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2015

A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen reduction

Mukherjee, S., Mukherjee, A., Bhagi-Damodaran, A., Mukherjee, M., Lu, Y. & Dey, A., Oct 12 2015, In : Nature communications. 6, 8467.

Research output: Contribution to journalArticle

electrocatalysts
Electrocatalysts
oxidase
cytochromes
Electron Transport Complex IV

Long-range electron transfer in engineered azurins exhibits Marcus inverted region behavior

Farver, O., Hosseinzadeh, P., Marshall, N. M., Wherland, S., Lu, Y. & Pecht, I., Jan 2 2015, In : Journal of Physical Chemistry Letters. 6, 1, p. 100-105 6 p.

Research output: Contribution to journalArticle

Azurin
electron transfer
Electrons
proteins
Proteins

A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme

Yu, Y., Cui, C., Liu, X., Petrik, I. D., Wang, J. & Lu, Y., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11570-11573 4 p.

Research output: Contribution to journalArticle

Oxidoreductases
Enzymes
catalyst
enzyme
electron
2017

“Dipstick” colorimetric detection of metal ions based on immobilization of DNAzyme and gold nanoparticles onto a lateral flow device

Mazumdar, D., Lan, T. & Lu, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 389-406 18 p. (Methods in Molecular Biology; vol. 1571).

Research output: Chapter in Book/Report/Conference proceedingChapter

Catalytic DNA
Immobilization
Gold
Nanoparticles
Metals

Biosynthetic approach to modeling and understanding metalloproteins using unnatural amino acids

Yu, Y., Cui, C., Wang, J. & Lu, Y., Feb 1 2017, In : Science China Chemistry. 60, 2, p. 188-200 13 p.

Research output: Contribution to journalReview article

Metalloproteins
Amino Acids
Enzymes
Azurin
Ribonucleotide Reductases
2018
Logic gates
Glucose
Enzymes
Catalytic DNA
Pyruvate Kinase
2017

Near-Infrared Photothermally Activated DNAzyme–Gold Nanoshells for Imaging Metal Ions in Living Cells

Wang, W., Satyavolu, N. S. R., Wu, Z., Zhang, J. R., Zhu, J. J. & Lu, Y., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 24, p. 6798-6802 5 p.

Research output: Contribution to journalArticle

Catalytic DNA
Nanoshells
Metal ions
Cells
Infrared radiation
2018

Translating molecular detections into a simple temperature test using a target-responsive smart thermometer

Zhang, J., Xing, H. & Lu, Y., Jan 1 2018, In : Chemical Science. 9, 16, p. 3906-3910 5 p.

Research output: Contribution to journalArticle

Thermometers
Liposomes
Coloring Agents
Phospholipases A2
DNA

Evidence of a General Acid-Base Catalysis Mechanism in the 8-17 DNAzyme

Cepeda-Plaza, M., McGhee, C. E. & Lu, Y., Mar 6 2018, In : Biochemistry. 57, 9, p. 1517-1522 6 p.

Research output: Contribution to journalArticle

Catalytic DNA
Catalysis
Guanine
Acids
Reaction rates
2016

Design of Heteronuclear Metalloenzymes

Bhagi-Damodaran, A., Hosseinzadeh, P., Mirts, E., Reed, J., Petrik, I. D. & Lu, Y., Jan 1 2016, Methods in Enzymology. Academic Press Inc., p. 501-537 37 p. (Methods in Enzymology; vol. 580).

Research output: Chapter in Book/Report/Conference proceedingChapter

Scaffolds
Metals
Proteins
Metal ions
Cytochrome-c Peroxidase
2019

CHAPTER 2: Design and Engineering of Heme Enzymes with O2-dependent Catalytic Activity

Cui, C., Reed, J. H., Mirts, E. N. & Lu, Y., Jan 1 2019, Dioxygen-dependent Heme Enzymes. Ikeda-Saito, M. & Raven, E. (eds.). 13 ed. Royal Society of Chemistry, p. 37-62 26 p. (RSC Metallobiology; vol. 2019-January, no. 13).

