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  • Jonathan V Sweedler
2017

The Chemistry of Thought: The Role of the Measurement Sciences in Brain Research

Andrews, A. M., Bhargava, R., Kennedy, R., Li, L. & Sweedler, J. V., May 2 2017, In : Analytical chemistry. 89, 9, 1 p.

Research output: Contribution to journalEditorial

2012

The Hypothalamic-Neurohypophyseal System: From Genome to Physiology

Murphy, D., Konopacka, A., Hindmarch, C., Paton, J. F. R., Sweedler, J. V., Gillette, M. U., Ueta, Y., Grinevich, V., Lozic, M. & Japundzic-Zigon, N., Apr 2012, In : Journal of Neuroendocrinology. 24, 4, p. 539-553 15 p.

Research output: Contribution to journalReview article

Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex

Fossat, P., Turpin, F. R., Sacchi, S., Dulong, J., Shi, T., Rivet, J. M., Sweedler, J. V., Pollegioni, L., Millan, M. J., Oliet, S. H. R. & Mothet, J. P., Mar 2012, In : Cerebral Cortex. 22, 3, p. 595-606 12 p.

Research output: Contribution to journalArticle

2019

Investigating brain d-serine: Advocacy for good practices

Mothet, J. P., Billard, J. M., Pollegioni, L., Coyle, J. T. & Sweedler, J. V., May 2019, In : Acta Physiologica. 226, 1, e13257.

Research output: Contribution to journalReview article

2017

Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia

Zhang, G., Vilim, F. S., Liu, D. D., Romanova, E. V., Yu, K., Yuan, W. D., Xiao, H., Hummon, A. B., Chen, T. T., Alexeeva, V., Yin, S. Y., Chen, S. A., Cropper, E. C., Sweedler, J. V., Weiss, K. R. & Jing, J., Nov 17 2017, In : Journal of Biological Chemistry. 292, 46, p. 18775-18789 15 p.

Research output: Contribution to journalArticle

2011

Neuropeptidomics: Mass spectrometry-based qualitative and quantitative analysis

Yin, P., Hou, X., Romanova, E. V. & Sweedler, J. V., 2011, Neuropeptides: Methods and Protocols. Merighi, A. (ed.). p. 223-236 14 p. (Methods in Molecular Biology; vol. 789).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017
2016

Label-free molecular imaging of bacterial communities of the opportunistic pathogen Pseudomonas aeruginosa

Baig, N., Polisetti, S., Morales-Soto, N., Dunham, S. J. B., Sweedler, J. V., Shrout, J. D. & Bohn, P. W., Jan 1 2016, Biosensing and Nanomedicine IX. Mohseni, H., Agahi, M. H. & Razeghi, M. (eds.). SPIE, 993004. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 9930).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2017

Mass spectrometry imaging of complex microbial communities

Dunham, S. J. B., Ellis, J. F., Li, B. & Sweedler, J. V., 2017, In : Accounts of chemical research. 50, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

2018

Exploring Exercise- and Context-Induced Peptide Changes in Mice by Quantitative Mass Spectrometry

Dowd, S. E., Mustroph, M. L., Romanova, E. V., Southey, B. R., Pinardo, H., Rhodes, J. S. & Sweedler, J. V., Oct 24 2018, In : ACS Omega. 3, 10, p. 13817-13827 11 p.

Research output: Contribution to journalArticle

A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes

Welle, T. M., Alanis, K., Colombo, M. L., Sweedler, J. V. & Shen, M., 2018, In : Chemical Science. 9, 22, p. 4937-4941 5 p.

