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  • Huimin Zhao
2011

Altering Enzyme Substrate and Cofactor Specificity via Protein Engineering

Desieno, M., Du, J. & Zhao, H., Mar 9 2011, Protein Engineering Handbook, Volume 1 & Volume 2. Wiley-VCH, Vol. 2. p. 777-796 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A new fluorescence complementation biosensor for detection of estrogenic compounds

Mclachlan, M. J., Katzenellenbogen, J. A. & Zhao, H., Dec 2011, In : Biotechnology and bioengineering. 108, 12, p. 2794-2803 10 p.

Research output: Contribution to journalArticle

Cell surface display of functional human MHC class II proteins: Yeast display versus insect cell display

Wen, F., Sethi, D. K., Wucherpfennig, K. W. & Zhao, H., Sep 1 2011, In : Protein Engineering, Design and Selection. 24, 9, p. 701-709 9 p.

Research output: Contribution to journalArticle

Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Desieno, M. A., Van Der Donk, W. A. & Zhao, H., Sep 28 2011, In : Chemical Communications. 47, 36, p. 10025-10027 3 p.

Research output: Contribution to journalArticle

Cloning and characterization of a type III polyketide synthase from Aspergillus niger

Li, J., Luo, Y., Lee, J. K. & Zhao, H., Oct 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 20, p. 6085-6089 5 p.

Research output: Contribution to journalArticle

Combinatorial optimization of a highly efficient xylose utilization pathway in saccharomyces cerevisiae

Du, J., Kim, B. & Zhao, H., Dec 1 2011, 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings. (11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo

Evans, B. S., Chen, Y., Metcalf, W. W., Zhao, H. & Kelleher, N. L., May 27 2011, In : Chemistry and Biology. 18, 5, p. 601-607 7 p.

Research output: Contribution to journalArticle

Drug Discovery and Development by Combinatorial Biosynthesis

Desieno, M. A., Denard, C. A. & Zhao, H., May 25 2011, Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis. John Wiley and Sons, p. 251-283 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Engineering microbial factories for synthesis of value-added products

Du, J., Shao, Z. & Zhao, H., Aug 2011, In : Journal of Industrial Microbiology and Biotechnology. 38, 8, p. 873-890 18 p.

Research output: Contribution to journalReview article

Engineering saccharomyces cerevisiae for biofuel production from lignocellulosic biomass

Du, J. & Zhao, H., Dec 1 2011, 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings. (11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Further biochemical studies on aminopyrrolnitrin oxygenase (PrnD)

Tiwari, M. K., Lee, J. K., Moon, H. J. & Zhao, H., May 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 10, p. 2873-2876 4 p.

Research output: Contribution to journalArticle

Genome-scale consequences of cofactor balancing in engineered pentose utilization pathways in Saccharomyces cerevisiae

Ghosh, A., Zhao, H. & Price, N. D., Nov 4 2011, In : PloS one. 6, 11, e27316.

Research output: Contribution to journalArticle

Highlights of biocatalysis and biomimetic catalysis

Zhao, H., Sep 2 2011, In : ACS Catalysis. 1, 9, p. 1119-1120 2 p.

Research output: Contribution to journalEditorial

New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF

Bae, B., Cobb, R. E., DeSieno, M. A., Zhao, H. & Nair, S. K., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 36132-36141 10 p.

Research output: Contribution to journalArticle

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler

Shao, Z., Luo, Y. & Zhao, H., Apr 1 2011, In : Molecular BioSystems. 7, 4, p. 1056-1059 4 p.

Research output: Contribution to journalArticle

Synthetic biology: Putting synthesis into biology

Liang, J., Luo, Y. & Zhao, H., Jan 2011, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 3, 1, p. 7-20 14 p.

Research output: Contribution to journalReview article

2012

A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

Jeya, M., Kim, T. S., Kumar Tiwari, M., Li, J., Zhao, H. & Lee, J. K., Dec 2012, In : Molecular BioSystems. 8, 12, p. 3103-3106 4 p.

Research output: Contribution to journalArticle

Biocatalyst development by directed evolution

Wang, M., Si, T. & Zhao, H., Jul 2012, In : Bioresource Technology. 115, p. 117-125 9 p.

Research output: Contribution to journalArticle

Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae

Sun, J., Shao, Z., Zhao, H., Nair, N., Wen, F., Xu, J. H. & Zhao, H., Aug 2012, In : Biotechnology and bioengineering. 109, 8, p. 2082-2092 11 p.

