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• 2019

  Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

  Ziegler, Y., Laws, M. J., Sanabria Guillen, V., Kim, S. H., Dey, P., Smith, B. P., Gong, P., Bindman, N., Zhao, Y., Carlson, K., Yasuda, M. A., Singh, D., Li, Z., El-Ashry, D., Madak-Erdogan, Z., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Dec 1 2019, In: npj Breast Cancer. 5, 1, 45.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms
  • Growth
  • Forkhead Box Protein M1
  • In Vitro Techniques
  • Triple Negative Breast Neoplasms
• 2018

  Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain

  Sharma, A., Toy, W., Guillen, V. S., Sharma, N., Min, J., Carlson, K. E., Mayne, C. G., Lin, S., Sabio, M., Greene, G., Katzenellenbogen, B. S., Chandarlapaty, S. & Katzenellenbogen, J. A., Dec 21 2018, In: ACS chemical biology. 13, 12, p. 3374-3384 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor Modulators
  • Estrogen Receptors
  • Ligands
  • Cell proliferation
  • Breast Neoplasms

• New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons

  Wang, L., Guillen, V. S., Sharma, N., Flessa, K., Min, J., Carlson, K. E., Toy, W., Braqi, S., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Chandarlapaty, S. & Sharma, A., Aug 9 2018, In: ACS Medicinal Chemistry Letters. 9, 8, p. 803-808 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Scaffolds
  • Fulvestrant
  • Proteins
  • Cell proliferation

• Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

  Miranda, C. L., Johnson, L. A., De Montgolfier, O., Elias, V. D., Ullrich, L. S., Hay, J. J., Paraiso, I. L., Choi, J., Reed, R. L., Revel, J. S., Kioussi, C., Bobe, G., Iwaniec, U. T., Turner, R. T., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Blakemore, P. R., Gombart, A. F., Maier, C. S., Raber, J. & 1 others, Stevens, J. F., Dec 1 2018, In: Scientific reports. 8, 1, 613.

  Research output: Contribution to journal › Article › peer-review

  • xanthohumol
  • Obese Mice
  • High Fat Diet
  • Cognitive Dysfunction
  • Insulin Resistance

• Predominant role of nuclear versus membrane estrogen receptor α in arterial protection: Implications for estrogen receptor α modulation in cardiovascular prevention/safety

  Guivarc’h, E., Buscato, M., Guihot, A. L., Favre, J., Vessières, E., Grimaud, L., Wakim, J., Melhem, N. J., Zahreddine, R., Adlanmerini, M., Loufrani, L., Knauf, C., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Foidart, J. M., Gourdy, P., Lenfant, F., Arnal, J. F., Henrion, D. & Fontaine, C., Jul 1 2018, In: Journal of the American Heart Association. 7, 13, e008950.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Envelope
  • Estrogen Receptors
  • Safety
  • Estrogens
  • Estetrol

• Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation

  Vinel, A., Coudert, A. E., Buscato, M., Valera, M. C., Ostertag, A., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Berdal, A., Babajko, S., Arnal, J. F. & Fontaine, C., Aug 2018, In: Journal of Bone and Mineral Research. 33, 8, p. 1520-1531 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mandible
  • Estrogen Receptors
  • Bone and Bones
  • Membranes
  • Estrogens

• Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice

  Selvaraj, U. M., Zuurbier, K. R., Whoolery, C. W., Plautz, E. J., Chambliss, K. L., Kong, X., Zhang, S., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C., Shaul, P. W. & Stowe, A. M., 2018, In: Endocrinology. 159, 11, p. 3848-3859 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Estrogens
  • Middle Cerebral Artery Infarction
  • Stroke
  • Uterine Neoplasms

• Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

  Katzenellenbogen, J. A., Mayne, C. G., Katzenellenbogen, B. S., Greene, G. L. & Chandarlapaty, S., Jun 1 2018, In: Nature Reviews Cancer. 18, 6, p. 377-388 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Estrogen Receptors
  • Ligands
  • Mutation
  • Androgen Receptors
  • Breast Neoplasms
• 2015

  Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

  Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C. M., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 21 2015, In: Science Translational Medicine. 7, 271, 271ra9.

