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2016

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5

Zhang, L., Chen, C. C., Ko, T. P., Huang, J. W., Zheng, Y., Liu, W., Wang, I., Malwal, S. R., Feng, X., Wang, K., Huang, C. H., Hsu, S. T. D., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4716-4720 5 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Biosynthesis
Antibiotics
Anti-Bacterial Agents
Glycosides
2011

Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

Durrant, J. D., Cao, R., Gorfe, A. A., Zhu, W., Li, J., Sankovsky, A., Oldfield, E. & Mccammon, J. A., Sep 1 2011, In : Chemical Biology and Drug Design. 78, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Geranyltranstransferase
Computer-Aided Design
Drug Design
Biosynthesis
2014

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

Benaim, G., Casanova, P., Hernandez-Rodriguez, V., Mujica-Gonzalez, S., Parra-Gimenez, N., Plaza-Rojas, L., Concepcion, J. L., Liu, Y. L., Oldfield, E., Paniz-Mondolfi, A. & Suarez, A. I., Apr 2014, In : Antimicrobial Agents and Chemotherapy. 58, 4, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Amiodarone
Ergosterol
Parasites
Trypanosoma cruzi

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Aripirala, S., Gonzalez-Pacanowska, D., Oldfield, E., Kaiser, M., Amzel, L. M. & Gabelli, S. B., Mar 1 2014, In : Acta Crystallographica Section D: Biological Crystallography. 70, 3, p. 802-810 9 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Leishmania major
Diphosphonates
Thermodynamics
Nitrogen
2012

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Lin, F. Y., Zhang, Y., Hensler, M., Liu, Y. L., Chow, O. A., Zhu, W., Wang, K., Pang, R., Thienphrapa, W., Nizet, V. & Oldfield, E., Apr 1 2012, In : ChemMedChem. 7, 4, p. 561-564 4 p.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Xanthophylls
High-Throughput Screening Assays
Bacterial Proteins
Enzyme Inhibitors
2011

Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism

Wang, H., Sarikonda, G., Puan, K. J., Tanaka, Y., Feng, J., Giner, J. L., Cao, R., Mönkkönen, J., Oldfield, E. & Morita, C. T., Nov 15 2011, In : Journal of Immunology. 187, 10, p. 5099-5113 15 p.

Research output: Contribution to journalArticle

Terpenes
Mevalonic Acid
Geranyltranstransferase
T-Lymphocytes
Organophosphonates
2010

Targeting isoprenoid biosynthesis for drug discovery: Bench to bedside

Oldfield, E., Sep 21 2010, In : Accounts of chemical research. 43, 9, p. 1216-1226 11 p.

Research output: Contribution to journalArticle

Biosynthesis
Terpenes
Pharmaceutical Preparations
Farnesyl-Diphosphate Farnesyltransferase
Antiparasitic Agents
2013

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus

Ren, F., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E. & Guo, R. T., Jan 1 2013, In : ChemBioChem. 14, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Triose-Phosphate Isomerase
Protein Conformation
Molecular Models
Transferases
2015

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

Li, K., Wang, Y., Yang, G., Byun, S., Rao, G., Shoen, C., Yang, H., Gulati, A., Crick, D. C., Cynamon, M., Huang, G., Docampo, R., No, J. H. & Oldfield, E., May 8 2015, In : ACS Infectious Diseases. 1, 5, p. 215-221 7 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Trypanosoma brucei brucei
ethylenediamine
Mycobacterium tuberculosis
African Trypanosomiasis
2016

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI

Li, J., Feng, X., Zhu, W., Oskolkov, N., Zhou, T., Kim, B. K., Baig, N., McMahon, M. T. & Oldfield, E., Jan 4 2016, In : Chemistry - A European Journal. 22, 1, p. 264-271 8 p.

Research output: Contribution to journalArticle

Quantum chemistry
Magnetic resonance imaging
Contrast Media
Toxicity
Protons
2012

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

Xia, Y., Yeddula, N., Leblanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R. J. & Verma, I. M., Mar 1 2012, In : Nature Cell Biology. 14, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Cell Proliferation
Neoplasms
Alveolar Epithelial Cells
Growth

Terpene biosynthesis: Modularity rules

Oldfield, E. & Lin, F. Y., Jan 27 2012, In : Angewandte Chemie - International Edition. 51, 5, p. 1124-1137 14 p.

