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  • Eric Oldfield
2016

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journalArticle

2018

“Head-to-Middle” and “Head-to-Tail” cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

Gao, J., Ko, T. P., Chen, L., Malwal, S. R., Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., Jan 15 2018, In : Angewandte Chemie - International Edition. 57, 3, p. 683-687 5 p.

Research output: Contribution to journalArticle

2016

Structure and Function of a "head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase

Liu, M., Chen, C. C., Chen, L., Xiao, X., Zheng, Y., Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E., Guo, R. T. & Ma, Y., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4721-4724 4 p.

Research output: Contribution to journalArticle

2018

Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design

Venkatramani, A., Gravina Ricci, C., Oldfield, E. & McCammon, J. A., Jun 2018, In : Chemical Biology and Drug Design. 91, 6, p. 1068-1077 10 p.

Research output: Contribution to journalEditorial

2016

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

Yang, G., Zhu, W., Wang, Y., Huang, G., Byun, S. Y., Choi, G., Li, K., Huang, Z., Docampo, R., Oldfield, E. & No, J. H., Jan 8 2016, In : ACS Infectious Diseases. 1, 8, p. 388-398 11 p.

Research output: Contribution to journalArticle

2017

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in Vitro and in Vivo Results

Boulmier, A., Feng, X., Oms, O., Mialane, P., Rivière, E., Shin, C. J., Yao, J., Kubo, T., Furuta, T., Oldfield, E. & Dolbecq, A., Jul 3 2017, In : Inorganic Chemistry. 56, 13, p. 7558-7565 8 p.

Research output: Contribution to journalArticle

2012

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

2014

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

2013

Chemo-immunotherapeutic antimalarials targeting isoprenoid biosynthesis

Zhang, Y., Zhu, W., Liu, Y. L., Wang, H., Wang, K., Li, K., No, J. H., Ayong, L., Gulati, A., Pang, R., Freitas-Junior, L., Morita, C. T. & Oldfield, E., Apr 11 2013, In : ACS Medicinal Chemistry Letters. 4, 4, p. 423-427 5 p.

Research output: Contribution to journalArticle

2012

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH

Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E. & Groll, M., Oct 8 2012, In : Nature communications. 3, 1042.

Research output: Contribution to journalArticle

2013

Farnesyl diphosphate synthase inhibitors from in silico screening

Lindert, S., Zhu, W., Liu, Y. L., Pang, R., Oldfield, E. & Mccammon, J. A., Jun 1 2013, In : Chemical Biology and Drug Design. 81, 6, p. 742-748 7 p.

Research output: Contribution to journalArticle

2014

Squalene Synthase As a Target for Chagas Disease Therapeutics

Shang, N., Li, Q., Ko, T. P., Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M. U., de Souza, W., Urbina, J. A., Wang, A. H. J., Docampo, R. & 4 others, Li, K., Liu, Y. L., Oldfield, E. & Guo, R. T., May 2014, In : PLoS pathogens. 10, 5, e1004114.

Research output: Contribution to journalArticle

2015

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

Li, K., Wang, Y., Yang, G., Byun, S., Rao, G., Shoen, C., Yang, H., Gulati, A., Crick, D. C., Cynamon, M., Huang, G., Docampo, R., No, J. H. & Oldfield, E., May 8 2015, In : ACS Infectious Diseases. 1, 5, p. 215-221 7 p.

Research output: Contribution to journalArticle

2019

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Han, S., Li, X., Xia, Y., Yu, Z., Cai, N., Malwal, S. R., Han, X., Oldfield, E. & Zhang, Y., Dec 12 2019, In : Journal of Medicinal Chemistry. 62, 23, p. 10867-10896 30 p.

Research output: Contribution to journalArticle

2014

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

2011

Ultrahigh resolution protein structures using NMR chemical shift tensors

Wylie, B. J., Sperling, L. J., Nieuwkoop, A. J., Franks, W. T., Oldfield, E. & Rienstra, C. M., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 16974-16979 6 p.

