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Author

  • Eric Oldfield
2017

Combining Vγ9Vδ2 T cells with a lipophilic bisphosphonate efficiently kills activated hepatic stellate cells

Zhou, X., Gu, Y., Xiao, H., Kang, N., Xie, Y., Zhang, G., Shi, Y., Hu, X., Oldfield, E., Zhang, X. & Zhang, Y., Oct 24 2017, In : Frontiers in immunology. 8, OCT, 1381.

Research output: Contribution to journalArticle

2015

IspH-RPS1 and IspH-UbiA: "rosetta stone" proteins

Rao, G., O'Dowd, B., Li, J., Wang, K. & Oldfield, E., Jan 1 2015, In : Chemical Science. 6, 12, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

2011

Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism

Wang, H., Sarikonda, G., Puan, K. J., Tanaka, Y., Feng, J., Giner, J. L., Cao, R., Mönkkönen, J., Oldfield, E. & Morita, C. T., Nov 15 2011, In : Journal of Immunology. 187, 10, p. 5099-5113 15 p.

Research output: Contribution to journalArticle

2016

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth

Desai, J., Wang, Y., Wang, K., Malwal, S. R. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 2205-2215 11 p.

Research output: Contribution to journalArticle

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI

Li, J., Feng, X., Zhu, W., Oskolkov, N., Zhou, T., Kim, B. K., Baig, N., McMahon, M. T. & Oldfield, E., Jan 4 2016, In : Chemistry - A European Journal. 22, 1, p. 264-271 8 p.

Research output: Contribution to journalArticle

2018

Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design

Venkatramani, A., Gravina Ricci, C., Oldfield, E. & McCammon, J. A., Jun 2018, In : Chemical Biology and Drug Design. 91, 6, p. 1068-1077 10 p.

Research output: Contribution to journalEditorial

2014

Resistance-resistant antibiotics

Oldfield, E. & Feng, X., Dec 2014, In : Trends in Pharmacological Sciences. 35, 12, p. 664-674 11 p.

Research output: Contribution to journalReview article

2012

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

Liu, Y. L., Guerra, F., Wang, K., Wang, W., Li, J., Huang, C., Zhu, W., Houlihan, K., Li, Z., Zhang, Y., Nair, S. K. & Oldfield, E., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8558-8563 6 p.

Research output: Contribution to journalArticle

Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Ren, F., Ko, T. P., Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 23 2012, In : Angewandte Chemie - International Edition. 51, 17, p. 4157-4160 4 p.

Research output: Contribution to journalArticle

2016

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase

Wang, Y., Desai, J., Zhang, Y., Malwal, S. R., Shin, C. J., Feng, X., Sun, H., Liu, G., Guo, R. T. & Oldfield, E., 2016, In : ChemMedChem. 11, 20, p. 2311-2319 9 p.

Research output: Contribution to journalArticle

2017

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase

Rao, G., Bansal, S., Law, W. X., O'Dowd, B., Dikanov, S. A. & Oldfield, E., Jul 25 2017, In : Biochemistry. 56, 29, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

2015

Atomic-resolution structures of discrete stages on the reaction coordinate of the [Fe4S4] enzyme IspG (GcpE)

Quitterer, F., Frank, A., Wang, K., Rao, G., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E. & Groll, M., Jun 19 2015, In : Journal of Molecular Biology. 427, 12, p. 2220-2228 9 p.

Research output: Contribution to journalArticle

2019

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W. X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C., Guo, R. T., Abdelkhalek, A., Seleem, M. N. & Oldfield, E., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2564-2581 18 p.

Research output: Contribution to journalArticle

2011

Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): A HYSCORE investigation

Wang, W., Li, J., Wang, K., Smirnova, T. I. & Oldfield, E., May 4 2011, In : Journal of the American Chemical Society. 133, 17, p. 6525-6528 4 p.

Research output: Contribution to journalArticle

2012

Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation

Wang, W., Wang, K., Span, I., Jauch, J., Bacher, A., Groll, M. & Oldfield, E., Jul 11 2012, In : Journal of the American Chemical Society. 134, 27, p. 11225-11234 10 p.

