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  • Stephen G Sligar
2020

Membrane-Bound Ras as a Conformational Clock

Gorfe, A. A. & Sligar, S. G., Jan 1 2020, (Accepted/In press) In : Biophysical journal.

Research output: Contribution to journalArticle

2012

Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase

Dalal, K., Chan, C. S., Sligar, S. G. & Duong, F., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4104-4109 6 p.

Research output: Contribution to journalArticle

2019

NMR analysis of free and lipid nanodisc anchored CEACAM1 membrane proximal peptides with Ca 2+ /CaM

Ghazarian, H., Hu, W., Mao, A., Nguyen, T., Vaidehi, N., Sligar, S. & Shively, J. E., Apr 1 2019, In : Biochimica et Biophysica Acta - Biomembranes. 1861, 4, p. 787-797 11 p.

Research output: Contribution to journalArticle

2014

Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps

Khatri, Y., Luthra, A., Duggal, R. & Sligar, S. G., Aug 25 2014, In : FEBS Letters. 588, 17, p. 3117-3122 6 p.

Research output: Contribution to journalArticle

2012

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer

Näsvik Öjemyr, L., Von Ballmoos, C., Gennis, R. B., Sligar, S. G. & Brzezinski, P., Mar 9 2012, In : FEBS Letters. 586, 5, p. 640-645 6 p.

Research output: Contribution to journalReview article

2018

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone

Mak, P. J., Duggal, R., Denisov, I. G., Gregory, M. C., Sligar, S. G. & Kincaid, J. R., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7324-7331 8 p.

Research output: Contribution to journalArticle

2016

Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form

Ye, X., McLean, M. A. & Sligar, S. G., Sep 13 2016, In : Biochemistry. 55, 36, p. 5038-5048 11 p.

Research output: Contribution to journalArticle

2020

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for membrane protein investigations

McLean, M. A., Denisov, I. G., Grinkova, Y. V. & Sligar, S. G., Oct 15 2020, In : Analytical Biochemistry. 607, 113860.

Research output: Contribution to journalArticle

2011

Cytochromes P450 in nanodiscs

Denisov, I. G. & Sligar, S. G., Jan 2011, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 223-229 7 p.

Research output: Contribution to journalReview article

2017

Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification

Wade, J. H., Jones, J. D., Lenov, I. L., Riordan, C. M., Sligar, S. G. & Bailey, R. C., Sep 7 2017, In : Lab on a chip. 17, 17, p. 2951-2959 9 p.

Research output: Contribution to journalArticle

2011

Temperature derivative spectroscopy to monitor the autoxidation decay of cytochromes P450

Luthra, A., Denisov, I. G. & Sligar, S. G., Jul 1 2011, In : Analytical chemistry. 83, 13, p. 5394-5399 6 p.

Research output: Contribution to journalArticle

2017

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell chemical biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

2018

SMPL synaptic membranes: Nanodisc-mediated synaptic membrane mimetics expand the toolkit for drug discovery and the molecular cell biology of synapses

Lo Bu, R., Clark, J., DiChiara, T., Sligar, S. G. & Klein, W. L., Jan 1 2018, Neuromethods. Humana Press Inc., p. 227-250 24 p. (Neuromethods; vol. 141).

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Nanodiscs as a therapeutic delivery agent: Inhibition of respiratory syncytial virus infection in the lung

Numata, M., Grinkova, Y. V., Mitchell, J. R., Chu, H. W., Sligar, S. G. & Voelker, D. R., Apr 12 2013, In : International journal of nanomedicine. 8, p. 1417-1427 11 p.

Research output: Contribution to journalArticle

2020

Molecular Orientation Determination in Nanodiscs at the Single-Molecule Level

Camp, T., Mehta, K., Sligar, S. G. & Zhang, K., Jan 21 2020, In : Analytical chemistry. 92, 2, p. 2229-2236 8 p.

Research output: Contribution to journalArticle

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S., Wraight, C. A. & Strano, M., Dec 1 2011, 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings. (11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2019

Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function

Mustafa, G., Nandekar, P. P., Camp, T. J., Bruce, N. J., Gregory, M. C., Sligar, S. G. & Wade, R. C., Feb 5 2019, In : Biophysical journal. 116, 3, p. 419-432 14 p.

Research output: Contribution to journalArticle

2012

Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes P450

Denisov, I. G., Grinkova, Y. V. & Sligar, S. G., 2012, Spectroscopic Methods of Analysis: Methods and Protocols. Humana Press Inc., p. 375-391 17 p. (Methods in Molecular Biology; vol. 875).