Research output: Chapter in Book/Report/Conference proceedingChapter

Heme
Catalyst activity
Enzymes
Oxidoreductases
Biological Phenomena
2018

Insights into the Competition between K+ and Pb2+ Binding to a G-Quadruplex and Discovery of a Novel K+-Pb2+-Quadruplex Intermediate

Yu, Z., Zhou, W., Ma, G., Li, Y., Fan, L., Li, X. & Lu, Y., Oct 11 2018, In : Journal of Physical Chemistry B. 122, 40, p. 9382-9388 7 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Cations
Positive ions
Electrospray ionization
Competitive Binding
2019

Point-of-care monitoring of intracellular glutathione and serum triglyceride levels using a versatile personal glucose meter

Xu, J., Qiao, X., Zhang, J., Cheng, N., Sheng, Q., Zheng, J., Cao, W., Yue, T. & Lu, Y., Apr 14 2019, In : Analytical Methods. 11, 14, p. 1849-1856 8 p.

Research output: Contribution to journalArticle

Coenzymes
Glutathione
Niacinamide
Glucose
Triglycerides
2015

Using the personal glucose meter to quantify a wide range of targets

Canyon, C., Lan, T., Xiang, Y. & Lu, Y., Jan 1 2015, Food, Pharmaceutical and Bioengineering Division 2015 - Core Programming Area at the 2015 AIChE Meeting. AIChE, p. 280-281 2 p. (Food, Pharmaceutical and Bioengineering Division 2015 - Core Programming Area at the 2015 AIChE Meeting; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Glucose
glucose
Costs and Cost Analysis
environmental monitoring
Environmental Monitoring

Identification of the Same Na+-Specific DNAzyme Motif from Two In Vitro Selections Under Different Conditions

Torabi, S. F. & Lu, Y., Dec 1 2015, In : Journal of Molecular Evolution. 81, 5-6, p. 225-234 10 p.

Research output: Contribution to journalArticle

Catalytic DNA
rare earth elements
rare earth element
gel
gels
2016

Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions

Hosseinzadeh, P., Mirts, E. N., Pfister, T. D., Gao, Y. G., Mayne, C., Robinson, H., Tajkhorshid, E. & Lu, Y., Mar 15 2016, In : Biochemistry. 55, 10, p. 1494-1502 9 p.

Research output: Contribution to journalArticle

manganese peroxidase
Cytochrome-c Peroxidase
Tuning
Metals
Mutation
2019

Enzyme-Mediated Endogenous and Bioorthogonal Control of a DNAzyme Fluorescent Sensor for Imaging Metal Ions in Living Cells

Lin, Y., Yang, Z., Lake, R. J., Zheng, C. & Lu, Y., Nov 18 2019, In : Angewandte Chemie - International Edition. 58, 47, p. 17061-17067 7 p.

Research output: Contribution to journalArticle

Catalytic DNA
Metal ions
Enzymes
Cells
Imaging techniques
Azurin
Nitrogen
nitrogen
Paramagnetic resonance
Electrons
2015

Nanomaterial-based biosensors using dual transducing elements for solution phase detection

Li, N., Su, X. & Lu, Y., May 7 2015, In : Analyst. 140, 9, p. 2916-2943 28 p.

Research output: Contribution to journalReview article

Nanostructures
Biosensing Techniques
transducer
Nanostructured materials
Biosensors
2016

Design of a single protein that spans the entire 2-V range of physiological redox potentials

Hosseinzadeh, P., Marshall, N. M., Chacón, K. N., Yu, Y., Nilges, M. J., New, S. Y., Tashkov, S. A., Blackburn, N. J. & Lu, Y., Jan 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Azurin
Metalloproteins
Surface Properties
Hydrogen
2017

DNAzyme sensors for detection of metal ions in the environment and imaging them in living cells

McGhee, C. E., Loh, K. Y. & Lu, Y., Jun 1 2017, In : Current Opinion in Biotechnology. 45, p. 191-201 11 p.

