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  • Eric Oldfield
2010

Binding of azole antibiotics to Staphylococcus aureus flavohemoglobin increases intracellular oxidative stress

Nobre, L. S., Todorovic, S., Tavares, A. F. N., Oldfield, E., Hildebrandt, P., Teixeira, M. & Saraiva, L. M., Mar 1 2010, In : Journal of bacteriology. 192, 6, p. 1527-1533 7 p.

Research output: Contribution to journalArticle

Binding of nitrogen-containing bisphosphonstes (N-BPs) to the Trypanosoma cruzi fernesyl diphosphate synthase homodimer

Huang, C. H., Gabelli, S. B., Oldfield, E. & Mario Amzel, L., Apr 28 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 4, p. 888-899 12 p.

Research output: Contribution to journalArticle

Bioorganometallic mechanism of action, and inhibition, of IspH

Wang, W., Wang, K., Liu, Y. L., No, J. H., Li, J., Nilges, M. J. & Oldfield, E., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4522-4527 6 p.

Research output: Contribution to journalArticle

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

Ramos, I. B., Miranda, K., Pace, D. A., Verbist, K. C., Lin, F. Y., Zhang, Y., Oldfield, E., Machado, E. A., De Souza, W. & Docampo, R., Aug 1 2010, In : Biochemical Journal. 429, 3, p. 485-495 11 p.

Research output: Contribution to journalArticle

Diterpene cyclases and the nature of the isoprene fold

Cao, R., Zhang, Y., Mann, F. M., Huang, C., Mukkamala, D., Hudock, M. P., Mead, M. E., Prisic, S., Wang, K., Lin, F. Y., Chang, T. K., Peters, R. J. & Oldfield, E., Aug 15 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 11, p. 2417-2432 16 p.

Research output: Contribution to journalArticle

Inhibition of the Fe4S4-cluster-containing protein IspH (LytB): Electron paramagnetic resonance, metallacycles, and mechanisms

Wang, K., Wang, W., No, J. H., Zhang, Y., Zhang, Y. & Oldfield, E., May 19 2010, In : Journal of the American Chemical Society. 132, 19, p. 6719-6727 9 p.

Research output: Contribution to journalArticle

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth

Singh, A. P., Zhang, Y., No, J. H., Docampo, R., Nussenzweig, V. & Oldfield, E., Jul 2010, In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2987-2993 7 p.

Research output: Contribution to journalArticle

Lipophilic pyridinium bisphosphonates: Potent γδ t cell stimulators

Zhang, Y., Cao, R., Yin, F., Lin, F. Y., Wang, H., Krysiak, K., No, J. H., Mukkamala, D., Houlihan, K., Li, J., Morita, C. T. & Oldfield, E., Feb 1 2010, In : Angewandte Chemie - International Edition. 49, 6, p. 1136-1138 3 p.

Research output: Contribution to journalArticle

Mechanism of action and inhibition of dehydrosqualene synthase

Lin, F. Y., Liu, C. I., Liu, Y. L., Zhang, Y., Wang, K., Jeng, W. Y., Ko, T. P., Cao, R., Wang, A. H. J. & Oldfield, E., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21337-21342 6 p.

Research output: Contribution to journalArticle

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

Wang, W., Li, J., Wang, K., Huang, C., Zhang, Y. & Oldfield, E., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11189-11193 5 p.

Research output: Contribution to journalArticle

Targeting isoprenoid biosynthesis for drug discovery: Bench to bedside

Oldfield, E., Sep 21 2010, In : Accounts of chemical research. 43, 9, p. 1216-1226 11 p.

Research output: Contribution to journalArticle

Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: Activity in killing tumor cells

Compain, J. D., Mialane, P., Marrot, J., Sécheresse, F., Zhu, W., Oldfield, E. & Dolbecq, A., Dec 10 2010, In : Chemistry - A European Journal. 16, 46, p. 13741-13748 8 p.

Research output: Contribution to journalArticle

2011

An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis

Wang, W., Wang, K., Li, J., Nellutla, S., Smirnova, T. I. & Oldfield, E., Jun 8 2011, In : Journal of the American Chemical Society. 133, 22, p. 8400-8403 4 p.

Research output: Contribution to journalArticle

Applying molecular dynamics simulations to identify rarely sampled ligand-bound conformational states of undecaprenyl pyrophosphate synthase, an antibacterial target

Sinko, W., de Oliveira, C., Williams, S., Van Wynsberghe, A., Durrant, J. D., Cao, R., Oldfield, E. & Mccammon, J. A., Jun 1 2011, In : Chemical Biology and Drug Design. 77, 6, p. 412-420 9 p.

Research output: Contribution to journalArticle

Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism

Wang, H., Sarikonda, G., Puan, K. J., Tanaka, Y., Feng, J., Giner, J. L., Cao, R., Mönkkönen, J., Oldfield, E. & Morita, C. T., Nov 15 2011, In : Journal of Immunology. 187, 10, p. 5099-5113 15 p.

Research output: Contribution to journalArticle

Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

Durrant, J. D., Cao, R., Gorfe, A. A., Zhu, W., Li, J., Sankovsky, A., Oldfield, E. & Mccammon, J. A., Sep 1 2011, In : Chemical Biology and Drug Design. 78, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): A HYSCORE investigation

Wang, W., Li, J., Wang, K., Smirnova, T. I. & Oldfield, E., May 4 2011, In : Journal of the American Chemical Society. 133, 17, p. 6525-6528 4 p.

Research output: Contribution to journalArticle

Ultrahigh resolution protein structures using NMR chemical shift tensors

Wylie, B. J., Sperling, L. J., Nieuwkoop, A. J., Franks, W. T., Oldfield, E. & Rienstra, C. M., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 16974-16979 6 p.

Research output: Contribution to journalArticle

2012

Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation

Wang, W., Wang, K., Span, I., Jauch, J., Bacher, A., Groll, M. & Oldfield, E., Jul 11 2012, In : Journal of the American Chemical Society. 134, 27, p. 11225-11234 10 p.

Research output: Contribution to journalArticle

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH

Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E. & Groll, M., Oct 8 2012, In : Nature communications. 3, 1042.

Research output: Contribution to journalArticle

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Lin, F. Y., Zhang, Y., Hensler, M., Liu, Y. L., Chow, O. A., Zhu, W., Wang, K., Pang, R., Thienphrapa, W., Nizet, V. & Oldfield, E., Apr 1 2012, In : ChemMedChem. 7, 4, p. 561-564 4 p.

Research output: Contribution to journalArticle

Head-to-head prenyl tranferases: Anti-infective drug targets

Lin, F. Y., Liu, Y. L., Li, K., Cao, R., Zhu, W., Axelson, J., Pang, R. & Oldfield, E., May 10 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4367-4372 6 p.

Research output: Contribution to journalArticle

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Ren, F., Ko, T. P., Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 23 2012, In : Angewandte Chemie - International Edition. 51, 17, p. 4157-4160 4 p.

Research output: Contribution to journalArticle

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

No, J. H., De Macedo Dossin, F., Zhang, Y., Liu, Y. L., Zhu, W., Feng, X., Yoo, J. A., Lee, E., Wang, K., Hui, R., Freitas-Junior, L. H. & Oldfield, E., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4058-4063 6 p.

Research output: Contribution to journalArticle

Polyoxometalates functionalized by bisphosphonate ligands: Synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines

El Moll, H., Zhu, W., Oldfield, E., Rodriguez-Albelo, L. M., Mialane, P., Marrot, J., Vila, N., Mbomekallé, I. M., Rivière, E., Duboc, C. & Dolbecq, A., Jul 16 2012, In : Inorganic Chemistry. 51, 14, p. 7921-7931 11 p.

Research output: Contribution to journalArticle

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

Xia, Y., Yeddula, N., Leblanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R. J. & Verma, I. M., Mar 1 2012, In : Nature Cell Biology. 14, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

Liu, Y. L., Guerra, F., Wang, K., Wang, W., Li, J., Huang, C., Zhu, W., Houlihan, K., Li, Z., Zhang, Y., Nair, S. K. & Oldfield, E., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8558-8563 6 p.

Research output: Contribution to journalArticle

Terpene biosynthesis: Modularity rules

Oldfield, E. & Lin, F. Y., Jan 27 2012, In : Angewandte Chemie - International Edition. 51, 5, p. 1124-1137 14 p.

Research output: Contribution to journalReview article

2013

Antibacterial drug leads targeting isoprenoid biosynthesis

Zhu, W., Zhang, Y., Sinko, W., Hensler, M. E., Olson, J., Molohon, K. J., Lindert, S., Cao, R., Li, K., Wang, K., Wang, Y., Liu, Y. L., Sankovsky, A., De Oliveira, C. A. F., Mitchell, D. A., Nizet, V., McCammon, J. A. & Oldfield, E., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

Ziniel, P. D., Desai, J., Cass, C. L., Gatto, C., Oldfield, E. & Williams, D. L., Dec 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 5969-5976 8 p.

Research output: Contribution to journalArticle

Chemo-immunotherapeutic antimalarials targeting isoprenoid biosynthesis

Zhang, Y., Zhu, W., Liu, Y. L., Wang, H., Wang, K., Li, K., No, J. H., Ayong, L., Gulati, A., Pang, R., Freitas-Junior, L., Morita, C. T. & Oldfield, E., Apr 11 2013, In : ACS Medicinal Chemistry Letters. 4, 4, p. 423-427 5 p.

Research output: Contribution to journalArticle

Farnesyl diphosphate synthase inhibitors from in silico screening

Lindert, S., Zhu, W., Liu, Y. L., Pang, R., Oldfield, E. & Mccammon, J. A., Jun 1 2013, In : Chemical Biology and Drug Design. 81, 6, p. 742-748 7 p.

Research output: Contribution to journalArticle

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus

Ren, F., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E. & Guo, R. T., Jan 1 2013, In : ChemBioChem. 14, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Isoprenoid biosynthesis: Ferraoxetane or allyl anion mechanism for IspH catalysis?

Li, J., Wang, K., Smirnova, T. I., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 17 2013, In : Angewandte Chemie - International Edition. 52, 25, p. 6522-6525 4 p.

Research output: Contribution to journalArticle

Structures of fluoro, amino, and thiol inhibitors bound to the [Fe 4S4] protein IspH

Span, I., Wang, K., Wang, W., Jauch, J., Eisenreich, W., Bacher, A., Oldfield, E. & Groll, M., Feb 11 2013, In : Angewandte Chemie - International Edition. 52, 7, p. 2118-2121 4 p.

Research output: Contribution to journalArticle

2014

A combination therapy for kras-Driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

Xia, Y., Liu, Y. L., Xie, Y., Zhu, W., Guerra, F., Shen, S., Yeddula, N., Fischer, W., Low, W., Zhou, X., Zhang, Y., Oldfield, E. & Verma, I. M., Nov 19 2014, In : Science Translational Medicine. 6, 263, 263ra161.

Research output: Contribution to journalArticle

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

Benaim, G., Casanova, P., Hernandez-Rodriguez, V., Mujica-Gonzalez, S., Parra-Gimenez, N., Plaza-Rojas, L., Concepcion, J. L., Liu, Y. L., Oldfield, E., Paniz-Mondolfi, A. & Suarez, A. I., Apr 2014, In : Antimicrobial Agents and Chemotherapy. 58, 4, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Insights into the binding of pyridines to the iron-sulfur enzyme IspH

Span, I., Wang, K., Eisenreich, W., Bacher, A., Zhang, Y., Oldfield, E. & Groll, M., Jun 4 2014, In : Journal of the American Chemical Society. 136, 22, p. 7926-7932 7 p.

Research output: Contribution to journalArticle

Iron porphyrin carbenes as catalytic intermediates: Structures, mössbauer and NMR spectroscopic properties, and bonding

Khade, R. L., Fan, W., Ling, Y., Yang, L., Oldfield, E. & Zhang, Y., Jul 14 2014, In : Angewandte Chemie - International Edition. 53, 29, p. 7574-7578 5 p.

Research output: Contribution to journalArticle

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journalReview article

Resistance-resistant antibiotics

Oldfield, E. & Feng, X., Dec 2014, In : Trends in Pharmacological Sciences. 35, 12, p. 664-674 11 p.

Research output: Contribution to journalReview article

Squalene Synthase As a Target for Chagas Disease Therapeutics

Shang, N., Li, Q., Ko, T. P., Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M. U., de Souza, W., Urbina, J. A., Wang, A. H. J., Docampo, R. & 4 others, Li, K., Liu, Y. L., Oldfield, E. & Guo, R. T., May 2014, In : PLoS pathogens. 10, 5, e1004114.

Research output: Contribution to journalArticle

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Aripirala, S., Gonzalez-Pacanowska, D., Oldfield, E., Kaiser, M., Amzel, L. M. & Gabelli, S. B., Mar 1 2014, In : Acta Crystallographica Section D: Biological Crystallography. 70, 3, p. 802-810 9 p.

Research output: Contribution to journalArticle

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Liu, W., Feng, X., Zheng, Y., Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T. D., Oldfield, E. & Guo, R. T., 2014, In : Scientific reports. 4, 6214.

Research output: Contribution to journalArticle

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from mycobacterium tuberculosis

Chan, H. C., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Feb 19 2014, In : Journal of the American Chemical Society. 136, 7, p. 2892-2896 5 p.

Research output: Contribution to journalArticle

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Liu, Y. L., Lindert, S., Zhu, W., Wang, K., McCammon, J. A. & Oldfield, E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. E2530-E2539

Research output: Contribution to journalArticle