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  • Eric Oldfield
2011

An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis

Wang, W., Wang, K., Li, J., Nellutla, S., Smirnova, T. I. & Oldfield, E., Jun 8 2011, In : Journal of the American Chemical Society. 133, 22, p. 8400-8403 4 p.

Research output: Contribution to journalArticle

Applying molecular dynamics simulations to identify rarely sampled ligand-bound conformational states of undecaprenyl pyrophosphate synthase, an antibacterial target

Sinko, W., de Oliveira, C., Williams, S., Van Wynsberghe, A., Durrant, J. D., Cao, R., Oldfield, E. & Mccammon, J. A., Jun 1 2011, In : Chemical Biology and Drug Design. 77, 6, p. 412-420 9 p.

Research output: Contribution to journalArticle

Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism

Wang, H., Sarikonda, G., Puan, K. J., Tanaka, Y., Feng, J., Giner, J. L., Cao, R., Mönkkönen, J., Oldfield, E. & Morita, C. T., Nov 15 2011, In : Journal of Immunology. 187, 10, p. 5099-5113 15 p.

Research output: Contribution to journalArticle

Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

Durrant, J. D., Cao, R., Gorfe, A. A., Zhu, W., Li, J., Sankovsky, A., Oldfield, E. & Mccammon, J. A., Sep 1 2011, In : Chemical Biology and Drug Design. 78, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): A HYSCORE investigation

Wang, W., Li, J., Wang, K., Smirnova, T. I. & Oldfield, E., May 4 2011, In : Journal of the American Chemical Society. 133, 17, p. 6525-6528 4 p.

Research output: Contribution to journalArticle

Ultrahigh resolution protein structures using NMR chemical shift tensors

Wylie, B. J., Sperling, L. J., Nieuwkoop, A. J., Franks, W. T., Oldfield, E. & Rienstra, C. M., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 16974-16979 6 p.

Research output: Contribution to journalArticle

2012

Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation

Wang, W., Wang, K., Span, I., Jauch, J., Bacher, A., Groll, M. & Oldfield, E., Jul 11 2012, In : Journal of the American Chemical Society. 134, 27, p. 11225-11234 10 p.

Research output: Contribution to journalArticle

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH

Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E. & Groll, M., Oct 8 2012, In : Nature communications. 3, 1042.

Research output: Contribution to journalArticle

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Lin, F. Y., Zhang, Y., Hensler, M., Liu, Y. L., Chow, O. A., Zhu, W., Wang, K., Pang, R., Thienphrapa, W., Nizet, V. & Oldfield, E., Apr 1 2012, In : ChemMedChem. 7, 4, p. 561-564 4 p.

Research output: Contribution to journalArticle

Head-to-head prenyl tranferases: Anti-infective drug targets

Lin, F. Y., Liu, Y. L., Li, K., Cao, R., Zhu, W., Axelson, J., Pang, R. & Oldfield, E., May 10 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4367-4372 6 p.

Research output: Contribution to journalArticle

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Ren, F., Ko, T. P., Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 23 2012, In : Angewandte Chemie - International Edition. 51, 17, p. 4157-4160 4 p.

Research output: Contribution to journalArticle

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

No, J. H., De Macedo Dossin, F., Zhang, Y., Liu, Y. L., Zhu, W., Feng, X., Yoo, J. A., Lee, E., Wang, K., Hui, R., Freitas-Junior, L. H. & Oldfield, E., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4058-4063 6 p.

Research output: Contribution to journalArticle

Polyoxometalates functionalized by bisphosphonate ligands: Synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines

El Moll, H., Zhu, W., Oldfield, E., Rodriguez-Albelo, L. M., Mialane, P., Marrot, J., Vila, N., Mbomekallé, I. M., Rivière, E., Duboc, C. & Dolbecq, A., Jul 16 2012, In : Inorganic Chemistry. 51, 14, p. 7921-7931 11 p.

Research output: Contribution to journalArticle

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

Xia, Y., Yeddula, N., Leblanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R. J. & Verma, I. M., Mar 1 2012, In : Nature Cell Biology. 14, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

Liu, Y. L., Guerra, F., Wang, K., Wang, W., Li, J., Huang, C., Zhu, W., Houlihan, K., Li, Z., Zhang, Y., Nair, S. K. & Oldfield, E., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8558-8563 6 p.

Research output: Contribution to journalArticle

Terpene biosynthesis: Modularity rules

Oldfield, E. & Lin, F. Y., Jan 27 2012, In : Angewandte Chemie - International Edition. 51, 5, p. 1124-1137 14 p.