Research output: Contribution to journalArticle

2011

Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

Durrant, J. D., Cao, R., Gorfe, A. A., Zhu, W., Li, J., Sankovsky, A., Oldfield, E. & Mccammon, J. A., Sep 2011, In : Chemical Biology and Drug Design. 78, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

2017

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in Vitro and in Vivo Results

Boulmier, A., Feng, X., Oms, O., Mialane, P., Rivière, E., Shin, C. J., Yao, J., Kubo, T., Furuta, T., Oldfield, E. & Dolbecq, A., Jul 3 2017, In : Inorganic Chemistry. 56, 13, p. 7558-7565 8 p.

Research output: Contribution to journalArticle

2012

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Lin, F. Y., Zhang, Y., Hensler, M., Liu, Y. L., Chow, O. A., Zhu, W., Wang, K., Pang, R., Thienphrapa, W., Nizet, V. & Oldfield, E., Apr 2012, In : ChemMedChem. 7, 4, p. 561-564 4 p.

Research output: Contribution to journalArticle

2013

Isoprenoid biosynthesis: Ferraoxetane or allyl anion mechanism for IspH catalysis?

Li, J., Wang, K., Smirnova, T. I., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 17 2013, In : Angewandte Chemie - International Edition. 52, 25, p. 6522-6525 4 p.

Research output: Contribution to journalArticle

2015

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD+, NADPH, or NAD+/10-Oxogeranial: Reaction Mechanisms

Hu, Y., Liu, W., Malwal, S. R., Zheng, Y., Feng, X., Ko, T. P., Chen, C. C., Xu, Z., Liu, M., Han, X., Gao, J., Oldfield, E. & Guo, R. T., Dec 14 2015, In : Angewandte Chemie - International Edition. 54, 51, p. 15478-15482 5 p.

Research output: Contribution to journalArticle

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

Saad, A., Zhu, W., Rousseau, G., Mialane, P., Marrot, J., Haouas, M., Taulelle, F., Dessapt, R., Serier-Brault, H., Rivière, E., Kubo, T., Oldfield, E. & Dolbecq, A., Jul 1 2015, In : Chemistry - A European Journal. 21, 29, p. 10537-10547 11 p.

Research output: Contribution to journalArticle

2018

Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes

Malwal, S. R., Gao, J., Hu, X., Yang, Y., Liu, W., Huang, J. W., Ko, T. P., Li, L., Chen, C. C., O'Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., May 4 2018, In : ACS Catalysis. 8, 5, p. 4299-4312 14 p.

Research output: Contribution to journalArticle

2015

Antibacterial drug leads: DNA and enzyme multitargeting

Zhu, W., Wang, Y., Li, K., Gao, J., Huang, C. H., Chen, C. C., Ko, T. P., Zhang, Y., Guo, R. T. & Oldfield, E., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

2014
2011

Ultrahigh resolution protein structures using NMR chemical shift tensors

Wylie, B. J., Sperling, L. J., Nieuwkoop, A. J., Franks, W. T., Oldfield, E. & Rienstra, C. M., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 16974-16979 6 p.

Research output: Contribution to journalArticle

2015

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

2019

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

Yang, Y., Li, L., Yuan, L., Zhou, X., Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y. & 3 others, Oldfield, E., Guo, R. T. & Zhang, Y., Apr 16 2019, In : Immunity. 50, 4, p. 1043-1053.e5

Research output: Contribution to journalArticle

2013

Chemo-immunotherapeutic antimalarials targeting isoprenoid biosynthesis

Zhang, Y., Zhu, W., Liu, Y. L., Wang, H., Wang, K., Li, K., No, J. H., Ayong, L., Gulati, A., Pang, R., Freitas-Junior, L., Morita, C. T. & Oldfield, E., Apr 11 2013, In : ACS Medicinal Chemistry Letters. 4, 4, p. 423-427 5 p.

Research output: Contribution to journalArticle

2015

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

Farha, M. A., Czarny, T. L., Myers, C. L., Worrall, L. J., French, S., Conrady, D. G., Wang, Y., Oldfield, E., Strynadka, N. C. J. & Brown, E. D., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. 11048-11053 6 p.

Research output: Contribution to journalArticle

2016

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

Yang, Y., Ko, T. P., Chen, C. C., Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M. R., Hsu, S. T. D., O'Dowd, B., Huff, H. C., Huang, C. H., Docampo, R., Oldfield, E. & Guo, R. T., May 20 2016, In : ACS chemical biology. 11, 5, p. 1362-1371 10 p.

