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• 2016

  Standardization for natural product synthetic biology

  Zhao, H. & Medema, M. H., Aug 2016, In: Natural Product Reports. 33, 8, p. 920-924 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Synthetic biology
  • Synthetic Biology
  • Biological Products
  • Standardization
  • Multigene Family

• TALE proteins search DNA using a rotationally decoupled mechanism

  Cuculis, L., Abil, Z., Zhao, H. & Schroeder, C. M., Oct 1 2016, In: Nature chemical biology. 12, 10, p. 831-837 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Transcription Activator-Like Effectors
  • DNA-Binding Proteins
  • DNA
  • Proteins
  • Nucleic Acid Conformation

• Tandem reactions combining biocatalysts and chemical catalysts for asymmetric synthesis

  Wang, Y. & Zhao, H., Dec 1 2016, In: Catalysts. 6, 12, 194.

  Research output: Contribution to journal › Review article › peer-review

  • Biocatalysts
  • catalysts
  • Catalysis
  • Catalysts
  • catalysis

• Use of genome-editing tools to treat sickle cell disease

  Tasan, I., Jain, S. & Zhao, H., Sep 1 2016, In: Human Genetics. 135, 9, p. 1011-1028 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Gene Editing
  • Sickle Cell Anemia
  • Globins
  • CRISPR-Associated Protein 9
  • Zinc Finger Nucleases
• 2015

  Alginate lyases from alginate-degrading Vibrio splendidus 12B01 are endolytic

  Badur, A. H., Jagtap, S. S., Yalamanchili, G., Lee, J. K., Zhao, H. & Rao, C. V., Jan 1 2015, In: Applied and environmental microbiology. 81, 5, p. 1865-1873 9 p.

  Research output: Contribution to journal › Article › peer-review

  • poly(beta-D-mannuronate) lyase
  • Vibrio splendidus
  • alginate lyase
  • Vibrio
  • alginate

• A Rewritable, Random-Access DNA-Based Storage System

  Tabatabaei Yazdi, S. M. H., Yuan, Y., Ma, J., Zhao, H. & Milenkovic, O., Sep 18 2015, In: Scientific reports. 5, 14138.

  Research output: Contribution to journal › Article › peer-review

  • DNA
  • Information Storage and Retrieval
  • Sensitivity and Specificity

• Building biological foundries for next-generation synthetic biology

  Chao, R., Yuan, Y. B. & Zhao, H. M., Jul 24 2015, In: Science China Life Sciences. 58, 7, p. 658-665 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Synthetic biology
  • Synthetic Biology
  • synthetic biology
  • Foundries
  • Metabolites

• Chromatin architecture reorganization during stem cell differentiation

  Dixon, J. R., Jung, I., Selvaraj, S., Shen, Y., Antosiewicz-Bourget, J. E., Lee, A. Y., Ye, Z., Kim, A., Rajagopal, N., Xie, W., Diao, Y., Liang, J., Zhao, H., Lobanenkov, V. V., Ecker, J. R., Thomson, J. A. & Ren, B., Feb 19 2015, In: Nature. 518, 7539, p. 331-336 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromatin
  • Cell Differentiation
  • Stem Cells
  • Human Embryonic Stem Cells
  • Cell Lineage

• Development of a One-Pot tandem reaction combining ruthenium-catalyzed alkene metathesis and enantioselective enzymatic oxidation to produce Aryl epoxides

  Denard, C. A., Bartlett, M. J., Wang, Y., Lu, L., Hartwig, J. F. & Zhao, H., Jun 5 2015, In: ACS Catalysis. 5, 6, p. 3817-3822 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Ruthenium
  • Alkenes
  • Epoxy Compounds
  • Olefins
  • Enantioselectivity

• Development of a Synthetic Malonyl-CoA Sensor in Saccharomyces cerevisiae for Intracellular Metabolite Monitoring and Genetic Screening

  Li, S., Si, T., Wang, M. & Zhao, H., Dec 18 2015, In: ACS synthetic biology. 4, 12, p. 1308-1315 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Malonyl Coenzyme A
  • Metabolites
  • Yeast
  • Genetic Testing
  • Screening

• Direct observation of TALE protein dynamics reveals a two-state search mechanism

  Cuculis, L., Abil, Z., Zhao, H. & Schroeder, C. M., Jun 1 2015, In: Nature communications. 6, 7277.

  Research output: Contribution to journal › Article › peer-review

  • Transcription Activator-Like Effectors
  • effectors
  • proteins
  • Observation
  • deoxyribonucleic acid

• DNA-Based Storage: Trends and Methods

  Yazdi, S. M. H. T., Kiah, H. M., Garcia-Ruiz, E., Ma, J., Zhao, H. & Milenkovic, O., Sep 2015, In: IEEE Transactions on Molecular, Biological, and Multi-Scale Communications. 1, 3, p. 230-248 19 p., 7423733.