Research output: Contribution to journalReview article

2013

Antibacterial drug leads targeting isoprenoid biosynthesis

Zhu, W., Zhang, Y., Sinko, W., Hensler, M. E., Olson, J., Molohon, K. J., Lindert, S., Cao, R., Li, K., Wang, K., Wang, Y., Liu, Y. L., Sankovsky, A., De Oliveira, C. A. F., Mitchell, D. A., Nizet, V., McCammon, J. A. & Oldfield, E., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

Ziniel, P. D., Desai, J., Cass, C. L., Gatto, C., Oldfield, E. & Williams, D. L., Dec 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 5969-5976 8 p.

Research output: Contribution to journalArticle

Chemo-immunotherapeutic antimalarials targeting isoprenoid biosynthesis

Zhang, Y., Zhu, W., Liu, Y. L., Wang, H., Wang, K., Li, K., No, J. H., Ayong, L., Gulati, A., Pang, R., Freitas-Junior, L., Morita, C. T. & Oldfield, E., Apr 11 2013, In : ACS Medicinal Chemistry Letters. 4, 4, p. 423-427 5 p.

Research output: Contribution to journalArticle

Farnesyl diphosphate synthase inhibitors from in silico screening

Lindert, S., Zhu, W., Liu, Y. L., Pang, R., Oldfield, E. & Mccammon, J. A., Jun 1 2013, In : Chemical Biology and Drug Design. 81, 6, p. 742-748 7 p.

Research output: Contribution to journalArticle

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus

Ren, F., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E. & Guo, R. T., Jan 1 2013, In : ChemBioChem. 14, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Isoprenoid biosynthesis: Ferraoxetane or allyl anion mechanism for IspH catalysis?

Li, J., Wang, K., Smirnova, T. I., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 17 2013, In : Angewandte Chemie - International Edition. 52, 25, p. 6522-6525 4 p.

Research output: Contribution to journalArticle

Structures of fluoro, amino, and thiol inhibitors bound to the [Fe 4S4] protein IspH

Span, I., Wang, K., Wang, W., Jauch, J., Eisenreich, W., Bacher, A., Oldfield, E. & Groll, M., Feb 11 2013, In : Angewandte Chemie - International Edition. 52, 7, p. 2118-2121 4 p.

Research output: Contribution to journalArticle

2014

A combination therapy for kras-Driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

Xia, Y., Liu, Y. L., Xie, Y., Zhu, W., Guerra, F., Shen, S., Yeddula, N., Fischer, W., Low, W., Zhou, X., Zhang, Y., Oldfield, E. & Verma, I. M., Nov 19 2014, In : Science Translational Medicine. 6, 263, 263ra161.

Research output: Contribution to journalArticle

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

Benaim, G., Casanova, P., Hernandez-Rodriguez, V., Mujica-Gonzalez, S., Parra-Gimenez, N., Plaza-Rojas, L., Concepcion, J. L., Liu, Y. L., Oldfield, E., Paniz-Mondolfi, A. & Suarez, A. I., Apr 2014, In : Antimicrobial Agents and Chemotherapy. 58, 4, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Insights into the binding of pyridines to the iron-sulfur enzyme IspH

Span, I., Wang, K., Eisenreich, W., Bacher, A., Zhang, Y., Oldfield, E. & Groll, M., Jun 4 2014, In : Journal of the American Chemical Society. 136, 22, p. 7926-7932 7 p.

Research output: Contribution to journalArticle

Iron porphyrin carbenes as catalytic intermediates: Structures, mössbauer and NMR spectroscopic properties, and bonding

Khade, R. L., Fan, W., Ling, Y., Yang, L., Oldfield, E. & Zhang, Y., Jul 14 2014, In : Angewandte Chemie - International Edition. 53, 29, p. 7574-7578 5 p.

Research output: Contribution to journalArticle

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journalReview article

Resistance-resistant antibiotics

Oldfield, E. & Feng, X., Dec 2014, In : Trends in Pharmacological Sciences. 35, 12, p. 664-674 11 p.

Research output: Contribution to journalReview article

Squalene Synthase As a Target for Chagas Disease Therapeutics

Shang, N., Li, Q., Ko, T. P., Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M. U., de Souza, W., Urbina, J. A., Wang, A. H. J., Docampo, R. & 4 others, Li, K., Liu, Y. L., Oldfield, E. & Guo, R. T., May 2014, In : PLoS pathogens. 10, 5, e1004114.

