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• A computational framework to explore large-scale biosynthetic diversity

  Navarro-Muñoz, J. C., Selem-Mojica, N., Mullowney, M. W., Kautsar, S. A., Tryon, J. H., Parkinson, E. I., De Los Santos, E. L. C., Yeong, M., Cruz-Morales, P., Abubucker, S., Roeters, A., Lokhorst, W., Fernandez-Guerra, A., Cappelini, L. T. D., Goering, A. W., Thomson, R. J., Metcalf, W. W., Kelleher, N. L., Barona-Gomez, F. & Medema, M. H., Jan 1 2020, In: Nature chemical biology. 16, 1, p. 60-68 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Multigene Family
  • Biological Products
  • Cluster Analysis
  • Genome
  • Metabolomics

• Biochemical characterization of the methylmercaptopropionate: Cob(I)alamin Methyltransferase from Methanosarcina acetivorans

  Fu, H., Goettge, M. N. & Metcalf, W. W., 2019, In: Journal of bacteriology. 201, 12, e00130-19.

  Research output: Contribution to journal › Article › peer-review

  • methyl coenzyme M
  • Methanosarcina
  • Corrinoids
  • Methyltransferases
  • Proteins

• Cas9-mediated genome editing in the methanogenic archaeon Methanosarcina acetivorans

  Nayak, D. D. & Metcalf, W. W., Mar 14 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 11, p. 2976-2981 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina
  • Gene Editing
  • Archaea
  • Guide RNA
  • Insertional Mutagenesis

• Classic Spotlights: Selected highlights from the first 100 years of the Journal of Bacteriology

  Armitage, J. P., Becker, A., Christie, P. J., de Boer, P. A. J., DiRita, V. J., Gourse, R. L., Henkin, T. M., Margolin, W., Metcalf, W. W., Mullineaux, C. W., O'Toole, G. A., Parkinson, J. S., Schneewind, O., Silhavy, T. J., Stock, A. M. & Zhulin, I. B., Jul 1 2017, In: Journal of bacteriology. 199, 13, e00062-17.

  Research output: Contribution to journal › Editorial › peer-review

• Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

  Parkinson, E. I., Tryon, J. H., Goering, A. W., Ju, K. S., McClure, R. A., Kemball, J. D., Zhukovsky, S., Labeda, D. P., Thomson, R. J., Kelleher, N. L. & Metcalf, W. W., Apr 20 2018, In: ACS chemical biology. 13, 4, p. 1029-1037 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Multigene Family
  • Biological Products
  • Genes
  • Metabolomics
  • Gene expression

• Draft genome sequence of Methanobrevibacter smithii isolate WWM1085, obtained from a human stool sample

  Jennings, M. E., Chia, N., Boardman, L. A. & Metcalf, W. W., Sep 1 2017, In: Genome Announcements. 5, 39, e01055-17.

  Research output: Contribution to journal › Article › peer-review

  • Methanobrevibacter
  • Genome
  • Genetic Variation

• Energy conservation and hydrogenase function in methanogenic archaea, in particular the genus methanosarcina

  Mand, T. D. & Metcalf, W. W., Dec 2019, In: Microbiology and Molecular Biology Reviews. 83, 4, e0002019.

  Research output: Contribution to journal › Review article › peer-review

  • Methanosarcina
  • Hydrogenase
  • Methane
  • Archaea
  • Cytochromes

• Energy conservation via hydrogen cycling in the methanogenic archaeon Methanosarcina barkeri

  Kulkarni, G., Mand, T. D. & Metcalf, W. W., Jul 1 2018, In: mBio. 9, 4, e01256-18.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina barkeri
  • Hydrogenase
  • Archaea
  • Hydrogen
  • Adenosine Triphosphate

• Fosmidomycin biosynthesis diverges from related phosphonate natural products

  Parkinson, E. I., Erb, A., Eliot, A. C., Ju, K. S. & Metcalf, W. W., Nov 1 2019, In: Nature chemical biology. 15, 11, p. 1049-1056 8 p.

