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  • Huimin Zhao
2019

A pathway for isethionate dissimilation in Bacillus krulwichiae

Tong, Y., Wei, Y., Hu, Y., Ang, E. L., Zhao, H. & Zhang, Y., 2019, In : Applied and environmental microbiology. 85, 15, e00793-19.

Research output: Contribution to journalArticle

2020

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Yeo, W. L., Heng, E., Tan, L. L., Lim, Y. W., Ching, K. C., Tsai, D. J., Jhang, Y. W., Lauderdale, T. L., Shia, K. S., Zhao, H., Ang, E. L., Zhang, M. M., Lim, Y. H. & Wong, F. T., Jan 6 2020, In : Microbial cell factories. 19, 1, 3.

Research output: Contribution to journalArticle

Open Access
2014

Directed evolution of enzymes for industrial biocatalysis

Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2014, Industrial Biocatalysis. Pan Stanford Publishing Pte. Ltd., p. 73-114 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Mechanistic studies on the flavin:NADH reductase (PrnF) from Pseudomonas fluorescens involved in arylamine oxygenation

Tiwari, M. K., Singh, R. K., Lee, J. K. & Zhao, H., Feb 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 3, p. 1344-1347 4 p.

Research output: Contribution to journalArticle

2019

Highly Efficient Single-Pot Scarless Golden Gate Assembly

Hamedirad, M., Weisberg, S., Chao, R., Lian, J. & Zhao, H., May 17 2019, In : ACS synthetic biology. 8, 5, p. 1047-1054 8 p.

Research output: Contribution to journalArticle

2020

A New Biosensor for Stilbenes and a Cannabinoid Enabled by Genome Mining of a Transcriptional Regulator

Sun, H., Zhao, H. & Ang, E. L., Apr 17 2020, In : ACS synthetic biology. 9, 4, p. 698-705 8 p.

Research output: Contribution to journalArticle

Emerging molecular biology tools and strategies for engineering natural product biosynthesis

Xu, W., Klumbys, E., Ang, E. L. & Zhao, H., Jun 2020, In : Metabolic Engineering Communications. 10, e00108.

Research output: Contribution to journalReview article

Open Access
2017

Probing the molecular determinants of fluorinase specificity

Yeo, W. L., Chew, X., Smith, D. J., Chan, K. P., Sun, H., Zhao, H., Lim, Y. H. & Ang, E. L., Jan 1 2017, In : Chemical Communications. 53, 17, p. 2559-2562 4 p.

Research output: Contribution to journalArticle

2019

Characterization of Cas proteins for CRISPR-Cas editing in streptomycetes

Yeo, W. L., Heng, E., Tan, L. L., Lim, Y. W., Lim, Y. H., Hoon, S., Zhao, H., Zhang, M. M. & Wong, F. T., 2019, In : Biotechnology and bioengineering. 116, 9, p. 2330-2338 9 p.

Research output: Contribution to journalArticle

2012

Role of conserved glycine in zinc-dependent medium chain dehydrogenase/reductase superfamily

Tiwari, M. K., Singh, R. K., Singh, R., Jeya, M., Zhao, H. & Lee, J. K., Jun 1 2012, In : Journal of Biological Chemistry. 287, 23, p. 19429-19439 11 p.

Research output: Contribution to journalArticle

2019

Biochemical and structural investigation of sulfoacetaldehyde reductase from Klebsiella oxytoca

Zhou, Y., Wei, Y., Lin, L., Xu, T., Ang, E. L., Zhao, H., Yuchi, Z. & Zhang, Y., Jan 1 2019, In : Biochemical Journal. 476, 4, p. 733-746 14 p.

Research output: Contribution to journalArticle

2013

Introduction

Zhao, H., Aug 27 2013, In : Synthetic Biology.

Research output: Contribution to journalArticle

2014

Preparing your manuscript for submission to ACS catalysis

Jones, C. W., Smith, D. J., Gunnoe, T. B., Zhao, H., Sautet, P., Scott, S. L. & Xu, B. Q., Jan 1 2014, In : ACS Catalysis. 4, 8, p. 2827-2828 2 p.