Research output: Contribution to journalArticle

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Aripirala, S., Gonzalez-Pacanowska, D., Oldfield, E., Kaiser, M., Amzel, L. M. & Gabelli, S. B., Mar 1 2014, In : Acta Crystallographica Section D: Biological Crystallography. 70, 3, p. 802-810 9 p.

Research output: Contribution to journalArticle

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Liu, W., Feng, X., Zheng, Y., Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T. D., Oldfield, E. & Guo, R. T., 2014, In : Scientific reports. 4, 6214.

Research output: Contribution to journalArticle

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from mycobacterium tuberculosis

Chan, H. C., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Feb 19 2014, In : Journal of the American Chemical Society. 136, 7, p. 2892-2896 5 p.

Research output: Contribution to journalArticle

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Liu, Y. L., Lindert, S., Zhu, W., Wang, K., McCammon, J. A. & Oldfield, E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. E2530-E2539

Research output: Contribution to journalArticle

Undecaprenyl diphosphate synthase inhibitors: Antibacterial drug leads

Sinko, W., Wang, Y., Zhu, W., Zhang, Y., Feixas, F., Cox, C. L., Mitchell, D. A., Oldfield, E. & McCammon, J. A., Jul 10 2014, In : Journal of Medicinal Chemistry. 57, 13, p. 5693-5701 9 p.

Research output: Contribution to journalArticle

2015

A molecular dynamics investigation of Mycobacterium tuberculosis prenyl synthases: Conformational flexibility and implications for computer-aided drug discovery

Kim, M. O., Feng, X., Feixas, F., Zhu, W., Lindert, S., Bogue, S., Sinko, W., De Oliveira, C., Rao, G., Oldfield, E. & McCammon, J. A., Jun 1 2015, In : Chemical Biology and Drug Design. 85, 6, p. 756-769 14 p.

Research output: Contribution to journalArticle

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

Farha, M. A., Czarny, T. L., Myers, C. L., Worrall, L. J., French, S., Conrady, D. G., Wang, Y., Oldfield, E., Strynadka, N. C. J. & Brown, E. D., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. 11048-11053 6 p.

Research output: Contribution to journalArticle

Antibacterial drug leads: DNA and enzyme multitargeting

Zhu, W., Wang, Y., Li, K., Gao, J., Huang, C. H., Chen, C. C., Ko, T. P., Zhang, Y., Guo, R. T. & Oldfield, E., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

Atomic-resolution structures of discrete stages on the reaction coordinate of the [Fe4S4] enzyme IspG (GcpE)

Quitterer, F., Frank, A., Wang, K., Rao, G., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E. & Groll, M., Jun 19 2015, In : Journal of Molecular Biology. 427, 12, p. 2220-2228 9 p.

Research output: Contribution to journalArticle

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms

Han, X., Chen, C. C., Kuo, C. J., Huang, C. H., Zheng, Y., Ko, T. P., Zhu, Z., Feng, X., Wang, K., Oldfield, E., Wang, A. H. J., Liang, P. H., Guo, R. T. & Ma, Y., Jan 1 2015, In : Proteins: Structure, Function and Bioinformatics. 83, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries

Liu, Y. L., Cao, R., Wang, Y. & Oldfield, E., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 349-354 6 p.

Research output: Contribution to journalArticle

In Vitro and in Vivo investigation of the inhibition of Trypanosoma brucei cell growth by lipophilic bisphosphonates

Yang, G., Zhu, W., Kim, K., Byun, S. Y., Choi, G., Wang, K., Cha, J. S., Cho, H. S., Oldfield, E. & No, J. H., Dec 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7530-7539 10 p.

Research output: Contribution to journalArticle

IspH-RPS1 and IspH-UbiA: "rosetta stone" proteins

Rao, G., O'Dowd, B., Li, J., Wang, K. & Oldfield, E., Jan 1 2015, In : Chemical Science. 6, 12, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

Li, K., Wang, Y., Yang, G., Byun, S., Rao, G., Shoen, C., Yang, H., Gulati, A., Crick, D. C., Cynamon, M., Huang, G., Docampo, R., No, J. H. & Oldfield, E., May 8 2015, In : ACS Infectious Diseases. 1, 5, p. 215-221 7 p.

Research output: Contribution to journalArticle

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

Saad, A., Zhu, W., Rousseau, G., Mialane, P., Marrot, J., Haouas, M., Taulelle, F., Dessapt, R., Serier-Brault, H., Rivière, E., Kubo, T., Oldfield, E. & Dolbecq, A., Jul 1 2015, In : Chemistry - A European Journal. 21, 29, p. 10537-10547 11 p.

Research output: Contribution to journalArticle