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  • Huimin Zhao
2016

A brief overview of synthetic biology research programs and roadmap studies in the United States

Si, T. & Zhao, H., Dec 1 2016, In : Synthetic and Systems Biotechnology. 1, 4, p. 258-264 7 p.

Research output: Contribution to journalReview article

Accelerated genome engineering through multiplexing

Bao, Z., Cobb, R. E. & Zhao, H., Jan 1 2016, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 8, 1, p. 5-21 17 p.

Research output: Contribution to journalReview article

ACS Catalysis and the Scope of Papers Sought in Three Catalysis Subdisciplines: Biocatalysis and Enzymology, Molecular Catalysis for Organic Synthesis, and Heterogeneous Photocatalysis

Chang, S., Fornasiero, P., Gunnoe, T. B., Jones, C. W., Linic, S., Ooi, T., Williams, R. M. & Zhao, H., Jul 1 2016, In : ACS Catalysis. 6, 7, p. 4782-4785 4 p.

Research output: Contribution to journalReview article

A highly efficient single-step, markerless strategy for multi-copy chromosomal integration of large biochemical pathways in Saccharomyces cerevisiae

Shi, S., Liang, Y., Zhang, M. M., Ang, E. L. & Zhao, H., Jan 1 2016, In : Metabolic Engineering. 33, p. 19-27 9 p.

Research output: Contribution to journalArticle

A step through the looking glass

Liang, Y., Ang, E. L. & Zhao, H., Sep 1 2016, In : Science China Life Sciences. 59, 9, p. 979-980 2 p.

Research output: Contribution to journalArticle

Biocatalysis for Drug Discovery and Development

Liang, Y., Zhang, M. M., Ang, E. L. & Zhao, H., May 13 2016, Green Biocatalysis. Wiley, p. 421-455 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Characterization of bacillus subtilis colony biofilms via mass spectrometry and fluorescence imaging

Si, T., Li, B., Zhang, K., Xu, Y., Zhao, H. & Sweedler, J. V., Jun 3 2016, In : Journal of Proteome Research. 15, 6, p. 1955-1962 8 p.

Research output: Contribution to journalArticle

Combinatorial pathway engineering for optimized production of the anti-malarial FR900098

Freestone, T. S. & Zhao, H., Feb 1 2016, In : Biotechnology and bioengineering. 113, 2, p. 384-392 9 p.

Research output: Contribution to journalArticle

Combined and iterative use of computational design and directed evolution for protein-ligand binding design

Wang, M. & Zhao, H., May 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 139-153 15 p. (Methods in Molecular Biology; vol. 1414).

Research output: Chapter in Book/Report/Conference proceedingChapter

CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973

Wendt, K. E., Ungerer, J., Cobb, R. E., Zhao, H. & Pakrasi, H. B., Jun 23 2016, In : Microbial cell factories. 15, 1, 115.

Research output: Contribution to journalArticle

Design and engineering of intracellular-metabolite-sensing/regulation gene circuits in Saccharomyces cerevisiae

Wang, M., Li, S. & Zhao, H., Jan 1 2016, In : Biotechnology and bioengineering. 113, 1, p. 206-215 10 p.

Research output: Contribution to journalArticle

Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate

Sun, H., Yeo, W. L., Lim, Y. H., Chew, X., Smith, D. J., Xue, B., Chan, K. P., Robinson, R. C., Robins, E. G., Zhao, H. & Ang, E. L., Jan 1 2016, In : Angewandte Chemie - International Edition. 55, 46, p. 14277-14280 4 p.

Research output: Contribution to journalArticle

Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization

Wang, M., Yu, C. & Zhao, H., Mar 1 2016, In : Biotechnology and bioengineering. 113, 3, p. 484-491 8 p.

Research output: Contribution to journalArticle

Editorial: Synthetic biology and bioinformatics

Medema, M. H. & Zhao, H., Aug 2016, In : Natural Product Reports. 33, 8, p. 913-914 2 p.

Research output: Contribution to journalEditorial

Engineered minicellulosomes for consolidated bioprocessing

Liang, Y., Ang, E. L. & Zhao, H., Jul 11 2016, Handbook of Carbohydrate-Modifying Biocatalysts. Pan Stanford Publishing Pte. Ltd., Vol. 2. p. 965-992 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Engineering microbial hosts for production of bacterial natural products

Zhang, M. M., Wang, Y., Ang, E. L. & Zhao, H., Aug 2016, In : Natural Product Reports. 33, 8, p. 963-987 25 p.

Research output: Contribution to journalReview article

Flexible and Versatile Strategy for the Construction of Large Biochemical Pathways

Yuan, Y., Andersen, E. & Zhao, H., Jan 15 2016, In : ACS synthetic biology. 5, 1, p. 46-52 7 p.