Research output: Contribution to journalArticle

2011

Neuropeptidomics of the mammalian brain

Xie, F., Romanova, E. V. & Sweedler, J. V., Jun 3 2011, Neuroproteomics. Li, K. W. (ed.). p. 229-242 14 p. (Neuromethods; vol. 57).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Mass spectrometry of proteins

Romanova, E. V., Annangudi, S. P., Tai, H. C. & Sweedler, J. V., Jan 1 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., p. 681-687 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Model of ion intensity from tandem mass spectra for improved peptide identification and simulation

Fazal, Z., Southey, B. R., Sadeque, A., Sweedler, J. V. & Rodriguez-Zas, S. L., Dec 1 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. p. 994-996 3 p. 6112534. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2018

Neuropeptidomics of the Rat Habenular Nuclei

Yang, N., Anapindi, K. D. B., Rubakhin, S. S., Wei, P., Yu, Q., Li, L., Kenny, P. J. & Sweedler, J. V., Apr 6 2018, In : Journal of Proteome Research. 17, 4, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

2013

Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission

Martineau, M., Shi, T., Puyal, J., Knolhoff, A. M., Dulong, J., Gasnier, B., Klingauf, J., Sweedler, J. V., Jahn, R. & Mothet, J. P., Feb 20 2013, In : Journal of Neuroscience. 33, 8, p. 3413-3423 11 p.

Research output: Contribution to journalArticle

2012

A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis

Erb, T. J., Evans, B. S., Cho, K., Warlick, B. P., Sriram, J., Wood, B. M. K., Imker, H. J., Sweedler, J. V., Tabita, F. R. & Gerlt, J. A., Nov 2012, In : Nature chemical biology. 8, 11, p. 926-932 7 p.

Research output: Contribution to journalArticle

2018

Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function

Zhang, G., Yuan, W. D., Vilim, F. S., Romanova, E. V., Yu, K., Yin, S. Y., Le, Z. W., Xue, Y. Y., Chen, T. T., Chen, G. K., Chen, S. A., Cropper, E. C., Sweedler, J. V., Weiss, K. R. & Jing, J., Aug 15 2018, In : ACS Chemical Neuroscience. 9, 8, p. 2041-2053 13 p.

Research output: Contribution to journalArticle

2013

Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit

Bai, L., Livnat, I., Romanova, E. V., Alexeeva, V., Yau, P. M., Vilim, F. S., Weiss, K. R., Jing, J. & Sweedler, J. V., Nov 15 2013, In : Journal of Biological Chemistry. 288, 46, p. 32837-32851 15 p.

Research output: Contribution to journalArticle

2011

Using microfluidics and mass spectrometry to study peptide release in neurons

Croushore, C. A., Lee, C. Y., Zhong, M. & Sweedler, J. V., Dec 1 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. p. 858-860 3 p. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2016

Metal-assisted polyatomic SIMS and laser desorption/ionization for enhanced small molecule imaging of bacterial biofilms

Dunham, S. J. B., Comi, T. J., Ko, K., Li, B., Baig, N. F., Morales-Soto, N., Shrout, J. D., Bohn, P. W. & Sweedler, J. V., Jun 1 2016, In : Biointerphases. 11, 2, 02A325.

Research output: Contribution to journalArticle

2013

Multifactorial understanding of ion abundance in tandem mass spectrometry experiments

Fazal, Z., Southey, B. R., Sweedler, J. V. & Rodriguez-Zas, S. L., Mar 12 2013, In : Journal of Proteomics and Bioinformatics. 6, 2, p. 23-29 7 p.

Research output: Contribution to journalArticle

Quantitative reflection imaging of fixed aplysia californica pedal ganglion neurons on nanostructured plasmonic crystals

Le, A. P., Kang, S., Thompson, L. B., Rubakhin, S. S., Sweedler, J. V., Rogers, J. A. & Nuzzo, R. G., Nov 4 2013, In : Journal of Physical Chemistry B. 117, 42, p. 13069-13081 13 p.

Research output: Contribution to journalArticle

2018

Expired Epinephrine Maintains Chemical Concentration and Sterility

Weir, W. B., Fred, L. Y., Pike, M., Rubakhin, S. S., Ludwig, T. J., Shar, A. M., Zhu, L., Frederick, A., Uzoaru, I., Wang, L. & Sweedler, J. V., Jul 4 2018, In : Prehospital Emergency Care. 22, 4, p. 414-418 5 p.

