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  • Eric Oldfield
2017

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase

Rao, G., Bansal, S., Law, W. X., O'Dowd, B., Dikanov, S. A. & Oldfield, E., Jul 25 2017, In : Biochemistry. 56, 29, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

2018

Structure–activity relationship investigation of coumarin–chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors

Kang, L., Gao, X. H., Liu, H. R., Men, X., Wu, H. N., Cui, P. W., Oldfield, E. & Yan, J. Y., Nov 1 2018, In : Molecular Diversity. 22, 4, p. 893-906 14 p.

Research output: Contribution to journalArticle

2020

SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes

Gil, Z., Martinez-Sotillo, N., Pinto-Martinez, A., Mejias, F., Martinez, J. C., Galindo, I., Oldfield, E. & Benaim, G., Feb 1 2020, In : Parasitology Research. 119, 2, p. 649-657 9 p.

Research output: Contribution to journalArticle

2017

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

2018

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

Xia, Y., Xie, Y., Yu, Z., Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X. & 3 others, Liu, W., Shi, Y. & Zhang, Y., Nov 1 2018, In : Cell. 175, 4, p. 1059-1073.e21

Research output: Contribution to journalArticle

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways

Malwal, S. R., O'Dowd, B., Feng, X., Turhanen, P., Shin, C., Yao, J., Kim, B. K., Baig, N., Zhou, T., Bansal, S., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 20 2018, In : Journal of the American Chemical Society. 140, 24, p. 7568-7578 11 p.

Research output: Contribution to journalArticle

2019

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W. X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C., Guo, R. T., Abdelkhalek, A., Seleem, M. N. & Oldfield, E., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2564-2581 18 p.

Research output: Contribution to journalArticle

2017

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors

O'Dowd, B., Williams, S., Wang, H., No, J. H., Rao, G., Wang, W., McCammon, J. A., Cramer, S. P. & Oldfield, E., May 18 2017, In : ChemBioChem. 18, 10, p. 914-920 7 p.

Research output: Contribution to journalArticle

2019

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Han, S., Li, X., Xia, Y., Yu, Z., Cai, N., Malwal, S. R., Han, X., Oldfield, E. & Zhang, Y., Dec 12 2019, In : Journal of Medicinal Chemistry. 62, 23, p. 10867-10896 30 p.

Research output: Contribution to journalArticle

2018

Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes

Malwal, S. R., Gao, J., Hu, X., Yang, Y., Liu, W., Huang, J. W., Ko, T. P., Li, L., Chen, C. C., O'Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., May 4 2018, In : ACS Catalysis. 8, 5, p. 4299-4312 14 p.

Research output: Contribution to journalArticle

Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design

Venkatramani, A., Gravina Ricci, C., Oldfield, E. & McCammon, J. A., Jun 2018, In : Chemical Biology and Drug Design. 91, 6, p. 1068-1077 10 p.

Research output: Contribution to journalEditorial

2019

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

Zhang, L., Ko, T. P., Malwal, S. R., Liu, W., Zhou, S., Yu, X., Oldfield, E., Guo, R. T. & Chen, C. C., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 800-805 6 p.

Research output: Contribution to journalArticle

2018

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Elsebaei, M. M., Mohammad, H., Abouf, M., Abutaleb, N. S., Hegazy, Y. A., Ghiaty, A., Chen, L., Zhang, J., Malwal, S. R., Oldfield, E., Seleem, M. N. & Mayhoub, A. S., Mar 25 2018, In : European Journal of Medicinal Chemistry. 148, p. 195-209 15 p.

Research output: Contribution to journalArticle

2019

Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Buter, J., Cheng, T. Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M. & 10 others, Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J. & Moody, D. B., Sep 1 2019, In : Nature chemical biology. 15, 9, p. 889-899 11 p.

Research output: Contribution to journalArticle

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

Song, J., Shang, N., Baig, N., Yao, J., Shin, C., Kim, B. K., Li, Q., Malwal, S. R., Oldfield, E., Feng, X. & Guo, R. T., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 517-523 7 p.

Research output: Contribution to journalArticle

2017

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in Vitro and in Vivo Results

Boulmier, A., Feng, X., Oms, O., Mialane, P., Rivière, E., Shin, C. J., Yao, J., Kubo, T., Furuta, T., Oldfield, E. & Dolbecq, A., Jul 3 2017, In : Inorganic Chemistry. 56, 13, p. 7558-7565 8 p.

Research output: Contribution to journalArticle

Combining Vγ9Vδ2 T cells with a lipophilic bisphosphonate efficiently kills activated hepatic stellate cells

Zhou, X., Gu, Y., Xiao, H., Kang, N., Xie, Y., Zhang, G., Shi, Y., Hu, X., Oldfield, E., Zhang, X. & Zhang, Y., Oct 24 2017, In : Frontiers in immunology. 8, OCT, 1381.

Research output: Contribution to journalArticle

2018

“Head-to-Middle” and “Head-to-Tail” cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

Gao, J., Ko, T. P., Chen, L., Malwal, S. R., Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., Jan 15 2018, In : Angewandte Chemie - International Edition. 57, 3, p. 683-687 5 p.

Research output: Contribution to journalArticle

2019

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

Yang, Y., Li, L., Yuan, L., Zhou, X., Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y. & 3 others, Oldfield, E., Guo, R. T. & Zhang, Y., Apr 16 2019, In : Immunity. 50, 4, p. 1043-1053.e5

Research output: Contribution to journalArticle