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  • Huimin Zhao
2020

A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens

Wang, F., Wei, Y., Lu, Q., Ang, E. L., Zhao, H. & Zhang, Y., Jul 31 2020, In : Bioscience Reports. 40, 7

Research output: Contribution to journalArticle

Open Access

A genetic toolbox for metabolic engineering of Issatchenkia orientalis

Cao, M., Fatma, Z., Song, X., Hsieh, P. H., Tran, V. G., Lyon, W. L., Sayadi, M., Shao, Z., Yoshikuni, Y. & Zhao, H., May 2020, In : Metabolic Engineering. 59, p. 87-97 11 p.

Research output: Contribution to journalArticle

A mass spectrometry-based high-throughput screening method for engineering fatty acid synthases with improved production of medium-chain fatty acids

Xue, P., Si, T., Mishra, S., Zhang, L., Choe, K., Sweedler, J. V. & Zhao, H., Jul 1 2020, In : Biotechnology and bioengineering. 117, 7, p. 2131-2138 8 p.

Research output: Contribution to journalArticle

A New Biosensor for Stilbenes and a Cannabinoid Enabled by Genome Mining of a Transcriptional Regulator

Sun, H., Zhao, H. & Ang, E. L., Apr 17 2020, In : ACS synthetic biology. 9, 4, p. 698-705 8 p.

Research output: Contribution to journalArticle

A Pathway for Degradation of Uracil to Acetyl Coenzyme A in Bacillus megaterium

Zhu, D., Wei, Y., Yin, J., Liu, D., Ang, E. L., Zhao, H. & Zhang, Y., Mar 18 2020, In : Applied and environmental microbiology. 86, 7

Research output: Contribution to journalArticle

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Yeo, W. L., Heng, E., Tan, L. L., Lim, Y. W., Ching, K. C., Tsai, D. J., Jhang, Y. W., Lauderdale, T. L., Shia, K. S., Zhao, H., Ang, E. L., Zhang, M. M., Lim, Y. H. & Wong, F. T., Jan 6 2020, In : Microbial cell factories. 19, 1, 3.

Research output: Contribution to journalArticle

Open Access

Biosystems design by directed evolution

Wang, Y., Yu, X. & Zhao, H., Mar 1 2020, In : AIChE Journal. 66, 3, e16716.

Research output: Contribution to journalReview article

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

Ren, H., Shi, C. & Zhao, H., Jan 24 2020, In : iScience. 23, 1, 100795.

Research output: Contribution to journalReview article

Open Access

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern

Ren, H., Shi, C., Bothwell, I. R., Van Der Donk, W. A., Van Der Donk, W. A., Van Der Donk, W. A., Zhao, H., Zhao, H., Zhao, H., Zhao, H. & Zhao, H., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Divalent cations promote TALE DNA-binding specificity

Cuculis, L., Zhao, C., Abil, Z., Zhao, H., Shukla, D. & Schroeder, C. M., Feb 20 2020, In : Nucleic acids research. 48, 3, p. 1406-1422 17 p.

Research output: Contribution to journalArticle

Open Access

DNA punch cards for storing data on native DNA sequences via enzymatic nicking

Tabatabaei, S. K., Wang, B., Athreya, N. B. M., Enghiad, B., Hernandez, A. G., Fields, C. J., Leburton, J. P., Soloveichik, D., Zhao, H. & Milenkovic, O., Dec 1 2020, In : Nature communications. 11, 1, 1742.

Research output: Contribution to journalArticle

Open Access

Emerging molecular biology tools and strategies for engineering natural product biosynthesis

Xu, W., Klumbys, E., Ang, E. L. & Zhao, H., Jun 2020, In : Metabolic Engineering Communications. 10, e00108.

Research output: Contribution to journalReview article

Open Access

Identification and Characterization of Citrus Peel Uronic Acid Oxidase

Wei, Y., Tan, Y. L., Ang, E. L. & Zhao, H., Mar 16 2020, In : ChemBioChem. 21, 6, p. 797-800 4 p.

Research output: Contribution to journalArticle

Integrating biocatalysis with chemocatalysis for selective transformations

Huang, X., Cao, M. & Zhao, H., Apr 2020, In : Current Opinion in Chemical Biology. 55, p. 161-170 10 p.

Research output: Contribution to journalReview article

Optically guided mass spectrometry to screen microbial colonies for directed enzyme evolution

Xue, P., Si, T. & Zhao, H., Jan 1 2020, (Accepted/In press) Methods in Enzymology. Academic Press Inc., (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Photoenzymatic enantioselective intermolecular radical hydroalkylation

Huang, X., Wang, B., Wang, Y., Jiang, G., Feng, J. & Zhao, H., Jan 1 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

Recent advances in domesticating non-model microorganisms

Fatma, Z., Schultz, J. C. & Zhao, H., Jan 1 2020, (Accepted/In press) In : Biotechnology Progress.