Research output: Contribution to journalArticle

2013

Stimulation and release from neurons via a dual capillary collection device interfaced to mass spectrometry

Fan, Y., Lee, C. Y., Rubakhin, S. S. & Sweedler, J. V., Nov 7 2013, In : Analyst. 138, 21, p. 6337-6346 10 p.

Research output: Contribution to journalArticle

2012

Evaluation of database search programs for accurate detection of neuropeptides in tandem mass spectrometry experiments

Akhtar, M. N., Southey, B. R., Andrén, P. E., Sweedler, J. V. & Rodriguez-Zas, S. L., Dec 7 2012, In : Journal of Proteome Research. 11, 12, p. 6044-6055 12 p.

Research output: Contribution to journalArticle

2011

A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the aplysia californica central nervous system

Wang, L., Ota, N., Romanova, E. V. & Sweedler, J. V., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13765-13774 10 p.

Research output: Contribution to journalArticle

Molecular organization of drosophila neuroendocrine cells by dimmed

Park, D., Hadžić, T., Yin, P., Rusch, J., Abruzzi, K., Rosbash, M., Skeath, J. B., Panda, S., Sweedler, J. V. & Taghert, P. H., Sep 27 2011, In : Current Biology. 21, 18, p. 1515-1524 10 p.

Research output: Contribution to journalArticle

2014

Spatial organization of pseudomonas aeruginosa biofilms probed by combined matrix-assisted laser desorption ionization mass spectrometry and confocal raman microscopy

Masyuko, R. N., Lanni, E. J., Driscoll, C. M., Shrout, J. D., Sweedler, J. V. & Bohn, P. W., Oct 15 2014, In : Analyst. 139, 22, p. 5700-5708 9 p.

Research output: Contribution to journalArticle

2011

The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary

Aujla, P. K., Bora, A., Monahan, P., Sweedler, J. V. & Raetzman, L. T., May 1 2011, In : Developmental Biology. 353, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

2014

D-Alanine in the islets of Langerhans of rat pancreas

Ota, N., Rubakhin, S. S. & Sweedler, J. V., May 2 2014, In : Biochemical and Biophysical Research Communications. 447, 2, p. 328-333 6 p.

Research output: Contribution to journalArticle

2018

Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging

Neumann, E. K., Comi, T. J., Spegazzini, N., Mitchell, J. W., Rubakhin, S. S., Gillette, M. U., Bhargava, R. & Sweedler, J. V., Oct 2 2018, In : Analytical chemistry. 90, 19, p. 11572-11580 9 p.

Research output: Contribution to journalArticle

2014

Correlated imaging with C60-SIMS and confocal raman microscopy: Visualization of cell-scale molecular distributions in bacterial biofilms

Lanni, E. J., Masyuko, R. N., Driscoll, C. M., Dunham, S. J. B., Shrout, J. D., Bohn, P. W. & Sweedler, J. V., Sep 30 2014, In : Analytical chemistry. 86, 21, p. 10885-10891 7 p.

Research output: Contribution to journalArticle

2012

Single-cell metabolomics: Changes in the metabolome of freshly isolated and cultured neurons

Nemes, P., Knolhoff, A. M., Rubakhin, S. S. & Sweedler, J. V., Oct 17 2012, In : ACS Chemical Neuroscience. 3, 10, p. 782-792 11 p.

Research output: Contribution to journalArticle

2018

Single Synaptic Observation of Cholinergic Neurotransmission on Living Neurons: Concentration and Dynamics

Shen, M., Qu, Z., Deslaurier, J., Welle, T. M., Sweedler, J. V. & Chen, R., Jun 27 2018, In : Journal of the American Chemical Society. 140, 25, p. 7764-7768 5 p.

Research output: Contribution to journalArticle

2015

Differential peptidomics assessment of strain and age differences in mice in response to acute cocaine administration

Romanova, E. V., Rubakhin, S. S., Ossyra, J. R., Zombeck, J. A., Nosek, M. R., Sweedler, J. V. & Rhodes, J. S., Dec 1 2015, In : Journal of Neurochemistry. 135, 5, p. 1038-1048 11 p.

