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Author

  • David J Shapiro
2013

Fluorescence anisotropy microplate assay to investigate the interaction of full-length steroid receptor coactivator-1a with steroid receptors

Zhang, C., Nordeen, S. K. & Shapiro, D. J., 2013, Gene Regulation: Methods and Protocols. Humana Press Inc., p. 339-351 13 p. (Methods in Molecular Biology; vol. 977).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016
2011

Small molecule inhibitors as probes for estrogen and androgen receptor action

Shapiro, D. J., Mao, C. & Cherian, M. T., Feb 11 2011, In : Journal of Biological Chemistry. 286, 6, p. 4043-4048 6 p.

Research output: Contribution to journalShort survey

2018

A new role for estrogen receptor a in cell proliferation and cancer: Activating the anticipatory unfolded protein response

Livezey, M., Kim, J. E. & Shapiro, D. J., Jun 15 2018, In : Frontiers in Endocrinology. 9, JUN, 325.

Research output: Contribution to journalShort survey

2017

A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation

Mahapatra, L., Andruska, N., Mao, C., Le, J. & Shapiro, D. J., Oct 2017, In : Translational Oncology. 10, 5, p. 818-827 10 p.

Research output: Contribution to journalArticle

2012

A competitive inhibitor that reduces recruitment of androgen receptor to androgen-responsive genes

Cherian, M. T., Wilson, E. M. & Shapiro, D. J., Jul 6 2012, In : Journal of Biological Chemistry. 287, 28, p. 23368-23380 13 p.

Research output: Contribution to journalArticle

2016

Anticipatory UPR Activation: A Protective Pathway and Target in Cancer

Shapiro, D. J., Livezey, M., Yu, L., Zheng, X. & Andruska, N., Oct 1 2016, In : Trends in Endocrinology and Metabolism. 27, 10, p. 731-741 11 p.

Research output: Contribution to journalReview article

2011

Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer

Woo, H. H., Yi, X., Lamb, T., Menzl, I., Baker, T., Shapiro, D. J. & Chambers, S. K., Jan 1 2011, In : Molecular and cellular biology. 31, 1, p. 215-225 11 p.

Research output: Contribution to journalArticle

2018

Targeting multidrug-resistant ovarian cancer through estrogen receptor a dependent ATP depletion caused by hyperactivation of the unfolded protein response

Zheng, X., Andruska, N., Lambrecht, M. J., He, S., Parissenti, A., Hergenrother, P. J., Nelson, E. R. & Shapiro, D. J., Jan 1 2018, In : Oncotarget. 9, 19, p. 14741-14753 13 p.

Research output: Contribution to journalArticle

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

Livezey, M., Huang, R., Hergenrother, P. J. & Shapiro, D. J., Oct 2018, In : Cell Death and Differentiation. 25, 10, p. 1796-1807 12 p.

Research output: Contribution to journalArticle

2012

8-Alkylthio-6-thio-substituted theophylline analogues as selective noncompetitive progesterone receptor antagonists

Aninye, I. O., Berg, K. C., Mollo, A. R., Nordeen, S. K., Wilson, E. M. & Shapiro, D. J., May 1 2012, In : Steroids. 77, 6, p. 596-601 6 p.

Research output: Contribution to journalArticle

2015

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

Andruska, N., Zheng, X., Yang, X., Helferich, W. G. & Shapiro, D. J., Jul 21 2015, In : Oncogene. 34, 29, p. 3760-3769 10 p.

Research output: Contribution to journalArticle

2020

Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress

Yu, L., Wang, L., Kim, J. E., Mao, C. & Shapiro, D. J., Jan 1 2020, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Cell Research. 118765.

Research output: Contribution to journalArticle

2017

Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In : Cancer Research. 77, 20, p. 5602-5613 12 p.

Research output: Contribution to journalArticle

2015

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Andruska, N. D., Zheng, X., Yang, X., Mao, C., Cherian, M. M., Mahapatra, L., Helferich, W. G. & Shapiro, D. J., Apr 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4737-4742 6 p.

Research output: Contribution to journalArticle

2016

Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI

Mao, C., Livezey, M., Kim, J. E. & Shapiro, D. J., Oct 7 2016, In : Scientific reports. 6, 34753.

Research output: Contribution to journalArticle

2014

The immune system and inflammation in breast cancer

Jiang, X. & Shapiro, D. J., Jan 25 2014, In : Molecular and Cellular Endocrinology. 382, 1, p. 673-682 10 p.

Research output: Contribution to journalArticle

High-throughput fluorescence anisotropy screen for inhibitors of the oncogenic mrna binding protein, IMP-1

Mahapatra, L., Mao, C., Andruska, N., Zhang, C. & Shapiro, D. J., Mar 1 2014, In : Journal of Biomolecular Screening. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

2016

Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action

Zheng, X., Andruska, N., Yu, L., Mao, C., Kim, J. E., Livezey, M., Helferich, W. G. & Shapiro, D. J., Jan 1 2016, In : Steroids. 114, p. 2-6 5 p.

Research output: Contribution to journalReview article

2012

RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

Huang, B., Qu, Z., Ong, C. W., Tsang, Y. H. N., Xiao, G., Shapiro, D., Salto-Tellez, M., Ito, K., Ito, Y. & Chen, L. F., Jan 26 2012, In : Oncogene. 31, 4, p. 527-534 8 p.

Research output: Contribution to journalArticle

Evaluation of a luciferase-based reporter assay as a screen for inhibitors of estrogen-ERα-induced proliferation of breast cancer cells

Andruska, N., Mao, C., Cherian, M., Zhang, C. & Shapiro, D. J., Aug 1 2012, In : Journal of Biomolecular Screening. 17, 7, p. 921-932 12 p.

Research output: Contribution to journalArticle