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  • Stephen G Sligar
2013

Investigations of heme ligation and ligand switching in cytochromes P450 and P420

Sun, Y., Zeng, W., Benabbas, A., Ye, X., Denisov, I., Sligar, S. G., Du, J., Dawson, J. H. & Champion, P. M., Aug 27 2013, In : Biochemistry. 52, 34, p. 5941-5951 11 p.

Research output: Contribution to journalArticle

2016

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4

Denisov, I. G., Mak, P. J., Grinkova, Y. V., Bastien, D., Bérubé, G., Sligar, S. G. & Kincaid, J. R., May 1 2016, In : Journal of Inorganic Biochemistry. 158, p. 77-85 9 p.

Research output: Contribution to journalArticle

2015

Metalloproteins: The long and the short of it

Denisov, I. G. & Sligar, S. G., Aug 20 2015, In : Nature Chemistry. 7, 9, p. 687-688 2 p.

Research output: Contribution to journalShort survey

2017

Conformational equilibria of light-activated rhodopsin in nanodiscs

Van Eps, N., Caro, L. N., Morizumi, T., Kusnetzow, A. K., Szczepek, M., Hofmann, K. P., Bayburt, T. H., Sligar, S. G., Ernst, O. P. & Hubbell, W. L., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. E3268-E3275

Research output: Contribution to journalArticle

2014

Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayers

D'Antona, A. M., Xie, G., Sligar, S. G. & Oprian, D. D., Jan 14 2014, In : Biochemistry. 53, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

2018

SMPL synaptic membranes: Nanodisc-mediated synaptic membrane mimetics expand the toolkit for drug discovery and the molecular cell biology of synapses

Lo Bu, R., Clark, J., DiChiara, T., Sligar, S. G. & Klein, W. L., Jan 1 2018, Neuromethods. Humana Press Inc., p. 227-250 24 p. (Neuromethods; vol. 141).

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Spectroscopic features of cytochrome P450 reaction intermediates

Luthra, A., Denisov, I. G. & Sligar, S. G., Mar 1 2011, In : Archives of Biochemistry and Biophysics. 507, 1, p. 26-35 10 p.

Research output: Contribution to journalReview article

2019

PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b

McLean, M. A., Stephen, A. G. & Sligar, S. G., Aug 20 2019, In : Biochemistry. 58, 33, p. 3537-3545 9 p.

Research output: Contribution to journalArticle

2018

Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins

McLean, M. A., Gregory, M. C. & Sligar, S. G., May 20 2018, In : Annual Review of Biophysics. 47, p. 107-124 18 p.

Research output: Contribution to journalReview article

2017

Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification

Wade, J. H., Jones, J. D., Lenov, I. L., Riordan, C. M., Sligar, S. G. & Bailey, R. C., Sep 7 2017, In : Lab on a chip. 17, 17, p. 2951-2959 9 p.

Research output: Contribution to journalArticle

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Sustainable Engineering Forum: Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 1161-1162 2 p. (Sustainable Engineering Forum: Core Programming Topic at the 2011 AIChE Annual Meeting; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2019

NMR analysis of free and lipid nanodisc anchored CEACAM1 membrane proximal peptides with Ca 2+ /CaM

Ghazarian, H., Hu, W., Mao, A., Nguyen, T., Vaidehi, N., Sligar, S. & Shively, J. E., Apr 1 2019, In : Biochimica et Biophysica Acta - Biomembranes. 1861, 4, p. 787-797 11 p.

Research output: Contribution to journalArticle

Biotransformation of the mycotoxin enniatin b1 by CYP P450 3A4 and potential for drug-drug interactions

Ivanova, L., Denisov, I. G., Grinkova, Y. V., Sligar, S. G. & Fæste, C. K., Aug 2019, In : Metabolites. 9, 8, 158.

Research output: Contribution to journalArticle

Open Access
2011

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

2014

Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps

Khatri, Y., Luthra, A., Duggal, R. & Sligar, S. G., Aug 25 2014, In : FEBS Letters. 588, 17, p. 3117-3122 6 p.

Research output: Contribution to journalArticle

2012

Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes P450

Denisov, I. G., Grinkova, Y. V. & Sligar, S. G., Jan 1 2012, Spectroscopic Methods of Analysis: Methods and Protocols. Humana Press Inc., p. 375-391 17 p. (Methods in Molecular Biology; vol. 875).

