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• 2012

  Mass spectrometry imaging and profiling of single cells

  Lanni, E. J., Rubakhin, S. S. & Sweedler, J. V., Aug 30 2012, In: Journal of Proteomics. 75, 16, p. 5036-5051 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Mass spectrometry
  • Secondary Ion Mass Spectrometry
  • Mass Spectrometry
  • Imaging techniques
  • Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

• Mechanical tension modulates local and global vesicle dynamics in neurons

  Ahmed, W. W., Li, T. C., Rubakhin, S. S., Chiba, A., Sweedler, J. V. & Saif, T. A., Jun 2012, In: Cellular and Molecular Bioengineering. 5, 2, p. 155-164 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Vesicles
  • Neuron
  • Aplysia
  • Drosophila
  • Neurons

• Metabolomics in analytical chemistry

  Sweedler, J. V., Jul 17 2012, In: Analytical chemistry. 84, 14, 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Microfluidic device for the selective chemical stimulation of neurons and characterization of peptide release with mass spectrometry

  Croushore, C. A., Supharoek, S. A., Lee, C. Y., Jakmunee, J. & Sweedler, J. V., Nov 6 2012, In: Analytical Chemistry. 84, 21, p. 9446-9452 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Microfluidics
  • Neurons
  • Characterization (materials science)
  • Peptides

• Now it is a highlight, not an acceleration

  Sweedler, J. V., Sep 4 2012, In: Analytical chemistry. 84, 17, 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Peptidomic analyses of mouse astrocytic cell lines and rat primary cultured astrocytes

  Yin, P., Knolhoff, A. M., Rosenberg, H. J., Millet, L. J., Gillette, M. U. & Sweedler, J. V., Aug 3 2012, In: Journal of Proteome Research. 11, 8, p. 3965-3973 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Astrocytes
  • Rats
  • Cells
  • Peptides
  • Cell Line

• Professional Editors or Scientist Editors? Both perspectives have value.

  Sweedler, J. V., Mar 6 2012, In: Analytical chemistry. 84, 5, 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Rejections with editorial expertise and without external review: Are these fair?

  Sweedler, J. V., Dec 4 2012, In: Analytical chemistry. 84, 23, 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Relative quantitation of neuropeptides over a thousand-fold concentration range

  Hou, X., Xie, F. & Sweedler, J. V., Dec 2012, In: Journal of the American Society for Mass Spectrometry. 23, 12, p. 2083-2093 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Neuropeptides
  • Mass Spectrometry
  • Electrospray ionization
  • Ionization

• Reviews, perspectives, features: What's the difference?

  Sweedler, J. V., Feb 7 2012, In: Analytical chemistry. 84, 3, 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Sampling techniques for single-cell electrophoresis

  Cecala, C. & Sweedler, J. V., Jul 7 2012, In: Analyst. 137, 13, p. 2922-2929 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Electrophoresis
  • sampling technique
  • electrokinesis
  • Sampling
  • Fluorescence

• Secondary ion mass spectrometry imaging of molecular distributions in cultured neurons and their processes: Comparative analysis of sample preparation

  Tucker, K. R., Li, Z., Rubakhin, S. S. & Sweedler, J. V., Nov 2012, In: Journal of the American Society for Mass Spectrometry. 23, 11, p. 1931-1938 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Secondary Ion Mass Spectrometry
  • Secondary ion mass spectrometry
  • Molecular Imaging
  • Neurons
  • Imaging techniques

• Serotonin of mast cell origin contributes to hippocampal function

  Nautiyal, K. M., Dailey, C. A., Jahn, J. L., Rodriquez, E., Son, N. H., Sweedler, J. V. & Silver, R., Aug 2012, In: European Journal of Neuroscience. 36, 3, p. 2347-2359 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Mast Cells
  • Serotonin
  • Neurogenesis
  • Hippocampus
  • Fluoxetine

• Single-cell metabolomics: Changes in the metabolome of freshly isolated and cultured neurons

  Nemes, P., Knolhoff, A. M., Rubakhin, S. S. & Sweedler, J. V., Oct 17 2012, In: ACS Chemical Neuroscience. 3, 10, p. 782-792 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolomics
  • Metabolome
  • Neurons
  • Glycerol
  • Metabolites

• Targeted single-cell microchemical analysis: MS-based peptidomics of individual paraformaldehyde-fixed and immunolabeled neurons

  Neupert, S., Rubakhin, S. S. & Sweedler, J. V., Aug 24 2012, In: Chemistry and Biology. 19, 8, p. 1010-1019 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Single-Cell Analysis
  • paraform
  • Mass spectrometry
  • Neuropeptides
  • Molecules

• The Hypothalamic-Neurohypophyseal System: From Genome to Physiology

  Murphy, D., Konopacka, A., Hindmarch, C., Paton, J. F. R., Sweedler, J. V., Gillette, M. U., Ueta, Y., Grinevich, V., Lozic, M. & Japundzic-Zigon, N., Apr 2012, In: Journal of Neuroendocrinology. 24, 4, p. 539-553 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oxytocin
  • Genome
  • Optogenetics
  • Neuroanatomy
  • Breeding

• Therapeutic peptide production in Drosophila

  Park, D., Hou, X., Sweedler, J. V. & Taghert, P. H., Aug 2012, In: Peptides. 36, 2, p. 251-256 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Drosophila
  • Peptides
  • Metabolic Engineering
  • Metabolic engineering
  • Synthetic Chemistry Techniques

• Two unrelated items to avoid, one for me and one for you

  Sweedler, J. V., Jun 5 2012, In: Analytical chemistry. 84, 11, p. 4635-4636 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Urotensin II in Invertebrates: From Structure to Function in Aplysia californica

  Romanova, E. V., Sasaki, K., Alexeeva, V., Vilim, F. S., Jing, J., Richmond, T. A., Weiss, K. R. & Sweedler, J. V., Nov 8 2012, In: PloS one. 7, 11, e48764.

  Research output: Contribution to journal › Article › peer-review

  • Invertebrates
  • urotensin II
  • Aplysia californica
  • Aplysia
  • invertebrates
• 2011

  A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus

  Gilly, W. F., Richmond, T. A., Duda, T. F., Elliger, C., Lebaric, Z., Schulz, J., Bingham, J. P. & Sweedler, J. V., Jan 2011, In: Journal of Experimental Biology. 214, 1, p. 147-161 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Conus Snail
  • Conus
  • seed cones
  • snail
  • toxin

• A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the aplysia californica central nervous system

  Wang, L., Ota, N., Romanova, E. V. & Sweedler, J. V., Apr 15 2011, In: Journal of Biological Chemistry. 286, 15, p. 13765-13774 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acid Isomerases
  • aspartate racemase
  • D-Aspartic Acid
  • Aplysia
  • Pyridoxal Phosphate

• Chronic morphine alters the presynaptic protein profile: Identification of novel molecular targets using proteomics and network analysis

  Abul-Husn, N. S., Annangudi, S. P., Ma'ayan, A., Ramos-Ortolaza, D. L., Stockton, S. D., Gomes, I., Sweedler, J. V. & Devi, L. A., Oct 17 2011, In: PloS one. 6, 10, e25535.

  Research output: Contribution to journal › Article › peer-review

  • Proteomics
  • morphine
  • Electric network analysis
  • protein composition
  • Morphine

• Collection of peptides released from single neurons with particle-embedded monolithic capillaries followed by detection with matrix-assisted laser desorption/ionization mass spectrometry

  Fan, Y., Rubakhin, S. & Sweedler, J. V., Dec 15 2011, In: Analytical Chemistry. 83, 24, p. 9557-9563 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ionization
  • Mass spectrometry
  • Desorption
  • Pyrrolidinones
  • ethylenediamine

• Comparison of tandem mass spectrometry search methods to identify neuropeptides

  Akhtar, M. N., Southey, B. R., Porter, K. I., Sweedler, J. V. & Rodriguez-Zas, S. L., 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. p. 982-984 3 p. 6112530. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Neuropeptides
  • Mass spectrometry
  • Tandem Mass Spectrometry
  • Peptides
  • Amino acids

• Direct cellular peptidomics of hypothalamic neurons

  Mitchell, J. W., Atkins, N., Sweedler, J. V. & Gillette, M. U., Oct 2011, In: Frontiers in Neuroendocrinology. 32, 4, p. 377-386 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neurons
  • Peptides
  • Cell signaling
  • Supraoptic Nucleus
  • Suprachiasmatic Nucleus

• Distinguishing endogenous d-amino acid-containing neuropeptides in individual neurons using tandem mass spectrometry

  Bai, L., Romanova, E. V. & Sweedler, J. V., Apr 1 2011, In: Analytical Chemistry. 83, 7, p. 2794-2800 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Neuropeptides
  • Neurons
  • Amino Acids
  • Peptides

• Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history

  Elliger, C. A., Richmond, T. A., Lebaric, Z. N., Pierce, N. T., Sweedler, J. V. & Gilly, W. F., Feb 2011, In: Toxicon. 57, 2, p. 311-322 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Conotoxins
  • History
  • Peptides
  • Molluscs
  • Gene encoding

• Integration of sequence and functional information to identify and annotate neuropeptides in the pig genome

  Porter, K. I., Southey, B. R., Akhtar, M. N., Sweedler, J. V. & Rodriguez-Zas, S. L., Dec 1 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. p. 988-990 3 p. 6112532. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Neuropeptides
  • Genes
  • Swine
  • Genome
  • proenkephalin

• MALDI mass spectrometry imaging of neuronal cell cultures

  Zimmerman, T. A., Rubakhin, S. S. & Sweedler, J. V., May 2011, In: Journal of the American Society for Mass Spectrometry. 22, 5, p. 828-836 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell culture
  • Mass spectrometry
  • Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
  • Aplysia
  • Mass Spectrometry

• Metabolic differentiation of neuronal phenotypes by single-cell capillary electrophoresis-electrospray ionization-mass spectrometry

  Nemes, P., Knolhoff, A. M., Rubakhin, S. S. & Sweedler, J. V., Sep 1 2011, In: Analytical chemistry. 83, 17, p. 6810-6817 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Electrospray ionization
  • Capillary electrophoresis
  • Mass spectrometry
  • Neurons
  • Metabolites

• Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord

  Miller, L. K., Hou, X., Rodriguiz, R. M., Gagnidze, K., Sweedler, J. V., Wetsel, W. C. & Devi, L. A., Dec 2011, In: Journal of Neurochemistry. 119, 5, p. 1074-1085 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin-Converting Enzymes
  • Morphine
  • Spinal Cord
  • Peptides
  • Neuropeptides

• Model of ion intensity from tandem mass spectra for improved peptide identification and simulation

  Fazal, Z., Southey, B. R., Sadeque, A., Sweedler, J. V. & Rodriguez-Zas, S. L., Dec 1 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. p. 994-996 3 p. 6112534. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Peptides
  • Ions
  • Mass spectrometry
  • Protons
  • Tandem Mass Spectrometry

• Molecular organization of drosophila neuroendocrine cells by dimmed

  Park, D., Hadžić, T., Yin, P., Rusch, J., Abruzzi, K., Rosbash, M., Skeath, J. B., Panda, S., Sweedler, J. V. & Taghert, P. H., Sep 27 2011, In: Current Biology. 21, 18, p. 1515-1524 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroendocrine Cells
  • Drosophila
  • Assays
  • Secretory Vesicles
  • cytochrome b561

• Neuropeptidomics: Mass spectrometry-based qualitative and quantitative analysis

  Yin, P., Hou, X., Romanova, E. V. & Sweedler, J. V., 2011, Neuropeptides: Methods and Protocols. Merighi, A. (ed.). p. 223-236 14 p. (Methods in Molecular Biology; vol. 789).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Neuropeptides
  • Mass Spectrometry
  • Liquid Chromatography
  • Peptides
  • Protein Precursors

• Neuropeptidomics

  Sweedler, J. V., Xie, F. & Bora, A., Sep 23 2011, Protein and Peptide Mass Spectrometry in Drug Discovery. John Wiley and Sons, p. 393-433 41 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Neuropeptidomics of the mammalian brain

