proteins

• Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

  Madak-Erdogan, Z., Charn, T. H., Jiang, Y., Liu, E. T., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., 2013, In: Molecular Systems Biology. 9, 201328.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor
  • Estrogens
  • Transcription Factor
  • Gene Regulation
  • Transcription factors

• Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

  Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Nov 2013, In: FASEB Journal. 27, 11, p. 4406-4418 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Estrogens
  • Gene expression
  • Chromatin
  • liquiritigenin

• Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass

  Bartell, S. M., Han, L., Kim, H. N., Kim, S. H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Chambliss, K. L., Shaul, P. W., Roberson, P. K., Weinstein, R. S., Jilka, R. L., Almeida, M. & Manolagas, S. C., Apr 1 2013, In: Molecular Endocrinology. 27, 4, p. 649-656 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendrimers
  • Cortical Bone
  • Estrogen Receptors
  • Estrogens
  • Skeleton

• The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization

  Zhao, Y., Park, S., Bagchi, M. K., Taylor, R. N. & Katzenellenbogen, B. S., Mar 1 2013, In: Endocrinology. 154, 3, p. 1349-1360 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stromal Cells
  • Estrogen Receptors
  • Pregnancy Maintenance
  • Interleukin-11
  • 8-Bromo Cyclic Adenosine Monophosphate
• 2014

  Endocrine Society 2014 Laureate Awards

  Gustafsson, J. A., Katzenellenbogen, B., Jameson, J. L., Roth, J., Melmed, S., McDonnell, D., Wartofsky, L., Crowley, W. F., Griz, L. H. E., Becker, C., Moore, D. D., Drucker, D., Singh, N. & O'Malley, B., Oct 1 2014, In: Hormones & cancer. 5, 5, p. 339-355 17 p.

  Research output: Contribution to journal › Article › peer-review

• Estrogen-induced CCN1 Is critical for establishment of endometriosis-like lesions in mice

  Zhao, Y., Li, Q., Katzenellenbogen, B. S., Lau, L. F., Taylor, R. N., Bagchi, I. C. & Bagchi, M. K., 2014, In: Molecular Endocrinology. 28, 12, p. 1934-1947 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Endometriosis
  • Estrogens
  • Choristoma
  • Vascular Endothelial Growth Factor C
  • Cell Proliferation

• Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells

  Clark, S., Rainville, J., Zhao, X., Katzenellenbogen, B. S., Pfaff, D. & Vasudevan, N., 2014, In: Journal of Steroid Biochemistry and Molecular Biology. 139, p. 45-53 9 p.

  Research output: Contribution to journal › Article › peer-review

  • estradiol-bovine serum albumin
  • Transcription
  • Neuroblastoma
  • Estrogen Receptors
  • Transcriptional Activation

• Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

  Aumsuwan, P., Khan, S. I., Khan, I. A., Avula, B., Walker, L. A., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K., Jan 2014, In: In Vitro Cellular and Developmental Biology - Animal. 51, 1, p. 59-71 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dioscorea
  • 5-methyldeoxycytidine
  • 5-hydroxymethylcytosine
  • Epigenomics
  • MCF-7 Cells

• Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response

  Mir, M., Bergamaschi, A., Katzenellenbogen, B. S. & Popescu, G., Feb 18 2014, In: PloS one. 9, 2, e89000.

  Research output: Contribution to journal › Article › peer-review

  • Light interference
  • Growth kinetics
  • Cell growth
  • Microscopic examination
  • Cells

• Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer

  Holton, S. E., Bergamaschi, A., Katzenellenbogen, B. S. & Bhargava, R., May 9 2014, In: PloS one. 9, 5, e96878.

  Research output: Contribution to journal › Article › peer-review

  • Fibroblasts
  • Endocrine Cells
  • breast neoplasms
  • Cells
  • neoplasm cells

• Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer

  Madak-Erdogan, Z., Ventrella, R., Petry, L. & Katzenellenbogen, B. S., May 2014, In: Molecular Cancer Research. 12, 5, p. 714-727 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Actin Depolymerizing Factors
  • Estrogen Receptors
  • Actins
  • Breast Neoplasms
  • Hormones

• The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells

  Bergamaschi, A., Madak-Erdogan, Z., Kim, Y. J., Choi, Y. L., Lu, H. & Katzenellenbogen, B. S., 2014, In: Breast Cancer Research. 16, 1, 436.