Research output: Contribution to journalReview article

Towards oilcane: Engineering hyperaccumulation of triacylglycerol into sugarcane stems

Parajuli, S., Kannan, B., Karan, R., Sanahuja, G., Liu, H., Garcia-Ruiz, E., Kumar, D., Singh, V., Zhao, H., Long, S., Shanklin, J. & Altpeter, F., Jul 1 2020, In : GCB Bioenergy. 12, 7, p. 476-490 15 p.

Research output: Contribution to journalArticle

Open Access

Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Wang, B. & Zhao, H., Mar 2020, In : Synthetic and Systems Biotechnology. 5, 1, p. 21-22 2 p.

Research output: Contribution to journalComment/debate

Open Access
2018

A coupled chlorinase-fluorinase system with a high efficiency of trans -halogenation and a shared substrate tolerance

Sun, H., Zhao, H. & Ang, E. L., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9458-9461 4 p.

Research output: Contribution to journalArticle

Advancing Metabolic Engineering of Saccharomyces cerevisiae Using the CRISPR/Cas System

Lian, J., HamediRad, M. & Zhao, H., Sep 2018, In : Biotechnology Journal. 13, 9, 1700601.

Research output: Contribution to journalReview article

Applying advanced dna assembly methods to generate pathway libraries

Eriksen, D. T., Chao, R. & Zhao, H., Mar 15 2018, Synthetic Biology: Parts, Devices and Applications. Wiley-VCH Verlag, p. 331-347 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR-Cas9 Activation

Lim, Y. H., Wong, F. T., Yeo, W. L., Ching, K. C., Lim, Y. W., Heng, E., Chen, S., Tsai, D. J., Lauderdale, T. L., Shia, K. S., Ho, Y. S., Hoon, S., Ang, E. L., Zhang, M. M. & Zhao, H., Aug 16 2018, In : ChemBioChem. 19, 16, p. 1716-1719 4 p.

Research output: Contribution to journalArticle

Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

Sun, H., Zhang, H., Ang, E. L. & Zhao, H., Apr 1 2018, In : Bioorganic and Medicinal Chemistry. 26, 7, p. 1275-1284 10 p.

Research output: Contribution to journalReview article

Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

Litman, Z. C., Wang, Y., Zhao, H. & Hartwig, J. F., Aug 16 2018, In : Nature. 560, 7718, p. 355-359 5 p.

Research output: Contribution to journalArticle

CRISPR/Cas9-mediated knock-in of an optimized TetO repeat for live cell imaging of endogenous loci

Tasan, I., Sustackova, G., Zhang, L., Kim, J., Sivaguru, M., HamediRad, M., Wang, Y., Genova, J., Ma, J., Belmont, A. S. & Zhao, H., Jan 1 2018, In : Nucleic acids research. 46, 17, e100.

Research output: Contribution to journalArticle

Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface

Limsakul, P., Peng, Q., Wu, Y., Allen, M. E., Liang, J., Remacle, A. G., Lopez, T., Ge, X., Kay, B. K., Zhao, H., Strongin, A. Y., Yang, X. L., Lu, S. & Wang, Y., Apr 19 2018, In : Cell chemical biology. 25, 4, p. 370-379.e4

Research output: Contribution to journalArticle

Engineered CRISPR/Cas9 system for multiplex genome engineering of polyploid industrial yeast strains

Lian, J., Bao, Z., Hu, S. & Zhao, H., Jun 2018, In : Biotechnology and bioengineering. 115, 6, p. 1630-1635 6 p.

Research output: Contribution to journalArticle

Genome-scale engineering of Saccharomyces cerevisiae with single-nucleotide precision

Bao, Z., HamediRad, M., Xue, P., Xiao, H., Tasan, I., Chao, R., Liang, J. & Zhao, H., Jul 1 2018, In : Nature Biotechnology. 36, 6, p. 505-508 4 p.

Research output: Contribution to journalArticle

Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes

Tapsin, S., Sun, M., Shen, Y., Zhang, H., Lim, X. N., Susanto, T. T., Yang, S. L., Zeng, G. S., Lee, J., Lezhava, A., Ang, E. L., Zhang, L. H., Wang, Y., Zhao, H., Nagarajan, N. & Wan, Y., Dec 1 2018, In : Nature communications. 9, 1, 1289.

Research output: Contribution to journalArticle

Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole

Liu, D., Wei, Y., Liu, X., Zhou, Y., Jiang, L., Yin, J., Wang, F., Hu, Y., Nanjaraj Urs, A. N., Liu, Y., Ang, E. L., Zhao, S., Zhao, H. & Zhang, Y., Dec 1 2018, In : Nature communications. 9, 1, 4224.

Research output: Contribution to journalArticle

Insights into Cell-Free Conversion of CO2 to Chemicals by a Multienzyme Cascade Reaction

Singh, R. K., Singh, R., Sivakumar, D., Kondaveeti, S., Kim, T., Li, J., Sung, B. H., Cho, B. K., Kim, D. R., Kim, S. C., Kalia, V. C., Zhang, Y. H. P. J., Zhao, H., Kang, Y. C. & Lee, J. K., Dec 7 2018, In : ACS Catalysis. 8, 12, p. 11085-11093 9 p.