Research output: Contribution to journalArticle

High-Efficiency Genome Editing of Streptomyces Species by an Engineered CRISPR/Cas System

Wang, Y., Cobb, R. E. & Zhao, H., 2016, Methods in Enzymology. O'Connor, S. E. (ed.). Academic Press Inc., p. 271-284 14 p. (Methods in Enzymology; vol. 575).

Research output: Chapter in Book/Report/Conference proceedingChapter

High-throughput screening or selection methods for evolutionary enzyme engineering

Shi, S., Zhang, H., Ang, E. L. & Zhao, H., May 17 2016, Understanding Enzymes: Function, Design, Engineering and Analysis. Pan Stanford Publishing Pte. Ltd., p. 707-744 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification and engineering of n-butanol biosensors by transcriptome analysis in yeast

Shi, S., Ang, E. L., Tan, M. H. & Zhao, H., Jan 1 2016, Metabolic Engineering 11. AIChE, p. 458-459 2 p. (Metabolic Engineering 11).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Identification of an important motif that controls the activity and specificity of sugar transporters

Wang, M., Yu, C. & Zhao, H., Jul 1 2016, In : Biotechnology and bioengineering. 113, 7, p. 1460-1467 8 p.

Research output: Contribution to journalArticle

Members of the rusc protein family interact with Sufu and inhibit vertebrate hedgehog signaling

Jin, Z., Schwend, T., Fu, J., Bao, Z., Liang, J., Zhao, H., Mei, W. & Yang, J., Nov 1 2016, In : Development (Cambridge). 143, 21, p. 3944-3955 12 p.

Research output: Contribution to journalArticle

Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae

Shi, S., Si, T., Liu, Z., Zhang, H., Ang, E. L. & Zhao, H., May 10 2016, In : Scientific reports. 6, 25675.

Research output: Contribution to journalArticle

Metabolic engineering of Saccharomyces cerevisiae to produce 1-hexadecanol from xylose

Guo, W., Sheng, J., Zhao, H. & Feng, X., Feb 1 2016, In : Microbial cell factories. 15, 1, 24.

Research output: Contribution to journalArticle

New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters

Luo, Y., Enghiad, B. & Zhao, H., Feb 2016, In : Natural Product Reports. 33, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis

Zhang, H., Li, X., Su, X., Ang, E. L., Zhang, Y. & Zhao, H., Apr 20 2016, In : ChemCatChem. 8, 8, p. 1500-1506 7 p.

Research output: Contribution to journalArticle

Rapid and efficient galactose fermentation by engineered Saccharomyces cerevisiae

Quarterman, J., Skerker, J. M., Feng, X., Liu, I. Y., Zhao, H., Arkin, A. P. & Jin, Y. S., Jul 10 2016, In : Journal of Biotechnology. 229, p. 13-21 9 p.

Research output: Contribution to journalArticle

RNAi-assisted genome evolution (RAGE) in Saccharomyces cerevisiae

Si, T. & Zhao, H., Jan 1 2016, In : Methods in Molecular Biology. 1470, p. 183-198 16 p.

Research output: Contribution to journalArticle

Standardization for natural product synthetic biology

Zhao, H. & Medema, M. H., Aug 2016, In : Natural Product Reports. 33, 8, p. 920-924 5 p.

Research output: Contribution to journalReview article

TALE proteins search DNA using a rotationally decoupled mechanism

Cuculis, L., Abil, Z., Zhao, H. & Schroeder, C. M., Oct 1 2016, In : Nature chemical biology. 12, 10, p. 831-837 7 p.

Research output: Contribution to journalArticle

Tandem reactions combining biocatalysts and chemical catalysts for asymmetric synthesis

Wang, Y. & Zhao, H., Dec 1 2016, In : Catalysts. 6, 12, 194.

Research output: Contribution to journalReview article

Use of genome-editing tools to treat sickle cell disease

Tasan, I., Jain, S. & Zhao, H., Sep 1 2016, In : Human Genetics. 135, 9, p. 1011-1028 18 p.

Research output: Contribution to journalReview article

2019

A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data

Dinh, H. V., Suthers, P. F., Chan, S. H. J., Shen, Y., Xiao, T., Deewan, A., Jagtap, S. S., Zhao, H., Rao, C. V., Rabinowitz, J. D. & Maranas, C. D., Dec 2019, In : Metabolic Engineering Communications. 9, e00101.

Research output: Contribution to journalArticle

Open Access

A continuing career in biocatalysis: Frances H. Arnold

Fasan, R., Jennifer Kan, S. B. & Zhao, H., Nov 1 2019, In : ACS Catalysis. 9, 11, p. 9775-9788 14 p.

Research output: Contribution to journalArticle

Activation of silent biosynthetic gene clusters using transcription factor decoys

Wang, B., Guo, F., Dong, S. H. & Zhao, H., Feb 1 2019, In : Nature chemical biology. 15, 2, p. 111-114 4 p.

