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  • Stephen G Sligar
2015

Unveiling the crucial intermediates in androgen production

Mak, P. J., Gregory, M. C., Denisov, I. G., Sligar, S. G. & Kincaid, J. R., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 15856-15861 6 p.

Research output: Contribution to journalArticle

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S., Wraight, C. A. & Strano, M., Jan 1 2011, Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 436-437 2 p. (Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2015

Metalloproteins: The long and the short of it

Denisov, I. G. & Sligar, S. G., Aug 20 2015, In : Nature Chemistry. 7, 9, p. 687-688 2 p.

Research output: Contribution to journalShort survey

2016

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4

Denisov, I. G., Mak, P. J., Grinkova, Y. V., Bastien, D., Bérubé, G., Sligar, S. G. & Kincaid, J. R., May 1 2016, In : Journal of Inorganic Biochemistry. 158, p. 77-85 9 p.

Research output: Contribution to journalArticle

2019

PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b

McLean, M. A., Stephen, A. G. & Sligar, S. G., Aug 20 2019, In : Biochemistry. 58, 33, p. 3537-3545 9 p.

Research output: Contribution to journalArticle

2018

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone

Mak, P. J., Duggal, R., Denisov, I. G., Gregory, M. C., Sligar, S. & Kincaid, J. R., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7324-7331 8 p.

Research output: Contribution to journalArticle

2013

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: Evidence for a reactive peroxoanion intermediate

Gregory, M. C., Denisov, I. G., Grinkova, Y. V., Khatri, Y. & Sligar, S. G., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16245-16247 3 p.

Research output: Contribution to journalArticle

2012

Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes P450

Denisov, I. G., Grinkova, Y. V. & Sligar, S. G., Jan 1 2012, Spectroscopic Methods of Analysis: Methods and Protocols. Humana Press Inc., p. 375-391 17 p. (Methods in Molecular Biology; vol. 875).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Interaction of KRas4b with anionic membranes: A special role for PIP2

Gregory, M. C., McLean, M. A. & Sligar, S. G., May 27 2017, In : Biochemical and Biophysical Research Communications. 487, 2, p. 351-355 5 p.

Research output: Contribution to journalArticle

2019

Nanodiscs as a New Tool to Examine Lipid–Protein Interactions

Denisov, I. G., Schuler, M. A. & Sligar, S., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 645-671 27 p. (Methods in Molecular Biology; vol. 2003).

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Oxidase uncoupling in heme monooxygenases: Human cytochrome P450 CYP3A4 in Nanodiscs

Grinkova, Y. V., Denisov, I. G., McLean, M. A. & Sligar, S., Jan 25 2013, In : Biochemical and Biophysical Research Communications. 430, 4, p. 1223-1227 5 p.

Research output: Contribution to journalArticle

2017

Alzheimer’s toxic amyloid beta oligomers: Unwelcome visitors to the Na/K ATPase alpha3 docking station

di Chiara, T., DiNunno, N., Clark, J., Bu, R. L., Cline, E. N., Rollins, M. G., Gong, Y., Brody, D. L., Sligar, S. G., Velasco, P. T., Viola, K. L. & Klein, W. L., Mar 2017, In : Yale Journal of Biology and Medicine. 90, 1, p. 45-61 17 p.

Research output: Contribution to journalArticle

2011

Temperature derivative spectroscopy to monitor the autoxidation decay of cytochromes P450

Luthra, A., Denisov, I. G. & Sligar, S., Jul 1 2011, In : Analytical chemistry. 83, 13, p. 5394-5399 6 p.

Research output: Contribution to journalArticle

2013

Nanodiscs as a new tool to examine lipid-protein interactions

Schuler, M. A., Denisov, I. G. & Sligar, S. G., 2013, Lipid-Protein Interactions: Methods and Protocols. Humana Press Inc., p. 415-433 19 p. (Methods in Molecular Biology; vol. 974).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes

Luthra, A., Gregory, M., Grinkova, Y. V., Denisov, I. G. & Sligar, S. G., 2013, Cytochrome P450 Protocols. Humana Press Inc., p. 115-127 13 p. (Methods in Molecular Biology; vol. 987).

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Nonlinear analyte concentration gradients for one-step kinetic analysis employing optical microring resonators

Marty, M. T., Sloan, C. D. K., Bailey, R. C. & Sligar, S., Jul 3 2012, In : Analytical chemistry. 84, 13, p. 5556-5564 9 p.