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-Assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 349-350 2 p. (Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2012

Tissue factor/factor VIIa complex: Role of the membrane surface

Morrissey, J. H., Tajkhorshid, E., Sligar, S. G. & Rienstra, C. M., May 1 2012, In : Thrombosis Research. 129, SUPPL. 2, p. S8-S10

Research output: Contribution to journalArticle

2019

Correction to: Allosteric interactions in human cytochrome P450 CYP3A4: The role of phenylalanine 213 (Biochemistry (2019) 58: 10 (1411-1422) DOI: 10.1021/acs.biochem.8b01268)

Denisov, I. G., Grinkova, Y. V., Nandigrami, P., Shekhar, M., Tajkhorshid, E. & Sligar, S. G., Jun 18 2019, In : Biochemistry. 58, 24, 1 p.

Research output: Contribution to journalComment/debate

2018

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4

Denisov, I. G., Baylon, J. L., Grinkova, Y. V., Tajkhorshid, E. & Sligar, S. G., Feb 6 2018, In : Biochemistry. 57, 5, p. 805-816 12 p.

Research output: Contribution to journalArticle

2015

Mechanism of Drug-Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer

Denisov, I. G., Grinkova, Y. V., Baylon, J. L., Tajkhorshid, E. & Sligar, S. G., Apr 7 2015, In : Biochemistry. 54, 13, p. 2227-2239 13 p.

Research output: Contribution to journalArticle

2019

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213

Denisov, I. G., Grinkova, Y. V., Nandigrami, P., Shekhar, M., Tajkhorshid, E. & Sligar, S. G., Mar 12 2019, In : Biochemistry. 58, 10, p. 1411-1422 12 p.

Research output: Contribution to journalArticle

2013

Characterizing the membrane-bound state of cytochrome P450 3A4: Structure, depth of insertion, and orientation

Baylon, J. L., Lenov, I. L., Sligar, S. G. & Tajkhorshid, E., Jun 12 2013, In : Journal of the American Chemical Society. 135, 23, p. 8542-8551 10 p.

Research output: Contribution to journalArticle

2011

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding

Bayburt, T. H., Vishnivetskiy, S. A., McLean, M. A., Morizumi, T., Huang, C. C., Tesmer, J. J. G., Ernst, O. P., Sligar, S. G. & Gurevich, V. V., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1420-1428 9 p.

Research output: Contribution to journalArticle

2016

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis

Duggal, R., Liu, Y., Gregory, M. C., Denisov, I. G., Kincaid, J. R. & Sligar, S. G., Aug 19 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

2013

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes

Luthra, A., Gregory, M., Grinkova, Y. V., Denisov, I. G. & Sligar, S. G., 2013, Cytochrome P450 Protocols. Humana Press Inc., p. 115-127 13 p. (Methods in Molecular Biology; vol. 987).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding

Reichart, T. M., Baksh, M. M., Rhee, J. K., Fiedler, J. D., Sligar, S. G., Finn, M. G., Zwick, M. B. & Dawson, P. E., Feb 18 2016, In : Angewandte Chemie - International Edition. 55, 8, p. 2688-2692 5 p.

Research output: Contribution to journalArticle

2013

Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry

Gregory, M., Mak, P. J., Sligar, S. G. & Kincaid, J. R., May 10 2013, In : Angewandte Chemie - International Edition. 52, 20, p. 5342-5345 4 p.

Research output: Contribution to journalArticle

2012

A novel type of allosteric regulation: Functional cooperativity in monomeric proteins

Denisov, I. G. & Sligar, S. G., Mar 15 2012, In : Archives of Biochemistry and Biophysics. 519, 2, p. 91-102 12 p.

Research output: Contribution to journalReview article

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S., Wraight, C. A. & Strano, M., Dec 1 2011, 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings. (11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2020

Molecular Orientation Determination in Nanodiscs at the Single-Molecule Level

Camp, T., Mehta, K., Sligar, S. G. & Zhang, K., Jan 21 2020, In : Analytical chemistry. 92, 2, p. 2229-2236 8 p.

Research output: Contribution to journalArticle

2018

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202

Gregory, M. C., Mak, P. J., Khatri, Y., Kincaid, J. R. & Sligar, S. G., Feb 6 2018, In : Biochemistry. 57, 5, p. 764-771 8 p.

Research output: Contribution to journalArticle

2013

Nanodisc-solubilized membrane protein library reflects the membrane proteome

Marty, M. T., Wilcox, K. C., Klein, W. L. & Sligar, S. G., Feb 12 2013, In : Analytical and bioanalytical chemistry. 405, 12, p. 4009-4016 8 p.

