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2011
Vibrio cholerae
Cholera
Glycerol
Phospholipids
Fatty Acids
2012

The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities

Bi, H., Christensen, Q. H., Feng, Y., Wang, H. & Cronan, J. E., Feb 1 2012, In : Molecular Microbiology. 83, 4, p. 840-855 16 p.

Research output: Contribution to journalArticle

Burkholderia cenocepacia
Enoyl-CoA Hydratase
Acyl Carrier Protein
Hydro-Lyases
Quorum Sensing
2017
Pimelic Acids
Biotin
Bacillus subtilis
Fatty Acids
Acids
2018

Advances in synthesis of biotin and assembly of lipoic acid

Cronan, J. E., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. 60-66 7 p.

Research output: Contribution to journalReview article

Thioctic Acid
Biotin
Methylation
Metabolism
Escherichia coli
2012

Crosstalk of Escherichia coli FadR with Global Regulators in Expression of Fatty Acid Transport Genes

Feng, Y. & Cronan, J. E., Sep 28 2012, In : PloS one. 7, 9, e46275.

Research output: Contribution to journalArticle

Crosstalk
Escherichia coli
binding sites
Fatty Acids
Genes
Acyl Carrier Protein
Esterification
Methyltransferases
Biotin
Malonyl Coenzyme A
2013

FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle

Bi, H., Wang, H. & Cronan, J. E., Sep 19 2013, In : Chemistry and Biology. 20, 9, p. 1157-1167 11 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Isomerases
Unsaturated Fatty Acids
Fatty Acids
Escherichia coli
2015

The conserved modular elements of the acyl carrier proteins of lipid synthesis are only partially interchangeable

Zhu, L. & Cronan, J. E., May 29 2015, In : Journal of Biological Chemistry. 290, 22, p. 13791-13799 9 p.

Research output: Contribution to journalArticle

Acyl Carrier Protein
Lactococcus lactis
Escherichia coli
Lipids
Proteins
2012

Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity In vivo

Smith, A. C. & Cronan, J. E., Jan 1 2012, In : Journal of bacteriology. 194, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

biotin carboxylase
Acetyl-CoA Carboxylase
Dimerization
Coenzyme A
Proteins
2011

Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters

Feng, Y. & Cronan, J. E., Apr 1 2011, In : Molecular Microbiology. 80, 1, p. 195-218 24 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Unsaturated Fatty Acids
Escherichia coli
Genetic Promoter Regions
Binding Sites
2013

Proofreading of noncognate Acyl adenylates by an acyl-coenzyme a ligase

Manandhar, M. & Cronan, J. E., Dec 19 2013, In : Chemistry and Biology. 20, 12, p. 1441-1446 6 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Coenzymes
Ligases
Dicarboxylic Acids
Substrates
2014
Succinic Acid
Escherichia coli
Growth
Succinate Dehydrogenase
Ligases
2011

Synthesis of the α,ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway

Cronan, J. E. & Lin, S., Jun 1 2011, In : Current Opinion in Chemical Biology. 15, 3, p. 407-413 7 p.

Research output: Contribution to journalReview article

Dicarboxylic Acids
Pimelic Acids
Biosynthetic Pathways
Biotin
Fatty Acids
2017

Expression and activity of the BioH esterase of biotin synthesis is independent of genome context

Cao, X., Zhu, L., Hu, Z. & Cronan, J. E., Dec 1 2017, In : Scientific reports. 7, 1, 2141.

Research output: Contribution to journalArticle

Esterases
Operon
Biotin
Genome
Hydrolases
2015

The atypical occurrence of two biotin protein ligases in Francisella novicida is due to distinct roles in virulence and biotin metabolism

Feng, Y., Chin, C. Y., Chakravartty, V., Gao, R., Crispell, E. K., Weiss, D. S. & Cronan, J. E., Jun 9 2015, In : mBio. 6, 3

Research output: Contribution to journalArticle

Francisella
Ligases
Biotin
Virulence
Proteins
2012

Altered regulation of escherichia coli biotin biosynthesis in bira superrepressor mutant strains

Chakravartty, V. & Cronan, J. E., Mar 1 2012, In : Journal of bacteriology. 194, 5, p. 1113-1126 14 p.

Research output: Contribution to journalArticle

Biotin
Escherichia coli
Operon
Mutation
Ligases
2018

Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor

Cao, X., Koch, T., Steffens, L., Finkensieper, J., Zigann, R., Cronan, J. E. & Dahl, C., Jul 13 2018, In : eLife. 7, e37439.

