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• A computational framework to explore large-scale biosynthetic diversity

  Navarro-Muñoz, J. C., Selem-Mojica, N., Mullowney, M. W., Kautsar, S. A., Tryon, J. H., Parkinson, E. I., De Los Santos, E. L. C., Yeong, M., Cruz-Morales, P., Abubucker, S., Roeters, A., Lokhorst, W., Fernandez-Guerra, A., Cappelini, L. T. D., Goering, A. W., Thomson, R. J., Metcalf, W. W., Kelleher, N. L., Barona-Gomez, F. & Medema, M. H., Jan 1 2020, In: Nature chemical biology. 16, 1, p. 60-68 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Multigene Family
  • Biological Products
  • Cluster Analysis
  • Genome
  • Metabolomics

• Classic spotlight: What's on (in) your plate today?

  Metcalf, W. W., 2016, In: Journal of bacteriology. 198, 21, p. 2897-2898 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Classic spotlight: Metabolic flux-which way to go?

  Metcalf, W. W., 2016, In: Journal of bacteriology. 198, 24, p. 3248-3249 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Classic spotlight: Electron bifurcation, a unifying concept for energy conservation in anaerobes

  Metcalf, W. W., May 1 2016, In: Journal of bacteriology. 198, 9, p. 1358 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products

  Blodgett, J. A., Zhang, J. K., Yu, X. & Metcalf, W. W., Jan 1 2016, In: Journal of Antibiotics. 69, 1, p. 15-25 11 p.

  Research output: Contribution to journal › Article › peer-review

  • bialaphos
  • phosphinothricin
  • phosphonic acid
  • Streptomyces
  • Biosynthetic Pathways

• Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

  Parkinson, E. I., Tryon, J. H., Goering, A. W., Ju, K. S., McClure, R. A., Kemball, J. D., Zhukovsky, S., Labeda, D. P., Thomson, R. J., Kelleher, N. L. & Metcalf, W. W., Apr 20 2018, In: ACS chemical biology. 13, 4, p. 1029-1037 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Multigene Family
  • Biological Products
  • Genes
  • Metabolomics
  • Gene expression

• Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations

  McClure, R. A., Goering, A. W., Ju, K. S., Baccile, J. A., Schroeder, F. C., Metcalf, W. W., Thomson, R. J. & Kelleher, N. L., Dec 16 2016, In: ACS chemical biology. 11, 12, p. 3452-3460 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Biosynthesis
  • Metabolites
  • Multigene Family
  • Biological Products
  • Genes

• Energy conservation via hydrogen cycling in the methanogenic archaeon Methanosarcina barkeri

  Kulkarni, G., Mand, T. D. & Metcalf, W. W., Jul 1 2018, In: mBio. 9, 4, e01256-18.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina barkeri
  • Hydrogenase
  • Archaea
  • Hydrogen
  • Adenosine Triphosphate

• Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

  Nayak, D. D., Liu, A., Agrawal, N., Rodriguez-Carerro, R., Dong, S. H., Mitchell, D. A., Nair, S. K. & Metcalf, W. W., Feb 2020, In: PLoS biology. 18, 2, e3000507.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • methyl coenzyme M reductase
  • Methanosarcina
  • Methanosarcina acetivorans
  • coenzyme-B sulfoethylthiotransferase
  • S-methylcysteine

• Genetic, biochemical, and molecular characterization of methanosarcina barkeri mutants lacking three distinct classes of hydrogenase

  Mand, T. D., Kulkarni, G. & Metcalf, W. W., Oct 1 2018, In: Journal of bacteriology. 200, 20, e00342.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina barkeri
  • Hydrogenase
  • Molecular Biology
  • Methanol
  • Methane

• Genetic techniques for studies of methyl-coenzyme M reductase from Methanosarcina acetivorans C2A

  Nayak, D. D. & Metcalf, W. W., 2018, Methods in Enzymology. Armstrong, F. (ed.). Academic Press Inc., p. 325-347 23 p. (Methods in Enzymology; vol. 613).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • methyl coenzyme M reductase
  • Methanosarcina
  • Methane
  • Genetic Techniques
  • Methanogens

• Genome mining and metabolomics uncover a rare D-capreomycidine containing natural product and its biosynthetic gene cluster

  Kelleher, N. L., Thomson, R. J., Tryon, J. H., Rote, J. C., Chen, L., Robey, M. T., Vega, M. M., Phua, W. C., Metcalf, W. W. & Ju, K. S., Nov 20 2020, In: ACS chemical biology. 15, 11, p. 3013-3020 8 p.

  Research output: Contribution to journal › Article › peer-review

  • capreomycidine
  • Metabolomics
  • Multigene Family
  • Biological Products
  • Genes

• Genome-wide gene expression and RNA half-life measurements allow predictions of regulation and metabolic behavior in Methanosarcina acetivorans

  Peterson, J. R., Thor, S. S., Kohler, L., Kohler, P. R. A., Metcalf, W. W. & Luthey-Schulten, Z., Nov 16 2016, In: BMC genomics. 17, 1, 924.

  Research output: Contribution to journal › Article › peer-review

  • Methanosarcina
  • Half-Life
  • RNA
  • Genome
  • Gene Expression

• Metabologenomics: Correlation of microbial gene clusters with metabolites drives discovery of a nonribosomal peptide with an unusual amino acid monomer

  Goering, A. W., McClure, R. A., Doroghazi, J. R., Albright, J. C., Haverland, N. A., Zhang, Y., Ju, K. S., Thomson, R. J., Metcalf, W. W. & Kelleher, N. L., Feb 24 2016, In: ACS Central Science. 2, 2, p. 99-108 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolites
  • Peptides
  • Amino acids
  • Monomers
  • Biological Products

• PcxL and HpxL are flavin-dependent, oxime-forming N-oxidases in phosphonocystoximic acid biosynthesis in Streptomyces

  Goettge, M. N., Cioni, J. P., Ju, K. S., Pallitsch, K. & Metcalf, W. W., May 4 2018, In: Journal of Biological Chemistry. 293, 18, p. 6859-6868 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Biosynthesis
  • 4,6-dinitro-o-cresol
  • Oximes
  • Streptomyces
  • Oxidoreductases

• Quinovosamycins: New tunicamycin-type antibiotics in which the α, β-1',11'-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine

  Price, N. P. J., Labeda, D. P., Naumann, T. A., Vermillion, K. E., Bowman, M. J., Berhow, M. A., Metcalf, W. W. & Bischoff, K. M., Aug 1 2016, In: Journal of Antibiotics. 69, 8, p. 637-646 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tunicamycin
  • Acetylglucosamine
  • Anti-Bacterial Agents
  • 5-phenylpent-4-enyl-1-hydroperoxide
  • UDP-GlcNAc-undecaprenyl phosphate N-acetylglucosaminyl 1-phosphate transferase

• Taxonomic evaluation of species in the streptomyces hirsutus clade using multi-locus sequence analysis and proposals to reclassify several species in this clade

  Labeda, D. P., Rong, X., Huang, Y., Doroghazi, J. R., Ju, K. S. & Metcalf, W. W., Jun 2016, In: International Journal of Systematic and Evolutionary Microbiology. 66, 6, p. 2444-2450 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Streptomyces hirsutus
  • Streptomyces
  • multilocus sequence typing
  • Streptomyces prasinopilosus
  • Sequence Analysis