Research output: Contribution to journalArticle

2014

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Liu, W., Feng, X., Zheng, Y., Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T. D., Oldfield, E. & Guo, R. T., 2014, In : Scientific reports. 4, 6214.

Research output: Contribution to journalArticle

2018

Structure–activity relationship investigation of coumarin–chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors

Kang, L., Gao, X. H., Liu, H. R., Men, X., Wu, H. N., Cui, P. W., Oldfield, E. & Yan, J. Y., Nov 1 2018, In : Molecular Diversity. 22, 4, p. 893-906 14 p.

Research output: Contribution to journalArticle

2016

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI

Li, J., Feng, X., Zhu, W., Oskolkov, N., Zhou, T., Kim, B. K., Baig, N., McMahon, M. T. & Oldfield, E., Jan 4 2016, In : Chemistry - A European Journal. 22, 1, p. 264-271 8 p.

Research output: Contribution to journalArticle

2017

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase

Rao, G., Bansal, S., Law, W. X., O'Dowd, B., Dikanov, S. A. & Oldfield, E., Jul 25 2017, In : Biochemistry. 56, 29, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

2014

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from mycobacterium tuberculosis

Chan, H. C., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Feb 19 2014, In : Journal of the American Chemical Society. 136, 7, p. 2892-2896 5 p.

Research output: Contribution to journalArticle

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Liu, Y. L., Lindert, S., Zhu, W., Wang, K., McCammon, J. A. & Oldfield, E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. E2530-E2539

Research output: Contribution to journalArticle

2019

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

Song, J., Shang, N., Baig, N., Yao, J., Shin, C., Kim, B. K., Li, Q., Malwal, S. R., Oldfield, E., Feng, X. & Guo, R. T., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 517-523 7 p.

Research output: Contribution to journalArticle

2015

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

2014

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journalReview article

2020

COVID-19 and Other Pandemics: How Might They Be Prevented?

Oldfield, E. & Malwal, S. R., Jun 1 2020, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

2018

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Elsebaei, M. M., Mohammad, H., Abouf, M., Abutaleb, N. S., Hegazy, Y. A., Ghiaty, A., Chen, L., Zhang, J., Malwal, S. R., Oldfield, E., Seleem, M. N. & Mayhoub, A. S., Mar 25 2018, In : European Journal of Medicinal Chemistry. 148, p. 195-209 15 p.

Research output: Contribution to journalArticle

2016

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 1915-1923 9 p.

Research output: Contribution to journalArticle

2015

IspH-RPS1 and IspH-UbiA: "rosetta stone" proteins

Rao, G., O'Dowd, B., Li, J., Wang, K. & Oldfield, E., Jan 1 2015, In : Chemical Science. 6, 12, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

2017

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

2012

Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Ren, F., Ko, T. P., Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 23 2012, In : Angewandte Chemie - International Edition. 51, 17, p. 4157-4160 4 p.

Research output: Contribution to journalArticle

2015

Atomic-resolution structures of discrete stages on the reaction coordinate of the [Fe4S4] enzyme IspG (GcpE)

Quitterer, F., Frank, A., Wang, K., Rao, G., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E. & Groll, M., Jun 19 2015, In : Journal of Molecular Biology. 427, 12, p. 2220-2228 9 p.

Research output: Contribution to journalArticle

2013

Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

Ziniel, P. D., Desai, J., Cass, C. L., Gatto, C., Oldfield, E. & Williams, D. L., Dec 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 5969-5976 8 p.

Research output: Contribution to journalArticle

2015

SQ109, a new drug lead for chagas disease

Veiga-Santos, P., Li, K., Lameira, L., De Carvalho, T. M. U., Huang, G., Galizzi, M., Shang, N., Li, Q., Gonzalez-Pacanowska, D., Hernandez-Rodriguez, V., Benaim, G., Guo, R. T., Urbina, J. A., Docampo, R., De Souza, W. & Oldfield, E., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 1950-1961 12 p.

