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  • Huimin Zhao
2019

Activation of silent biosynthetic gene clusters using transcription factor decoys

Wang, B., Guo, F., Dong, S. H. & Zhao, H., Feb 1 2019, In : Nature chemical biology. 15, 2, p. 111-114 4 p.

Research output: Contribution to journalArticle

2014

Manipulating natural product biosynthetic pathways via DNA assembler

Shao, Z. & Zhao, H., 2014, In : Current protocols in chemical biology. 6, 2, p. 65-100 36 p.

Research output: Contribution to journalArticle

2020

Biosystems Design by Machine Learning

Volk, M. J., Lourentzou, I., Mishra, S., Vo, L. T., Zhai, C. & Zhao, H., Jul 17 2020, In : ACS synthetic biology. 9, 7, p. 1514-1533 20 p.

Research output: Contribution to journalArticle

2013

Investigating glucose and xylose metabolism in Saccharomyces cerevisiae and Scheffersomyces stipitis via 13C metabolic flux analysis

Feng, X. & Zhao, H., Sep 1 2013, In : AIChE Journal. 59, 9, p. 3195-3202 8 p.

Research output: Contribution to journalArticle

2018

Applying advanced dna assembly methods to generate pathway libraries

Eriksen, D. T., Chao, R. & Zhao, H., Mar 15 2018, Synthetic Biology: Parts, Devices and Applications. Wiley-VCH Verlag, p. 331-347 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Metabolic engineering of oleaginous yeasts for production of fuels and chemicals

Shi, S. & Zhao, H., Nov 8 2017, In : Frontiers in Microbiology. 8, NOV, 2185.

Research output: Contribution to journalReview article

2020

Identification and Characterization of Citrus Peel Uronic Acid Oxidase

Wei, Y., Tan, Y. L., Ang, E. L. & Zhao, H., Mar 16 2020, In : ChemBioChem. 21, 6, p. 797-800 4 p.

Research output: Contribution to journalArticle

2012

Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae

Sun, J., Shao, Z., Zhao, H., Nair, N., Wen, F., Xu, J. H. & Zhao, H., Aug 2012, In : Biotechnology and bioengineering. 109, 8, p. 2082-2092 11 p.

Research output: Contribution to journalArticle

2018

A coupled chlorinase-fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance

Sun, H., Zhao, H. & Ang, E. L., 2018, In : Chemical Communications. 54, 68, p. 9458-9461 4 p.

Research output: Contribution to journalArticle

2012

Direct conversion of xylan to ethanol by recombinant Saccharomyces cerevisiae strains displaying an engineered minihemicellulosome

Sun, J., Wen, F., Si, T., Xu, J. H. & Zhao, H., Jun 2012, In : Applied and environmental microbiology. 78, 11, p. 3837-3845 9 p.

Research output: Contribution to journalArticle

2019

Towards a fully automated algorithm driven platform for biosystems design

HamediRad, M., Chao, R., Weisberg, S., Lian, J., Sinha, S. & Zhao, H., Nov 13 2019, In : Nature communications. 10, 1, 5150.

Research output: Contribution to journalArticle

Open Access
2016

Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization

Wang, M., Yu, C. & Zhao, H., Mar 1 2016, In : Biotechnology and bioengineering. 113, 3, p. 484-491 8 p.

Research output: Contribution to journalArticle

Engineering microbial hosts for production of bacterial natural products

Zhang, M. M., Wang, Y., Ang, E. L. & Zhao, H., Aug 2016, In : Natural Product Reports. 33, 8, p. 963-987 25 p.

Research output: Contribution to journalReview article

Characterization of bacillus subtilis colony biofilms via mass spectrometry and fluorescence imaging

Si, T., Li, B., Zhang, K., Xu, Y., Zhao, H. & Sweedler, J. V., Jun 3 2016, In : Journal of Proteome Research. 15, 6, p. 1955-1962 8 p.

Research output: Contribution to journalArticle

2011

Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo

Evans, B. S., Chen, Y., Metcalf, W. W., Zhao, H. & Kelleher, N. L., May 27 2011, In : Chemistry and Biology. 18, 5, p. 601-607 7 p.

Research output: Contribution to journalArticle

2012

Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase

Hung, J. E., Fogle, E. J., Christman, H. D., Johannes, T. W., Zhao, H., Metcalf, W. W. & Van Der Donk, W. A., May 29 2012, In : Biochemistry. 51, 21, p. 4254-4262 9 p.

Research output: Contribution to journalArticle

2016

Rapid and efficient galactose fermentation by engineered Saccharomyces cerevisiae

Quarterman, J., Skerker, J. M., Feng, X., Liu, I. Y., Zhao, H., Arkin, A. P. & Jin, Y. S., Jul 10 2016, In : Journal of Biotechnology. 229, p. 13-21 9 p.