Research output: Contribution to journalArticle

2019

Correction to: Allosteric interactions in human cytochrome P450 CYP3A4: The role of phenylalanine 213 (Biochemistry (2019) 58: 10 (1411-1422) DOI: 10.1021/acs.biochem.8b01268)

Denisov, I. G., Grinkova, Y. V., Nandigrami, P., Shekhar, M., Tajkhorshid, E. & Sligar, S. G., Jun 18 2019, In : Biochemistry. 58, 24, 1 p.

Research output: Contribution to journalComment/debate

2014

Interpretation and deconvolution of nanodisc native mass spectra

Marty, M. T., Zhang, H., Cui, W., Gross, M. L. & Sligar, S. G., Feb 1 2014, In : Journal of the American Society for Mass Spectrometry. 25, 2, p. 269-277 9 p.

Research output: Contribution to journalArticle

2019

The hydrodynamic motion of Nanodiscs

Camp, T., McLean, M., Kato, M., Cheruzel, L. & Sligar, S., May 2019, In : Chemistry and Physics of Lipids. 220, p. 28-35 8 p.

Research output: Contribution to journalArticle

2011

Spectroscopic features of cytochrome P450 reaction intermediates

Luthra, A., Denisov, I. G. & Sligar, S. G., Mar 1 2011, In : Archives of Biochemistry and Biophysics. 507, 1, p. 26-35 10 p.

Research output: Contribution to journalReview article

2020

Membrane-Bound Ras as a Conformational Clock

Gorfe, A. A. & Sligar, S. G., Jan 1 2020, (Accepted/In press) In : Biophysical journal.

Research output: Contribution to journalArticle

2013

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding

Vishnivetskiy, S. A., Ostermaier, M. K., Singhal, A., Panneels, V., Homan, K. T., Glukhova, A., Sligar, S. G., Tesmer, J. J. G., Schertler, G. F. X., Standfuss, J. & Gurevich, V. V., Nov 1 2013, In : Cellular Signalling. 25, 11, p. 2155-2162 8 p.

Research output: Contribution to journalArticle

2011

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-Assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 349-350 2 p. (Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2017

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell chemical biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

2014

Active site proton delivery and the lyase activity of human CYP17A1

Khatri, Y., Gregory, M. C., Grinkova, Y. V., Denisov, I. G. & Sligar, S., Jan 3 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 179-184 6 p.

Research output: Contribution to journalArticle

2011

(609d) Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S., Wraight, C. A. & Strano, M., Jan 1 2011, Nanomaterials for Energy Applications - Topical Conference at the 2011 AIChE Annual Meeting. AIChE, p. 92-93 2 p. (Nanomaterials for Energy Applications - Topical Conference at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2015

Nanodiscs as a modular platform for multimodal MR-optical imaging

Carney, C. E., Lenov, I. L., Baker, C. J., Macrenaris, K. W., Eckermann, A. L., Sligar, S. & Meade, T. J., May 20 2015, In : Bioconjugate Chemistry. 26, 5, p. 899-905 7 p.

Research output: Contribution to journalArticle

2011

Anomalous transitions of DODAB using fast scanning liquid calorimetry

De La Rama, L. P., Hu, L., Efremov, M. Y., Olson, E. A., Nealey, P. F., McLean, M. A., Sligar, S. G. & Allen, L. H., Aug 10 2011, In : Thermochimica Acta. 522, 1-2, p. 72-76 5 p.

Research output: Contribution to journalArticle

2013

Nanodiscs as a therapeutic delivery agent: Inhibition of respiratory syncytial virus infection in the lung

Numata, M., Grinkova, Y. V., Mitchell, J. R., Chu, H. W., Sligar, S. G. & Voelker, D. R., Apr 12 2013, In : International journal of nanomedicine. 8, p. 1417-1427 11 p.

Research output: Contribution to journalArticle

2019

Biotransformation of the mycotoxin enniatin b1 by CYP P450 3A4 and potential for drug-drug interactions

Ivanova, L., Denisov, I. G., Grinkova, Y. V., Sligar, S. G. & Fæste, C. K., Aug 2019, In : Metabolites. 9, 8, 158.

Research output: Contribution to journalArticle

Open Access
2012

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer

Näsvik Öjemyr, L., Von Ballmoos, C., Gennis, R. B., Sligar, S. G. & Brzezinski, P., Mar 9 2012, In : FEBS Letters. 586, 5, p. 640-645 6 p.

Research output: Contribution to journalReview article

2015

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment

Skar-Gislinge, N., Kynde, S. A. R., Denisov, I. G., Ye, X., Lenov, I., Sligar, S. & Arleth, L., Jan 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 2412-2421 10 p.