Research output: Contribution to journalReview article

Catalytic DNA
Metal ions
Metals
Cells
Ions
2019

A NIR Light Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals

Zhao, J., Chu, H., Zhao, Y., Lu, Y. & Li, L., May 1 2019, In : Journal of the American Chemical Society. 141, 17, p. 7056-7062 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Animals
DNA
Imaging techniques
Light
2015

A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

Pallares, R. M., Kong, S. L., Hui Ru, T., Thanh, N. T. K., Lu, Y. & Su, X., Aug 6 2015, In : Chemical Communications. 51, 77, p. 14524-14527 4 p.

Research output: Contribution to journalArticle

Nanosensors
Nanorods
Gold
DNA
Assays
2016

Design and engineering of artificial oxygen-activating metalloenzymes

Nastri, F., Chino, M., Maglio, O., Bhagi-Damodaran, A., Lu, Y. & Lombardi, A., Sep 21 2016, In : Chemical Society Reviews. 45, 18, p. 5020-5054 35 p.

Research output: Contribution to journalReview article

Oxygen
Enzymes
Metals
Proteins
2018

A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme

Mirts, E. N., Petrik, I. D., Hosseinzadeh, P., Nilges, M. J. & Lu, Y., Sep 14 2018, In : Science. 361, 6407, p. 1098-1101 4 p.

Research output: Contribution to journalArticle

Sulfites
Heme
Enzymes
Protons
Oxidoreductases Acting on Sulfur Group Donors
2016

Spectroscopic and Crystallographic Evidence for the Role of a Water-Containing H-Bond Network in Oxidase Activity of an Engineered Myoglobin

Petrik, I. D., Davydov, R., Ross, M., Zhao, X., Hoffman, B. & Lu, Y., Feb 3 2016, In : Journal of the American Chemical Society. 138, 4, p. 1134-1137 4 p.

Research output: Contribution to journalArticle

Myoglobin
Oxidoreductases
electron spin resonance
Oxygen
Heme
2018

O 2 Reduction by Biosynthetic Models of Cytochrome c Oxidase: Insights into Role of Proton Transfer Residues from Perturbed Active Sites Models of CcO

Mukherjee, S., Mukherjee, M., Mukherjee, A., Bhagi-Damodaran, A., Lu, Y. & Dey, A., Sep 7 2018, In : ACS Catalysis. 8, 9, p. 8915-8924 10 p.

Research output: Contribution to journalArticle

Proton transfer
Electron Transport Complex IV
Heme
Isotopes
Glutamic Acid
2015

Mechanistic Insight into DNA-Guided Control of Nanoparticle Morphologies

Tan, L. H., Yue, Y., Satyavolu, N. S. R., Ali, A. S., Wang, Z., Wu, Y. & Lu, Y., Oct 22 2015, In : Journal of the American Chemical Society. 137, 45, p. 14456-14464 9 p.

Research output: Contribution to journalArticle

Nanoparticles
DNA
Nanostructures
Nanostructured materials
Seed
2016

Size-dependent modulation of graphene oxide-aptamer interactions for an amplified fluorescence-based detection of aflatoxin B1 with a tunable dynamic range

Zhang, J., Li, Z., Zhao, S. & Lu, Y., Jul 7 2016, In : Analyst. 141, 13, p. 4029-4034 6 p.

Research output: Contribution to journalArticle

Aflatoxins
Aflatoxin B1
Graphite
Oxides
Graphene
2019

Silver-Assisted Synthesis of High-Indexed Palladium Tetrahexahedral Nanoparticles and Their Morphological Variants

Satyavolu, N. S. R., Peinetti, A. S., Wang, Y., Ali, A. S., Lin, J. W. & Lu, Y., Apr 23 2019, In : Chemistry of Materials. 31, 8, p. 2923-2929 7 p.

Research output: Contribution to journalArticle

Palladium
Silver
Nanoparticles
Interfacial energy
Seed
2018

DNA-encoded morphological evolution of bimetallic Pd@Au core-shell nanoparticles from a high-indexed core

Satyavolu, N. S. R., Pishevaresfahani, N., Tan, L. H. & Lu, Y., Sep 1 2018, In : Nano Research. 11, 9, p. 4549-4561 13 p.