Research output: Contribution to journalArticle

2017

CRISPR-Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters

Zhang, M. M., Wong, F. T., Wang, Y., Luo, S., Lim, Y. H., Heng, E., Yeo, W. L., Cobb, R. E., Enghiad, B., Ang, E. L. & Zhao, H., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 607-609 3 p.

Research output: Contribution to journalArticle

2018

Recent advances in metabolic engineering of Saccharomyces cerevisiae: New tools and their applications

Lian, J., Mishra, S. & Zhao, H., Nov 2018, In : Metabolic Engineering. 50, p. 85-108 24 p.

Research output: Contribution to journalReview article

2014

Protein design for pathway engineering

Eriksen, D. T., Lian, J. & Zhao, H., Feb 2014, In : Journal of Structural Biology. 185, 2, p. 234-242 9 p.

Research output: Contribution to journalArticle

2019

Development of a CRISPR/Cas9 system for high efficiency multiplexed gene deletion in Rhodosporidium toruloides

Schultz, J. C., Cao, M. & Zhao, H., Aug 2019, In : Biotechnology and bioengineering. 116, 8, p. 2103-2109 7 p.

Research output: Contribution to journalArticle

2018

Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

Litman, Z. C., Wang, Y., Zhao, H. & Hartwig, J. F., Aug 16 2018, In : Nature. 560, 7718, p. 355-359 5 p.

Research output: Contribution to journalArticle

2011

Engineering microbial factories for synthesis of value-added products

Du, J., Shao, Z. & Zhao, H., Aug 2011, In : Journal of Industrial Microbiology and Biotechnology. 38, 8, p. 873-890 18 p.

Research output: Contribution to journalReview article

2013

Directed evolution: Past, present, and future

Cobb, R. E., Chao, R. & Zhao, H., May 2013, In : AIChE Journal. 59, 5, p. 1432-1440 9 p.

Research output: Contribution to journalArticle

2016

TALE proteins search DNA using a rotationally decoupled mechanism

Cuculis, L., Abil, Z., Zhao, H. & Schroeder, C. M., Oct 1 2016, In : Nature chemical biology. 12, 10, p. 831-837 7 p.

Research output: Contribution to journalArticle

2020

Biosystems design by directed evolution

Wang, Y., Yu, X. & Zhao, H., Mar 1 2020, In : AIChE Journal. 66, 3, e16716.

Research output: Contribution to journalReview article

2014

Exploiting Issatchenkia orientalis SD108 for succinic acid production

Xiao, H., Shao, Z., Jiang, Y., Dole, S. & Zhao, H., Aug 27 2014, In : Microbial cell factories. 13, 1, 121.

Research output: Contribution to journalReview article

2016

CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973

Wendt, K. E., Ungerer, J., Cobb, R. E., Zhao, H. & Pakrasi, H. B., Jun 23 2016, In : Microbial cell factories. 15, 1, 115.

Research output: Contribution to journalArticle

2014

Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae

Si, T., Luo, Y., Xiao, H. & Zhao, H., Mar 1 2014, In : Metabolic Engineering. 22, p. 60-68 9 p.

Research output: Contribution to journalArticle

2019

Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria

Xing, M., Wei, Y., Zhou, Y., Zhang, J., Lin, L., Hu, Y., Hua, G., N. Nanjaraj Urs, A., Liu, D., Wang, F., Guo, C., Tong, Y., Li, M., Liu, Y., Ang, E. L., Zhao, H., Yuchi, Z. & Zhang, Y., Dec 1 2019, In : Nature communications. 10, 1, 1609.

Research output: Contribution to journalArticle

Open Access
2016

Combined and iterative use of computational design and directed evolution for protein-ligand binding design

Wang, M. & Zhao, H., May 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 139-153 15 p. (Methods in Molecular Biology; vol. 1414).

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense

Zhou, Y., Wei, Y., Nanjaraj Urs, A. N., Lin, L., Xu, T., Hu, Y., Ang, E. L., Zhao, H., Yuchi, Z. & Zhang, Y., 2019, In : Bioscience Reports. 39, 6, Y.

Research output: Contribution to journalArticle

Open Access
2017

Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae

Shi, S., Choi, Y. W., Zhao, H., Tan, M. H. & Ang, E. L., Dec 2017, In : Bioresource Technology. 245, p. 1343-1351 9 p.

Research output: Contribution to journalArticle

2011

Highlights of biocatalysis and biomimetic catalysis

Zhao, H., Sep 2 2011, In : ACS Catalysis. 1, 9, p. 1119-1120 2 p.

