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• 2011

  Estrogen receptor β ligands: Recent advances and biomedical applications

  Minutolo, F., Macchia, M., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., May 2011, In: Medicinal Research Reviews. 31, 3, p. 364-442 79 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Ligands
  • Non-Steroidal Estrogens
  • Endometriosis
  • Cytoplasmic and Nuclear Receptors

• Estrogen-regulated prohibitin is required for mouse uterine development and adult function

  He, B., Kim, T. H., Kommagani, R., Feng, Q., Lanz, R. B., Jeong, J. W., DeMayo, F. J., Katzenellenbogen, B. S., Lydon, J. P. & O'Malley, B. W., Mar 2011, In: Endocrinology. 152, 3, p. 1047-1056 10 p.

  Research output: Contribution to journal › Article › peer-review

  • prohibitin
  • Estrogens
  • Estrogen Receptors
  • Uterus
  • Steroid Receptors

• Genomic collaboration of estrogen receptor α and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs

  Madak-Erdogan, Z., Lupien, M., Stossi, F., Brown, M. & Katzenellenbogen, B. S., Jan 2011, In: Molecular and cellular biology. 31, 1, p. 226-236 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase 1
  • Estrogen Receptors
  • Genes
  • Cytoplasmic and Nuclear Receptors
  • Mitogen-Activated Protein Kinases

• Repressor of Estrogen Receptor Activity (REA) is essential for mammary gland morphogenesis and functional activities: Studies in conditional knockout mice

  Park, S., Zhao, Y., Yoon, S., Xu, J., Liao, L., Lydon, J., DeMayo, F., O'Malley, B. W. & Katzenellenbogen, B. S., Nov 2011, In: Endocrinology. 152, 11, p. 4336-4349 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Mammary Glands
  • Morphogenesis
  • Estrogen Receptors
  • Knockout Mice
  • Breast

• Reversal of endocrine resistance in breast cancer: Interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis

  Bergamaschi, A., Christensen, B. L. & Katzenellenbogen, B. S., Jun 29 2011, In: Breast Cancer Research. 13, 3, R70.

  Research output: Contribution to journal › Article › peer-review

  • Mitosis
  • Breast Neoplasms
  • Estrogen Receptors
  • Genes
  • Aurora Kinase B

• The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells

  Stender, J. D., Stossi, F., Funk, C. C., Charn, T. H., Barnett, D. H. & Katzenellenbogen, B. S., Oct 1 2011, In: Molecular Endocrinology. 25, 10, p. 1699-1709 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Estrogen Receptors
  • Estrogens
  • Transcription Factors
  • Breast Neoplasms
• 2012

  Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140

  Madak-Erdogan, Z. & Katzenellenbogen, B. S., Feb 2012, In: Toxicological Sciences. 125, 2, p. 401-411 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Receptor Co-Repressor 1
  • Aryl Hydrocarbon Receptors
  • Gene expression
  • Estrogen Receptors
  • Chromatin

• Macrophage-elicited loss of estrogen receptor-α in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus

  Stossi, F., Madak-Erdoǧan, Z. & Katzenellenbogen, B. S., Apr 5 2012, In: Oncogene. 31, 14, p. 1825-1834 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinases
  • Estrogen Receptors
  • Macrophages
  • Breast Neoplasms
  • Macrophage Activation

• Phosphorylation by p38 mitogen-activated protein kinase promotes estrogen receptor α turnover and functional activity via the SCF^skp2 proteasomal complex

  Bhatt, S., Xiao, Z., Meng, Z. & Katzenellenbogen, B. S., May 2012, In: Molecular and cellular biology. 32, 10, p. 1928-1943 16 p.

  Research output: Contribution to journal › Article › peer-review

  • p38 Mitogen-Activated Protein Kinases
  • Estrogen Receptors
  • Phosphorylation
  • Breast Neoplasms
  • Estrogens

• Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance

  Bergamaschi, A. & Katzenellenbogen, B. S., Jan 5 2012, In: Oncogene. 31, 1, p. 39-47 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Cancer 3
  • Tamoxifen
  • MicroRNAs
  • Cell Survival
  • Down-Regulation

• Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA

  Park, S., Yoon, S., Zhao, Y., Park, S. E., Liao, L., Xu, J., Lydon, J. P., DeMayo, F. J., O'Malley, B. W., Bagchi, M. K. & Katzenellenbogen, B. S., Aug 1 2012, In: Endocrinology. 153, 8, p. 3982-3994 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Dosage
  • Cytoplasmic and Nuclear Receptors
  • Fertility
  • Infertility
  • Estrogen Receptors
• 2013

  14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers

  Bergamaschi, A., Frasor, J., Borgen, K., Stanculescu, A., Johnson, P., Rowland, K., Wiley, E. L. & Katzenellenbogen, B. S., Feb 2013, In: Breast Cancer Research and Treatment. 137, 3, p. 689-696 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hormones
  • Breast Neoplasms
  • Neoplasm Metastasis
  • Recurrence
  • Estrogen Receptors

• A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-α and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties

  Kim, K., Madak-Erdogan, Z., Ventrella, R. & Katzenellenbogen, B. S., Apr 2013, In: Hormones and Cancer. 4, 2, p. 78-91 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase 1
  • Estrogen Receptors
  • Breast Neoplasms
  • MicroRNAs
  • Proteins

• Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

  Madak-Erdogan, Z., Charn, T. H., Jiang, Y., Liu, E. T., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., 2013, In: Molecular Systems Biology. 9, 201328.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor
  • Estrogens
  • Transcription Factor
  • Gene Regulation
  • Transcription factors

• Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

  Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Nov 2013, In: FASEB Journal. 27, 11, p. 4406-4418 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Estrogens
  • Gene expression
  • Chromatin
  • liquiritigenin

• Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass

  Bartell, S. M., Han, L., Kim, H. N., Kim, S. H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Chambliss, K. L., Shaul, P. W., Roberson, P. K., Weinstein, R. S., Jilka, R. L., Almeida, M. & Manolagas, S. C., Apr 1 2013, In: Molecular Endocrinology. 27, 4, p. 649-656 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendrimers
  • Cortical Bone
  • Estrogen Receptors
  • Estrogens
  • Skeleton

• The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization

  Zhao, Y., Park, S., Bagchi, M. K., Taylor, R. N. & Katzenellenbogen, B. S., Mar 1 2013, In: Endocrinology. 154, 3, p. 1349-1360 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stromal Cells
  • Estrogen Receptors
  • Pregnancy Maintenance
  • Interleukin-11
  • 8-Bromo Cyclic Adenosine Monophosphate
• 2016

  Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

  Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 24 2016, In: Science Signaling. 9, 429, ra53.

  Research output: Contribution to journal › Article › peer-review

  • Tissue
  • Estrogens
  • Blood Vessels
  • Ligands
  • Estrogen Receptors

• Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

  Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G., Feb 1 2016, In: Molecular Nutrition and Food Research. 60, 2, p. 369-380 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycyrrhiza
  • licorice
  • fatty liver
  • isoliquiritigenin
  • Human Mammary Glands

• Differential utilization of nuclear and extranuclear receptor signaling pathways in the actions of estrogens, SERMs, and a tissue-selective estrogen complex (TSEC)

  Madak-Erdogan, Z., Gong, P. & Katzenellenbogen, B. S., Apr 1 2016, In: Journal of Steroid Biochemistry and Molecular Biology. 158, p. 198-206 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Conjugated (USP) Estrogens
  • Selective Estrogen Receptor Modulators
  • Cytoplasmic and Nuclear Receptors
  • Tissue
  • Estrogens

• Endocrine treatment in breast cancer: Cure, resistance and beyond

  Tryfonidis, K., Zardavas, D., Katzenellenbogen, B. S. & Piccart, M., Nov 1 2016, In: Cancer Treatment Reviews. 50, p. 68-81 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • Breast Neoplasms
  • Tumor Microenvironment
  • Therapeutics
  • Hormones
  • Biomarkers

• Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

  Fanning, S. W., Mayne, C. G., Dharmarajan, V., Carlson, K. E., Martin, T. A., Novick, S. J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B. S., Tajkhorshid, E., Griffin, P. R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J. A. & Greene, G. L., Feb 2 2016, In: eLife. 5, FEBRUARY2016, e12792.

  Research output: Contribution to journal › Article › peer-review

  • Conformations
  • Estrogen Receptor alpha
  • Estrogen Receptor Modulators
  • Breast Neoplasms
  • Mutation

• Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

  Gong, P., Madak-Erdogan, Z., Flaws, J. A., Shapiro, D. J., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Dec 5 2016, In: Molecular and Cellular Endocrinology. 437, p. 190-200 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Aryl Hydrocarbon Receptors
  • Estrogen Receptors
  • Estrogens
  • Gene expression
  • Crosstalk

• Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

  Boonmuen, N., Gong, P., Ali, Z., Chittiboyina, A. G., Khan, I., Doerge, D. R., Helferich, W. G., Carlson, K. E., Martin, T., Piyachaturawat, P., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2016, In: Steroids. 105, p. 42-49 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dietary supplements
  • liquiritigenin
  • isoliquiritigenin
  • Glycyrrhiza
  • Selective Estrogen Receptor Modulators

• Multiple beneficial roles of repressor of estrogen receptor activity (REA) in suppressing the progression of endometriosis

  Zhao, Y., Chen, Y., Kuang, Y., Bagchi, M. K., Taylor, R. N., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 2016, In: Endocrinology. 157, 2, p. 900-912 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Endometriosis
  • Estrogen Receptors
  • Tissue Donors
  • prohibitin
  • Estradiol Receptors

• Nonnuclear estrogen receptor activation improves hepatic steatosis in female mice

  Chambliss, K. L., Barrera, J., Umetani, M., Umetani, J., Kim, S. H., Madak-Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C. & Shaul, P. W., 2016, In: Endocrinology. 157, 10, p. 3731-3741 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendrimers
  • Estrogen Receptors
  • Estrogens
  • Liver
  • Adiposity

• OCT-4: A novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells

  Bhatt, S., Stender, J. D., Joshi, S., Wu, G. & Katzenellenbogen, B. S., Nov 3 2016, In: Oncogene. 35, 44, p. 5722-5734 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Tamoxifen
  • Estrogen Receptors
  • Breast Neoplasms
  • Binding Sites
  • MCF-7 Cells

• Science Signaling podcast for 24 May 2016: Designer estrogens

  Katzenellenbogen, B. S., Katzenellenbogen, J. A., Madak-Erdogan, Z. & Van hook, A. M., May 24 2016, In: Science Signaling. 9, 429, pc13.

  Research output: Contribution to journal › Review article › peer-review

  • Webcasts
  • Estrogens
  • Metabolism
  • Bone
  • Estradiol Congeners

• The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

  Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L. A., Shariat-Madar, Z., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K., Feb 1 2016, In: Archives of Biochemistry and Biophysics. 591, p. 98-110 13 p.

  Research output: Contribution to journal › Article › peer-review

  • dioscin
  • Dioscorea
  • Saponins
  • Cells
  • Breast Neoplasms
• 2017

  Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells

  Min, J., Guillen, V. S., Sharma, A., Zhao, Y., Ziegler, Y., Gong, P., Mayne, C. G., Srinivasan, S., Kim, S. H., Carlson, K. E., Nettles, K. W., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jul 27 2017, In: Journal of Medicinal Chemistry. 60, 14, p. 6321-6336 16 p.

