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  • Eric Oldfield
2016

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth

Desai, J., Wang, Y., Wang, K., Malwal, S. R. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 2205-2215 11 p.

Research output: Contribution to journalArticle

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase

Wang, Y., Desai, J., Zhang, Y., Malwal, S. R., Shin, C. J., Feng, X., Sun, H., Liu, G., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. 11, 20, p. 2311-2319 9 p.

Research output: Contribution to journalArticle

2017

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in Vitro and in Vivo Results

Boulmier, A., Feng, X., Oms, O., Mialane, P., Rivière, E., Shin, C. J., Yao, J., Kubo, T., Furuta, T., Oldfield, E. & Dolbecq, A., Jul 3 2017, In : Inorganic Chemistry. 56, 13, p. 7558-7565 8 p.

Research output: Contribution to journalArticle

Combining Vγ9Vδ2 T cells with a lipophilic bisphosphonate efficiently kills activated hepatic stellate cells

Zhou, X., Gu, Y., Xiao, H., Kang, N., Xie, Y., Zhang, G., Shi, Y., Hu, X., Oldfield, E., Zhang, X. & Zhang, Y., Oct 24 2017, In : Frontiers in immunology. 8, OCT, 1381.

Research output: Contribution to journalArticle

2019

Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Buter, J., Cheng, T. Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M. & 10 others, Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J. & Moody, D. B., Sep 1 2019, In : Nature chemical biology. 15, 9, p. 889-899 11 p.

Research output: Contribution to journalArticle

2016

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI

Li, J., Feng, X., Zhu, W., Oskolkov, N., Zhou, T., Kim, B. K., Baig, N., McMahon, M. T. & Oldfield, E., Jan 4 2016, In : Chemistry - A European Journal. 22, 1, p. 264-271 8 p.

Research output: Contribution to journalArticle

2019

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Han, S., Li, X., Xia, Y., Yu, Z., Cai, N., Malwal, S. R., Han, X., Oldfield, E. & Zhang, Y., Dec 12 2019, In : Journal of Medicinal Chemistry. 62, 23, p. 10867-10896 30 p.

Research output: Contribution to journalArticle

2017

Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors

O'Dowd, B., Williams, S., Wang, H., No, J. H., Rao, G., Wang, W., McCammon, J. A., Cramer, S. P. & Oldfield, E., May 18 2017, In : ChemBioChem. 18, 10, p. 914-920 7 p.

Research output: Contribution to journalArticle

2019

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

Song, J., Shang, N., Baig, N., Yao, J., Shin, C., Kim, B. K., Li, Q., Malwal, S. R., Oldfield, E., Feng, X. & Guo, R. T., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 517-523 7 p.

Research output: Contribution to journalArticle

2016

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5

Zhang, L., Chen, C. C., Ko, T. P., Huang, J. W., Zheng, Y., Liu, W., Wang, I., Malwal, S. R., Feng, X., Wang, K., Huang, C. H., Hsu, S. T. D., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4716-4720 5 p.

Research output: Contribution to journalArticle

Inhibition of Leishmania mexicana growth by the tuberculosis drug SQ109

García-García, V., Oldfield, E. & Benaim, G., Oct 2016, In : Antimicrobial Agents and Chemotherapy. 60, 10, p. 6386-6389 4 p.

Research output: Contribution to journalArticle

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

Yang, G., Zhu, W., Wang, Y., Huang, G., Byun, S. Y., Choi, G., Li, K., Huang, Z., Docampo, R., Oldfield, E. & No, J. H., Jan 8 2016, In : ACS Infectious Diseases. 1, 8, p. 388-398 11 p.

Research output: Contribution to journalArticle

2020

SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes

Gil, Z., Martinez-Sotillo, N., Pinto-Martinez, A., Mejias, F., Martinez, J. C., Galindo, I., Oldfield, E. & Benaim, G., Feb 1 2020, In : Parasitology Research. 119, 2, p. 649-657 9 p.

Research output: Contribution to journalArticle

2019

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

Yang, Y., Li, L., Yuan, L., Zhou, X., Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y. & 3 others, Oldfield, E., Guo, R. T. & Zhang, Y., Apr 16 2019, In : Immunity. 50, 4, p. 1043-1053.e5

Research output: Contribution to journalArticle

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

Zhang, L., Ko, T. P., Malwal, S. R., Liu, W., Zhou, S., Yu, X., Oldfield, E., Guo, R. T. & Chen, C. C., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 800-805 6 p.

Research output: Contribution to journalArticle

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W. X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C., Guo, R. T., Abdelkhalek, A., Seleem, M. N. & Oldfield, E., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2564-2581 18 p.

Research output: Contribution to journalArticle

2016

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

Yang, Y., Ko, T. P., Chen, C. C., Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M. R., Hsu, S. T. D., O'Dowd, B., Huff, H. C., Huang, C. H., Docampo, R., Oldfield, E. & Guo, R. T., May 20 2016, In : ACS chemical biology. 11, 5, p. 1362-1371 10 p.

Research output: Contribution to journalArticle

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

Ricci, C. G., Liu, Y. L., Zhang, Y., Wang, Y., Zhu, W., Oldfield, E. & McCammon, J. A., Sep 13 2016, In : Biochemistry. 55, 36, p. 5180-5190 11 p.

Research output: Contribution to journalArticle

Structure and Function of a "head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase

Liu, M., Chen, C. C., Chen, L., Xiao, X., Zheng, Y., Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E., Guo, R. T. & Ma, Y., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4721-4724 4 p.

Research output: Contribution to journalArticle

Structure and Function of Four Classes of the 4Fe-4S Protein, IspH

Rao, G. & Oldfield, E., Jul 26 2016, In : Biochemistry. 55, 29, p. 4119-4129 11 p.

Research output: Contribution to journalArticle

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 1915-1923 9 p.

Research output: Contribution to journalArticle

2017

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

2016

Back Cover: Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase (ChemMedChem 17/2016)

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. 11, 17, 1 p.

Research output: Contribution to journalComment/debate

2017

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase

Rao, G., Bansal, S., Law, W. X., O'Dowd, B., Dikanov, S. A. & Oldfield, E., Jul 25 2017, In : Biochemistry. 56, 29, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

2016

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journalArticle

2020

COVID-19 and Other Pandemics: How Might They Be Prevented?

Oldfield, E. & Malwal, S. R., Jul 10 2020, In : ACS Infectious Diseases. 6, 7, p. 1563-1566 4 p.

Research output: Contribution to journalArticle