Research output: Contribution to journalEditorial

2017

A New Era of Genome Integration - Simply Cut and Paste!

Liu, Z., Liang, Y., Ang, E. L. & Zhao, H., Apr 21 2017, In : ACS synthetic biology. 6, 4, p. 601-609 9 p.

Research output: Contribution to journalReview article

Twin-primer non-enzymatic DNA assembly: An efficient and accurate multi-part DNA assembly method

Liang, J., Liu, Z., Low, X. Z., Ang, E. L. & Zhao, H., Jun 1 2017, In : Nucleic acids research. 45, 11, p. e94

Research output: Contribution to journalArticle

2019

Delta integration CRISPR-Cas (Di-CRISPR) in saccharomyces cerevisiae

Shi, S., Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 73-91 19 p. (Methods in Molecular Biology; vol. 1927).

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

The Botrytis cinerea type III polyketide synthase shows unprecedented high catalytic efficiency toward long chain acyl-CoAs

Jeya, M., Kim, T. S., Tiwari, M. K., Li, J., Zhao, H. & Lee, J. K., Nov 1 2012, In : Molecular BioSystems. 8, 11, p. 2864-2867 4 p.

Research output: Contribution to journalArticle

2019

A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium

Xing, M., Wei, Y., Hua, G., Li, M., Nanjaraj Urs, A. N., Wang, F., Hu, Y., Zhai, W., Liu, Y., Ang, E. L., Zhao, H. & Zhang, Y., Aug 15 2019, In : Biochemical Journal. 476, 15, p. 2271-2279 9 p.

Research output: Contribution to journalArticle

2016

A step through the looking glass

Liang, Y., Ang, E. L. & Zhao, H., Sep 1 2016, In : Science China Life Sciences. 59, 9, p. 979-980 2 p.

Research output: Contribution to journalArticle

2018

Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR-Cas9 Activation

Lim, Y. H., Wong, F. T., Yeo, W. L., Ching, K. C., Lim, Y. W., Heng, E., Chen, S., Tsai, D. J., Lauderdale, T. L., Shia, K. S., Ho, Y. S., Hoon, S., Ang, E. L., Zhang, M. M. & Zhao, H., Aug 16 2018, In : ChemBioChem. 19, 16, p. 1716-1719 4 p.

Research output: Contribution to journalArticle

2019

A continuing career in biocatalysis: Frances H. Arnold

Fasan, R., Jennifer Kan, S. B. & Zhao, H., Nov 1 2019, In : ACS Catalysis. 9, 11, p. 9775-9788 14 p.

Research output: Contribution to journalArticle

2020

Unlocking nature's biosynthetic potential by directed genome evolution

Cao, M., Tran, V. G. & Zhao, H., Dec 2020, In : Current Opinion in Biotechnology. 66, p. 95-104 10 p.

Research output: Contribution to journalReview article

2018

Metabolic Engineering of Saccharomyces cerevisiae Using a Trifunctional CRISPR/Cas System for Simultaneous Gene Activation, Interference, and Deletion

Schultz, C., Lian, J. & Zhao, H., Jan 1 2018, Methods in Enzymology. Scrutton, N. (ed.). Academic Press Inc., p. 265-276 12 p. (Methods in Enzymology; vol. 608).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Identification of an important motif that controls the activity and specificity of sugar transporters

Wang, M., Yu, C. & Zhao, H., Jul 1 2016, In : Biotechnology and bioengineering. 113, 7, p. 1460-1467 8 p.

Research output: Contribution to journalArticle

2014

Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains

Lian, J., Si, T., Nair, N. U. & Zhao, H., Jul 2014, In : Metabolic Engineering. 24, p. 139-149 11 p.

Research output: Contribution to journalArticle

2013

Directed evolution of a highly efficient cellobiose utilizing pathway in an industrial saccharomyces cerevisiae strain

Yuan, Y. & Zhao, H., Nov 2013, In : Biotechnology and bioengineering. 110, 11, p. 2874-2881 8 p.

Research output: Contribution to journalArticle

2011

Drug Discovery and Development by Combinatorial Biosynthesis

Desieno, M. A., Denard, C. A. & Zhao, H., May 25 2011, Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis. John Wiley and Sons, p. 251-283 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Combinatorial pathway engineering for optimized production of the anti-malarial FR900098

Freestone, T. S. & Zhao, H., Feb 1 2016, In : Biotechnology and bioengineering. 113, 2, p. 384-392 9 p.

Research output: Contribution to journalArticle

2013

Directed evolution as a powerful synthetic biology tool

Cobb, R. E., Sun, N. & Zhao, H., Mar 15 2013, In : Methods. 60, 1, p. 81-90 10 p.

Research output: Contribution to journalReview article