Research output: Contribution to journalArticle

2018

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Rodriguez-Zas, S. L., Wu, C., Southey, B. R., O'Connor, J. C., Nixon, S. E., Garcia, R., Zavala, C., Lawson, M., McCusker, R. H., Romanova, E. V., Sweedler, J. V., Kelley, K. W. & Dantzer, R., Nov 2018, In : Psychoneuroendocrinology. 97, p. 47-58 12 p.

Research output: Contribution to journalArticle

2016

Single-cell analysis at the threshold

Chen, X., Love, J. C., Navin, N. E., Pachter, L., Stubbington, M. J. T., Svensson, V., Sweedler, J. V. & Teichmann, S. A., Nov 8 2016, In : Nature Biotechnology. 34, 11, p. 1111-1118 8 p.

Research output: Contribution to journalReview article

2012

Label-free quantitation of peptide release from neurons in a microfluidic device with mass spectrometry imaging

Zhong, M., Lee, C. Y., Croushore, C. A. & Sweedler, J. V., May 8 2012, In : Lab on a chip. 12, 11, p. 2037-2045 9 p.

Research output: Contribution to journalArticle

2016

A D-amino acid-containing neuropeptide discovery funnel

Livnat, I., Tai, H. C., Jansson, E. T., Bai, L., Romanova, E. V., Chen, T. T., Yu, K., Chen, S. A., Zhang, Y., Wang, Z. Y., Liu, D. D., Weiss, K. R., Jing, J. & Sweedler, J. V., 2016, In : Analytical chemistry. 88, 23, p. 11868-11876 9 p.

Research output: Contribution to journalArticle

2012

D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems

Ota, N., Shi, T. & Sweedler, J. V., Nov 2012, In : Amino Acids. 43, 5, p. 1873-1886 14 p.

Research output: Contribution to journalReview article

2017
2012

Peptidomic analyses of mouse astrocytic cell lines and rat primary cultured astrocytes

Yin, P., Knolhoff, A. M., Rosenberg, H. J., Millet, L. J., Gillette, M. U. & Sweedler, J. V., Aug 3 2012, In : Journal of Proteome Research. 11, 8, p. 3965-3973 9 p.

Research output: Contribution to journalArticle

2014

Identification of best indicators of peptide-spectrum match using a permutation resampling approach

Akhtar, M. N., Southey, B. R., Andrén, P. E., Sweedler, J. V. & Rodriguez-Zas, S. L., Oct 30 2014, In : Journal of Bioinformatics and Computational Biology. 12, 5, 1440001.

Research output: Contribution to journalArticle

Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine

Kumar, R., Zhao, S., Vetting, M. W., Wood, B. M. K., Sakai, A., Cho, K., Solbiati, J., Almo, S. C., Sweedler, J. V., Jacobson, M. P., Gerlt, J. A. & Cronan, J. E., Feb 11 2014, In : mBio. 5, 1, e00933-13.

Research output: Contribution to journalArticle

2020

Single-Cell Classification Using Mass Spectrometry through Interpretable Machine Learning

Xie, Y. R., Castro, D. C., Bell, S. E., Rubakhin, S. & Sweedler, J. V., Jul 7 2020, In : Analytical chemistry. 92, 13, p. 9338-9347 10 p.

Research output: Contribution to journalArticle

2013

Discovery of new enzymes and metabolic pathways by using structure and genome context

Zhao, S., Kumar, R., Sakai, A., Vetting, M. W., Wood, B. M. K., Brown, S., Bonanno, J. B., Hillerich, B. S., Seidel, R. D., Babbitt, P. C., Almo, S. C., Sweedler, J. V., Gerlt, J. A., Cronan, J. E. & Jacobson, M. P., 2013, In : Nature. 502, 7473, p. 698-702 5 p.

Research output: Contribution to journalArticle

2017

Improved identification and quantitation of mature endogenous peptides in the rodent hypothalamus using a rapid conductive sample heating system

Yang, N., Anapindi, K. D. B., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Dec 7 2017, In : Analyst. 142, 23, p. 4476-4485 10 p.

Research output: Contribution to journalArticle