Research output: Contribution to journalArticle

CmlI is an N-oxygenase in the biosynthesis of chloramphenicol

Lu, H., Chanco, E. & Zhao, H., Sep 16 2012, In : Tetrahedron. 68, 37, p. 7651-7654 4 p.

Research output: Contribution to journalArticle

Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration

Zou, Y., Zhang, H., Brunzelle, J. S., Johannes, T. W., Woodyer, R., Hung, J. E., Nair, N., Van Der Donk, W. A., Zhao, H. & Nair, S. K., May 29 2012, In : Biochemistry. 51, 21, p. 4263-4270 8 p.

Research output: Contribution to journalArticle

Customized optimization of metabolic pathways by combinatorial transcriptional engineering

Du, J., Yuan, Y., Si, T., Lian, J. & Zhao, H., Oct 2012, In : Nucleic acids research. 40, 18, p. e142

Research output: Contribution to journalArticle

Direct cloning of large genomic sequences

Cobb, R. E. & Zhao, H., May 1 2012, In : Nature Biotechnology. 30, 5, p. 405-406 2 p.

Research output: Contribution to journalShort survey

Direct conversion of xylan to ethanol by recombinant Saccharomyces cerevisiae strains displaying an engineered minihemicellulosome

Sun, J., Wen, F., Si, T., Xu, J. H. & Zhao, H., Jun 2012, In : Applied and environmental microbiology. 78, 11, p. 3837-3845 9 p.

Research output: Contribution to journalArticle

Directed evolution: An evolving and enabling synthetic biology tool

Cobb, R. E., Si, T. & Zhao, H., Aug 1 2012, In : Current Opinion in Chemical Biology. 16, 3-4, p. 285-291 7 p.

Research output: Contribution to journalReview article

DNA assembler: A synthetic biology tool for characterizing and engineering natural product gene clusters

Shao, Z. & Zhao, H., 2012, Natural Product Biosynthesis by Microorganisms and Plants, Part C. Academic Press Inc., p. 203-224 22 p. (Methods in Enzymology; vol. 517).

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA assembler method for construction of zeaxanthin-producing strains of saccharomyces cerevisiae

Shao, Z., Luo, Y. & Zhao, H., 2012, Microbial Carotenoids From Fungi: Methods and Protocols. Jose-Luis, B. (ed.). p. 251-262 12 p. (Methods in Molecular Biology; vol. 898).

Research output: Chapter in Book/Report/Conference proceedingChapter

Improving the thermostability of lipase Lip2 from Yarrowia lipolytica

Wen, S., Tan, T. & Zhao, H., Dec 5 2012, In : Journal of Biotechnology. 164, 2, p. 248-253 6 p.

Research output: Contribution to journalArticle

Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase

Hung, J. E., Fogle, E. J., Christman, H. D., Johannes, T. W., Zhao, H., Metcalf, W. W. & Van Der Donk, W. A., May 29 2012, In : Biochemistry. 51, 21, p. 4254-4262 9 p.

Research output: Contribution to journalArticle

Mechanistic studies on the flavin:NADH reductase (PrnF) from Pseudomonas fluorescens involved in arylamine oxygenation

Tiwari, M. K., Singh, R. K., Lee, J. K. & Zhao, H., Feb 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 3, p. 1344-1347 4 p.

Research output: Contribution to journalArticle

Mutagenic inverted repeats assisted genome engineering (MIRAGE) in saccharomyces cerevisiae: Deletion of gal7

Nair, N. U. & Zhao, H., Jan 20 2012, Microbial Metabolic Engineering: Methods and Protocols. Cheng, Q. (ed.). p. 63-73 11 p. (Methods in Molecular Biology; vol. 834).

Research output: Chapter in Book/Report/Conference proceedingChapter

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease

Sun, N., Liang, J., Abil, Z. & Zhao, H., Mar 1 2012, In : Molecular BioSystems. 8, 4, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

Recent advances in targeted genome engineering in mammalian systems

Sun, N., Abil, Z. & Zhao, H., Sep 2012, In : Biotechnology Journal. 7, 9, p. 1074-1087 14 p.

Research output: Contribution to journalReview article

Role of conserved glycine in zinc-dependent medium chain dehydrogenase/reductase superfamily

Tiwari, M. K., Singh, R. K., Singh, R., Jeya, M., Zhao, H. & Lee, J. K., Jun 1 2012, In : Journal of Biological Chemistry. 287, 23, p. 19429-19439 11 p.