Research output: Contribution to journalArticle

Sulfur
Carrier Proteins
Oxidation
Genes
Bacillus subtilis
2013

Discovery of new enzymes and metabolic pathways by using structure and genome context

Zhao, S., Kumar, R., Sakai, A., Vetting, M. W., Wood, B. M. K., Brown, S., Bonanno, J. B., Hillerich, B. S., Seidel, R. D., Babbitt, P. C., Almo, S. C., Sweedler, J. V., Gerlt, J. A., Cronan, J. E. & Jacobson, M. P., Sep 24 2013, In : Nature. 502, 7473, p. 698-702 5 p.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Genome
Multigene Family
Substrate Specificity
Enzymes
2010

Lipoic acid synthesis: A new family of octanoyltransferases generally annotated as lipoate protein ligases

Christensen, Q. H. & Cronan, J. E., Nov 23 2010, In : Biochemistry. 49, 46, p. 10024-10036 13 p.

Research output: Contribution to journalArticle

Thioctic Acid
Escherichia coli
Bacillus subtilis
Enzymes
Ligases
2011

A complex lipoate utilization pathway in Listeria monocytogenes

Christensen, Q. H., Hagar, J. A., O'Riordan, M. X. D. & Cronan, J. E., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31447-31456 10 p.

Research output: Contribution to journalArticle

Listeria
Thioctic Acid
Listeria monocytogenes
Scavenging
Metabolism
2018
8-amino-7-oxononanoate synthase
coenzyme A
biotin
Biotin
Bacillus subtilis
2010

Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase

Zhu, L., Lin, J., Ma, J., Cronan, J. E. & Wang, H., Feb 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 2, p. 689-698 10 p.

Research output: Contribution to journalArticle

Triclosan
Acyl Carrier Protein
Pseudomonas aeruginosa
Oxidoreductases
Disinfectants
2012

Evolution of a new function in an esterase: Simple amino acid substitutions enable the activity present in the larger paralog, BioH

Flores, H., Lin, S., Contreras-Ferrat, G., Cronan, J. E. & Morett, E., Aug 1 2012, In : Protein Engineering, Design and Selection. 25, 8, p. 387-395 9 p.

Research output: Contribution to journalArticle

Esterases
Amino Acid Substitution
Amino acids
Substitution reactions
Biotin
2018
Glycine
Keto Acids
Proteins
Oxidoreductases
Bacillus subtilis
2016
Operon
Ligases
Biotin
Staphylococcus aureus
DNA
2015

Biosynthesis of squalene from farnesyl diphosphate in Bacteria: Three steps catalyzed by three enzymes

Pan, J. J., Solbiati, J. O., Ramamoorthy, G., Hillerich, B. S., Seidel, R. D., Cronan, J. E., Almo, S. C. & Poulter, C. D., May 27 2015, In : ACS Central Science. 1, 2, p. 77-82 6 p.

Research output: Contribution to journalArticle

Squalene
Biosynthesis
Bacteria
Enzymes
Genes
2014

Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme a carboxylase

Smith, A. C. & Cronan, J. E., Jan 1 2014, In : Journal of bacteriology. 196, 21, p. 3768-3775 8 p.

Research output: Contribution to journalArticle

Carboxyl and Carbamoyl Transferases
Coenzymes
Escherichia coli
Messenger RNA
Acetyl-CoA Carboxylase

PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis

Feng, Y. & Cronan, J. E., Jul 2014, In : Research in Microbiology. 165, 6, p. 429-438 10 p.

Research output: Contribution to journalArticle

Thioctic Acid
Pyruvic Acid
Oxidoreductases
Binding Sites
Galactosidases
2010
Transcription
Operon
Biotin
Escherichia coli
Switches
2016
Thioctic Acid
Biosynthetic Pathways
Keto Acids
Enzymes
Bacillus subtilis
2019
Isomerases
Pseudomonas putida
isomerization
isomerases
soil bacteria
2014

Roles of small laccases from streptomyces in lignin degradation

Majumdar, S., Lukk, T., Solbiati, J. O., Bauer, S., Nair, S. K., Cronan, J. E. & Gerlt, J. A., Jun 24 2014, In : Biochemistry. 53, 24, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

Laccase
Lignin
Streptomyces
Degradation
Streptomyces coelicolor
2013

Profligate biotin synthesis in α-proteobacteria - a developing or degenerating regulatory system?

Feng, Y., Zhang, H. & Cronan, J. E., Apr 1 2013, In : Molecular Microbiology. 88, 1, p. 77-92 16 p.

Research output: Contribution to journalArticle

Proteobacteria
Biotin
Ligases
Bacteria
Proteins
2010

Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA

Feng, Y. & Cronan, J. E., Sep 1 2010, In : Journal of bacteriology. 192, 17, p. 4289-4299 11 p.

Research output: Contribution to journalArticle

Cyclic AMP Receptor Protein
Cyclic AMP
Binding Sites
Escherichia coli
Fatty Acids
2014

Successful conversion of the Bacillus subtilis BirA group II biotin protein ligase into a group I ligase

Henke, S. K. & Cronan, J. E., May 9 2014, In : PloS one. 9, 5, e96757.