  Research output: Contribution to journal › Article › peer-review

  • Endometriosis
  • Estrogen Receptors
  • Estrogens
  • Fertility
  • Ligands

• Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

  Paterni, I., Bertini, S., Granchi, C., Tuccinardi, T., Macchia, M., Martinelli, A., Caligiuri, I., Toffoli, G., Rizzolio, F., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Minutolo, F., Feb 12 2015, In: Journal of Medicinal Chemistry. 58, 3, p. 1184-1194 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Glioma
  • Estrogens
  • Heterografts
  • Ligands

• Ligand accessibility and bioactivity of a hormone-dendrimer conjugate depend on pH and pH history

  Kim, S. H., Madak-Erdogan, Z., Bae, S. C., Carlson, K. E., Mayne, C. G., Granick, S., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Aug 19 2015, In: Journal of the American Chemical Society. 137, 32, p. 10326-10335 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendrimers
  • Estrogens
  • Poly(amidoamine)
  • Hormones
  • Bioactivity

• Protective hematopoietic effect of estrogens in a mouse model of thrombosis: Respective roles of nuclear versus membrane estrogen receptor α

  Valera, M. C., Fontaine, C., Lenfant, F., Cabou, C., Guillaume, M., Smirnova, N., Kim, S. H., Chambon, P., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Payrastre, B. & Arnal, J. F., Nov 2015, In: Endocrinology. 156, 11, p. 4293-4301 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Nuclear Envelope
  • Estrogen Receptors
  • Estrogens
  • Thrombosis

• Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination

  Poitelon, Y., Bogni, S., Matafora, V., Della-Flora Nunes, G., Hurley, E., Ghidinelli, M., Katzenellenbogen, B. S., Taveggia, C., Silvestri, N., Bachi, A., Sannino, A., Wrabetz, L. & Feltri, M. L., Sep 18 2015, In: Nature communications. 6, 8303.

  Research output: Contribution to journal › Article › peer-review

  • Neuroglia
  • Molecules
  • axons
  • molecules
  • prohibitin

• The activation function-1 of estrogen receptor alpha prevents arterial neointima development through a direct effect on smooth muscle cells

  Smirnova, N. F., Fontaine, C., Buscato, M., Lupieri, A., Vinel, A., Valera, M. C., Guillaume, M., Malet, N., Foidart, J. M., Raymond-Letron, I., Lenfant, F., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Laffargue, M. & Arnal, J. F., Oct 9 2015, In: Circulation Research. 117, 9, p. 770-777 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Neointima
  • Estrogen Receptor alpha
  • Estrogen Receptors
  • Smooth Muscle Myocytes
  • Vascular Smooth Muscle
• 2014

  Endocrine Society 2014 Laureate Awards

  Gustafsson, J. A., Katzenellenbogen, B., Jameson, J. L., Roth, J., Melmed, S., McDonnell, D., Wartofsky, L., Crowley, W. F., Griz, L. H. E., Becker, C., Moore, D. D., Drucker, D., Singh, N. & O'Malley, B., Oct 1 2014, In: Hormones & cancer. 5, 5, p. 339-355 17 p.

  Research output: Contribution to journal › Article › peer-review

• Estrogen-induced CCN1 Is critical for establishment of endometriosis-like lesions in mice

  Zhao, Y., Li, Q., Katzenellenbogen, B. S., Lau, L. F., Taylor, R. N., Bagchi, I. C. & Bagchi, M. K., 2014, In: Molecular Endocrinology. 28, 12, p. 1934-1947 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Endometriosis
  • Estrogens
  • Choristoma
  • Vascular Endothelial Growth Factor C
  • Cell Proliferation

• Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells

  Clark, S., Rainville, J., Zhao, X., Katzenellenbogen, B. S., Pfaff, D. & Vasudevan, N., 2014, In: Journal of Steroid Biochemistry and Molecular Biology. 139, p. 45-53 9 p.

  Research output: Contribution to journal › Article › peer-review

  • estradiol-bovine serum albumin
  • Transcription
  • Neuroblastoma
  • Estrogen Receptors
  • Transcriptional Activation

• Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

  Aumsuwan, P., Khan, S. I., Khan, I. A., Avula, B., Walker, L. A., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K., Jan 2014, In: In Vitro Cellular and Developmental Biology - Animal. 51, 1, p. 59-71 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dioscorea
  • 5-methyldeoxycytidine
  • 5-hydroxymethylcytosine
  • Epigenomics
  • MCF-7 Cells

• Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response

  Mir, M., Bergamaschi, A., Katzenellenbogen, B. S. & Popescu, G., Feb 18 2014, In: PloS one. 9, 2, e89000.

  Research output: Contribution to journal › Article › peer-review

  • Light interference
  • Growth kinetics
  • Cell growth
  • Microscopic examination
  • Cells

• Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer

  Holton, S. E., Bergamaschi, A., Katzenellenbogen, B. S. & Bhargava, R., May 9 2014, In: PloS one. 9, 5, e96878.

  Research output: Contribution to journal › Article › peer-review

  • Fibroblasts
  • Endocrine Cells
  • breast neoplasms
  • Cells
  • neoplasm cells

• Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer

  Madak-Erdogan, Z., Ventrella, R., Petry, L. & Katzenellenbogen, B. S., May 2014, In: Molecular Cancer Research. 12, 5, p. 714-727 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Actin Depolymerizing Factors
  • Estrogen Receptors
  • Actins
  • Breast Neoplasms
  • Hormones

• The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells

  Bergamaschi, A., Madak-Erdogan, Z., Kim, Y. J., Choi, Y. L., Lu, H. & Katzenellenbogen, B. S., 2014, In: Breast Cancer Research. 16, 1, 436.

  Research output: Contribution to journal › Article › peer-review

  • Forkhead Transcription Factors
  • Neoplastic Stem Cells
  • Estrogen Receptors
  • Breast Neoplasms
  • Forkhead Box Protein M1

• The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

  Abot, A., Fontaine, C., Buscato, M., Solinhac, R., Flouriot, G., Fabre, A., Drougard, A., Rajan, S., Laine, M., Milon, A., Muller, I., Henrion, D., Adlanmerini, M., Valéra, M. C., Gompel, A., Gerard, C., Péqueux, C., Mestdagt, M., Raymond-Letron, I., Knauf, C. & 9 others, Ferriere, F., Valet, P., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Lenfant, F., Greene, G. L., Foidart, J. M. & Arnal, J. F., Oct 1 2014, In: EMBO Molecular Medicine. 6, 10, p. 1328-1346 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Estetrol
  • Nuclear Envelope
  • Estrogen Receptors
  • Blood Vessels
  • Furylfuramide

• Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens

  Gong, P., Madak-Erdogan, Z., Li, J., Cheng, J., Greenlief, C. M., Helferich, W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., 2014, In: Nuclear receptor signaling. 12, p. e001

  Research output: Contribution to journal › Article › peer-review

  • Gene Regulatory Networks
  • Estrogen Receptors
  • Estrogens
  • Gene Expression
  • Glycyrrhiza
• 2012

  Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140

  Madak-Erdogan, Z. & Katzenellenbogen, B. S., Feb 2012, In: Toxicological Sciences. 125, 2, p. 401-411 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Receptor Co-Repressor 1
  • Aryl Hydrocarbon Receptors
  • Gene expression
  • Estrogen Receptors
  • Chromatin

• Macrophage-elicited loss of estrogen receptor-α in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus

  Stossi, F., Madak-Erdoǧan, Z. & Katzenellenbogen, B. S., Apr 5 2012, In: Oncogene. 31, 14, p. 1825-1834 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinases
  • Estrogen Receptors
  • Macrophages
  • Breast Neoplasms
  • Macrophage Activation

• Phosphorylation by p38 mitogen-activated protein kinase promotes estrogen receptor α turnover and functional activity via the SCF^skp2 proteasomal complex

  Bhatt, S., Xiao, Z., Meng, Z. & Katzenellenbogen, B. S., May 2012, In: Molecular and cellular biology. 32, 10, p. 1928-1943 16 p.

