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  • Jie Chen
2019

Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

Zhang, Q., Duplany, A., Moncollin, V., Mouradian, S., Goillot, E., Mazelin, L., Gauthier, K., Streichenberger, N., Angleraux, C., Chen, J., Ding, S., Schaeffer, L. & Gangloff, Y. G., Feb 2019, In : Journal of Cachexia, Sarcopenia and Muscle. 10, 1, p. 35-53 19 p.

Research output: Contribution to journalArticle

Lentivirus-mediated RNAi in skeletal myogenesis

Kim, D., Reyes-Ordoñez, A. & Chen, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 95-110 16 p. (Methods in Molecular Biology; vol. 1889).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

Son, K., You, J. S., Yoon, M. S., Dai, C., Kim, J. H., Khanna, N., Banerjee, A., Martinis, S. A., Han, G., Han, J. M., Kim, S. & Chen, J., May 1 2019, In : Journal of Clinical Investigation. 129, 5, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

Open Access
2017

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

Arif, A., Terenzi, F., Potdar, A. A., Jia, J., Sacks, J., China, A., Halawani, D., Vasu, K., Li, X., Brown, J. M., Chen, J., Kozma, S. C., Thomas, G. & Fox, P. L., Feb 16 2017, In : Nature. 542, 7641, p. 357-361 5 p.

Research output: Contribution to journalArticle

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals

He, C., Zeng, M., Dutta, D., Koh, T. H., Chen, J. & Van Der Donk, W. A., Jan 20 2017, In : Scientific reports. 7, 40980.

Research output: Contribution to journalArticle

α7β1 integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise

Mahmassani, Z. S., Son, K., Pincu, Y., Munroe, M., Drnevich, J., Chen, J. & Boppart, M. D., May 11 2017, In : American Journal of Physiology - Cell Physiology. 312, 5, p. 638-650 13 p.

Research output: Contribution to journalArticle

2016

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

Yoon, M. S., Son, K., Arauz, E., Han, J. M., Kim, S. & Chen, J., Aug 9 2016, In : Cell Reports. 16, 6, p. 1510-1517 8 p.

Research output: Contribution to journalArticle

Single-Molecule Analysis of Lipid-Protein Interactions in Crude Cell Lysates

Arauz, E., Aggarwal, V., Jain, A., Ha, T. & Chen, J., May 3 2016, In : Analytical chemistry. 88, 8, p. 4269-4276 8 p.

Research output: Contribution to journalArticle

2015

Rapid mitogenic regulation of the mTORC1 Inhibitor, DEPTOR, by phosphatidic acid

Yoon, M. S., Rosenberger, C. L., Wu, C., Truong, N., Sweedler, J. V. & Chen, J., May 7 2015, In : Molecular cell. 58, 3, p. 549-556 8 p.

Research output: Contribution to journalArticle

2014

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

Fang, X., Nevo, E., Han, L., Levanon, E. Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., Fishman, A., Feng, Y., Sher, N., Xiong, Z., Hankeln, T., Huang, Z., Gorbunova, V., Zhang, L., Zhao, W., Wildman, D. E. & 33 others, Xiong, Y., Gudkov, A., Zheng, Q., Rechavi, G., Liu, S., Bazak, L., Chen, J., Knisbacher, B. A., Lu, Y., Shams, I., Gajda, K., Farré, M., Kim, J., Lewin, H. A., Ma, J., Band, M., Bicker, A., Kranz, A., Mattheus, T., Schmidt, H., Seluanov, A., Azpurua, J., McGowen, M. R., Ben Jacob, E., Li, K., Peng, S., Zhu, X., Liao, X., Li, S., Krogh, A., Zhou, X., Brodsky, L. & Wang, J., Jun 3 2014, In : Nature communications. 5, 3966.

Research output: Contribution to journalArticle

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt

Zeng, M., Van Der Donk, W. A. & Chen, J., Dec 1 2014, In : Molecular biology of the cell. 25, 24, p. 3954-3961 8 p.

Research output: Contribution to journalArticle

MicroRNA-146b promotes myogenic differentiation and modulates multiple gene targets in muscle cells

Khanna, N., Ge, Y. & Chen, J., Jun 23 2014, In : PloS one. 9, 6, e100657.

Research output: Contribution to journalArticle

Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown

Jain, A., Arauz, E., Aggarwal, V., Ikon, N., Chen, J. & Ha, T., Dec 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17833-17838 6 p.

Research output: Contribution to journalArticle

2013

Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis

Yoon, M. S. & Chen, J., Dec 1 2013, In : Molecular biology of the cell. 24, 23, p. 3754-3763 10 p.

Research output: Contribution to journalArticle

Duration of rapamycin treatment has differential effects on metabolism in mice

Fang, Y., Westbrook, R., Hill, C., Boparai, R. K., Arum, O., Spong, A., Wang, F., Javors, M. A., Chen, J., Sun, L. Y. & Bartke, A., Mar 5 2013, In : Cell Metabolism. 17, 3, p. 456-462 7 p.

Research output: Contribution to journalArticle

Flt3L is a novel regulator of skeletal myogenesis

Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., 2013, In : Journal of cell science. 126, 15, p. 3370-3379 10 p.

Research output: Contribution to journalArticle

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

He, Y., Li, D., Cook, S. L., Yoon, M. S., Kapoor, A., Rao, C. V., Kenis, P. J. A., Chen, J. & Wang, F., Nov 1 2013, In : Molecular biology of the cell. 24, 21, p. 3369-3380 12 p.

Research output: Contribution to journalArticle

Mechanistic target of rapamycin controls homeostasis of adipogenesis

Yoon, M. S., Zhang, C., Sun, Y., Schoenherr, C. J. & Chen, J., Aug 1 2013, In : Journal of Lipid Research. 54, 8, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation

Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., Jul 2 2013, In : PloS one. 8, 7, e68068.

Research output: Contribution to journalArticle

XPLN is an endogenous inhibitor of mTORC2

Khanna, N., Fang, Y., Yoon, M. S. & Chen, J., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 15979-15984 6 p.

Research output: Contribution to journalArticle

2012

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Zhang, C., Wendel, A. A., Keogh, M. R., Harris, T. E., Chen, J. & Coleman, R. A., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1667-1672 6 p.

Research output: Contribution to journalArticle

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., Sztalryd, C., Bennett, M. J., Ahima, R. S., Birnbaum, M. J. & Lazar, M. A., Jun 1 2012, In : Nature Medicine. 18, 6, p. 934-942 9 p.

Research output: Contribution to journalArticle

Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis

Ge, Y. & Chen, J., Dec 21 2012, In : Journal of Biological Chemistry. 287, 52, p. 43928-43935 8 p.

Research output: Contribution to journalShort survey

2011

Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway

Yoon, M. S., Du, G., Backer, J. M., Frohman, M. A. & Chen, J., Oct 31 2011, In : Journal of Cell Biology. 195, 3, p. 435-447 13 p.

Research output: Contribution to journalArticle

IGF-II is regulated by microRNA-125b in skeletal myogenesis

Ge, Y., Sun, Y. & Chen, J., Jan 10 2011, In : Journal of Cell Biology. 192, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

MicroRNAs in skeletal myogenesis

Ge, Y. & Chen, J., Feb 1 2011, In : Cell Cycle. 10, 3, p. 441-448 8 p.

Research output: Contribution to journalReview article

Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect

Yoon, M. S., Sun, Y., Arauz, E., Jiang, Y. & Chen, J., Aug 26 2011, In : Journal of Biological Chemistry. 286, 34, p. 29568-29574 7 p.

Research output: Contribution to journalArticle

Probing cellular protein complexes using single-molecule pull-down

Jain, A., Liu, R., Ramani, B., Arauz, E., Ishitsuka, Y., Ragunathan, K., Park, J., Chen, J., Xiang, Y. K. & Ha, T., May 26 2011, In : Nature. 473, 7348, p. 484-488 5 p.

Research output: Contribution to journalArticle

Raptor and rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1)

Ge, Y., Yoon, M. S. & Chen, J., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35675-35682 8 p.

Research output: Contribution to journalArticle