Research output: Contribution to journalArticle

Bacilli
Ligases
Biotin
Bacillus subtilis
ligases
2019
Lysogeny
Bacteriophages
Escherichia coli
Temperature
Microbiological Attachment Sites
2012

Only one of the five Ralstonia solanacearum long-chain 3-ketoacyl-acyl carrier protein synthase homologues functions in fatty acid synthesis

Cheng, J., Ma, J., Lin, J., Fan, Z. C., Cronan, J. E. & Wang, H., Mar 1 2012, In : Applied and environmental microbiology. 78, 5, p. 1563-1573 11 p.

Research output: Contribution to journalArticle

holo-(acyl-carrier-protein) synthase
Ralstonia solanacearum
acyl carrier protein
Fatty Acids
fatty acid
2013

Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation

Goble, A. M., Feng, Y., Raushel, F. M. & Cronan, J. E., Dec 20 2013, In : ACS chemical biology. 8, 12, p. 2622-2629 8 p.

Research output: Contribution to journalArticle

Adenosine Deaminase
Adenosine Monophosphate
Cyclic AMP
Inosine Monophosphate
Genes

The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis

Hermes, F. A. & Cronan, J. E., Oct 1 2013, In : Yeast. 30, 10, p. 415-427 13 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae Proteins
Thioctic Acid
Yeast
Amino acids
Enzymes
2010

Intein-mediated cyclization of bacterial acyl carrier protein stabilizes its folded conformation but does not abolish function

Volkmann, G., Murphy, P. W., Rowland, E. E., Cronan, J. E., Liu, X. Q., Blouin, C. & Byers, D. M., Mar 19 2010, In : Journal of Biological Chemistry. 285, 12, p. 8605-8614 10 p.

Research output: Contribution to journalArticle

Inteins
Acyl Carrier Protein
Cyclization
Conformations
Protein Unfolding

Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis

Wier, A. M., Nyholm, S. V., Mandel, M. J., Massengo-Tiassé, R. P., Schaefer, A. L., Koroleva, I., Splinter-BonDurant, S., Brown, B., Manzella, L., Snir, E., Almabrazi, H., Scheetz, T. E., Bonaldo, M. D. F., Casavant, T. L., Soares, M. B., Cronan, J. E., Reed, J. L., Ruby, E. G. & McFall-Ngai, M. J., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2259-2264 6 p.

Research output: Contribution to journalArticle

Symbiosis
Bacteria
Decapodiformes
Epithelium
Population

Expression of Vibrio harveyi Acyl-ACP synthetase allows efficient entry of exogenous fatty acids into the Escherichia coli fatty acid and lipid a synthetic pathways

Jiang, Y., Morgan-Kiss, R. M., Campbell, J. W., Chan, C. H. & Cronan, J. E., Feb 2 2010, In : Biochemistry. 49, 4, p. 718-726 9 p.

Research output: Contribution to journalArticle

Vibrio
Escherichia coli
Fatty Acids
Lipids
Nonesterified Fatty Acids
2012
Acyl Carrier Protein
Biotin
Esters
Gatekeeping
Enzymes
2011

Probing protein dynamics in vivo using backbone cyclization: Bacterial acyl carrier protein as a case study

Volkmann, G., Murphy, P. W., Rowland, E. E., Cronan, J. E. & Byers, D. M., Dec 23 2011, Methods in Protein Biochemistry. Walter de Gruyter GmbH and Co. KG, p. 271-293 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Acyl Carrier Protein
acyl carrier protein
Cyclization
case studies
Proteins
2014

Xanthomonas campestrisRpfB is a fatty Acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase

Bi, H., Yu, Y., Dong, H., Wang, H. & Cronan, J. E., Jul 2014, In : Molecular Microbiology. 93, 2, p. 262-275 14 p.

Research output: Contribution to journalArticle

Xanthomonas
Acyl Coenzyme A
Ligases
Acyl Carrier Protein
Fatty Acids
Fatty Acid Synthesis Inhibitors
Fatty Acids
Bacteria
Anhydrides
Infection
2017

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

Estrada, P., Manandhar, M., Dong, S. H., Deveryshetty, J., Agarwal, V., Cronan, J. E. & Nair, S. K., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 668-674 7 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Catalytic Domain
Coenzyme A Ligases
Enzymes
Coenzyme A
2013

The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance

Zhu, L., Bi, H., Ma, J., Hu, Z., Zhang, W., Cronan, J. E. & Wang, H., Oct 1 2013, In : mBio. 4, 5, e00613-13.

Research output: Contribution to journalArticle

Triclosan
Acyl Carrier Protein
Enterococcus faecalis
Oxidoreductases
Fatty Acids
2019

Enterococcus faecalis encodes an atypical auxiliary acyl carrier protein required for efficient regulation of fatty acid synthesis by exogenous fatty acids

Zhu, L., Zou, Q., Cao, X. & Cronan, J. E., May 1 2019, In : mBio. 10, 3, e00577-19.

Research output: Contribution to journalArticle

Open Access
Acyl Carrier Protein
Enterococcus faecalis
Fatty Acids
Operon
Oleic Acid
2013
Poisons
Bacteriophages
Plasmids
Escherichia coli
Gene Expression