  Research output: Contribution to journal › Article › peer-review

  • Forkhead Transcription Factors
  • Neoplastic Stem Cells
  • Estrogen Receptors
  • Breast Neoplasms
  • Forkhead Box Protein M1

• The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

  Abot, A., Fontaine, C., Buscato, M., Solinhac, R., Flouriot, G., Fabre, A., Drougard, A., Rajan, S., Laine, M., Milon, A., Muller, I., Henrion, D., Adlanmerini, M., Valéra, M. C., Gompel, A., Gerard, C., Péqueux, C., Mestdagt, M., Raymond-Letron, I., Knauf, C. & 9 others, Ferriere, F., Valet, P., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Lenfant, F., Greene, G. L., Foidart, J. M. & Arnal, J. F., Oct 1 2014, In: EMBO Molecular Medicine. 6, 10, p. 1328-1346 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Estetrol
  • Nuclear Envelope
  • Estrogen Receptors
  • Blood Vessels
  • Furylfuramide

• Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens

  Gong, P., Madak-Erdogan, Z., Li, J., Cheng, J., Greenlief, C. M., Helferich, W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., 2014, In: Nuclear receptor signaling. 12, p. e001

  Research output: Contribution to journal › Article › peer-review

  • Gene Regulatory Networks
  • Estrogen Receptors
  • Estrogens
  • Gene Expression
  • Glycyrrhiza
• 2017

  Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells

  Min, J., Guillen, V. S., Sharma, A., Zhao, Y., Ziegler, Y., Gong, P., Mayne, C. G., Srinivasan, S., Kim, S. H., Carlson, K. E., Nettles, K. W., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jul 27 2017, In: Journal of Medicinal Chemistry. 60, 14, p. 6321-6336 16 p.

  Research output: Contribution to journal › Article › peer-review

  • acrylic acid
  • Estrogen Receptor Modulators
  • Estrogen Receptors
  • Breast Neoplasms
  • Down-Regulation

• Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

  Nelson, A. W., Groen, A. J., Miller, J. L., Warren, A. Y., Holmes, K. A., Tarulli, G. A., Tilley, W. D., Katzenellenbogen, B. S., Hawse, J. R., Gnanapragasam, V. J. & Carroll, J. S., Jan 15 2017, In: Molecular and Cellular Endocrinology. 440, p. 138-150 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor beta
  • Cells
  • Estrogen Receptors
  • Tissue
  • Cell Line

• Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer

  Lu, W. & Katzenellenbogen, B. S., Aug 1 2017, In: Hormones and Cancer. 8, 4, p. 230-242 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Breast Neoplasms
  • Apoptosis
  • Gene Expression
  • Histones

• Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms

  Martin, A., Yu, J., Xiong, J., Khalid, A. B., Katzenellenbogen, B., Kim, S. H., Katzenellenbogen, J. A., Malaivijitnond, S., Gabet, Y., Krum, S. A. & Frenkel, B., Dec 2017, In: Journal of Cellular Physiology. 232, 12, p. 3798-3807 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoblasts
  • Dihydrotestosterone
  • Androgens
  • Membranes
  • Estrogens

• Full antagonism of the estrogen receptor without a prototypical ligand side chain

  Srinivasan, S., Nwachukwu, J. C., Bruno, N. E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Cavett, V., Zhou, H. B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B. S., Griffin, P. R., Katzenellenbogen, J. A. & Nettles, K. W., Jan 1 2017, In: Nature chemical biology. 13, 1, p. 111-118 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Ligands
  • Breast Neoplasms
  • Chemoprevention
  • Patient Compliance

• Membrane and nuclear estrogen receptor alpha actions: From tissue specificity to medical implications

  Arnal, J. F., Lenfant, F., Metivier, R., Flouriot, G., Henrion, D., Adlanmerini, M., Fontaine, C., Gourdy, P., Chambon, P., Katzenellenbogen, B. & Katzenellenbogen, J., Jul 2017, In: Physiological Reviews. 97, 3, p. 1045-1087 43 p.