  Research output: Contribution to journal › Article › peer-review

  • acrylic acid
  • Estrogen Receptor Modulators
  • Estrogen Receptors
  • Breast Neoplasms
  • Down-Regulation

• Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

  Nelson, A. W., Groen, A. J., Miller, J. L., Warren, A. Y., Holmes, K. A., Tarulli, G. A., Tilley, W. D., Katzenellenbogen, B. S., Hawse, J. R., Gnanapragasam, V. J. & Carroll, J. S., Jan 15 2017, In: Molecular and Cellular Endocrinology. 440, p. 138-150 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor beta
  • Cells
  • Estrogen Receptors
  • Tissue
  • Cell Line

• Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer

  Lu, W. & Katzenellenbogen, B. S., Aug 1 2017, In: Hormones and Cancer. 8, 4, p. 230-242 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Breast Neoplasms
  • Apoptosis
  • Gene Expression
  • Histones

• Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms

  Martin, A., Yu, J., Xiong, J., Khalid, A. B., Katzenellenbogen, B., Kim, S. H., Katzenellenbogen, J. A., Malaivijitnond, S., Gabet, Y., Krum, S. A. & Frenkel, B., Dec 2017, In: Journal of Cellular Physiology. 232, 12, p. 3798-3807 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoblasts
  • Dihydrotestosterone
  • Androgens
  • Membranes
  • Estrogens

• Full antagonism of the estrogen receptor without a prototypical ligand side chain

  Srinivasan, S., Nwachukwu, J. C., Bruno, N. E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Cavett, V., Zhou, H. B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B. S., Griffin, P. R., Katzenellenbogen, J. A. & Nettles, K. W., Jan 1 2017, In: Nature chemical biology. 13, 1, p. 111-118 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Ligands
  • Breast Neoplasms
  • Chemoprevention
  • Patient Compliance

• Membrane and nuclear estrogen receptor alpha actions: From tissue specificity to medical implications

  Arnal, J. F., Lenfant, F., Metivier, R., Flouriot, G., Henrion, D., Adlanmerini, M., Fontaine, C., Gourdy, P., Chambon, P., Katzenellenbogen, B. & Katzenellenbogen, J., Jul 2017, In: Physiological Reviews. 97, 3, p. 1045-1087 43 p.

  Research output: Contribution to journal › Review article › peer-review

  • Organ Specificity
  • Estrogen Receptor alpha
  • Nuclear Envelope
  • Steroids
  • Membranes

• MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression

  Christenson, J. L., Butterfield, K. T., Spoelstra, N. S., Norris, J. D., Josan, J. S., Pollock, J. A., McDonnell, D. P., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Richer, J. K., Apr 1 2017, In: Hormones and Cancer. 8, 2, p. 69-77 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mouse mammary tumor virus
  • Triple Negative Breast Neoplasms
  • Androgen Receptors
  • Neoplasm Antigens
  • Breast Neoplasms

• Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

  Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W. & Murphy, E., Jun 1 2017, In: Journal of Molecular and Cellular Cardiology. 107, p. 41-51 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Reperfusion Injury
  • Estrogen Receptors
  • Endothelium
  • Dendrimers

• Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

  Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In: Cancer Research. 77, 20, p. 5602-5613 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor Modulators
  • Estrogen Receptors
  • Breast Neoplasms
  • Neoplasms
  • Inbred NOD Mouse
• 2019

  Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

  Ziegler, Y., Laws, M. J., Sanabria Guillen, V., Kim, S. H., Dey, P., Smith, B. P., Gong, P., Bindman, N., Zhao, Y., Carlson, K., Yasuda, M. A., Singh, D., Li, Z., El-Ashry, D., Madak-Erdogan, Z., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Dec 1 2019, In: npj Breast Cancer. 5, 1, 45.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms
  • Growth
  • Forkhead Box Protein M1
  • In Vitro Techniques
  • Triple Negative Breast Neoplasms