Research output: Contribution to journalArticle

In vivo biosensors: mechanisms, development, and applications

Shi, S., Ang, E. L. & Zhao, H., Jul 1 2018, In : Journal of Industrial Microbiology and Biotechnology. 45, 7, p. 491-516 26 p.

Research output: Contribution to journalArticle

Metabolic Engineering of Saccharomyces cerevisiae Using a Trifunctional CRISPR/Cas System for Simultaneous Gene Activation, Interference, and Deletion

Schultz, C., Lian, J. & Zhao, H., Jan 1 2018, Methods in Enzymology. Scrutton, N. (ed.). Academic Press Inc., p. 265-276 12 p. (Methods in Enzymology; vol. 608).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pathway design, engineering, and optimization

Garcia-Ruiz, E., HamediRad, M. & Zhao, H., Jan 1 2018, Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, (Advances in Biochemical Engineering/Biotechnology; vol. 162).

Research output: Chapter in Book/Report/Conference proceedingChapter

Quantifying the effects of pollen nutrition on honey bee queen egg laying with a new laboratory system

Fine, J. D., Shpigler, H. Y., Ray, A. M., Beach, N. J., Sankey, A. L., Cash-Ahmed, A., Huang, Z. Y., Astrauskaite, I., Chao, R., Zhao, H. & Robinson, G. E., Sep 2018, In : PloS one. 13, 9, e0203444.

Research output: Contribution to journalArticle

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli

Ren, H., Biswas, S., Ho, S., Van Der Donk, W. A. & Zhao, H., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2966-2972 7 p.

Research output: Contribution to journalArticle

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli

Si, T., Tian, Q., Min, Y., Zhang, L., Sweedler, J. V., Van Der Donk, W. A. & Zhao, H., Sep 26 2018, In : Journal of the American Chemical Society. 140, 38, p. 11884-11888 5 p.

Research output: Contribution to journalArticle

Recent advances in metabolic engineering of Saccharomyces cerevisiae: New tools and their applications

Lian, J., Mishra, S. & Zhao, H., Nov 2018, In : Metabolic Engineering. 50, p. 85-108 24 p.

Research output: Contribution to journalReview article

Recent developments in the application of P450 based biocatalysts

Wei, Y., Ang, E. L. & Zhao, H., Apr 2018, In : Current Opinion in Chemical Biology. 43, p. 1-7 7 p.

Research output: Contribution to journalReview article

RNAi assisted genome evolution unveils yeast mutants with improved xylose utilization

HamediRad, M., Lian, J., Li, H. & Zhao, H., Jun 2018, In : Biotechnology and bioengineering. 115, 6, p. 1552-1560 9 p.

Research output: Contribution to journalArticle

Synthetic biology advances and applications in the biotechnology industry: a perspective

Katz, L., Chen, Y. Y., Gonzalez, R., Peterson, T. C., Zhao, H. & Baltz, R. H., Jul 1 2018, In : Journal of Industrial Microbiology and Biotechnology. 45, 7, p. 449-461 13 p.

Research output: Contribution to journalArticle

Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding

Wang, P., Liang, J., Shi, L. Z., Wang, Y., Zhang, P., Ouyang, M., Preece, D., Peng, Q., Shao, L., Fan, J., Sun, J., Li, S. S., Berns, M. W., Zhao, H. & Wang, Y., Sep 19 2018, In : ACS Photonics. 5, 9, p. 3565-3574 10 p.

Research output: Contribution to journalArticle

2017

A New Era of Genome Integration - Simply Cut and Paste!

Liu, Z., Liang, Y., Ang, E. L. & Zhao, H., Apr 21 2017, In : ACS synthetic biology. 6, 4, p. 601-609 9 p.

Research output: Contribution to journalReview article

A plug-and-play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae

Ren, H., Hu, P. & Zhao, H., Aug 2017, In : Biotechnology and bioengineering. 114, 8, p. 1847-1854 8 p.

Research output: Contribution to journalArticle

A Scalable Epitope Tagging Approach for High Throughput ChIP-Seq Analysis

Xiong, X., Zhang, Y., Yan, J., Jain, S., Chee, S., Ren, B. & Zhao, H., Jun 16 2017, In : ACS synthetic biology. 6, 6, p. 1034-1042 9 p.

Research output: Contribution to journalArticle

Automated multiplex genome-scale engineering in yeast

Si, T., Chao, R., Min, Y., Wu, Y., Ren, W. & Zhao, H., Jan 1 2017, In : Nature communications. 8, 15187.

Research output: Contribution to journalArticle

Breaking the silence: new strategies for discovering novel natural products

Ren, H., Wang, B. & Zhao, H., Dec 1 2017, In : Current Opinion in Biotechnology. 48, p. 21-27 7 p.

Research output: Contribution to journalReview article

Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system

Lian, J., Hamedirad, M., Hu, S. & Zhao, H., Dec 1 2017, In : Nature communications. 8, 1, 1688.

Research output: Contribution to journalArticle