Research output: Contribution to journalArticle

2013

Structures of fluoro, amino, and thiol inhibitors bound to the [Fe 4S4] protein IspH

Span, I., Wang, K., Wang, W., Jauch, J., Eisenreich, W., Bacher, A., Oldfield, E. & Groll, M., Feb 11 2013, In : Angewandte Chemie - International Edition. 52, 7, p. 2118-2121 4 p.

Research output: Contribution to journalArticle

Antibacterial drug leads targeting isoprenoid biosynthesis

Zhu, W., Zhang, Y., Sinko, W., Hensler, M. E., Olson, J., Molohon, K. J., Lindert, S., Cao, R., Li, K., Wang, K., Wang, Y., Liu, Y. L., Sankovsky, A., De Oliveira, C. A. F., Mitchell, D. A., Nizet, V., McCammon, J. A. & Oldfield, E., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

2016

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

Ricci, C. G., Liu, Y. L., Zhang, Y., Wang, Y., Zhu, W., Oldfield, E. & McCammon, J. A., Sep 13 2016, In : Biochemistry. 55, 36, p. 5180-5190 11 p.

Research output: Contribution to journalArticle

Structure and Function of Four Classes of the 4Fe-4S Protein, IspH

Rao, G. & Oldfield, E., Jul 26 2016, In : Biochemistry. 55, 29, p. 4119-4129 11 p.

Research output: Contribution to journalArticle

Structure and Function of a "head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase

Liu, M., Chen, C. C., Chen, L., Xiao, X., Zheng, Y., Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E., Guo, R. T. & Ma, Y., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4721-4724 4 p.

Research output: Contribution to journalArticle

2012

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

2015

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms

Han, X., Chen, C. C., Kuo, C. J., Huang, C. H., Zheng, Y., Ko, T. P., Zhu, Z., Feng, X., Wang, K., Oldfield, E., Wang, A. H. J., Liang, P. H., Guo, R. T. & Ma, Y., Jan 1 2015, In : Proteins: Structure, Function and Bioinformatics. 83, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

2016

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 1915-1923 9 p.

Research output: Contribution to journalArticle

2014

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

2011

Applying molecular dynamics simulations to identify rarely sampled ligand-bound conformational states of undecaprenyl pyrophosphate synthase, an antibacterial target

Sinko, W., de Oliveira, C., Williams, S., Van Wynsberghe, A., Durrant, J. D., Cao, R., Oldfield, E. & Mccammon, J. A., Jun 2011, In : Chemical Biology and Drug Design. 77, 6, p. 412-420 9 p.

Research output: Contribution to journalArticle

2013

Farnesyl diphosphate synthase inhibitors from in silico screening

Lindert, S., Zhu, W., Liu, Y. L., Pang, R., Oldfield, E. & Mccammon, J. A., Jun 2013, In : Chemical Biology and Drug Design. 81, 6, p. 742-748 7 p.

Research output: Contribution to journalArticle

2016

Back Cover: Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase (ChemMedChem 17/2016)

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., 2016, In : ChemMedChem. 11, 17, p. 1968 1 p.

Research output: Contribution to journalComment/debate

2012

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH

Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E. & Groll, M., 2012, In : Nature communications. 3, 1042.

Research output: Contribution to journalArticle

2019

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Han, S., Li, X., Xia, Y., Yu, Z., Cai, N., Malwal, S. R., Han, X., Oldfield, E. & Zhang, Y., Dec 12 2019, In : Journal of Medicinal Chemistry. 62, 23, p. 10867-10896 30 p.

Research output: Contribution to journalArticle

2012

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

No, J. H., De Macedo Dossin, F., Zhang, Y., Liu, Y. L., Zhu, W., Feng, X., Yoo, J. A., Lee, E., Wang, K., Hui, R., Freitas-Junior, L. H. & Oldfield, E., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4058-4063 6 p.

Research output: Contribution to journalArticle

2017

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

2011

An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis

Wang, W., Wang, K., Li, J., Nellutla, S., Smirnova, T. I. & Oldfield, E., Jun 8 2011, In : Journal of the American Chemical Society. 133, 22, p. 8400-8403 4 p.

Research output: Contribution to journalArticle

2018

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Elsebaei, M. M., Mohammad, H., Abouf, M., Abutaleb, N. S., Hegazy, Y. A., Ghiaty, A., Chen, L., Zhang, J., Malwal, S. R., Oldfield, E., Seleem, M. N. & Mayhoub, A. S., Mar 25 2018, In : European Journal of Medicinal Chemistry. 148, p. 195-209 15 p.

Research output: Contribution to journalArticle