Research output: Contribution to journalArticle

Seed
DNA
Nanoparticles
Palladium
Interfacial energy
2017

The "ok, molly" chemistry

Lu, Y., Jan 1 2017, In : Accounts of chemical research. 50, 3, p. 647-651 5 p.

Research output: Contribution to journalReview article

Education
2015

Significant improvement of oxidase activity through the genetic incorporation of a redox-active unnatural amino acid

Yu, Y., Zhou, Q., Wang, L., Liu, X., Zhang, W., Hu, M., Dong, J., Li, J., Lv, X., Ouyang, H., Li, H., Gao, F., Gong, W., Lu, Y. & Wang, J., Jul 1 2015, In : Chemical Science. 6, 7, p. 3881-3885 5 p.

Research output: Contribution to journalArticle

Oxidoreductases
Amino Acids
Electron Transport Complex IV
Tyrosine
Metalloproteins

Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups

Bai, Y., Xing, H., Wu, P., Feng, X., Hwang, K., Lee, J. M., Phang, X. Y., Lu, Y. & Zimmerman, S. C., Sep 1 2015, In : ACS Nano. 9, 10, p. 10227-10236 10 p.

Research output: Contribution to journalArticle

Functional groups
Tuning
tuning
Nanoparticles
nanoparticles
2017

Advances in the development of aptamer drug conjugates for targeted drug delivery

Chen, K., Liu, B., Yu, B., Zhong, W., Lu, Y., Zhang, J., Liao, J., Liu, J., Pu, Y., Qiu, L., Zhang, L., Liu, H. & Tan, W., May 1 2017, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 9, 3, e1438.

Research output: Contribution to journalReview article

Oligonucleotides
Biomarkers
Pharmaceutical Preparations
Medicine
Toxicity
2016

Effect of Outer-Sphere Side Chain Substitutions on the Fate of the trans Iron-Nitrosyl Dimer in Heme/Nonheme Engineered Myoglobins (FeBMbs): Insights into the Mechanism of Denitrifying NO Reductases

Matsumura, H., Chakraborty, S., Reed, J., Lu, Y. & Moënne-Loccoz, P., Apr 12 2016, In : Biochemistry. 55, 14, p. 2091-2099 9 p.

Research output: Contribution to journalArticle

Myoglobin
Heme
Dimers
Oxidoreductases
Substitution reactions
2015

Using aptamers to elucidate esophageal cancer clinical samples

Liu, Z., Lu, Y., Pu, Y., Liu, J., Liu, B., Yu, B., Chen, K., Fu, T., Yang, C. J., Liu, H. & Tan, W., Dec 21 2015, In : Scientific reports. 5, 18516.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Epithelial Cell Adhesion Molecule
Staining and Labeling
Antibody Binding Sites
Competitive Binding
2017

Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases

Bhagi-Damodaran, A., Michael, M. A., Zhu, Q., Reed, J., Sandoval, B. A., Mirts, E. N., Chakraborty, S., Moënne-Loccoz, P., Zhang, Y. & Lu, Y., Mar 1 2017, In : Nature Chemistry. 9, 3, p. 257-263 7 p.

Research output: Contribution to journalArticle

Heme
Copper
Iron
Metals
Chemical activation
2016

The Effects of Spacer Length and Composition on Aptamer-Mediated Cell-Specific Targeting with Nanoscale PEGylated Liposomal Doxorubicin

Xing, H., Li, J., Xu, W., Hwang, K., Wu, P., Yin, Q., Li, Z., Cheng, J. & Lu, Y., Jun 16 2016, In : ChemBioChem. p. 1111-1117 7 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Polyethylene glycols
Drug Delivery Systems
Liposomes
Chemical analysis
2015

Detection of protein biomarker using a blood glucose meter

Lan, T., Xiang, Y. & Lu, Y., Jan 1 2015, In : Methods in Molecular Biology. 1256, p. 99-109 11 p.