Research output: Contribution to journalArticle

2016

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding

Reichart, T. M., Baksh, M. M., Rhee, J. K., Fiedler, J. D., Sligar, S. G., Finn, M. G., Zwick, M. B. & Dawson, P. E., Feb 18 2016, In : Angewandte Chemie - International Edition. 55, 8, p. 2688-2692 5 p.

Research output: Contribution to journalArticle

2013

Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening

Sloan, C. D. K., Marty, M. T., Sligar, S. G. & Bailey, R. C., Mar 5 2013, In : Analytical chemistry. 85, 5, p. 2970-2976 7 p.

Research output: Contribution to journalArticle

2020

Molecular Orientation Determination in Nanodiscs at the Single-Molecule Level

Camp, T., Mehta, K., Sligar, S. G. & Zhang, K., Jan 21 2020, In : Analytical chemistry. 92, 2, p. 2229-2236 8 p.

Research output: Contribution to journalArticle

2014

Resonance raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic Ligands of CYP17

Mak, P. J., Gregory, M. C., Sligar, S. G. & Kincaid, J. R., Jan 14 2014, In : Biochemistry. 53, 1, p. 90-100 11 p.

Research output: Contribution to journalArticle

2018

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step

Duggal, R., Denisov, I. G. & Sligar, S. G., Jul 2018, In : FEBS Letters. 592, 13, p. 2282-2288 7 p.

Research output: Contribution to journalLetter

2016

Conformational equilibrium of talin is regulated by anionic lipids

Ye, X., McLean, M. A. & Sligar, S. G., Aug 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 8, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

2015

Mechanism of Drug-Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer

Denisov, I. G., Grinkova, Y. V., Baylon, J. L., Tajkhorshid, E. & Sligar, S. G., Apr 7 2015, In : Biochemistry. 54, 13, p. 2227-2239 13 p.

Research output: Contribution to journalArticle

2012

Incorporation of NADH-ubiquinone Oxidoreductase (Mitochondrial Complex I) into Lipid Nanodiscs

Fowler, D. J., Sligar, S., Zickermann, V., Brandt, U., Ruiz, T. & Radermacher, M., Jul 2012, In : Microscopy and Microanalysis. 18, S2, p. 88-89 2 p.

Research output: Contribution to journalArticle

2011

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

2014

Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayers

D'Antona, A. M., Xie, G., Sligar, S. G. & Oprian, D. D., Jan 14 2014, In : Biochemistry. 53, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

2016

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis

Duggal, R., Liu, Y., Gregory, M. C., Denisov, I. G., Kincaid, J. R. & Sligar, S. G., Aug 19 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

2018

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202

Gregory, M. C., Mak, P. J., Khatri, Y., Kincaid, J. R. & Sligar, S. G., Feb 6 2018, In : Biochemistry. 57, 5, p. 764-771 8 p.

Research output: Contribution to journalArticle

2014

Resonance raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step

Mak, P. J., Luthra, A., Sligar, S. G. & Kincaid, J. R., Apr 2 2014, In : Journal of the American Chemical Society. 136, 13, p. 4825-4828 4 p.

Research output: Contribution to journalArticle

2013

Characterizing the membrane-bound state of cytochrome P450 3A4: Structure, depth of insertion, and orientation

Baylon, J. L., Lenov, I. L., Sligar, S. G. & Tajkhorshid, E., Jun 12 2013, In : Journal of the American Chemical Society. 135, 23, p. 8542-8551 10 p.

Research output: Contribution to journalArticle

2011

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding

Bayburt, T. H., Vishnivetskiy, S. A., McLean, M. A., Morizumi, T., Huang, C. C., Tesmer, J. J. G., Ernst, O. P., Sligar, S. G. & Gurevich, V. V., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1420-1428 9 p.

Research output: Contribution to journalArticle

2017

Nanodiscs in Membrane Biochemistry and Biophysics

Denisov, I. G. & Sligar, S. G., Mar 22 2017, In : Chemical reviews. 117, 6, p. 4669-4713 45 p.

Research output: Contribution to journalReview article

2012

Tissue factor/factor VIIa complex: Role of the membrane surface

Morrissey, J. H., Tajkhorshid, E., Sligar, S. G. & Rienstra, C. M., May 1 2012, In : Thrombosis Research. 129, SUPPL. 2, p. S8-S10

Research output: Contribution to journalArticle

2019

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213

Denisov, I. G., Grinkova, Y. V., Nandigrami, P., Shekhar, M., Tajkhorshid, E. & Sligar, S. G., Mar 12 2019, In : Biochemistry. 58, 10, p. 1411-1422 12 p.

Research output: Contribution to journalArticle