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  • Huimin Zhao
Article

Metabolic engineering of Saccharomyces cerevisiae to produce 1-hexadecanol from xylose

Guo, W., Sheng, J., Zhao, H. & Feng, X., Feb 1 2016, In : Microbial cell factories. 15, 1, 24.

Research output: Contribution to journalArticle

Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping

Lian, J., Schultz, C., Cao, M., HamediRad, M. & Zhao, H., Dec 1 2019, In : Nature communications. 10, 1, 5794.

Research output: Contribution to journalArticle

Open Access

New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters

Luo, Y., Enghiad, B. & Zhao, H., Feb 2016, In : Natural Product Reports. 33, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Orthogonal Genetic Regulation in Human Cells Using Chemically Induced CRISPR/Cas9 Activators

Bao, Z., Jain, S., Jaroenpuntaruk, V. & Zhao, H., Apr 21 2017, In : ACS synthetic biology. 6, 4, p. 686-693 8 p.

Research output: Contribution to journalArticle

Probing the molecular determinants of fluorinase specificity

Yeo, W. L., Chew, X., Smith, D. J., Chan, K. P., Sun, H., Zhao, H., Lim, Y. H. & Ang, E. L., Jan 1 2017, In : Chemical Communications. 53, 17, p. 2559-2562 4 p.

Research output: Contribution to journalArticle

Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis

Zhang, H., Li, X., Su, X., Ang, E. L., Zhang, Y. & Zhao, H., Apr 20 2016, In : ChemCatChem. 8, 8, p. 1500-1506 7 p.

Research output: Contribution to journalArticle

Programmable DNA-Guided Artificial Restriction Enzymes

Enghiad, B. & Zhao, H., May 19 2017, In : ACS synthetic biology. 6, 5, p. 752-757 6 p.

Research output: Contribution to journalArticle

Quantifying the effects of pollen nutrition on honey bee queen egg laying with a new laboratory system

Fine, J. D., Shpigler, H. Y., Ray, A. M., Beach, N. J., Sankey, A. L., Cash-Ahmed, A., Huang, Z. Y., Astrauskaite, I., Chao, R., Zhao, H. & Robinson, G. E., Sep 2018, In : PloS one. 13, 9, e0203444.

Research output: Contribution to journalArticle

Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria

Xing, M., Wei, Y., Zhou, Y., Zhang, J., Lin, L., Hu, Y., Hua, G., N. Nanjaraj Urs, A., Liu, D., Wang, F., Guo, C., Tong, Y., Li, M., Liu, Y., Ang, E. L., Zhao, H., Yuchi, Z. & Zhang, Y., Dec 1 2019, In : Nature communications. 10, 1, 1609.

Research output: Contribution to journalArticle

Open Access

Rapid and efficient galactose fermentation by engineered Saccharomyces cerevisiae

Quarterman, J., Skerker, J. M., Feng, X., Liu, I. Y., Zhao, H., Arkin, A. P. & Jin, Y. S., Jul 10 2016, In : Journal of Biotechnology. 229, p. 13-21 9 p.

Research output: Contribution to journalArticle

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli

Ren, H., Biswas, S., Ho, S., Van Der Donk, W. A. & Zhao, H., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2966-2972 7 p.

Research output: Contribution to journalArticle

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli

Si, T., Tian, Q., Min, Y., Zhang, L., Sweedler, J. V., Van Der Donk, W. A. & Zhao, H., Sep 26 2018, In : Journal of the American Chemical Society. 140, 38, p. 11884-11888 5 p.

Research output: Contribution to journalArticle

RNAi-assisted genome evolution (RAGE) in Saccharomyces cerevisiae

Si, T. & Zhao, H., Jan 1 2016, In : Methods in Molecular Biology. 1470, p. 183-198 16 p.

Research output: Contribution to journalArticle

RNAi assisted genome evolution unveils yeast mutants with improved xylose utilization

HamediRad, M., Lian, J., Li, H. & Zhao, H., Jun 2018, In : Biotechnology and bioengineering. 115, 6, p. 1552-1560 9 p.

Research output: Contribution to journalArticle

Synthetic biology advances and applications in the biotechnology industry: a perspective

Katz, L., Chen, Y. Y., Gonzalez, R., Peterson, T. C., Zhao, H. & Baltz, R. H., Jul 1 2018, In : Journal of Industrial Microbiology and Biotechnology. 45, 7, p. 449-461 13 p.

Research output: Contribution to journalArticle

SynV and SynX: A story more than DNA synthesis

Ren, H. & Zhao, H., May 1 2017, In : Science China Life Sciences. 60, 5, p. 558-560 3 p.

Research output: Contribution to journalArticle

TALE proteins search DNA using a rotationally decoupled mechanism

Cuculis, L., Abil, Z., Zhao, H. & Schroeder, C. M., Oct 1 2016, In : Nature chemical biology. 12, 10, p. 831-837 7 p.

Research output: Contribution to journalArticle

Towards a fully automated algorithm driven platform for biosystems design

HamediRad, M., Chao, R., Weisberg, S., Lian, J., Sinha, S. & Zhao, H., Nov 13 2019, In : Nature communications. 10, 1, 5150.

Research output: Contribution to journalArticle

Open Access

Twin-primer non-enzymatic DNA assembly: An efficient and accurate multi-part DNA assembly method

Liang, J., Liu, Z., Low, X. Z., Ang, E. L. & Zhao, H., Jun 1 2017, In : Nucleic acids research. 45, 11, p. e94

Research output: Contribution to journalArticle

Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding

Wang, P., Liang, J., Shi, L. Z., Wang, Y., Zhang, P., Ouyang, M., Preece, D., Peng, Q., Shao, L., Fan, J., Sun, J., Li, S. S., Berns, M. W., Zhao, H. & Wang, Y., Sep 19 2018, In : ACS Photonics. 5, 9, p. 3565-3574 10 p.

Research output: Contribution to journalArticle

Chapter

Applying advanced dna assembly methods to generate pathway libraries

Eriksen, D. T., Chao, R. & Zhao, H., Mar 15 2018, Synthetic Biology: Parts, Devices and Applications. Wiley-VCH Verlag, p. 331-347 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biocatalysis for Drug Discovery and Development

Liang, Y., Zhang, M. M., Ang, E. L. & Zhao, H., May 13 2016, Green Biocatalysis. Wiley, p. 421-455 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Combined and iterative use of computational design and directed evolution for protein-ligand binding design

Wang, M. & Zhao, H., May 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 139-153 15 p. (Methods in Molecular Biology; vol. 1414).

Research output: Chapter in Book/Report/Conference proceedingChapter

Construction and Screening of an Antigen-Derived Peptide Library Displayed on Yeast Cell Surface for CD4+ T Cell Epitope Identification

Wen, F., Smith, M. R. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 213-234 22 p. (Methods in Molecular Biology; vol. 2024).

Research output: Chapter in Book/Report/Conference proceedingChapter

Delta integration CRISPR-Cas (Di-CRISPR) in saccharomyces cerevisiae

Shi, S., Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 73-91 19 p. (Methods in Molecular Biology; vol. 1927).

Research output: Chapter in Book/Report/Conference proceedingChapter

Engineered minicellulosomes for consolidated bioprocessing

Liang, Y., Ang, E. L. & Zhao, H., Jul 11 2016, Handbook of Carbohydrate-Modifying Biocatalysts. Pan Stanford Publishing Pte. Ltd., Vol. 2. p. 965-992 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

High-Efficiency Genome Editing of Streptomyces Species by an Engineered CRISPR/Cas System

Wang, Y., Cobb, R. E. & Zhao, H., 2016, Methods in Enzymology. O'Connor, S. E. (ed.). Academic Press Inc., p. 271-284 14 p. (Methods in Enzymology; vol. 575).

Research output: Chapter in Book/Report/Conference proceedingChapter

High-throughput screening or selection methods for evolutionary enzyme engineering

Shi, S., Zhang, H., Ang, E. L. & Zhao, H., May 17 2016, Understanding Enzymes: Function, Design, Engineering and Analysis. Pan Stanford Publishing Pte. Ltd., p. 707-744 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolic Engineering of Saccharomyces cerevisiae Using a Trifunctional CRISPR/Cas System for Simultaneous Gene Activation, Interference, and Deletion

Schultz, C., Lian, J. & Zhao, H., Jan 1 2018, Methods in Enzymology. Scrutton, N. (ed.). Academic Press Inc., p. 265-276 12 p. (Methods in Enzymology; vol. 608).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pathway design, engineering, and optimization

Garcia-Ruiz, E., HamediRad, M. & Zhao, H., Jan 1 2018, Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, (Advances in Biochemical Engineering/Biotechnology; vol. 162).

Research output: Chapter in Book/Report/Conference proceedingChapter

Strain development by whole-cell directed evolution

Si, T., Lian, J. & Zhao, H., Jan 1 2017, Directed Enzyme Evolution: Advances and Applications. Springer International Publishing, p. 173-200 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Comment/debate

Building a global alliance of biofoundries

Hillson, N., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., Bell, D. J., Le Feuvre, R., Friedman, D. C., Fu, X., Gold, N. D., Herrgård, M. J., Holowko, M. B., Johnson, J. R., Johnson, R. A., Keasling, J. D., Kitney, R. I., Kondo, A., Liu, C., Martin, V. J. J. & 16 others, Menolascina, F., Ogino, C., Patron, N. J., Pavan, M., Poh, C. L., Pretorius, I. S., Rosser, S. J., Scrutton, N. S., Storch, M., Tekotte, H., Travnik, E., Vickers, C. E., Yew, W. S., Yuan, Y., Zhao, H. & Freemont, P. S., Dec 1 2019, In : Nature communications. 10, 1, 2040.