Research output: Contribution to journalArticle

Blood Glucose
Biomarkers
beta-Fructofuranosidase
Telemedicine
Body Fluids
2019

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

Zhang, J. J., Lan, T. & Lu, Y., Mar 21 2019, In : Advanced Healthcare Materials. 8, 6, 1801158.

Research output: Contribution to journalReview article

Nanostructures
Nucleic acids
Nanostructured materials
Nucleic Acids
Point-of-Care Systems
2018

Nitric Oxide Reductase Activity in Heme-Nonheme Binuclear Engineered Myoglobins through a One-Electron Reduction Cycle

Sabuncu, S., Reed, J. H., Lu, Y. & Moënne-Loccoz, P., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17389-17393 5 p.

Research output: Contribution to journalArticle

Myoglobin
Nitric oxide
nitric oxide
Heme
Electrons
2019

DNAzymes as Activity-Based Sensors for Metal Ions: Recent Applications, Demonstrated Advantages, Current Challenges, and Future Directions

Lake, R. J., Yang, Z., Zhang, J. J. & Lu, Y., Dec 17 2019, In : Accounts of chemical research. 52, 12, p. 3275-3286 12 p.

Research output: Contribution to journalArticle

Catalytic DNA
Metal ions
Sensors
Imaging techniques
Fluorophores
2016

Transforming the blood glucose meter into a general healthcare meter for in vitro diagnostics in mobile health

Lan, T., Zhang, J. & Lu, Y., May 1 2016, In : Biotechnology Advances. 34, 3, p. 331-341 11 p.

Research output: Contribution to journalReview article

Point-of-Care Systems
Telemedicine
Glucose
Blood Glucose
Blood
2019

S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials

Xia, L., Han, M. J., Zhou, L., Huang, A., Yang, Z., Wang, T., Li, F., Yu, L., Tian, C., Zang, Z., Yang, Q. Z., Liu, C., Hong, W., Lu, Y., Alfonta, L. & Wang, J., Nov 11 2019, In : Angewandte Chemie - International Edition. 58, 46, p. 16480-16484 5 p.

Research output: Contribution to journalArticle

Oxidoreductases
Enzymes
Electrochemical sensors
Electrodes
Electrons
2015

Regiospecific hetero-assembly of DNA-functionalized plasmonic upconversion superstructures

Li, L. L. & Lu, Y., Apr 29 2015, In : Journal of the American Chemical Society. 137, 16, p. 5272-5275 4 p.

Research output: Contribution to journalArticle

Nanoparticles
DNA
stoichiometry
Stoichiometry
nanoparticle
2019

Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors

Mirts, E. N., Bhagi-Damodaran, A. & Lu, Y., Apr 16 2019, In : Accounts of chemical research. 52, 4, p. 935-944 10 p.

Research output: Contribution to journalArticle

Azurin
Metal ions
Metals
Ions
Amino Acids
2017
Azurin
Electron transitions
Amides
Peptides
Electronic structure
2018

A new era for electron bifurcation

Peters, J. W., Beratan, D. N., Bothner, B., Dyer, R. B., Harwood, C. S., Heiden, Z. M., Hille, R., Jones, A. K., King, P. W., Lu, Y., Lubner, C. E., Minteer, S. D., Mulder, D. W., Raugei, S., Schut, G. J., Seefeldt, L. C., Tokmina-Lukaszewska, M., Zadvornyy, O. A., Zhang, P. & Adams, M. WW., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. 32-38 7 p.

Research output: Contribution to journalReview article

Electrons
Biochemical Phenomena
Anaerobiosis
Electron Transport Complex III
Redox reactions
2015

Graphene-DNAzyme junctions: A platform for direct metal ion detection with ultrahigh sensitivity

Gao, L., Li, L. L., Wang, X., Wu, P., Cao, Y., Liang, B., Li, X., Lin, Y., Lu, Y. & Guo, X., Apr 1 2015, In : Chemical Science. 6, 4, p. 2469-2473 5 p.

Research output: Contribution to journalArticle

Catalytic DNA
Graphite
Metal ions
Metals
Molecules