  Xie, F., Romanova, E. V. & Sweedler, J. V., Jun 3 2011, Neuroproteomics. Li, K. W. (ed.). p. 229-242 14 p. (Neuromethods; vol. 57).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Brain
  • Mass spectrometry
  • Peptides
  • Mass Spectrometry
  • Liquid chromatography

• Probing the production of amidated peptides following genetic and dietary copper manipulations

  Yin, P., Bousquet-Moore, D., Annangudi, S. P., Southey, B. R., Mains, R. E., Eipper, B. A. & Sweedler, J. V., Dec 16 2011, In: PloS one. 6, 12, e28679.

  Research output: Contribution to journal › Article › peer-review

  • peptidylglycine monooxygenase
  • Mixed Function Oxygenases
  • Copper
  • copper
  • peptides

• Profiling metabolites and peptides in single cells

  Rubakhin, S. S., Romanova, E. V., Nemes, P. & Sweedler, J. V., Apr 2011, In: Nature Methods. 8, 4, p. S20-S29

  Research output: Contribution to journal › Article › peer-review

  • Metabolites
  • Developmental Biology
  • Cytology
  • Stem cells
  • Microanalysis

• Small molecule analysis and imaging of fatty acids in the zebra finch song system using time-of-flight-secondary ion mass spectrometry

  Amaya, K. R., Sweedler, J. V. & Clayton, D. F., Aug 2011, In: Journal of Neurochemistry. 118, 4, p. 499-511 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Secondary Ion Mass Spectrometry
  • Secondary ion mass spectrometry
  • Finches
  • Equidae
  • Music

• Stretched tissue mounting for MALDI mass spectrometry imaging

  Tucker, K. R., Lanni, E. J., Serebryannyy, L. A., Rubakhin, S. & Sweedler, J. V., Dec 1 2011, In: Analytical Chemistry. 83, 23, p. 9181-9185 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ionization
  • Mass spectrometry
  • Desorption
  • Mountings
  • Tissue

• The enzyme function initiative

  Gerlt, J. A., Allen, K. N., Almo, S. C., Armstrong, R. N., Babbitt, P. C., Cronan, J. E., Dunaway-Mariano, D., Imker, H. J., Jacobson, M. P., Minor, W., Poulter, C. D., Raushel, F. M., Sali, A., Shoichet, B. K. & Sweedler, J. V., Nov 22 2011, In: Biochemistry. 50, 46, p. 9950-9962 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Enzymes
  • Microbiology
  • Genes
  • Amidohydrolases
  • Genome

• The mechanical sensitivity of vesicle dynamics in in vivo and in vitro neurons

  Ahmed, W. W., Li, T. C., Rubakhin, S., Chiba, A., Sweedler, J. V. & Saif, M. T. A., Nov 23 2011, Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. p. 436-439 4 p. (Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011; vol. 3).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Neurons
  • Cones
  • Imaging techniques

• The modified-bead stretched sample method: Development and application to MALDI-MS imaging of protein localization in the spinal cord

  Tucker, K. R., Serebryannyy, L. A., Zimmerman, T. A., Rubakhin, S. S. & Sweedler, J. V., 2011, In: Chemical Science. 2, 4, p. 785-795 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ionization
  • Mass spectrometry
  • Desorption
  • Imaging techniques
  • Lasers

• The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary

  Aujla, P. K., Bora, A., Monahan, P., Sweedler, J. V. & Raetzman, L. T., May 1 2011, In: Developmental Biology. 353, 1, p. 61-71 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginine Vasopressin
  • Neuropeptides
  • Axons
  • Supraoptic Nucleus
  • Paraventricular Hypothalamic Nucleus

• Using microfluidics and mass spectrometry to study peptide release in neurons

  Croushore, C. A., Lee, C. Y., Zhong, M. & Sweedler, J. V., Dec 1 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. p. 858-860 3 p. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; vol. 2).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Peptides
  • Mass spectrometry
  • Microfluidics
  • Neurons
  • Neuropeptides