  Research output: Contribution to journal › Article › peer-review

  • fosmidomycin
  • Organophosphonates
  • Biological Products
  • Biosynthetic Pathways
  • 3-(N-acetyl-N-hydroxy)aminopropylphosphonic acid

• Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

  Nayak, D. D., Liu, A., Agrawal, N., Rodriguez-Carerro, R., Dong, S. H., Mitchell, D. A., Nair, S. K. & Metcalf, W. W., Feb 2020, In: PLoS biology. 18, 2, e3000507.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • methyl coenzyme M reductase
  • Methanosarcina
  • Methanosarcina acetivorans
  • coenzyme-B sulfoethylthiotransferase
  • S-methylcysteine

• GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean

  Zeng, Z., Liu, X. L., Farley, K. R., Wei, J. H., Metcalf, W. W., Summons, R. E. & Welander, P. V., Nov 5 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 45, p. 22505-22511 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclization
  • Oceans and Seas
  • Glycerol
  • Lipids
  • Proteins

• Genetic, biochemical, and molecular characterization of methanosarcina barkeri mutants lacking three distinct classes of hydrogenase

  Mand, T. D., Kulkarni, G. & Metcalf, W. W., Oct 1 2018, In: Journal of bacteriology. 200, 20, e00342.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina barkeri
  • Hydrogenase
  • Molecular Biology
  • Methanol
  • Methane

• Genetic techniques for studies of methyl-coenzyme M reductase from Methanosarcina acetivorans C2A

  Nayak, D. D. & Metcalf, W. W., 2018, Methods in Enzymology. Armstrong, F. (ed.). Academic Press Inc., p. 325-347 23 p. (Methods in Enzymology; vol. 613).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • methyl coenzyme M reductase
  • Methanosarcina
  • Methane
  • Genetic Techniques
  • Methanogens

• Genome mining and metabolomics uncover a rare D-capreomycidine containing natural product and its biosynthetic gene cluster

  Kelleher, N. L., Thomson, R. J., Tryon, J. H., Rote, J. C., Chen, L., Robey, M. T., Vega, M. M., Phua, W. C., Metcalf, W. W. & Ju, K. S., Nov 20 2020, In: ACS chemical biology. 15, 11, p. 3013-3020 8 p.

  Research output: Contribution to journal › Article › peer-review

  • capreomycidine
  • Metabolomics
  • Multigene Family
  • Biological Products
  • Genes

• Methylamine-specific methyltransferase paralogs in Methanosarcina are functionally distinct despite frequent gene conversion

  Nayak, D. D. & Metcalf, W. W., Sep 1 2019, In: ISME Journal. 13, 9, p. 2173-2182 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina
  • methylamine
  • Gene Conversion
  • Gene Duplication
  • gene conversion

• Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin

  Petronikolou, N., Ortega, M. A., Borisova, S. A., Nair, S. K. & Metcalf, W. W., Apr 19 2019, In: ACS chemical biology. 14, 4, p. 742-750 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-amino-5-phosphono-3-pentenoic acid
  • Bacilli
  • Oligopeptides
  • Bacillus subtilis
  • threonine synthase

• PcxL and HpxL are flavin-dependent, oxime-forming N-oxidases in phosphonocystoximic acid biosynthesis in Streptomyces

  Goettge, M. N., Cioni, J. P., Ju, K. S., Pallitsch, K. & Metcalf, W. W., May 4 2018, In: Journal of Biological Chemistry. 293, 18, p. 6859-6868 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Biosynthesis
  • 4,6-dinitro-o-cresol
  • Oximes
  • Streptomyces
  • Oxidoreductases

• Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis

  Labeda, D. P., Dunlap, C. A., Rong, X., Huang, Y., Doroghazi, J. R., Ju, K. S. & Metcalf, W. W., Apr 1 2017, In: Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. 110, 4, p. 563-583 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Streptomycetaceae
  • Streptomyces
  • Sequence Analysis
  • Genome
  • Phylogeny

• Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic archaea

  Nayak, D. D., Mahanta, N., Mitchell, D. A. & Metcalf, W. W., Sep 7 2017, In: eLife. 6, e29218.

  Research output: Contribution to journal › Article › peer-review

  • methyl coenzyme M reductase
  • Archaea
  • thioviridamide
  • Glycine
  • Thioamides

• The streptothricin acetyltransferase (sat) gene as a positive selectable marker for methanogenic archaea

  Farley, K. R. & Metcalf, W. W., Oct 12 2019, In: FEMS microbiology letters. 366, 17, fnz216.

  Research output: Contribution to journal › Article › peer-review

  • streptothricin acetyltransferase
  • Methanosarcina
  • Streptothricins
  • Archaea
  • nourseothricin acetyltransferase