  Research output: Contribution to journal › Article › peer-review

  • DNA
  • Trends
  • Storage System
  • Archives
  • Random Access

• Editorial overview: Opportunities and challenges in synthetic biology

  Chang, M. C. Y. & Zhao, H., Oct 1 2015, In: Current Opinion in Chemical Biology. 28, p. 5-6 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Engineered biosynthesis of natural products in heterologous hosts

  Luo, Y., Li, B. Z., Liu, D., Zhang, L., Chen, Y., Jia, B., Zeng, B. X., Zhao, H. & Yuan, Y. J., Aug 7 2015, In: Chemical Society Reviews. 44, 15, p. 5265-5290 26 p.

  Research output: Contribution to journal › Article › peer-review

  • Biosynthesis
  • Biological Products
  • Genes
  • Polyketides
  • Terpenes

• Engineering reprogrammable RNA-binding proteins for study and manipulation of the transcriptome

  Abil, Z. & Zhao, H., Jul 6 2015, In: Molecular BioSystems. 11, 10, p. 2658-2665 8 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA-Binding Proteins
  • Transcriptome
  • Protein Engineering
  • RNA
  • RNA-Binding Motifs

• High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System

  Cobb, R. E., Wang, Y. & Zhao, H., Jun 19 2015, In: ACS synthetic biology. 4, 6, p. 723-728 6 p.

  Research output: Contribution to journal › Article › peer-review

  • CRISPR-Cas Systems
  • Gene Editing
  • Streptomyces
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Genes

• High throughput screening and selection methods for directed enzyme evolution

  Xiao, H., Bao, Z. & Zhao, H., Apr 29 2015, In: Industrial and Engineering Chemistry Research. 54, 16, p. 4011-4020 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Enzymes
  • Screening
  • Throughput
  • Costs

• Homology-Integrated CRISPR-Cas (HI-CRISPR) System for One-Step Multigene Disruption in Saccharomyces cerevisiae

  Bao, Z., Xiao, H., Liang, J., Zhang, L., Xiong, X., Sun, N., Si, T. & Zhao, H., May 15 2015, In: ACS synthetic biology. 4, 5, p. 585-594 10 p.

  Research output: Contribution to journal › Article › peer-review

  • CRISPR-Associated Proteins
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Yeast
  • Saccharomyces cerevisiae
  • Proteins

• Illinois Biological Foundry for Advanced Biomanufacturing (iBioFAB)

  Zhao, H., Jan 1 2015, Synthetic Biology: Engineering, Evolution, and Design Conference 2015, SEED 2015. AIChE, p. 784-785 2 p. (Synthetic Biology: Engineering, Evolution, and Design Conference 2015, SEED 2015; vol. 2).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Improving and repurposing biocatalysts via directed evolution

  Denard, C. A., Ren, H. & Zhao, H., Apr 1 2015, In: Current Opinion in Chemical Biology. 25, p. 55-64 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Enzymes
  • Stereoselectivity
  • Biocatalysis
  • Chemical reactivity
  • Protein Engineering

• Industrial biotechnology: Tools and applications

  Zhao, H. & Tan, T., Nov 15 2015, In: Biotechnology Advances. 33, 7, p. 1393-1394 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• In Situ Assembly of Antifouling/Bacterial Silver Nanoparticle-Hydrogel Composites with Controlled Particle Release and Matrix Softening

  Baek, K., Liang, J., Lim, W. T., Zhao, H., Kim, D. H. & Kong, H., Jul 22 2015, In: ACS Applied Materials and Interfaces. 7, 28, p. 15359-15367 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Silver nanoparticles
  • Hydrogels
  • Polyethylene Glycol Dimethacrylate Hydrogel
  • Gels
  • Composite materials

• Metabolic engineering of Saccharomyces cerevisiae to improve 1-hexadecanol production

  Feng, X., Lian, J. & Zhao, H., Jan 1 2015, In: Metabolic Engineering. 27, p. 10-19 10 p.

  Research output: Contribution to journal › Article › peer-review

  • cetyl alcohol
  • Metabolic engineering
  • Metabolic Engineering
  • Yeast
  • Saccharomyces cerevisiae

• Orthogonal Fatty Acid Biosynthetic Pathway Improves Fatty Acid Ethyl Ester Production in Saccharomyces cerevisiae

  Eriksen, D. T., HamediRad, M., Yuan, Y. & Zhao, H., Jul 17 2015, In: ACS synthetic biology. 4, 7, p. 808-814 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Biosynthetic Pathways
  • Fatty acids
  • Yeast
  • Esters
  • Saccharomyces cerevisiae

• Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid synthase in E. coli

  Coursolle, D., Lian, J., Shanklin, J. & Zhao, H., Jun 17 2015, In: Molecular BioSystems. 11, 9, p. 2464-2472 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Type I Fatty Acid Synthase
  • Alkanes
  • Oxygenases
  • Aldehyde Reductase
  • Alcohols

• Rapid prototyping of microbial cell factories via genome-scale engineering

  Si, T., Xiao, H. & Zhao, H., Nov 15 2015, In: Biotechnology Advances. 33, 7, p. 1420-1432 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Rapid prototyping
  • Industrial plants
  • Genes
  • Genome
  • Nucleotides

• Recent advances in combinatorial biosynthesis for drug discovery

  Sun, H., Liu, Z., Zhao, H. & Ang, E. L., Feb 12 2015, In: Drug Design, Development and Therapy. 9, p. 823-833 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Drug Discovery
  • Biological Products
  • Biosynthetic Pathways
  • Biodiversity
  • Pharmaceutical Preparations

• Recent advances in DNA assembly technologies

  Chao, R., Yuan, Y. & Zhao, H., 2015, In: FEMS yeast research. 15, 1, 12171.

  Research output: Contribution to journal › Short survey › peer-review

  • Technology
  • DNA
  • Synthetic Biology
  • Metabolic Engineering
  • Digestion

• Regulatory RNA-assisted genome engineering in microorganisms

  Si, T., HamediRad, M. & Zhao, H., Dec 1 2015, In: Current Opinion in Biotechnology. 36, p. 85-90 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • RNA
  • Microorganisms
  • Genes
  • Genome
  • Metabolic engineering

• Reversal of the β-oxidation cycle in saccharomyces cerevisiae for production of fuels and chemicals

  Lian, J. & Zhao, H., Mar 20 2015, In: ACS synthetic biology. 4, 3, p. 332-341 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Yeast
  • Saccharomyces cerevisiae
  • Oxidation
  • Fatty Acids
  • 1-Butanol

• RNAi-assisted genome evolution in saccharomyces cerevisiae for complex phenotype engineering

  Si, T., Luo, Y., Bao, Z. & Zhao, H., Mar 20 2015, In: ACS synthetic biology. 4, 3, p. 283-291 9 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA
  • Yeast
  • RNA Interference
  • Saccharomyces cerevisiae
  • Genes

• Selective elimination of mitochondrial mutations in the germline by genome editing

  Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S. R., Williams, S. L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C. R., Liu, G. H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O'Callaghan, M. & 5 others, Campistol, J., Zhao, H., Campistol, J. M., Moraes, C. T. & Izpisua Belmonte, J. C., Apr 23 2015, In: Cell. 161, 3, p. 459-469 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Editing
  • Germ-Line Mutation
  • Mitochondrial DNA
  • Genes
  • Mitochondrial Diseases

• Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor

  Cobb, R. E., Bae, B., Li, Z., Desieno, M. A., Nair, S. K. & Zhao, H., Feb 14 2015, In: Chemical Communications. 51, 13, p. 2526-2528 3 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(N-acetyl-N-hydroxy)aminopropylphosphonic acid
  • xylulose-5-phosphate
  • Biosynthesis
  • Phosphates
  • Antimalarials

• Synthetic biology for therapeutic applications

  Abil, Z., Xiong, X. & Zhao, H., Feb 2 2015, In: Molecular pharmaceutics. 12, 2, p. 322-331 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Synthetic Biology
  • Bacterial Drug Resistance
  • Drug Discovery
  • Communicable Diseases
  • Vaccines

• Systematic Identification of a Panel of Strong Constitutive Promoters from Streptomyces albus

  Luo, Y., Zhang, L., Barton, K. W. & Zhao, H., Apr 29 2015, In: ACS synthetic biology. 4, 9, p. 1001-1010 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Actinobacteria
  • Streptomyces
  • Biological Products
  • Biosynthetic Pathways
  • Gene encoding
• 2014

  Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism

  Wang, M., Beissner, M. & Zhao, H., Feb 20 2014, In: Chemistry and Biology. 21, 2, p. 257-263 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Polyketide Synthases
  • Polyketides
  • Aldehydes
  • non-ribosomal peptide synthase
  • Aspergillus

• A single-chain TALEN architecture for genome engineering

  Sun, N. & Zhao, H., Mar 1 2014, In: Molecular BioSystems. 10, 3, p. 446-453 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Transcription Activator-Like Effector Nucleases
  • Genome
  • DNA Cleavage
  • Peptides
  • Deoxyribonuclease I

• A synthetic device for intracellular mRNA transport and local protein translation in eukaryotes

  Abil, Z., Hoogenraad, C. & Zhao, H., 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. AIChE, Vol. 1. p. 104-113 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Carrier Proteins
  • RNA transport
  • Messenger RNA
  • Protein Biosynthesis
  • transport proteins

• A two-plasmid bacterial selection system for characterization and engineering of homing endonucleases

  Sun, N. & Zhao, H., 2014, Homing Endonucleases: Methods and Protocols. Humana Press Inc., p. 87-96 10 p. (Methods in Molecular Biology; vol. 1123).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Endonucleases
  • Plasmids
  • DNA Cleavage
  • Double-Stranded DNA Breaks
  • Cell Survival

• Characterization and engineering of the adenylation domain of a NRPS-like protein: A potential biocatalyst for aldehyde generation

  Wang, M. & Zhao, H., Apr 4 2014, In: ACS Catalysis. 4, 4, p. 1219-1225 7 p.