Research output: Contribution to journalReview article

2013

Drug Discovery and Development via Synthetic Biology

Cobb, R. E., Luo, Y., Freestone, T. & Zhao, H., Aug 27 2013, Synthetic Biology. Elsevier Inc., p. 183-206 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

A synthetic device for intracellular mRNA transport and local protein translation in eukaryotes

Abil, Z., Hoogenraad, C. & Zhao, H., 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. AIChE, Vol. 1. p. 104-113 10 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2013

Modular assembly of designer Puf proteins for specific post-transcriptional regulation of endogenous RNA

Abil, Z. & Zhao, H., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, 1 p. (Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014

Homology-integrated CRISPR-cas (HI-CRISPR) system for one-step multigene disruption in saccharomyces cerevisiae

Bao, Z., Xiao, H., Liang, J., Zhang, L., Xiong, X., Sun, N., Si, T. & Zhao, H., Jan 1 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. AIChE, p. 27-36 10 p. (Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2017

Programmable DNA-Guided Artificial Restriction Enzymes

Enghiad, B. & Zhao, H., May 19 2017, In : ACS synthetic biology. 6, 5, p. 752-757 6 p.

Research output: Contribution to journalArticle

2020

DNA punch cards for storing data on native DNA sequences via enzymatic nicking

Tabatabaei, S. K., Wang, B., Athreya, N. B. M., Enghiad, B., Hernandez, A. G., Fields, C. J., Leburton, J. P., Soloveichik, D., Zhao, H. & Milenkovic, O., Dec 1 2020, In : Nature communications. 11, 1, 1742.

Research output: Contribution to journalArticle

Open Access
2013

Pathway engineering as an enabling synthetic biology tool

Eriksen, D. T., Li, S. & Zhao, H., Aug 27 2013, Synthetic Biology. Elsevier Inc., p. 43-61 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Characterization and engineering of the adenylation domain of a NRPS-like protein: A potential biocatalyst for aldehyde generation

Wang, M. & Zhao, H., Apr 4 2014, In : ACS Catalysis. 4, 4, p. 1219-1225 7 p.

Research output: Contribution to journalArticle

2012

Biocatalyst development by directed evolution

Wang, M., Si, T. & Zhao, H., Jul 2012, In : Bioresource Technology. 115, p. 117-125 9 p.

Research output: Contribution to journalArticle

2018

Synthetic biology advances and applications in the biotechnology industry: a perspective

Katz, L., Chen, Y. Y., Gonzalez, R., Peterson, T. C., Zhao, H. & Baltz, R. H., Jul 1 2018, In : Journal of Industrial Microbiology and Biotechnology. 45, 7, p. 449-461 13 p.

Research output: Contribution to journalArticle

2013

Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing.

Sun, N. & Zhao, H., Jul 2013, In : Biotechnology and bioengineering. 110, 7, p. 1811-1821 11 p.

Research output: Contribution to journalReview article

2012

Customized optimization of metabolic pathways by combinatorial transcriptional engineering

Du, J., Yuan, Y., Si, T., Lian, J. & Zhao, H., Oct 2012, In : Nucleic acids research. 40, 18, p. e142

Research output: Contribution to journalArticle

2017

SynV and SynX: A story more than DNA synthesis

Ren, H. & Zhao, H., May 1 2017, In : Science China Life Sciences. 60, 5, p. 558-560 3 p.

Research output: Contribution to journalArticle

2011

Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Desieno, M. A., Van Der Donk, W. A. & Zhao, H., Sep 28 2011, In : Chemical Communications. 47, 36, p. 10025-10027 3 p.

Research output: Contribution to journalArticle

2017

Targeting Specificity of the CRISPR/Cas9 System

Tasan, I. & Zhao, H., Sep 15 2017, In : ACS synthetic biology. 6, 9, p. 1609-1613 5 p.

Research output: Contribution to journalReview article

2013

Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins

Eriksen, D. T., Hsieh, P. C. H., Lynn, P. & Zhao, H., Jun 26 2013, In : Microbial cell factories. 12, 1, 61.

Research output: Contribution to journalArticle

2018

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli

Ren, H., Biswas, S., Ho, S., Van Der Donk, W. A. & Zhao, H., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2966-2972 7 p.

Research output: Contribution to journalArticle

2017

Engineering biological systems using automated biofoundries

Chao, R., Mishra, S., Si, T. & Zhao, H., Jul 2017, In : Metabolic Engineering. 42, p. 98-108 11 p.

Research output: Contribution to journalReview article

2012

Mutagenic inverted repeats assisted genome engineering (MIRAGE) in saccharomyces cerevisiae: Deletion of gal7

Nair, N. U. & Zhao, H., Jan 20 2012, Microbial Metabolic Engineering: Methods and Protocols. Cheng, Q. (ed.). p. 63-73 11 p. (Methods in Molecular Biology; vol. 834).