  Research output: Contribution to journal › Article › peer-review

  • p38 Mitogen-Activated Protein Kinases
  • Estrogen Receptors
  • Phosphorylation
  • Breast Neoplasms
  • Estrogens

• Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance

  Bergamaschi, A. & Katzenellenbogen, B. S., Jan 5 2012, In: Oncogene. 31, 1, p. 39-47 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Cancer 3
  • Tamoxifen
  • MicroRNAs
  • Cell Survival
  • Down-Regulation

• Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA

  Park, S., Yoon, S., Zhao, Y., Park, S. E., Liao, L., Xu, J., Lydon, J. P., DeMayo, F. J., O'Malley, B. W., Bagchi, M. K. & Katzenellenbogen, B. S., Aug 1 2012, In: Endocrinology. 153, 8, p. 3982-3994 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Dosage
  • Cytoplasmic and Nuclear Receptors
  • Fertility
  • Infertility
  • Estrogen Receptors
• 2010

  Activation of ERα is necessary for estradiol's anorexigenic effect in female rats

  Santollo, J., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Eckel, L. A., Nov 2010, In: Hormones and Behavior. 58, 5, p. 872-877 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Estradiol
  • Eating
  • Estrogen Receptor Antagonists
  • Hormones

• Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs)

  Kieser, K. J., Kim, D. W., Carlson, K. E., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Apr 22 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3320-3329 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • acrylic acid
  • Ligands
  • bicyclo(3.3.1)nonane
  • Cyclofenil

• Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

  Wong, W. P. S., Tiano, J. P., Liu, S., Hewitt, S. C., Le May, C., Dalle, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Korach, K. S. & Mauvais-Jarvis, F., Jul 20 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 29, p. 13057-13062 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Insulin
  • Response Elements
  • Islets of Langerhans
  • Estrogens

• Genome-wide analysis of estrogen receptor α DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

  Stender, J. D., Kim, K., Charn, T. H., Komm, B., Chang, K. C. N., Kraus, W. L., Benner, C., Glass, C. K. & Katzenellenbogen, B. S., Aug 2010, In: Molecular and cellular biology. 30, 16, p. 3943-3955 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Estrogen Receptors
  • Transcriptional Activation
  • Genome
  • Response Elements

• Genome-wide dynamics of chromatin binding of estrogen receptors α and β: Mutual restriction and competitive site selection

  Charn, T. H., Liu, E. T. B., Chang, E. C., Lee, Y. K., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 2010, In: Molecular Endocrinology. 24, 1, p. 47-59 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Chromatin
  • Binding Sites
  • Genome
  • Cytoplasmic and Nuclear Receptors

• Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

  Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In: Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Uterine Neoplasms
  • Dendrimers
  • Estrogen Receptors
  • Estrogens
  • Breast Neoplasms

• Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

  Marshall, G. M., Gherardi, S., Xu, N., Neiron, Z., Trahair, T., Scarlett, C. J., Chang, D. K., Liu, P. Y., Jankowski, K., Iraci, N., Haber, M., Norris, M. D., Keating, J., Sekyere, E., Jonquieres, G., Stossi, F., Katzenellenbogen, B. S., Biankin, A. V., Perini, G. & Liu, T., Nov 4 2010, In: Oncogene. 29, 44, p. 5957-5968 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin G2
  • Histone Deacetylase 2
  • Histone Deacetylases
  • Up-Regulation
  • Neuroblastoma