Research output: Contribution to journalComment/debate

Open Access
Conference contribution

Identification and engineering of n-butanol biosensors by transcriptome analysis in yeast

Shi, S., Ang, E. L., Tan, M. H. & Zhao, H., Jan 1 2016, Metabolic Engineering 11. AIChE, p. 458-459 2 p. (Metabolic Engineering 11).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Twin-primer non-enzymatic DNA assembly: An efficient and accurate multi-part DNA assembly method

Liang, J., Liu, Z., Ang, E. L. & Zhao, H., 2017, Synthetic Biology Conference, SEED 2017: Engineering, Evolution, and Design. AIChE, p. 45-46 2 p. (Synthetic Biology Conference, SEED 2017: Engineering, Evolution, and Design).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Editorial

Editorial: Synthetic biology and bioinformatics

Medema, M. H. & Zhao, H., Aug 2016, In : Natural Product Reports. 33, 8, p. 913-914 2 p.

Research output: Contribution to journalEditorial

Review article

A brief overview of synthetic biology research programs and roadmap studies in the United States

Si, T. & Zhao, H., Dec 1 2016, In : Synthetic and Systems Biotechnology. 1, 4, p. 258-264 7 p.

Research output: Contribution to journalReview article

Accelerated genome engineering through multiplexing

Bao, Z., Cobb, R. E. & Zhao, H., Jan 1 2016, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 8, 1, p. 5-21 17 p.

Research output: Contribution to journalReview article

ACS Catalysis and the Scope of Papers Sought in Three Catalysis Subdisciplines: Biocatalysis and Enzymology, Molecular Catalysis for Organic Synthesis, and Heterogeneous Photocatalysis

Chang, S., Fornasiero, P., Gunnoe, T. B., Jones, C. W., Linic, S., Ooi, T., Williams, R. M. & Zhao, H., Jul 1 2016, In : ACS Catalysis. 6, 7, p. 4782-4785 4 p.

Research output: Contribution to journalReview article

Advancing Metabolic Engineering of Saccharomyces cerevisiae Using the CRISPR/Cas System

Lian, J., HamediRad, M. & Zhao, H., Sep 2018, In : Biotechnology Journal. 13, 9, 1700601.

Research output: Contribution to journalReview article

A New Era of Genome Integration - Simply Cut and Paste!

Liu, Z., Liang, Y., Ang, E. L. & Zhao, H., Apr 21 2017, In : ACS synthetic biology. 6, 4, p. 601-609 9 p.

Research output: Contribution to journalReview article

Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

Sun, H., Zhang, H., Ang, E. L. & Zhao, H., Apr 1 2018, In : Bioorganic and Medicinal Chemistry. 26, 7, p. 1275-1284 10 p.

Research output: Contribution to journalReview article

Breaking the silence: new strategies for discovering novel natural products

Ren, H., Wang, B. & Zhao, H., Dec 1 2017, In : Current Opinion in Biotechnology. 48, p. 21-27 7 p.

Research output: Contribution to journalReview article

Engineering biological systems using automated biofoundries

Chao, R., Mishra, S., Si, T. & Zhao, H., Jul 2017, In : Metabolic Engineering. 42, p. 98-108 11 p.

Research output: Contribution to journalReview article

Engineering microbial hosts for production of bacterial natural products

Zhang, M. M., Wang, Y., Ang, E. L. & Zhao, H., Aug 2016, In : Natural Product Reports. 33, 8, p. 963-987 25 p.

Research output: Contribution to journalReview article

Metabolic engineering of oleaginous yeasts for production of fuels and chemicals

Shi, S. & Zhao, H., Nov 8 2017, In : Frontiers in Microbiology. 8, NOV, 2185.

Research output: Contribution to journalReview article

Recent advances in metabolic engineering of Saccharomyces cerevisiae: New tools and their applications

Lian, J., Mishra, S. & Zhao, H., Nov 2018, In : Metabolic Engineering. 50, p. 85-108 24 p.

Research output: Contribution to journalReview article

Recent developments in the application of P450 based biocatalysts

Wei, Y., Ang, E. L. & Zhao, H., Apr 2018, In : Current Opinion in Chemical Biology. 43, p. 1-7 7 p.

Research output: Contribution to journalReview article

Standardization for natural product synthetic biology

Zhao, H. & Medema, M. H., Aug 2016, In : Natural Product Reports. 33, 8, p. 920-924 5 p.

Research output: Contribution to journalReview article