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Comparative biochemical characterization of three exolytic oligoalginate lyases from Vibrio splendidus reveals complementary substrate scope, temperature, and pH adaptations

Jagtap, S. S., Hehemann, J. H., Polz, M. F., Lee, J. K. & Zhao, H., 2014, In : Applied and environmental microbiology. 80, 14, p. 4207-4214 8 p.

Research output: Contribution to journalArticle

2012

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease

Sun, N., Liang, J., Abil, Z. & Zhao, H., Mar 1 2012, In : Molecular BioSystems. 8, 4, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

2011

Engineering saccharomyces cerevisiae for biofuel production from lignocellulosic biomass

Du, J. & Zhao, H., Dec 1 2011, 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings. (11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2020

Evolutionary context-integrated deep sequence modeling for protein engineering

Luo, Y., Vo, L., Ding, H., Su, Y., Liu, Y., Qian, W. W., Zhao, H. & Peng, J., 2020, Research in Computational Molecular Biology - 24th Annual International Conference, RECOMB 2020, Proceedings. Schwartz, R. (ed.). Springer, p. 261-263 3 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12074 LNBI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2017

Breaking the silence: new strategies for discovering novel natural products

Ren, H., Wang, B. & Zhao, H., Dec 1 2017, In : Current Opinion in Biotechnology. 48, p. 21-27 7 p.

Research output: Contribution to journalReview article

2020

Photoenzymatic enantioselective intermolecular radical hydroalkylation

Huang, X., Wang, B., Wang, Y., Jiang, G., Feng, J. & Zhao, H., Aug 6 2020, In : Nature. 584, 7819, p. 69-74 6 p.

Research output: Contribution to journalArticle

2018

Pathway design, engineering, and optimization

Garcia-Ruiz, E., HamediRad, M. & Zhao, H., Jan 1 2018, Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, (Advances in Biochemical Engineering/Biotechnology; vol. 162).

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Investigation of the functional role of aldose 1-epimerase in engineered cellobiose utilization

Li, S., Ha, S. J., Kim, H. J., Galazka, J. M., Cate, J. H. D., Jin, Y. S. & Zhao, H., Oct 10 2013, In : Journal of Biotechnology. 168, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

2019

Activation of silent biosynthetic gene clusters using transcription factor decoys

Wang, B., Guo, F., Dong, S. H. & Zhao, H., Feb 1 2019, In : Nature chemical biology. 15, 2, p. 111-114 4 p.

Research output: Contribution to journalArticle

2014

Manipulating natural product biosynthetic pathways via DNA assembler

Shao, Z. & Zhao, H., 2014, In : Current protocols in chemical biology. 6, 2, p. 65-100 36 p.

Research output: Contribution to journalArticle

2020

Biosystems Design by Machine Learning

Volk, M. J., Lourentzou, I., Mishra, S., Vo, L. T., Zhai, C. & Zhao, H., Jul 17 2020, In : ACS synthetic biology. 9, 7, p. 1514-1533 20 p.

Research output: Contribution to journalArticle

2013

Investigating glucose and xylose metabolism in Saccharomyces cerevisiae and Scheffersomyces stipitis via 13C metabolic flux analysis

Feng, X. & Zhao, H., Sep 1 2013, In : AIChE Journal. 59, 9, p. 3195-3202 8 p.

Research output: Contribution to journalArticle

2018

Applying advanced dna assembly methods to generate pathway libraries

Eriksen, D. T., Chao, R. & Zhao, H., Mar 15 2018, Synthetic Biology: Parts, Devices and Applications. Wiley-VCH Verlag, p. 331-347 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Metabolic engineering of oleaginous yeasts for production of fuels and chemicals

Shi, S. & Zhao, H., Nov 8 2017, In : Frontiers in Microbiology. 8, NOV, 2185.

Research output: Contribution to journalReview article

2020

Identification and Characterization of Citrus Peel Uronic Acid Oxidase

Wei, Y., Tan, Y. L., Ang, E. L. & Zhao, H., Mar 16 2020, In : ChemBioChem. 21, 6, p. 797-800 4 p.

Research output: Contribution to journalArticle

2012

Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae

Sun, J., Shao, Z., Zhao, H., Nair, N., Wen, F., Xu, J. H. & Zhao, H., Aug 2012, In : Biotechnology and bioengineering. 109, 8, p. 2082-2092 11 p.

Research output: Contribution to journalArticle

2018

A coupled chlorinase-fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance

Sun, H., Zhao, H. & Ang, E. L., 2018, In : Chemical Communications. 54, 68, p. 9458-9461 4 p.

Research output: Contribution to journalArticle