Research output: Contribution to journalReview article

Terpenes
Biosynthesis
Enzymes
Diphosphates
Triterpenes

Head-to-head prenyl tranferases: Anti-infective drug targets

Lin, F. Y., Liu, Y. L., Li, K., Cao, R., Zhu, W., Axelson, J., Pang, R. & Oldfield, E., May 10 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4367-4372 6 p.

Research output: Contribution to journalArticle

Quinuclidines
Adamantane
Diphosphates
Drug Design
Transferases

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
HIV Integrase Inhibitors
Integrase Inhibitors
Keto Acids
Biosynthesis
2014

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Liu, Y. L., Lindert, S., Zhu, W., Wang, K., McCammon, J. A. & Oldfield, E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. E2530-E2539

Research output: Contribution to journalArticle

zoledronic acid
Geranyltranstransferase
Allosteric Site
Trypanosoma brucei brucei
Diphosphonates
2010

Bioorganometallic mechanism of action, and inhibition, of IspH

Wang, W., Wang, K., Liu, Y. L., No, J. H., Li, J., Nilges, M. J. & Oldfield, E., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4522-4527 6 p.

Research output: Contribution to journalArticle

Diphosphates
Electron Spin Resonance Spectroscopy
Spectrum Analysis
Molybdoferredoxin
Nitrogenase

Mechanism of action and inhibition of dehydrosqualene synthase

Lin, F. Y., Liu, C. I., Liu, Y. L., Zhang, Y., Wang, K., Jeng, W. Y., Ko, T. P., Cao, R., Wang, A. H. J. & Oldfield, E., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21337-21342 6 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Alkenes
Sterols
Carotenoids
2015

IspH-RPS1 and IspH-UbiA: "rosetta stone" proteins

Rao, G., O'Dowd, B., Li, J., Wang, K. & Oldfield, E., Jan 1 2015, In : Chemical Science. 6, 12, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

Proteins
Terpenes
Dimethylallyltranstransferase
Clostridium
Tandem Repeat Sequences
2016

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

Yang, G., Zhu, W., Wang, Y., Huang, G., Byun, S. Y., Choi, G., Li, K., Huang, Z., Docampo, R., Oldfield, E. & No, J. H., Jan 8 2016, In : ACS Infectious Diseases. 1, 8, p. 388-398 11 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Geranyltranstransferase
Kinetoplast DNA
Parasites
Amidines
2017

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase

Rao, G., Bansal, S., Law, W. X., O'Dowd, B., Dikanov, S. A. & Oldfield, E., Jul 25 2017, In : Biochemistry. 56, 29, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Electron Spin Resonance Spectroscopy
Drosophila
Paramagnetic resonance
Copper
2018

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

Xia, Y., Xie, Y., Yu, Z., Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X. & 3 others, Liu, W., Shi, Y. & Zhang, Y., Nov 1 2018, In : Cell. 175, 4, p. 1059-1073.e21

Research output: Contribution to journalArticle

Mevalonic Acid
Vaccines
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diphosphonates
CD27 Antigens
2015

A molecular dynamics investigation of Mycobacterium tuberculosis prenyl synthases: Conformational flexibility and implications for computer-aided drug discovery

Kim, M. O., Feng, X., Feixas, F., Zhu, W., Lindert, S., Bogue, S., Sinko, W., De Oliveira, C., Rao, G., Oldfield, E. & McCammon, J. A., Jun 1 2015, In : Chemical Biology and Drug Design. 85, 6, p. 756-769 14 p.

Research output: Contribution to journalArticle

Drug Discovery
Molecular Dynamics Simulation
Mycobacterium tuberculosis
undecaprenyl pyrophosphate synthetase
Geranyltranstransferase
2019

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

Zhang, L., Ko, T. P., Malwal, S. R., Liu, W., Zhou, S., Yu, X., Oldfield, E., Guo, R. T. & Chen, C. C., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 800-805 6 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Branched-Chain Oligosaccharides
Substrates
Crystal structure
Derivatives
2014

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Functional analysis
Biofilms
Bacilli
Bacillus subtilis
Farnesol

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Liu, W., Feng, X., Zheng, Y., Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T. D., Oldfield, E. & Guo, R. T., 2014, In : Scientific reports. 4, 6214.

Research output: Contribution to journalArticle

Bradyrhizobium
Terpenes
Kaurane Diterpenes
Diterpenes
Bryopsida
2016

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

Ricci, C. G., Liu, Y. L., Zhang, Y., Wang, Y., Zhu, W., Oldfield, E. & McCammon, J. A., Sep 13 2016, In : Biochemistry. 55, 36, p. 5180-5190 11 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
zoledronic acid
Malaria
Molecular Dynamics Simulation
Pharmaceutical Preparations
2015

Antibacterial drug leads: DNA and enzyme multitargeting

Zhu, W., Wang, Y., Li, K., Gao, J., Huang, C. H., Chen, C. C., Ko, T. P., Zhang, Y., Guo, R. T. & Oldfield, E., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Inhibitory Concentration 50
Staphylococcus aureus
DNA
Enzymes
2013

Farnesyl diphosphate synthase inhibitors from in silico screening

Lindert, S., Zhu, W., Liu, Y. L., Pang, R., Oldfield, E. & Mccammon, J. A., Jun 1 2013, In : Chemical Biology and Drug Design. 81, 6, p. 742-748 7 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Computer Simulation
Screening
Preclinical Drug Evaluations
Bone Diseases
2017

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

Cell Wall
undecaprenyl pyrophosphate synthetase
Diphosphates
Anti-Bacterial Agents
Phosphoric Monoester Hydrolases
2014

Squalene Synthase As a Target for Chagas Disease Therapeutics

Shang, N., Li, Q., Ko, T. P., Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M. U., de Souza, W., Urbina, J. A., Wang, A. H. J., Docampo, R. & 4 others, Li, K., Liu, Y. L., Oldfield, E. & Guo, R. T., May 2014, In : PLoS pathogens. 10, 5, e1004114.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Chagas Disease
Trypanosoma cruzi
Quinuclidines
Diphosphonates
2015

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

Saad, A., Zhu, W., Rousseau, G., Mialane, P., Marrot, J., Haouas, M., Taulelle, F., Dessapt, R., Serier-Brault, H., Rivière, E., Kubo, T., Oldfield, E. & Dolbecq, A., Jul 1 2015, In : Chemistry - A European Journal. 21, 29, p. 10537-10547 11 p.

Research output: Contribution to journalArticle

Diphosphonates
Cells
Biosynthesis
Magnetic variables measurement
Ions
2010

Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: Activity in killing tumor cells

Compain, J. D., Mialane, P., Marrot, J., Sécheresse, F., Zhu, W., Oldfield, E. & Dolbecq, A., Dec 10 2010, In : Chemistry - A European Journal. 16, 46, p. 13741-13748 8 p.

Research output: Contribution to journalArticle

Alendronate
Diphosphonates
Tumors
Ligands
Cells
2012

Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Ren, F., Ko, T. P., Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 23 2012, In : Angewandte Chemie - International Edition. 51, 17, p. 4157-4160 4 p.

Research output: Contribution to journalArticle

Antibiotics
Phosphates
Enzymes
Crystal structure
Ligands

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

Liu, Y. L., Guerra, F., Wang, K., Wang, W., Li, J., Huang, C., Zhu, W., Houlihan, K., Li, Z., Zhang, Y., Nair, S. K. & Oldfield, E., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8558-8563 6 p.

Research output: Contribution to journalArticle

Mutation
Ligands
Proteins
Drug Design
Terpenes
2011

Applying molecular dynamics simulations to identify rarely sampled ligand-bound conformational states of undecaprenyl pyrophosphate synthase, an antibacterial target

Sinko, W., de Oliveira, C., Williams, S., Van Wynsberghe, A., Durrant, J. D., Cao, R., Oldfield, E. & Mccammon, J. A., Jun 1 2011, In : Chemical Biology and Drug Design. 77, 6, p. 412-420 9 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Molecular dynamics
Ligands
Computer simulation
Crystal structure
2012

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

No, J. H., De Macedo Dossin, F., Zhang, Y., Liu, Y. L., Zhu, W., Feng, X., Yoo, J. A., Lee, E., Wang, K., Hui, R., Freitas-Junior, L. H. & Oldfield, E., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4058-4063 6 p.