Research output: Contribution to journalArticle

A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium

Xing, M., Wei, Y., Hua, G., Li, M., Nanjaraj Urs, A. N., Wang, F., Hu, Y., Zhai, W., Liu, Y., Ang, E. L., Zhao, H. & Zhang, Y., Aug 15 2019, In : Biochemical Journal. 476, 15, p. 2271-2279 9 p.

Research output: Contribution to journalArticle

An efficient gene knock-in strategy using 5′-modified double-stranded DNA donors with short homology arms

Yu, Y., Guo, Y., Tian, Q., Lan, Y., Yeh, H., Zhang, M., Tasan, I., Jain, S. & Zhao, H., Dec 23 2019, (Accepted/In press) In : Nature chemical biology. 16, 4, p. 387-390 4 p.

Research output: Contribution to journalArticle

An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from β-alanine

Yin, J., Wei, Y., Liu, D., Hu, Y., Lu, Q., Lui Ang, E., Zhao, H. & Zhang, Y., Oct 25 2019, In : Journal of Biological Chemistry. 294, 43, p. 15662-15671 10 p.

Research output: Contribution to journalArticle

A pathway for isethionate dissimilation in Bacillus krulwichiae

Tong, Y., Wei, Y., Hu, Y., Ang, E. L., Zhao, H. & Zhang, Y., 2019, In : Applied and environmental microbiology. 85, 15, e00793-19.

Research output: Contribution to journalArticle

Biochemical and structural investigation of sulfoacetaldehyde reductase from Klebsiella oxytoca

Zhou, Y., Wei, Y., Lin, L., Xu, T., Ang, E. L., Zhao, H., Yuchi, Z. & Zhang, Y., Jan 1 2019, In : Biochemical Journal. 476, 4, p. 733-746 14 p.

Research output: Contribution to journalArticle

Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase from Bifidobacterium kashiwanohense

Li, M., Wei, Y., Yin, J., Lin, L., Zhou, Y., Hua, G., Cao, P., Ang, E. L., Zhao, H., Yuchi, Z. & Zhang, Y., Jan 1 2019, In : Biochemical Journal. 476, 11, p. 1605-1619 15 p.

Research output: Contribution to journalArticle

Building a global alliance of biofoundries

Hillson, N., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., Bell, D. J., Le Feuvre, R., Friedman, D. C., Fu, X., Gold, N. D., Herrgård, M. J., Holowko, M. B., Johnson, J. R., Johnson, R. A., Keasling, J. D., Kitney, R. I., Kondo, A., Liu, C., Martin, V. J. J. & 16 others, Menolascina, F., Ogino, C., Patron, N. J., Pavan, M., Poh, C. L., Pretorius, I. S., Rosser, S. J., Scrutton, N. S., Storch, M., Tekotte, H., Travnik, E., Vickers, C. E., Yew, W. S., Yuan, Y., Zhao, H. & Freemont, P. S., Dec 1 2019, In : Nature communications. 10, 1, 2040.

Research output: Contribution to journalComment/debate

Open Access

Characterization of Cas proteins for CRISPR-Cas editing in streptomycetes

Yeo, W. L., Heng, E., Tan, L. L., Lim, Y. W., Lim, Y. H., Hoon, S., Zhao, H., Zhang, M. M. & Wong, F. T., Jan 1 2019, In : Biotechnology and bioengineering. 116, 9, p. 2330-2338 9 p.

Research output: Contribution to journalArticle

Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098

Nguyen, K., DeSieno, M. A., Bae, B., Johannes, T. W., Cobb, R. E., Zhao, H. & Nair, S. K., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 6, p. 1506-1518 13 p.

Research output: Contribution to journalArticle

Construction and Screening of an Antigen-Derived Peptide Library Displayed on Yeast Cell Surface for CD4+ T Cell Epitope Identification

Wen, F., Smith, M. R. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 213-234 22 p. (Methods in Molecular Biology; vol. 2024).

Research output: Chapter in Book/Report/Conference proceedingChapter

Delta integration CRISPR-Cas (Di-CRISPR) in saccharomyces cerevisiae

Shi, S., Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 73-91 19 p. (Methods in Molecular Biology; vol. 1927).

Research output: Chapter in Book/Report/Conference proceedingChapter

Development of a CRISPR/Cas9-based tool for gene deletion in Issatchenkia orientalis

Tran, V. G., Cao, M., Fatma, Z., Song, X. & Zhao, H., May 1 2019, In : mSphere. 4, 3, e00345-19.

Research output: Contribution to journalArticle

Open Access

Development of a CRISPR/Cas9 system for high efficiency multiplexed gene deletion in Rhodosporidium toruloides

Schultz, J. C., Cao, M. & Zhao, H., Aug 2019, In : Biotechnology and bioengineering. 116, 8, p. 2103-2109 7 p.

Research output: Contribution to journalArticle