Research output: Contribution to journalArticle

Strain Improvement via Evolutionary Engineering

Kim, B., Du, J. & Zhao, H., Oct 24 2012, Engineering Complex Phenotypes in Industrial Strains. John Wiley and Sons, p. 111-131 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The Botrytis cinerea type III polyketide synthase shows unprecedented high catalytic efficiency toward long chain acyl-CoAs

Jeya, M., Kim, T. S., Tiwari, M. K., Li, J., Zhao, H. & Lee, J. K., Nov 1 2012, In : Molecular BioSystems. 8, 11, p. 2864-2867 4 p.

Research output: Contribution to journalArticle

2013

Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster

Luo, Y., Huang, H., Liang, J., Wang, M., Lu, L., Shao, Z., Cobb, R. E. & Zhao, H., Dec 5 2013, In : Nature communications. 4, 2894.

Research output: Contribution to journalArticle

Challenges and opportunities in synthetic biology for chemical engineers

Luo, Y., Lee, J. K. & Zhao, H., Nov 5 2013, In : Chemical Engineering Science. 103, p. 115-119 5 p.

Research output: Contribution to journalArticle

Combinatorial design of a highly efficient xylose-utilizing pathway in Saccharomyces cerevisiae for the production of cellulosic biofuels

Kim, B., Du, J., Eriksen, D. T. & Zhao, H., Feb 2013, In : Applied and environmental microbiology. 79, 3, p. 931-941 11 p.

Research output: Contribution to journalArticle

Construction and engineering of large biochemical pathways via DNA assembler

Shao, Z. & Zhao, H., 2013, Synthetic Biology. Polizzi, K. & Kontoravdi, C. (eds.). p. 85-106 22 p. (Methods in Molecular Biology; vol. 1073).

Research output: Chapter in Book/Report/Conference proceedingChapter

Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification

Wen, F. & Zhao, H., Sep 20 2013, Immunoproteomics: Methods and Protocols. Fulton, K. & Twine, S. (eds.). p. 245-264 20 p. (Methods in Molecular Biology; vol. 1061).

Research output: Chapter in Book/Report/Conference proceedingChapter

Coordinated induction of multi-gene pathways in Saccharomyces cerevisiae

Liang, J., Ning, J. C. & Zhao, H., Feb 2013, In : Nucleic acids research. 41, 4, p. e54

Research output: Contribution to journalArticle

Customized optimization of metabolic pathways by combinatorial transcriptional engineering.

Yuan, Y., Du, J. & Zhao, H., Aug 2 2013, In : Methods in molecular biology (Clifton, N.J.). 985, p. 177-209 33 p.

Research output: Contribution to journalArticle

Directed evolution: Past, present, and future

Cobb, R. E., Chao, R. & Zhao, H., May 2013, In : AIChE Journal. 59, 5, p. 1432-1440 9 p.

Research output: Contribution to journalArticle

Directed evolution as a powerful synthetic biology tool

Cobb, R. E., Sun, N. & Zhao, H., Mar 15 2013, In : Methods. 60, 1, p. 81-90 10 p.

Research output: Contribution to journalReview article

Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins

Eriksen, D. T., Hsieh, P. C. H., Lynn, P. & Zhao, H., Jun 26 2013, In : Microbial cell factories. 12, 1, 61.

Research output: Contribution to journalArticle

Directed evolution of a highly efficient cellobiose utilizing pathway in an industrial saccharomyces cerevisiae strain

Yuan, Y. & Zhao, H., Nov 2013, In : Biotechnology and bioengineering. 110, 11, p. 2874-2881 8 p.

Research output: Contribution to journalArticle

Directed evolution of phloroglucinol synthase PhlD with increased stability for phloroglucinol production

Rao, G., Lee, J. K. & Zhao, H., Jul 1 2013, In : Applied Microbiology and Biotechnology. 97, 13, p. 5861-5867 7 p.

Research output: Contribution to journalArticle

Drug Discovery and Development via Synthetic Biology

Cobb, R. E., Luo, Y., Freestone, T. & Zhao, H., Aug 27 2013, Synthetic Biology. Elsevier Inc., p. 183-206 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Engineering novel tandem catalytic reactions using organometallic catalysts and metalloenzymes

Denard, C. A., Huang, H., Lu, L., Bartlett, M. J., Hartwig, J. F. & Zhao, H., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, 1 p. (Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future).

Research output: Chapter in Book/Report/Conference proceedingConference contribution