Research output: Contribution to journalArticle

zoledronic acid
Farnesyltranstransferase
Plasmodium
Diphosphonates
Antimalarials
2010

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

Wang, W., Li, J., Wang, K., Huang, C., Zhang, Y. & Oldfield, E., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11189-11193 5 p.

Research output: Contribution to journalArticle

Terpenes
Electron Spin Resonance Spectroscopy
Protein Biosynthesis
Alkynes
Diphosphates

Binding of azole antibiotics to Staphylococcus aureus flavohemoglobin increases intracellular oxidative stress

Nobre, L. S., Todorovic, S., Tavares, A. F. N., Oldfield, E., Hildebrandt, P., Teixeira, M. & Saraiva, L. M., Mar 1 2010, In : Journal of bacteriology. 192, 6, p. 1527-1533 7 p.

Research output: Contribution to journalArticle

Azoles
Staphylococcus aureus
Oxidative Stress
Anti-Bacterial Agents
Miconazole
2018

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Elsebaei, M. M., Mohammad, H., Abouf, M., Abutaleb, N. S., Hegazy, Y. A., Ghiaty, A., Chen, L., Zhang, J., Malwal, S. R., Oldfield, E., Seleem, M. N. & Mayhoub, A. S., Mar 25 2018, In : European Journal of Medicinal Chemistry. 148, p. 195-209 15 p.

Research output: Contribution to journalArticle

Methicillin
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Metabolism
undecaprenyl pyrophosphate synthetase

“Head-to-Middle” and “Head-to-Tail” cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

Gao, J., Ko, T. P., Chen, L., Malwal, S. R., Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., Jan 15 2018, In : Angewandte Chemie - International Edition. 57, 3, p. 683-687 5 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Diphosphates
Antibiotics
Tunnels
Dimethylallyltranstransferase
2017

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

Neisseria
Pathogens
Staphylococcus aureus
Bacteria
Farnesyl-Diphosphate Farnesyltransferase
2015

Tuberculosis Terpene Targets

Oldfield, E., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 437-438 2 p.

Research output: Contribution to journalShort survey

Terpenes
Mycobacterium tuberculosis
Adenosine
Tuberculosis
Biomarkers
2014

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Paramagnetic resonance
Dithionite
Acetylene
Diphosphates
Proteins
Biosynthesis
Terpenes
Enzymes
Proteins
Polyisoprenyl Phosphates

Iron porphyrin carbenes as catalytic intermediates: Structures, mössbauer and NMR spectroscopic properties, and bonding

Khade, R. L., Fan, W., Ling, Y., Yang, L., Oldfield, E. & Zhang, Y., Jul 14 2014, In : Angewandte Chemie - International Edition. 53, 29, p. 7574-7578 5 p.

Research output: Contribution to journalArticle

Porphyrins
Iron
Nuclear magnetic resonance
Metalloporphyrins
Hemeproteins
2010

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth

Singh, A. P., Zhang, Y., No, J. H., Docampo, R., Nussenzweig, V. & Oldfield, E., Jul 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2987-2993 7 p.

Research output: Contribution to journalArticle

Plasmodium
Diphosphonates
Liver
Farnesyltranstransferase
Growth
2012

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH

Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E. & Groll, M., Oct 8 2012, In : Nature communications. 3, 1042.

Research output: Contribution to journalArticle

Iron-Sulfur Proteins
Aldehydes
acetylene
Polyisoprenyl Phosphates
diphosphates
2015

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

Proton-Motive Force
Mycobacterium tuberculosis
undecaprenyl pyrophosphate synthetase
Membranes
Staphylococcus aureus
2016

Structure and Function of a "head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase

Liu, M., Chen, C. C., Chen, L., Xiao, X., Zheng, Y., Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E., Guo, R. T. & Ma, Y., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4721-4724 4 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Monoterpenes
Fragrances
Nucleophiles
Diphosphates