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Author

  • Stephen G Sligar
2011

(609d) Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Nanomaterials for Energy Applications - Topical Conference at the 2011 AIChE Annual Meeting. AIChE, p. 92-93 2 p. (Nanomaterials for Energy Applications - Topical Conference at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Analysis of heterotropic cooperativity in cytochrome P450 3A4 using α-Naphthoflavone and testosterone

Frank, D. J., Denisov, I. G. & Sligar, S. G., Feb 18 2011, In : Journal of Biological Chemistry. 286, 7, p. 5540-5545 6 p.

Research output: Contribution to journalArticle

Anomalous transitions of DODAB using fast scanning liquid calorimetry

De La Rama, L. P., Hu, L., Efremov, M. Y., Olson, E. A., Nealey, P. F., McLean, M. A., Sligar, S. G. & Allen, L. H., Aug 10 2011, In : Thermochimica Acta. 522, 1-2, p. 72-76 5 p.

Research output: Contribution to journalArticle

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Goldsmith, B. R., Mitala, J. J., Josue, J., Castro, A., Lerner, M. B., Bayburt, T. H., Khamis, S. M., Jones, R. A., Brand, J. G., Sligar, S. G., Luetje, C. W., Gelperin, A., Rhodes, P. A., Discher, B. M. & Johnson, A. T. C., Jul 26 2011, In : ACS Nano. 5, 7, p. 5408-5416 9 p.

Research output: Contribution to journalArticle

Cytochromes P450 in nanodiscs

Denisov, I. G. & Sligar, S. G., Jan 1 2011, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 223-229 7 p.

Research output: Contribution to journalReview article

Defining CYP3A4 structural responses to substrate binding. raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450

Mak, P. J., Denisov, I. G., Grinkova, Y. V., Sligar, S. G. & Kincaid, J. R., Feb 9 2011, In : Journal of the American Chemical Society. 133, 5, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

Investigation of the low frequency dynamics of heme proteins: Native and mutant cytochrome P450cam and redox partner complexes

Karunakaran, V., Denisov, I., Sligar, S. G. & Champion, P. M., May 12 2011, In : Journal of Physical Chemistry B. 115, 18, p. 5665-5677 13 p.

Research output: Contribution to journalArticle

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding

Bayburt, T. H., Vishnivetskiy, S. A., McLean, M. A., Morizumi, T., Huang, C. C., Tesmer, J. J. G., Ernst, O. P., Sligar, S. G. & Gurevich, V. V., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1420-1428 9 p.

Research output: Contribution to journalArticle

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 436-437 2 p. (Energy and Transport Processes - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Sustainable Engineering Forum: Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 1161-1162 2 p. (Sustainable Engineering Forum: Core Programming Topic at the 2011 AIChE Annual Meeting; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S., Wraight, C. A. & Strano, M., Dec 1 2011, 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings. (11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photoelectrochemical complexes for solar energy conversion that dynamically, reversibly and autonomously self-Assemble

Boghossian, A. A., Choi, J. H., Ham, M. H., Jeng, E. S., Graff, R. A., Heller, D. A., Chang, A. C., Mattis, A., Bayburt, T. H., Grinkova, Y. V., Zeiger, A. S., Van Vliet, K. J., Hobbie, E. K., Sligar, S. G., Wraight, C. A. & Strano, M., Jan 1 2011, Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, p. 349-350 2 p. (Fuels and Petrochemicals Division - Core Programming Topic at the 2011 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Spectroscopic features of cytochrome P450 reaction intermediates

Luthra, A., Denisov, I. G. & Sligar, S. G., Mar 1 2011, In : Archives of Biochemistry and Biophysics. 507, 1, p. 26-35 10 p.

Research output: Contribution to journalReview article

Temperature derivative spectroscopy to monitor the autoxidation decay of cytochromes P450

Luthra, A., Denisov, I. G. & Sligar, S., Jul 1 2011, In : Analytical chemistry. 83, 13, p. 5394-5399 6 p.

Research output: Contribution to journalArticle

2012

A novel type of allosteric regulation: Functional cooperativity in monomeric proteins

Denisov, I. G. & Sligar, S. G., Mar 15 2012, In : Archives of Biochemistry and Biophysics. 519, 2, p. 91-102 12 p.

Research output: Contribution to journalReview article

Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes P450

Denisov, I. G., Grinkova, Y. V. & Sligar, S. G., Jan 1 2012, Spectroscopic Methods of Analysis: Methods and Protocols. Humana Press Inc., p. 375-391 17 p. (Methods in Molecular Biology; vol. 875).

