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• 2013

  XPLN is an endogenous inhibitor of mTORC2

  Khanna, N., Fang, Y., Yoon, M. S. & Chen, J., Oct 1 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 15979-15984 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 2
  • TOR Serine-Threonine Kinases
  • Guanine Nucleotide Exchange Factors
  • Mechanistic Target of Rapamycin Complex 1
  • Phosphotransferases

• Flt3L is a novel regulator of skeletal myogenesis

  Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., 2013, In: Journal of cell science. 126, 15, p. 3370-3379 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscle Development
  • Phosphotransferases
  • Ligands
  • Myoblasts
  • flt3 ligand protein

• RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation

  Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., Jul 2 2013, In: PloS one. 8, 7, e68068.

  Research output: Contribution to journal › Article › peer-review

  • myoblasts
  • Myoblasts
  • RNA Interference
  • cytokines
  • Cytokines
• 2012

  Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis

  Ge, Y. & Chen, J., Dec 21 2012, In: Journal of Biological Chemistry. 287, 52, p. 43928-43935 8 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Muscle Development
  • TOR Serine-Threonine Kinases
  • Cell growth
  • Nutrients
  • Sirolimus

• Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

  Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., Sztalryd, C., Bennett, M. J., Ahima, R. S., Birnbaum, M. J. & Lazar, M. A., Jun 1 2012, In: Nature Medicine. 18, 6, p. 934-942 9 p.

  Research output: Contribution to journal › Article › peer-review

  • histone deacetylase 3
  • Gluconeogenesis
  • Lipids
  • Perilipin-2
  • Insulin
• 2018

  Effects of rapamycin on growth hormone receptor knockout mice

  Fang, Y., Hill, C. M., Darcy, J., Reyes-Ordoñez, A., Arauz, E., McFadden, S., Zhang, C., Osland, J., Gao, J., Zhang, T., Frank, S. J., Javors, M. A., Yuan, R., Kopchick, J. J., Sun, L. Y., Chen, J. & Bartke, A., Feb 13 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. E1495-E1503

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 2
  • Somatotropin Receptors
  • Sirolimus
  • Knockout Mice
  • Mechanistic Target of Rapamycin Complex 1

• Mutually inhibitory Ras-PI(3,4)P₂ feedback loops mediate cell migration

  Li, X., Edwards, M., Swaney, K. F., Singh, N., Bhattacharya, S., Borleis, J., Long, Y., Iglesias, P. A., Chen, J. & Devreotes, P. N., Sep 25 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9125-E9134

  Research output: Contribution to journal › Article › peer-review

  • phosphoinositide-3,4-bisphosphate
  • Cell Movement
  • Phosphoric Monoester Hydrolases
  • phosphatidylinositol 3,4-diphosphate
  • Chemotactic Factors
• 2013

  Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis

  Yoon, M. S. & Chen, J., Dec 1 2013, In: Molecular biology of the cell. 24, 23, p. 3754-3763 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscle Development
  • TOR Serine-Threonine Kinases
  • Amino Acids
  • Phosphatidylinositol 3-Kinase
  • 1-dodecylpyridoxal
• 2018

  To Grow or Not to Grow: TOR and SnRK2 Coordinate Growth and Stress Response in Arabidopsis

  Rosenberger, C. L. & Chen, J., Jan 4 2018, In: Molecular cell. 69, 1, p. 3-4 2 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Arabidopsis
  • Growth
• 2013

  Duration of rapamycin treatment has differential effects on metabolism in mice

  Fang, Y., Westbrook, R., Hill, C., Boparai, R. K., Arum, O., Spong, A., Wang, F., Javors, M. A., Chen, J., Sun, L. Y. & Bartke, A., Mar 5 2013, In: Cell Metabolism. 17, 3, p. 456-462 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sirolimus
  • Longevity
  • Life Expectancy
  • Metabolome
  • Oxygen Consumption

• Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

  He, Y., Li, D., Cook, S. L., Yoon, M. S., Kapoor, A., Rao, C. V., Kenis, P. J. A., Chen, J. & Wang, F., Nov 1 2013, In: Molecular biology of the cell. 24, 21, p. 3369-3380 12 p.

  Research output: Contribution to journal › Article › peer-review

  • TOR Serine-Threonine Kinases
  • Chemotaxis
  • Actin Cytoskeleton
  • Neutrophils
  • Mechanistic Target of Rapamycin Complex 2
• 2018

  Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

  Kim, I. J., Lee, J., Oh, S. J., Yoon, M. S., Jang, S. S., Holland, R. L., Reno, M. L., Hamad, M. N., Maeda, T., Chung, H. J., Chen, J. & Blanke, S. R., May 9 2018, In: Cell Host and Microbe. 23, 5, p. 583-593.e8

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Helicobacter Infections
  • Helicobacter pylori
  • Amino Acids
• 2012

  Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

  Zhang, C., Wendel, A. A., Keogh, M. R., Harris, T. E., Chen, J. & Coleman, R. A., Jan 31 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1667-1672 6 p.

  Research output: Contribution to journal › Article › peer-review

  • alpha-glycerophosphoric acid
  • Acyltransferases
  • Phosphatidic Acids
  • Insulin
  • Hepatocytes
• 2013

  Mechanistic target of rapamycin controls homeostasis of adipogenesis

  Yoon, M. S., Zhang, C., Sun, Y., Schoenherr, C. J. & Chen, J., Aug 1 2013, In: Journal of Lipid Research. 54, 8, p. 2166-2173 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Adipogenesis
  • Sirolimus
  • Homeostasis
  • Mechanistic Target of Rapamycin Complex 1
  • Peroxisome Proliferator-Activated Receptors
• 2018

  Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation

  Dutta, D., Lai, K. Y., Reyes-Ordoñez, A., Chen, J. & van der Donk, W. A., 2018, In: Journal of Lipid Research. 59, 8, p. 1433-1445 13 p.

  Research output: Contribution to journal › Article › peer-review

  • lanthionine
  • Ligases
  • Peroxisome Proliferator-Activated Receptors
  • CCAAT-Enhancer-Binding Proteins
  • Proteins
• 2015

  Rapid mitogenic regulation of the mTORC1 Inhibitor, DEPTOR, by phosphatidic acid

  Yoon, M. S., Rosenberger, C. L., Wu, C., Truong, N., Sweedler, J. V. & Chen, J., May 7 2015, In: Molecular cell. 58, 3, p. 549-556 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidic Acids
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Phospholipase D
  • Unsaturated Fatty Acids
• 2016

  Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

  Yoon, M. S., Son, K., Arauz, E., Han, J. M., Kim, S. & Chen, J., Aug 9 2016, In: Cell Reports. 16, 6, p. 1510-1517 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acyl-tRNA Synthetases
  • Mechanistic Target of Rapamycin Complex 1
  • Amino Acids
  • Chemical activation
  • Leucine

• Single-Molecule Analysis of Lipid-Protein Interactions in Crude Cell Lysates

  Arauz, E., Aggarwal, V., Jain, A., Ha, T. & Chen, J., May 3 2016, In: Analytical chemistry. 88, 8, p. 4269-4276 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecules
  • Lipids
  • Assays
  • Proteins
  • Phospholipids