  Research output: Contribution to journal › Article › peer-review

  • non-ribosomal peptide synthase
  • Biocatalysts
  • Aldehydes
  • Peptides
  • Staphylococcal Protein A

• Characterization of the N-oxygenase AurF from Streptomyces thioletus

  Chanco, E., Choi, Y. S., Sun, N., Vu, M. & Zhao, H., Oct 15 2014, In: Bioorganic and Medicinal Chemistry. 22, 20, p. 5569-5577 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-nitrobenzoic acid
  • Methylphenazonium Methosulfate
  • Oxygenases
  • Streptomyces
  • aureothin

• Cloning and characterization of a galactitol 2-dehydrogenase from Rhizobium legumenosarum and its application in d-tagatose production

  Jagtap, S. S., Singh, R., Kang, Y. C., Zhao, H. & Lee, J. K., May 10 2014, In: Enzyme and Microbial Technology. 58-59, p. 44-51 8 p.

  Research output: Contribution to journal › Article › peer-review

  • galactitol 2-dehydrogenase
  • tagatose
  • Rhizobium
  • Oxidoreductases
  • Cloning

• Comparative biochemical characterization of three exolytic oligoalginate lyases from Vibrio splendidus reveals complementary substrate scope, temperature, and pH adaptations

  Jagtap, S. S., Hehemann, J. H., Polz, M. F., Lee, J. K. & Zhao, H., 2014, In: Applied and environmental microbiology. 80, 14, p. 4207-4214 8 p.

  Research output: Contribution to journal › Article › peer-review

  • poly(beta-D-mannuronate) lyase
  • Vibrio splendidus
  • alginate lyase
  • Vibrio
  • alginate

• Cooperative tandem catalysis by an organometallic complex and a metalloenzyme

  Denard, C. A., Huang, H., Bartlett, M. J., Lu, L., Tan, Y., Zhao, H. & Hartwig, J. F., Jan 7 2014, In: Angewandte Chemie - International Edition. 53, 2, p. 465-469 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Organometallics
  • Catalysis
  • Catalysts
  • Alkenes
  • Olefins

• Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains

  Lian, J., Si, T., Nair, N. U. & Zhao, H., 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. American Institute of Chemical Engineers, p. 750-760 11 p. (Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting; vol. 2).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Acetyl Coenzyme A
  • Butenes
  • Yeast
  • 1-Butanol
  • butanol

• Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains

  Lian, J., Si, T., Nair, N. U. & Zhao, H., Jul 2014, In: Metabolic Engineering. 24, p. 139-149 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetyl Coenzyme A
  • Butenes
  • Yeast
  • 1-Butanol
  • Saccharomyces cerevisiae

• Directed evolution of a cellodextrin transporter for improved biofuel production under anaerobic conditions in Saccharomyces cerevisiae

  Lian, J., Li, Y., HamediRad, M. & Zhao, H., Aug 2014, In: Biotechnology and bioengineering. 111, 8, p. 1521-1531 11 p.

  Research output: Contribution to journal › Article › peer-review

  • cellodextrin
  • Cellobiose
  • Biofuels
  • Yeast
  • Fermentation

• Directed evolution of enzymes for industrial biocatalysis

  Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2014, Industrial Biocatalysis. Pan Stanford Publishing Pte. Ltd., p. 73-114 42 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• DNA assembly techniques for next-generation combinatorial biosynthesis of natural products

  Cobb, R. E., Ning, J. C. & Zhao, H., Feb 2014, In: Journal of Industrial Microbiology and Biotechnology. 41, 2, p. 469-477 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Biosynthesis
  • DNA
  • Biological Products
  • Biosynthetic Pathways
  • Synthetic biology

• Engineered pentafunctional minicellulosome for simultaneous saccharification and ethanol fermentation in Saccharomyces cerevisiae

  Liang, Y., Si, T., Ang, E. L. & Zhao, H., Jan 1 2014, In: Applied and environmental microbiology. 80, 21, p. 6677-6684 8 p.

  Research output: Contribution to journal › Article › peer-review

  • ethanol fermentation
  • saccharification
  • Fermentation
  • yeast
  • ethanol