Research output: Contribution to journalArticle

2011

Investigation of the low frequency dynamics of heme proteins: Native and mutant cytochrome P450cam and redox partner complexes

Karunakaran, V., Denisov, I., Sligar, S. G. & Champion, P. M., May 12 2011, In : Journal of Physical Chemistry B. 115, 18, p. 5665-5677 13 p.

Research output: Contribution to journalArticle

Analysis of heterotropic cooperativity in cytochrome P450 3A4 using α-Naphthoflavone and testosterone

Frank, D. J., Denisov, I. G. & Sligar, S. G., Feb 18 2011, In : Journal of Biological Chemistry. 286, 7, p. 5540-5545 6 p.

Research output: Contribution to journalArticle

2013

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: Evidence for a reactive peroxoanion intermediate

Gregory, M. C., Denisov, I. G., Grinkova, Y. V., Khatri, Y. & Sligar, S. G., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16245-16247 3 p.

Research output: Contribution to journalArticle

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 436-437 2 p. (Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2019

The hydrodynamic motion of Nanodiscs

Camp, T., McLean, M., Kato, M., Cheruzel, L. & Sligar, S., May 2019, In : Chemistry and Physics of Lipids. 220, p. 28-35 8 p.

Research output: Contribution to journalArticle

2016

The Charge Properties of Phospholipid Nanodiscs

Her, C., Filoti, D. I., McLean, M. A., Sligar, S. G., Alexander Ross, J. B., Steele, H. & Laue, T. M., Sep 6 2016, In : Biophysical journal. 111, 5, p. 989-998 10 p.

Research output: Contribution to journalArticle

2015

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment

Skar-Gislinge, N., Kynde, S. A. R., Denisov, I. G., Ye, X., Lenov, I., Sligar, S. G. & Arleth, L., Jan 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 2412-2421 10 p.

Research output: Contribution to journalArticle

2011

Defining CYP3A4 structural responses to substrate binding. raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450

Mak, P. J., Denisov, I. G., Grinkova, Y. V., Sligar, S. G. & Kincaid, J. R., Feb 9 2011, In : Journal of the American Chemical Society. 133, 5, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

2020

Membrane-Bound Ras as a Conformational Clock

Gorfe, A. A. & Sligar, S. G., Jan 1 2020, (Accepted/In press) In : Biophysical journal.

Research output: Contribution to journalArticle

2011

Cytochromes P450 in nanodiscs

Denisov, I. G. & Sligar, S. G., Jan 1 2011, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 223-229 7 p.

Research output: Contribution to journalReview article

2019

Nanodiscs as a New Tool to Examine Lipid–Protein Interactions

Denisov, I. G., Schuler, M. A. & Sligar, S. G., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 645-671 27 p. (Methods in Molecular Biology; vol. 2003).

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Nanodiscs as a modular platform for multimodal MR-optical imaging

Carney, C. E., Lenov, I. L., Baker, C. J., Macrenaris, K. W., Eckermann, A. L., Sligar, S. G. & Meade, T. J., May 20 2015, In : Bioconjugate Chemistry. 26, 5, p. 899-905 7 p.

Research output: Contribution to journalArticle

2017

Interaction of KRas4b with anionic membranes: A special role for PIP2

Gregory, M. C., McLean, M. A. & Sligar, S. G., May 27 2017, In : Biochemical and Biophysical Research Communications. 487, 2, p. 351-355 5 p.

Research output: Contribution to journalArticle

2014

Resonance raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic Ligands of CYP17

Mak, P. J., Gregory, M. C., Sligar, S. G. & Kincaid, J. R., Jan 14 2014, In : Biochemistry. 53, 1, p. 90-100 11 p.

Research output: Contribution to journalArticle

2011

Anomalous transitions of DODAB using fast scanning liquid calorimetry

De La Rama, L. P., Hu, L., Efremov, M. Y., Olson, E. A., Nealey, P. F., McLean, M. A., Sligar, S. G. & Allen, L. H., Aug 10 2011, In : Thermochimica Acta. 522, 1-2, p. 72-76 5 p.

Research output: Contribution to journalArticle

2018

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step

Duggal, R., Denisov, I. G. & Sligar, S. G., Jul 2018, In : FEBS Letters. 592, 13, p. 2282-2288 7 p.

Research output: Contribution to journalLetter

2012

Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase

Dalal, K., Chan, C. S., Sligar, S. G. & Duong, F., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4104-4109 6 p.

Research output: Contribution to journalArticle