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry

Gregory, M., Mak, P. J., Sligar, S. G. & Kincaid, J. R., May 10 2013, In : Angewandte Chemie - International Edition. 52, 20, p. 5342-5345 4 p.

Research output: Contribution to journalArticle

2016

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4

Denisov, I. G., Mak, P. J., Grinkova, Y. V., Bastien, D., Bérubé, G., Sligar, S. G. & Kincaid, J. R., May 1 2016, In : Journal of Inorganic Biochemistry. 158, p. 77-85 9 p.

Research output: Contribution to journalArticle

2013

Investigations of heme ligation and ligand switching in cytochromes P450 and P420

Sun, Y., Zeng, W., Benabbas, A., Ye, X., Denisov, I., Sligar, S. G., Du, J., Dawson, J. H. & Champion, P. M., Aug 27 2013, In : Biochemistry. 52, 34, p. 5941-5951 11 p.

Research output: Contribution to journalArticle

2019

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213

Denisov, I. G., Grinkova, Y. V., Nandigrami, P., Shekhar, M., Tajkhorshid, E. & Sligar, S. G., Mar 12 2019, In : Biochemistry. 58, 10, p. 1411-1422 12 p.

Research output: Contribution to journalArticle

2013

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes

Luthra, A., Gregory, M., Grinkova, Y. V., Denisov, I. G. & Sligar, S. G., 2013, Cytochrome P450 Protocols. Humana Press Inc., p. 115-127 13 p. (Methods in Molecular Biology; vol. 987).

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Active site proton delivery and the lyase activity of human CYP17A1

Khatri, Y., Gregory, M. C., Grinkova, Y. V., Denisov, I. G. & Sligar, S. G., Jan 3 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 179-184 6 p.

Research output: Contribution to journalArticle

2018

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step

Duggal, R., Denisov, I. G. & Sligar, S. G., Jul 2018, In : FEBS Letters. 592, 13, p. 2282-2288 7 p.

Research output: Contribution to journalLetter

2016

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis

Duggal, R., Liu, Y., Gregory, M. C., Denisov, I. G., Kincaid, J. R. & Sligar, S. G., Aug 19 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

2017

Alzheimer’s toxic amyloid beta oligomers: Unwelcome visitors to the Na/K ATPase alpha3 docking station

di Chiara, T., DiNunno, N., Clark, J., Bu, R. L., Cline, E. N., Rollins, M. G., Gong, Y., Brody, D. L., Sligar, S. G., Velasco, P. T., Viola, K. L. & Klein, W. L., Mar 2017, In : Yale Journal of Biology and Medicine. 90, 1, p. 45-61 17 p.

Research output: Contribution to journalArticle

2016

The Charge Properties of Phospholipid Nanodiscs

Her, C., Filoti, D. I., McLean, M. A., Sligar, S. G., Alexander Ross, J. B., Steele, H. & Laue, T. M., Sep 6 2016, In : Biophysical journal. 111, 5, p. 989-998 10 p.

Research output: Contribution to journalArticle

2019

PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b

McLean, M. A., Stephen, A. G. & Sligar, S. G., Aug 20 2019, In : Biochemistry. 58, 33, p. 3537-3545 9 p.

Research output: Contribution to journalArticle

2017

Conformational equilibria of light-activated rhodopsin in nanodiscs

Van Eps, N., Caro, L. N., Morizumi, T., Kusnetzow, A. K., Szczepek, M., Hofmann, K. P., Bayburt, T. H., Sligar, S. G., Ernst, O. P. & Hubbell, W. L., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. E3268-E3275

Research output: Contribution to journalArticle

2011

Analysis of heterotropic cooperativity in cytochrome P450 3A4 using α-Naphthoflavone and testosterone

Frank, D. J., Denisov, I. G. & Sligar, S. G., Feb 18 2011, In : Journal of Biological Chemistry. 286, 7, p. 5540-5545 6 p.

Research output: Contribution to journalArticle

2012

Native mass spectrometry characterization of intact nanodisc lipoprotein complexes

Marty, M. T., Zhang, H., Cui, W., Blankenship, R. E., Gross, M. L. & Sligar, S. G., Nov 6 2012, In : Analytical chemistry. 84, 21, p. 8957-8960 4 p.