Research output: Contribution to journalArticle

2018

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

Xia, Y., Xie, Y., Yu, Z., Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X. & 3 others, Liu, W., Shi, Y. & Zhang, Y., Nov 1 2018, In : Cell. 175, 4, p. 1059-1073.e21

Research output: Contribution to journalArticle

2019

Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Buter, J., Cheng, T. Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M. & 10 others, Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J. & Moody, D. B., Sep 1 2019, In : Nature chemical biology. 15, 9, p. 889-899 11 p.

Research output: Contribution to journalArticle

2015

Tuberculosis Terpene Targets

Oldfield, E., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 437-438 2 p.

Research output: Contribution to journalShort survey

2018

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways

Malwal, S. R., O'Dowd, B., Feng, X., Turhanen, P., Shin, C., Yao, J., Kim, B. K., Baig, N., Zhou, T., Bansal, S., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 20 2018, In : Journal of the American Chemical Society. 140, 24, p. 7568-7578 11 p.

Research output: Contribution to journalArticle

2012

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Lin, F. Y., Zhang, Y., Hensler, M., Liu, Y. L., Chow, O. A., Zhu, W., Wang, K., Pang, R., Thienphrapa, W., Nizet, V. & Oldfield, E., Apr 1 2012, In : ChemMedChem. 7, 4, p. 561-564 4 p.

Research output: Contribution to journalArticle

2014

Resistance-resistant antibiotics

Oldfield, E. & Feng, X., Dec 2014, In : Trends in Pharmacological Sciences. 35, 12, p. 664-674 11 p.

Research output: Contribution to journalReview article

Iron porphyrin carbenes as catalytic intermediates: Structures, mössbauer and NMR spectroscopic properties, and bonding

Khade, R. L., Fan, W., Ling, Y., Yang, L., Oldfield, E. & Zhang, Y., Jul 14 2014, In : Angewandte Chemie - International Edition. 53, 29, p. 7574-7578 5 p.

Research output: Contribution to journalArticle

2015

Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries

Liu, Y. L., Cao, R., Wang, Y. & Oldfield, E., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 349-354 6 p.

Research output: Contribution to journalArticle

2012

Head-to-head prenyl tranferases: Anti-infective drug targets

Lin, F. Y., Liu, Y. L., Li, K., Cao, R., Zhu, W., Axelson, J., Pang, R. & Oldfield, E., May 10 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4367-4372 6 p.

Research output: Contribution to journalArticle

2015

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD+, NADPH, or NAD+/10-Oxogeranial: Reaction Mechanisms

Hu, Y., Liu, W., Malwal, S. R., Zheng, Y., Feng, X., Ko, T. P., Chen, C. C., Xu, Z., Liu, M., Han, X., Gao, J., Oldfield, E. & Guo, R. T., Dec 14 2015, In : Angewandte Chemie - International Edition. 54, 51, p. 15478-15482 5 p.

Research output: Contribution to journalArticle

2016

Back Cover: Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase (ChemMedChem 17/2016)

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. 11, 17, 1 p.

Research output: Contribution to journalComment/debate

2013

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus

Ren, F., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E. & Guo, R. T., Jan 1 2013, In : ChemBioChem. 14, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

2011

Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): A HYSCORE investigation

Wang, W., Li, J., Wang, K., Smirnova, T. I. & Oldfield, E., May 4 2011, In : Journal of the American Chemical Society. 133, 17, p. 6525-6528 4 p.

Research output: Contribution to journalArticle

An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis

Wang, W., Wang, K., Li, J., Nellutla, S., Smirnova, T. I. & Oldfield, E., Jun 8 2011, In : Journal of the American Chemical Society. 133, 22, p. 8400-8403 4 p.

Research output: Contribution to journalArticle

2016

Inhibition of Leishmania mexicana growth by the tuberculosis drug SQ109

García-García, V., Oldfield, E. & Benaim, G., Oct 2016, In : Antimicrobial Agents and Chemotherapy. 60, 10, p. 6386-6389 4 p.

Research output: Contribution to journalArticle