  Research output: Contribution to journal › Review article › peer-review

  • Organ Specificity
  • Estrogen Receptor alpha
  • Nuclear Envelope
  • Steroids
  • Membranes

• MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression

  Christenson, J. L., Butterfield, K. T., Spoelstra, N. S., Norris, J. D., Josan, J. S., Pollock, J. A., McDonnell, D. P., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Richer, J. K., Apr 1 2017, In: Hormones and Cancer. 8, 2, p. 69-77 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mouse mammary tumor virus
  • Triple Negative Breast Neoplasms
  • Androgen Receptors
  • Neoplasm Antigens
  • Breast Neoplasms

• Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

  Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W. & Murphy, E., Jun 1 2017, In: Journal of Molecular and Cellular Cardiology. 107, p. 41-51 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Reperfusion Injury
  • Estrogen Receptors
  • Endothelium
  • Dendrimers

• Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

  Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In: Cancer Research. 77, 20, p. 5602-5613 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor Modulators
  • Estrogen Receptors
  • Breast Neoplasms
  • Neoplasms
  • Inbred NOD Mouse
• 2018

  Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain

  Sharma, A., Toy, W., Guillen, V. S., Sharma, N., Min, J., Carlson, K. E., Mayne, C. G., Lin, S., Sabio, M., Greene, G., Katzenellenbogen, B. S., Chandarlapaty, S. & Katzenellenbogen, J. A., Dec 21 2018, In: ACS chemical biology. 13, 12, p. 3374-3384 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor Modulators
  • Estrogen Receptors
  • Ligands
  • Cell proliferation
  • Breast Neoplasms

• New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons

  Wang, L., Guillen, V. S., Sharma, N., Flessa, K., Min, J., Carlson, K. E., Toy, W., Braqi, S., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Chandarlapaty, S. & Sharma, A., Aug 9 2018, In: ACS Medicinal Chemistry Letters. 9, 8, p. 803-808 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Scaffolds
  • Fulvestrant
  • Proteins
  • Cell proliferation

• Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

  Miranda, C. L., Johnson, L. A., De Montgolfier, O., Elias, V. D., Ullrich, L. S., Hay, J. J., Paraiso, I. L., Choi, J., Reed, R. L., Revel, J. S., Kioussi, C., Bobe, G., Iwaniec, U. T., Turner, R. T., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Blakemore, P. R., Gombart, A. F., Maier, C. S., Raber, J. & 1 others, Stevens, J. F., Dec 1 2018, In: Scientific reports. 8, 1, 613.

  Research output: Contribution to journal › Article › peer-review

  • xanthohumol
  • Obese Mice
  • High Fat Diet
  • Cognitive Dysfunction
  • Insulin Resistance

• Predominant role of nuclear versus membrane estrogen receptor α in arterial protection: Implications for estrogen receptor α modulation in cardiovascular prevention/safety

  Guivarc’h, E., Buscato, M., Guihot, A. L., Favre, J., Vessières, E., Grimaud, L., Wakim, J., Melhem, N. J., Zahreddine, R., Adlanmerini, M., Loufrani, L., Knauf, C., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Foidart, J. M., Gourdy, P., Lenfant, F., Arnal, J. F., Henrion, D. & Fontaine, C., Jul 1 2018, In: Journal of the American Heart Association. 7, 13, e008950.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Envelope
  • Estrogen Receptors
  • Safety
  • Estrogens
  • Estetrol

• Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation

  Vinel, A., Coudert, A. E., Buscato, M., Valera, M. C., Ostertag, A., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Berdal, A., Babajko, S., Arnal, J. F. & Fontaine, C., Aug 2018, In: Journal of Bone and Mineral Research. 33, 8, p. 1520-1531 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mandible
  • Estrogen Receptors
  • Bone and Bones
  • Membranes
  • Estrogens

• Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice

  Selvaraj, U. M., Zuurbier, K. R., Whoolery, C. W., Plautz, E. J., Chambliss, K. L., Kong, X., Zhang, S., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C., Shaul, P. W. & Stowe, A. M., 2018, In: Endocrinology. 159, 11, p. 3848-3859 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Estrogens
  • Middle Cerebral Artery Infarction
  • Stroke
  • Uterine Neoplasms

• Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

  Katzenellenbogen, J. A., Mayne, C. G., Katzenellenbogen, B. S., Greene, G. L. & Chandarlapaty, S., Jun 1 2018, In: Nature Reviews Cancer. 18, 6, p. 377-388 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Estrogen Receptors
  • Ligands
  • Mutation
  • Androgen Receptors
  • Breast Neoplasms
• 2019

  Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

  Ziegler, Y., Laws, M. J., Sanabria Guillen, V., Kim, S. H., Dey, P., Smith, B. P., Gong, P., Bindman, N., Zhao, Y., Carlson, K., Yasuda, M. A., Singh, D., Li, Z., El-Ashry, D., Madak-Erdogan, Z., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Dec 1 2019, In: npj Breast Cancer. 5, 1, 45.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms
  • Growth
  • Forkhead Box Protein M1
  • In Vitro Techniques
  • Triple Negative Breast Neoplasms