Research output: Contribution to journalArticle

2019

Biotransformation of the mycotoxin enniatin b1 by CYP P450 3A4 and potential for drug-drug interactions

Ivanova, L., Denisov, I. G., Grinkova, Y. V., Sligar, S. G. & Fæste, C. K., Aug 2019, In : Metabolites. 9, 8, 158.

Research output: Contribution to journalArticle

Open Access
2013

Nanodisc-solubilized membrane protein library reflects the membrane proteome

Marty, M. T., Wilcox, K. C., Klein, W. L. & Sligar, S. G., Feb 12 2013, In : Analytical and bioanalytical chemistry. 405, 12, p. 4009-4016 8 p.

Research output: Contribution to journalArticle

2018

Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins

McLean, M. A., Gregory, M. C. & Sligar, S. G., May 20 2018, In : Annual Review of Biophysics. 47, p. 107-124 18 p.

Research output: Contribution to journalReview article

2020

Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors

Wong, P., Li, L., Chea, J., Hu, W., Poku, E., Ebner, T., Bowles, N., Wong, J. Y. C., Yazaki, P. J., Sligar, S. & Shively, J. E., Mar 18 2020, In : Bioconjugate Chemistry. 31, 3, p. 743-753 11 p.

Research output: Contribution to journalArticle

2012

Tissue factor/factor VIIa complex: Role of the membrane surface

Morrissey, J. H., Tajkhorshid, E., Sligar, S. G. & Rienstra, C. M., May 2012, In : Thrombosis Research. 129, SUPPL. 2, p. S8-S10

Research output: Contribution to journalArticle

2016

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding

Reichart, T. M., Baksh, M. M., Rhee, J. K., Fiedler, J. D., Sligar, S. G., Finn, M. G., Zwick, M. B. & Dawson, P. E., Feb 18 2016, In : Angewandte Chemie - International Edition. 55, 8, p. 2688-2692 5 p.

Research output: Contribution to journalArticle

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-Assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 349-350 2 p. (Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2012

Nonlinear analyte concentration gradients for one-step kinetic analysis employing optical microring resonators

Marty, M. T., Sloan, C. D. K., Bailey, R. C. & Sligar, S. G., Jul 3 2012, In : Analytical chemistry. 84, 13, p. 5556-5564 9 p.

Research output: Contribution to journalArticle

2015

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment

Skar-Gislinge, N., Kynde, S. A. R., Denisov, I. G., Ye, X., Lenov, I., Sligar, S. G. & Arleth, L., Jan 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 2412-2421 10 p.

Research output: Contribution to journalArticle

2012

Structural differences between soluble and membrane bound cytochrome P450s

Denisov, I. G., Shih, A. Y. & Sligar, S. G., Mar 1 2012, In : Journal of Inorganic Biochemistry. 108, p. 150-158 9 p.

Research output: Contribution to journalArticle

2020

Nanodisc self-assembly is thermodynamically reversible and controllable

Camp, T., Sligar, S. G., Sligar, S. G. & Sligar, S. G., Jun 28 2020, In : Soft Matter. 16, 24, p. 5615-5623 9 p.

Research output: Contribution to journalArticle

2015

Unveiling the crucial intermediates in androgen production

Mak, P. J., Gregory, M. C., Denisov, I. G., Sligar, S. G. & Kincaid, J. R., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 15856-15861 6 p.

Research output: Contribution to journalArticle

Nanodiscs as a modular platform for multimodal MR-optical imaging

Carney, C. E., Lenov, I. L., Baker, C. J., Macrenaris, K. W., Eckermann, A. L., Sligar, S. G. & Meade, T. J., May 20 2015, In : Bioconjugate Chemistry. 26, 5, p. 899-905 7 p.

Research output: Contribution to journalArticle

2014

Resonance raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic Ligands of CYP17

Mak, P. J., Gregory, M. C., Sligar, S. G. & Kincaid, J. R., Jan 14 2014, In : Biochemistry. 53, 1, p. 90-100 11 p.

Research output: Contribution to journalArticle

2016

Conformational equilibrium of talin is regulated by anionic lipids

Ye, X., McLean, M. A. & Sligar, S. G., Aug 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 8, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

2014

Resonance raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step

Mak, P. J., Luthra, A., Sligar, S. G. & Kincaid, J. R., Apr 2 2014, In : Journal of the American Chemical Society. 136, 13, p. 4825-4828 4 p.

Research output: Contribution to journalArticle

2011

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 436-437 2 p. (Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution