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  • John E Cronan
2011

Probing protein dynamics in vivo using backbone cyclization: Bacterial acyl carrier protein as a case study

Volkmann, G., Murphy, P. W., Rowland, E. E., Cronan, J. E. & Byers, D. M., Dec 23 2011, Methods in Protein Biochemistry. Walter de Gruyter GmbH and Co. KG, p. 271-293 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Remarkable Diversity in the Enzymes Catalyzing the Last Step in Synthesis of the Pimelate Moiety of Biotin

Shapiro, M. M., Chakravartty, V. & Cronan, J. E., Nov 9 2012, In : PloS one. 7, 11, e49440.

Research output: Contribution to journalArticle

Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity In vivo

Smith, A. C. & Cronan, J. E., Jan 2012, In : Journal of bacteriology. 194, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

2013

FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle

Bi, H., Wang, H. & Cronan, J. E., Sep 19 2013, In : Chemistry and Biology. 20, 9, p. 1157-1167 11 p.

Research output: Contribution to journalArticle

2018

Novel Xanthomonas campestris long-chain-specific 3-oxoacyl- acyl carrier protein reductase involved in diffusible signal factor synthesis

Hu, Z., Dong, H., Ma, J. C., Yu, Y., Li, K. H., Guo, Q. Q., Zhang, C., Zhang, W. B., Cao, X., Cronan, J. E. & Wang, H., May 1 2018, In : mBio. 9, 3, e00596-18.

Research output: Contribution to journalArticle

2015

Biosynthesis of squalene from farnesyl diphosphate in Bacteria: Three steps catalyzed by three enzymes

Pan, J. J., Solbiati, J. O., Ramamoorthy, G., Hillerich, B. S., Seidel, R. D., Cronan, J. E., Almo, S. C. & Poulter, C. D., May 27 2015, In : ACS Central Science. 1, 2, p. 77-82 6 p.

Research output: Contribution to journalArticle

2018

Advances in synthesis of biotin and assembly of lipoic acid

Cronan, J. E., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. 60-66 7 p.

Research output: Contribution to journalReview article

2019
2017

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

Estrada, P., Manandhar, M., Dong, S. H., Deveryshetty, J., Agarwal, V., Cronan, J. E. & Nair, S. K., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 668-674 7 p.

Research output: Contribution to journalArticle

2012

The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities

Bi, H., Christensen, Q. H., Feng, Y., Wang, H. & Cronan, J. E., Feb 2012, In : Molecular Microbiology. 83, 4, p. 840-855 16 p.

Research output: Contribution to journalArticle

2016
2012

Evolution of a new function in an esterase: Simple amino acid substitutions enable the activity present in the larger paralog, BioH

Flores, H., Lin, S., Contreras-Ferrat, G., Cronan, J. E. & Morett, E., Aug 2012, In : Protein Engineering, Design and Selection. 25, 8, p. 387-395 9 p.

Research output: Contribution to journalArticle

2019

Escherichia coli vectors having stringently repressible replication origins allow a streamlining of Crispr/Cas9 gene editing

Srinivas, S., Hu, Z. & Cronan, J. E., May 2019, In : Plasmid. 103, p. 53-62 10 p.

Research output: Contribution to journalArticle

2018
2017
2012

Crosstalk of Escherichia coli FadR with Global Regulators in Expression of Fatty Acid Transport Genes

Feng, Y. & Cronan, J. E., Sep 28 2012, In : PloS one. 7, 9, e46275.

Research output: Contribution to journalArticle

2013
2011

Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism

Hassan, B. H. & Cronan, J. E., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8263-8276 14 p.

Research output: Contribution to journalArticle

The enzyme function initiative

Gerlt, J. A., Allen, K. N., Almo, S. C., Armstrong, R. N., Babbitt, P. C., Cronan, J. E., Dunaway-Mariano, D., Imker, H. J., Jacobson, M. P., Minor, W., Poulter, C. D., Raushel, F. M., Sali, A., Shoichet, B. K. & Sweedler, J. V., Nov 22 2011, In : Biochemistry. 50, 46, p. 9950-9962 13 p.

Research output: Contribution to journalReview article

A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis

Martin, N., Christensen, Q. H., Mansilla, M. C., Cronan, J. E. & de Mendoza, D., Apr 2011, In : Molecular Microbiology. 80, 2, p. 335-349 15 p.

Research output: Contribution to journalArticle

2013

Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation

Goble, A. M., Feng, Y., Raushel, F. M. & Cronan, J. E., Dec 20 2013, In : ACS chemical biology. 8, 12, p. 2622-2629 8 p.

Research output: Contribution to journalArticle

2015
2018

Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor

Cao, X., Koch, T., Steffens, L., Finkensieper, J., Zigann, R., Cronan, J. E. & Dahl, C., Jul 13 2018, In : eLife. 7, e37439.

Research output: Contribution to journalArticle

2015

The conserved modular elements of the acyl carrier proteins of lipid synthesis are only partially interchangeable

Zhu, L. & Cronan, J. E., May 29 2015, In : Journal of Biological Chemistry. 290, 22, p. 13791-13799 9 p.

Research output: Contribution to journalArticle

2012

Altered regulation of escherichia coli biotin biosynthesis in bira superrepressor mutant strains

Chakravartty, V. & Cronan, J. E., Mar 2012, In : Journal of bacteriology. 194, 5, p. 1113-1126 14 p.

Research output: Contribution to journalArticle

2019

A novel synthesis of trans-unsaturated fatty acids by the Gram-positive commensal bacterium Enterococcus faecalis FA2-2

Kondakova, T., Kumar, S. & Cronan, J. E., Aug 2019, In : Chemistry and Physics of Lipids. 222, p. 23-35 13 p.

Research output: Contribution to journalArticle

2015

A series of medium and high copy number arabinose-inducible Escherichia coli expression vectors compatible with pBR322 and pACYC184

Chakravartty, V. & Cronan, J. E., Sep 1 2015, In : Plasmid. 81, p. 21-26 6 p.

Research output: Contribution to journalArticle

2016

PBR322 vectors having tetracycline-dependent replication

Cronan, J. E., Mar 1 2016, In : Plasmid. 84-85, p. 20-26 7 p.

Research output: Contribution to journalArticle

An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae

Shi, J., Cao, X., Chen, Y., Cronan, J. E. & Guo, Z., Dec 6 2016, In : Biochemistry. 55, 48, p. 6705-6717 13 p.

Research output: Contribution to journalArticle

2012
2015

Experimental strategies for functional annotation and metabolism discovery: Targeted screening of solute binding proteins and unbiased panning of metabolomes

Vetting, M. W., Al-Obaidi, N., Zhao, S., San Francisco, B., Kim, J., Wichelecki, D. J., Bouvier, J. T., Solbiati, J. O., Vu, H., Zhang, X., Rodionov, D. A., Love, J. D., Hillerich, B. S., Seidel, R. D., Quinn, R. J., Osterman, A. L., Cronan, J. E., Jacobson, M. P., Gerlt, J. A. & Almo, S. C., Jan 27 2015, In : Biochemistry. 54, 3, p. 909-931 23 p.

Research output: Contribution to journalArticle

2011

A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis

Christensen, Q. H., Martin, N., Mansilla, M. C., de Mendoza, D. & Cronan, J. E., Apr 2011, In : Molecular Microbiology. 80, 2, p. 350-363 14 p.

Research output: Contribution to journalArticle

2020

Progress in the Enzymology of the Mitochondrial Diseases of Lipoic Acid Requiring Enzymes

Cronan, J. E., May 21 2020, In : Frontiers in Genetics. 11, 510.

Research output: Contribution to journalReview article

Open Access
2012

Only one of the five Ralstonia solanacearum long-chain 3-ketoacyl-acyl carrier protein synthase homologues functions in fatty acid synthesis

Cheng, J., Ma, J., Lin, J., Fan, Z. C., Cronan, J. E. & Wang, H., Mar 2012, In : Applied and environmental microbiology. 78, 5, p. 1563-1573 11 p.

Research output: Contribution to journalArticle

2013

Proofreading of noncognate Acyl adenylates by an acyl-coenzyme a ligase

Manandhar, M. & Cronan, J. E., Dec 19 2013, In : Chemistry and Biology. 20, 12, p. 1441-1446 6 p.

Research output: Contribution to journalArticle

2016

A Biotin Biosynthesis Gene Restricted to Helicobacter

Bi, H., Zhu, L., Jia, J. & Cronan, J. E., Feb 12 2016, In : Scientific reports. 6, 21162.

Research output: Contribution to journalArticle

2015

The atypical occurrence of two biotin protein ligases in Francisella novicida is due to distinct roles in virulence and biotin metabolism

Feng, Y., Chin, C. Y., Chakravartty, V., Gao, R., Crispell, E. K., Weiss, D. S. & Cronan, J. E., Jun 9 2015, In : mBio. 6, 3, e00591-15.

Research output: Contribution to journalArticle

2019
2011

A complex lipoate utilization pathway in Listeria monocytogenes

Christensen, Q. H., Hagar, J. A., O'Riordan, M. X. D. & Cronan, J. E., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31447-31456 10 p.

Research output: Contribution to journalArticle

2013

Profligate biotin synthesis in α-proteobacteria - a developing or degenerating regulatory system?

Feng, Y., Zhang, H. & Cronan, J. E., Apr 2013, In : Molecular Microbiology. 88, 1, p. 77-92 16 p.

Research output: Contribution to journalArticle

2011

Closing in on complete pathways of biotin biosynthesis

Lin, S. & Cronan, J. E., Jun 1 2011, In : Molecular BioSystems. 7, 6, p. 1811-1821 11 p.

Research output: Contribution to journalReview article

2013

The wing of a winged helix-turn-helix transcription factor organizes the active site of BirA, a bifunctional repressor/ligase

Chakravartty, V. & Cronan, J. E., Dec 13 2013, In : Journal of Biological Chemistry. 288, 50, p. 36029-36039 11 p.

Research output: Contribution to journalArticle

2019

Enterococcus faecalis encodes an atypical auxiliary acyl carrier protein required for efficient regulation of fatty acid synthesis by exogenous fatty acids

Zhu, L., Zou, Q., Cao, X. & Cronan, J. E., May 1 2019, In : mBio. 10, 3, e00577-19.

Research output: Contribution to journalArticle

Open Access
2018
2012
2011
2017
2011

Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters

Feng, Y. & Cronan, J. E., Apr 2011, In : Molecular Microbiology. 80, 1, p. 195-218 24 p.

Research output: Contribution to journalArticle

2018
2013

Discovery of new enzymes and metabolic pathways by using structure and genome context

Zhao, S., Kumar, R., Sakai, A., Vetting, M. W., Wood, B. M. K., Brown, S., Bonanno, J. B., Hillerich, B. S., Seidel, R. D., Babbitt, P. C., Almo, S. C., Sweedler, J. V., Gerlt, J. A., Cronan, J. E. & Jacobson, M. P., 2013, In : Nature. 502, 7473, p. 698-702 5 p.

Research output: Contribution to journalArticle