Research output: Chapter in Book/Report/Conference proceedingChapter

Incorporation of NADH-ubiquinone Oxidoreductase (Mitochondrial Complex I) into Lipid Nanodiscs

Fowler, D. J., Sligar, S., Zickermann, V., Brandt, U., Ruiz, T. & Radermacher, M., Jul 2012, In : Microscopy and Microanalysis. 18, S2, p. 88-89 2 p.

Research output: Contribution to journalArticle

Native mass spectrometry characterization of intact nanodisc lipoprotein complexes

Marty, M. T., Zhang, H., Cui, W., Blankenship, R. E., Gross, M. L. & Sligar, S. G., Nov 6 2012, In : Analytical chemistry. 84, 21, p. 8957-8960 4 p.

Research output: Contribution to journalArticle

Nonlinear analyte concentration gradients for one-step kinetic analysis employing optical microring resonators

Marty, M. T., Sloan, C. D. K., Bailey, R. C. & Sligar, S. G., Jul 3 2012, In : Analytical chemistry. 84, 13, p. 5556-5564 9 p.

Research output: Contribution to journalArticle

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer

Näsvik Öjemyr, L., Von Ballmoos, C., Gennis, R. B., Sligar, S. G. & Brzezinski, P., Mar 9 2012, In : FEBS Letters. 586, 5, p. 640-645 6 p.

Research output: Contribution to journalReview article

Structural differences between soluble and membrane bound cytochrome P450s

Denisov, I. G., Shih, A. Y. & Sligar, S. G., Mar 1 2012, In : Journal of Inorganic Biochemistry. 108, p. 150-158 9 p.

Research output: Contribution to journalArticle

Tissue factor/factor VIIa complex: Role of the membrane surface

Morrissey, J. H., Tajkhorshid, E., Sligar, S. G. & Rienstra, C. M., May 1 2012, In : Thrombosis Research. 129, SUPPL. 2, p. S8-S10

Research output: Contribution to journalArticle

Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase

Dalal, K., Chan, C. S., Sligar, S. G. & Duong, F., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4104-4109 6 p.

Research output: Contribution to journalArticle

Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs

Marty, M. T., Das, A. & Sligar, S. G., Jan 1 2012, In : Analytical and bioanalytical chemistry. 402, 2, p. 721-729 9 p.

Research output: Contribution to journalArticle

2013

Characterizing the membrane-bound state of cytochrome P450 3A4: Structure, depth of insertion, and orientation

Baylon, J. L., Lenov, I. L., Sligar, S. G. & Tajkhorshid, E., Jun 12 2013, In : Journal of the American Chemical Society. 135, 23, p. 8542-8551 10 p.

Research output: Contribution to journalArticle

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding

Vishnivetskiy, S. A., Ostermaier, M. K., Singhal, A., Panneels, V., Homan, K. T., Glukhova, A., Sligar, S. G., Tesmer, J. J. G., Schertler, G. F. X., Standfuss, J. & Gurevich, V. V., Nov 1 2013, In : Cellular Signalling. 25, 11, p. 2155-2162 8 p.

Research output: Contribution to journalArticle

Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry

Gregory, M., Mak, P. J., Sligar, S. G. & Kincaid, J. R., May 10 2013, In : Angewandte Chemie - International Edition. 52, 20, p. 5342-5345 4 p.

Research output: Contribution to journalArticle

Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening

Sloan, C. D. K., Marty, M. T., Sligar, S. G. & Bailey, R. C., Mar 5 2013, In : Analytical chemistry. 85, 5, p. 2970-2976 7 p.

Research output: Contribution to journalArticle

Investigations of heme ligation and ligand switching in cytochromes P450 and P420

Sun, Y., Zeng, W., Benabbas, A., Ye, X., Denisov, I., Sligar, S. G., Du, J., Dawson, J. H. & Champion, P. M., Aug 27 2013, In : Biochemistry. 52, 34, p. 5941-5951 11 p.

Research output: Contribution to journalArticle

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: Evidence for a reactive peroxoanion intermediate

Gregory, M. C., Denisov, I. G., Grinkova, Y. V., Khatri, Y. & Sligar, S. G., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16245-16247 3 p.

Research output: Contribution to journalArticle

Nanodiscs as a new tool to examine lipid-protein interactions

Schuler, M. A., Denisov, I. G. & Sligar, S. G., 2013, Lipid-Protein Interactions: Methods and Protocols. Humana Press Inc., p. 415-433 19 p. (Methods in Molecular Biology; vol. 974).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanodiscs as a therapeutic delivery agent: Inhibition of respiratory syncytial virus infection in the lung

Numata, M., Grinkova, Y. V., Mitchell, J. R., Chu, H. W., Sligar, S. G. & Voelker, D. R., Apr 12 2013, In : International journal of nanomedicine. 8, p. 1417-1427 11 p.

Research output: Contribution to journalArticle

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes

Luthra, A., Gregory, M., Grinkova, Y. V., Denisov, I. G. & Sligar, S. G., 2013, Cytochrome P450 Protocols. Humana Press Inc., p. 115-127 13 p. (Methods in Molecular Biology; vol. 987).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanodisc-solubilized membrane protein library reflects the membrane proteome

Marty, M. T., Wilcox, K. C., Klein, W. L. & Sligar, S. G., Feb 12 2013, In : Analytical and bioanalytical chemistry. 405, 12, p. 4009-4016 8 p.

Research output: Contribution to journalArticle

Oxidase uncoupling in heme monooxygenases: Human cytochrome P450 CYP3A4 in Nanodiscs

Grinkova, Y. V., Denisov, I. G., McLean, M. A. & Sligar, S. G., Jan 25 2013, In : Biochemical and Biophysical Research Communications. 430, 4, p. 1223-1227 5 p.

Research output: Contribution to journalArticle

2014

Active site proton delivery and the lyase activity of human CYP17A1

Khatri, Y., Gregory, M. C., Grinkova, Y. V., Denisov, I. G. & Sligar, S. G., Jan 3 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 179-184 6 p.

Research output: Contribution to journalArticle

Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayers

D'Antona, A. M., Xie, G., Sligar, S. G. & Oprian, D. D., Jan 14 2014, In : Biochemistry. 53, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

Interpretation and deconvolution of nanodisc native mass spectra

Marty, M. T., Zhang, H., Cui, W., Gross, M. L. & Sligar, S. G., Feb 1 2014, In : Journal of the American Society for Mass Spectrometry. 25, 2, p. 269-277 9 p.

Research output: Contribution to journalArticle

Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps

Khatri, Y., Luthra, A., Duggal, R. & Sligar, S. G., Aug 25 2014, In : FEBS Letters. 588, 17, p. 3117-3122 6 p.

Research output: Contribution to journalArticle

Resonance raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step

Mak, P. J., Luthra, A., Sligar, S. G. & Kincaid, J. R., Apr 2 2014, In : Journal of the American Chemical Society. 136, 13, p. 4825-4828 4 p.

Research output: Contribution to journalArticle

Resonance raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic Ligands of CYP17

Mak, P. J., Gregory, M. C., Sligar, S. G. & Kincaid, J. R., Jan 14 2014, In : Biochemistry. 53, 1, p. 90-100 11 p.

Research output: Contribution to journalArticle

2015

Activation of molecular oxygen in cytochromes P450

Denisov, I. G. & Sligar, S. G., Jan 1 2015, Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition. Springer International Publishing, p. 69-109 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mechanism of Drug-Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer

Denisov, I. G., Grinkova, Y. V., Baylon, J. L., Tajkhorshid, E. & Sligar, S. G., Apr 7 2015, In : Biochemistry. 54, 13, p. 2227-2239 13 p.

Research output: Contribution to journalArticle

Metalloproteins: The long and the short of it

Denisov, I. G. & Sligar, S. G., Aug 20 2015, In : Nature Chemistry. 7, 9, p. 687-688 2 p.

Research output: Contribution to journalShort survey

Nanodiscs as a modular platform for multimodal MR-optical imaging

Carney, C. E., Lenov, I. L., Baker, C. J., Macrenaris, K. W., Eckermann, A. L., Sligar, S. G. & Meade, T. J., May 20 2015, In : Bioconjugate Chemistry. 26, 5, p. 899-905 7 p.

Research output: Contribution to journalArticle

Nanoscale synaptic membrane mimetic allows unbiased high throughput screen that targets binding sites for Alzheimer's-associated Aβ oligomers

Wilcox, K. C., Marunde, M. R., Das, A., Velasco, P. T., Kuhns, B. D., Marty, M. T., Jiang, H., Luan, C. H., Sligar, S. G. & Klein, W. L., Apr 1 2015, In : PloS one. 10, 4, e0125263.

Research output: Contribution to journalArticle

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment

Skar-Gislinge, N., Kynde, S. A. R., Denisov, I. G., Ye, X., Lenov, I., Sligar, S. G. & Arleth, L., Jan 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 2412-2421 10 p.

Research output: Contribution to journalArticle

Unveiling the crucial intermediates in androgen production

Mak, P. J., Gregory, M. C., Denisov, I. G., Sligar, S. G. & Kincaid, J. R., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 15856-15861 6 p.

Research output: Contribution to journalArticle

2016

Conformational equilibrium of talin is regulated by anionic lipids

Ye, X., McLean, M. A. & Sligar, S. G., Aug 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 8, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis

Duggal, R., Liu, Y., Gregory, M. C., Denisov, I. G., Kincaid, J. R. & Sligar, S. G., Aug 19 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle