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2010

A highly selective lead sensor based on a classic lead DNAzyme

Lan, T., Furuya, K. & Lu, Y., Jun 14 2010, In : Chemical Communications. 46, 22, p. 3896-3898 3 p.

Research output: Contribution to journalArticle

Catalytic DNA
Lead
Sensors
Metal ions

Branched silica nanostructures oriented by dynamic G-quadruplex transformation

Zhang, J., Zheng, L., Wang, X., Xiao, Y., Lu, Y. & Li, W., Dec 1 2010, In : Materials Research Bulletin. 45, 12, p. 1954-1959 6 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Nanostructures
Silica
silicon dioxide
oligonucleotides

Catalytic and molecular beacons for amplified detection of metal ions and organic molecules with high sensitivity

Zhang, X. B., Wang, Z., Xing, H., Xiang, Y. & Lu, Y., Jun 15 2010, In : Analytical chemistry. 82, 12, p. 5005-5011 7 p.

Research output: Contribution to journalArticle

Catalytic DNA
Metal ions
Molecules
Quenching
Substrates

Controlled alignment of multiple proteins and nanoparticles with nanometer resolution via backbone-modified phosphorothioate DNA and bifunctional linkers

Lee, J. H., Wong, N. Y., Tan, L. H., Wang, Z. & Lu, Y., Jul 7 2010, In : Journal of the American Chemical Society. 132, 26, p. 8906-8908 3 p.

Research output: Contribution to journalArticle

Streptavidin
Nanoparticles
DNA
Proteins
protein

CuA centers and their biosynthetic models in azurin

Savelieff, M. G. & Lu, Y., May 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 4, p. 461-483 23 p.

Research output: Contribution to journalShort survey

Azurin
Copper
Electrons
Proteins
Ions

Direct, electrocatalytic oxygen reduction by laccase on anthracene-2-methanethiol-modified gold

Thorum, M. S., Anderson, C. A., Hatch, J. J., Campbell, A. S., Marshall, N. M., Zimmerman, S. C., Lu, Y. & Gewirth, A. A., Aug 5 2010, In : Journal of Physical Chemistry Letters. 1, 15, p. 2251-2254 4 p.

Research output: Contribution to journalArticle

Laccase
Anthracene
anthracene
Gold
gold

DNA-mediated control of metal nanoparticle shape: One-pot synthesis and cellular uptake of highly stable and functional gold nanoflowers

Wang, Z., Zhang, J., Ekman, J. M., Kenis, P. J. A. & Lu, Y., May 12 2010, In : Nano Letters. 10, 5, p. 1886-1891 6 p.

Research output: Contribution to journalArticle

Nanoflowers
Metal nanoparticles
Gold
DNA
deoxyribonucleic acid

Easy-to-use dipstick tests for detection of lead in paints using non-cross-linked gold nanoparticle-DNAzyme conjugates

Mazumdar, D., Liu, J., Lu, G., Zhou, J. & Lu, Y., Feb 24 2010, In : Chemical Communications. 46, 9, p. 1416-1418 3 p.

Research output: Contribution to journalArticle

Catalytic DNA
Paint
Gold
Lead
Nanoparticles

Introducing a 2-His-1-Glu nonheme iron center into myoglobin confers nitric oxide reductase activity

Lin, Y. W., Yeung, N., Gao, Y. G., Miner, K. D., Lei, L., Robinson, H. & Lu, Y., Jul 28 2010, In : Journal of the American Chemical Society. 132, 29, p. 9970-9972 3 p.

Research output: Contribution to journalArticle

Myoglobin
Nitric oxide
nitric oxide
Nitric Oxide
Iron

Label-free fluorescent aptamer sensor based on regulation of malachite green fluorescence

Xu, W. & Lu, Y., Jan 15 2010, In : Analytical chemistry. 82, 2, p. 574-578 5 p.

Research output: Contribution to journalArticle

Adenosine
Labels
Fluorescence
Sensors
malachite green

Label-free fluorescent functional DNA sensors using unmodified DNA: A vacant site approach

Xiang, Y., Wang, Z., Xing, H., Wong, N. Y. & Lu, Y., May 15 2010, In : Analytical chemistry. 82, 10, p. 4122-4129 8 p.

Research output: Contribution to journalArticle

Labels
DNA
Sensors
Catalytic DNA
Adenosine

Lysozyme-stabilized gold fluorescent cluster: Synthesis and application as Hg2+ sensor

Wei, H., Wang, Z., Yang, L., Tian, S., Hou, C. & Lu, Y., Jun 1 2010, In : Analyst. 135, 6, p. 1406-1410 5 p.

Research output: Contribution to journalArticle

Muramidase
Gold
Enzymes
gold
sensor

Metal ions as matchmakers for proteins

Lu, Y., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 1811-1812 2 p.

Research output: Contribution to journalComment/debate

Protein Interaction Domains and Motifs
Protein Engineering
Cations
Metals
Binding Sites

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Lee, J. H., Yigit, M. V., Mazumdar, D. & Lu, Y., Apr 1 2010, In : Advanced Drug Delivery Reviews. 62, 6, p. 592-605 14 p.

Research output: Contribution to journalReview article

Molecular Pathology
Nanostructures
Nanoparticles
Quantum Dots
Carbon Nanotubes

Rapid determination of enantiomeric ratio using fluorescent DNA or RNA aptamers

Null, E. L. & Lu, Y., Feb 22 2010, In : Analyst. 135, 2, p. 419-422 4 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Arginine
Chirality
RNA
DNA

Role of copper ion in regulating ligand binding in a myoglobin-based cytochrome c oxidase model

Lu, C., Zhao, X., Lu, Y., Rousseau, D. L. & Yeh, S. R., Feb 10 2010, In : Journal of the American Chemical Society. 132, 5, p. 1598-1605 8 p.

Research output: Contribution to journalArticle

Myoglobin
Electron Transport Complex IV
ligand
cytochrome
Copper

Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin

Lin, Y. W., Yeung, N., Gao, Y. G., Miner, K. D., Tian, S., Robinson, H. & Lu, Y., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8581-8586 6 p.

Research output: Contribution to journalArticle

Glutamates
Myoglobin
Metals
Ions
Heme

Transforming a blue copper into a red copper protein: Engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation

Clark, K. M., Yu, Y., Marshall, N. M., Sieracki, N. A., Nilges, M. J., Blackburn, N. J., Van Der Donk, W. A. & Lu, Y., Jul 28 2010, In : Journal of the American Chemical Society. 132, 29, p. 10093-10101 9 p.

Research output: Contribution to journalArticle

Azurin
Protein Engineering
Mutagenesis
Homocysteine
Site-Directed Mutagenesis
2011

A novel terpyridine/benzofurazan hybrid fluorophore: Metal sensing behavior and application

Yang, Z., Yan, C., Chen, Y., Zhu, C., Zhang, C., Dong, X., Yang, W., Guo, Z., Lu, Y. & He, W., Mar 14 2011, In : Dalton Transactions. 40, 10, p. 2173-2176 4 p.

Research output: Contribution to journalArticle

Fluorophores
Metals
Imaging techniques
Biological systems
Cations

A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

Xu, W. & Lu, Y., May 7 2011, In : Chemical Communications. 47, 17, p. 4998-5000 3 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Gadolinium
Magnetic resonance
Adenosine
Magnetic resonance imaging

Competencies: A cure for pre-med curriculum

Anderson, W. A., Amasino, R. M., Ares, M., Banerjee, U., Bartel, B., Corces, V. G., Drennan, C. L., Elgin, S. C. R., Epstein, I. R., Fanning, E., Guillette, L. J., Handelsman, J. O., Hatfull, G. F., Hoy, R. R., Kelley, D., Leinwand, L. A., Losick, R., Lu, Y., Lynn, D. G., Neuhauser, C. & 13 others, O'Dowd, D. K., Olivera, T., Pevzner, P., Richards-Kortum, R. R., Rine, J., Sah, R. L., Strobel, S. A., Walker, G. C., Walt, D. R., Warner, I. M., Wessler, S., Willard, H. F. & Zare, R. N., Nov 11 2011, In : Science. 334, 6057, p. 760-761 2 p.

Research output: Contribution to journalLetter

Curriculum

Kinetics of copper incorporation into a biosynthetic purple Cu A azurin: Characterization of red, blue, and a new intermediate species

Wilson, T. D., Savelieff, M. G., Nilges, M. J., Marshall, N. M. & Lu, Y., Dec 28 2011, In : Journal of the American Chemical Society. 133, 51, p. 20778-20792 15 p.

Research output: Contribution to journalArticle

Azurin
Copper
copper
kinetics
Kinetics
Catalytic DNA
Metal ions
Ionic strength
Fluorescence Resonance Energy Transfer
Catalysis

Metal ion sensors based on DNAzymes and related DNA molecules

Zhang, X. B., Kong, R. M. & Lu, Y., Jul 19 2011, In : Annual Review of Analytical Chemistry. 4, p. 105-128 24 p.

Research output: Contribution to journalArticle

Catalytic DNA
Metal ions
Metals
Ions
Molecules

Site-specific attachment of proteins onto a 3D DNA tetrahedron through backbone-modified phosphorothioate DNA

Wong, N. Y., Zhang, C., Tan, L. H. & Lu, Y., May 23 2011, In : Small. 7, 10, p. 1427-1430 4 p.

Research output: Contribution to journalArticle

DNA
Proteins
Nanostructures

Small-molecule diagnostics based on functional DNA nanotechnology: A dipstick test for mercury

Torabi, S. F. & Lu, Y., Jan 17 2011, In : Faraday Discussions. 149, p. 125-135 11 p.

Research output: Contribution to journalArticle

Nanotechnology
nanotechnology
Mercury
deoxyribonucleic acid
Metal ions

Spectroscopic characterization of mononitrosyl complexes in heme-nonheme diiron centers within the myoglobin scaffold (FeBMbs): Relevance to denitrifying No reductase

Hayashi, T., Miner, K. D., Yeung, N., Lin, Y. W., Lu, Y. & Moënne-Loccoz, P., Jul 5 2011, In : Biochemistry. 50, 26, p. 5939-5947 9 p.

Research output: Contribution to journalArticle

Myoglobin
Heme
Scaffolds
Oxidoreductases
Paramagnetic resonance

The important role of covalent anchor positions in tuning catalytic properties of a rationally designed Mnsalen-containing metalloenzyme

Garner, D. K., Liang, L., Barrios, D. A., Zhang, J. L. & Lu, Y., Sep 2 2011, In : ACS Catalysis. 1, 9, p. 1083-1089 7 p.

Research output: Contribution to journalArticle

Anchors
Tuning
Myoglobin
Catalyst selectivity
Enantioselectivity

Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme

Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y. G., Yang, L., Robinson, H., Tan, L. H., Xing, H., Hou, C., Robertson, I. M., Zuo, J-M. & Lu, Y., Feb 2011, In : Nature Nanotechnology. 6, 2, p. 93-97 5 p.

Research output: Contribution to journalArticle

lysozyme
Muramidase
Gold
Enzymes
Single crystals

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

Xiang, Y. & Lu, Y., Sep 1 2011, In : Nature Chemistry. 3, 9, p. 697-703 7 p.

Research output: Contribution to journalArticle

beta-Fructofuranosidase
Glucose
DNA
Sensors
Catalytic DNA
2012

A designed functional metalloenzyme that reduces O 2 to H 2 O with over one thousand turnovers

Miner, K. D., Mukherjee, A., Gao, Y. G., Null, E. L., Petrik, I. D., Zhao, X., Yeung, N., Robinson, H. & Lu, Y., Jun 4 2012, In : Angewandte Chemie - International Edition. 51, 23, p. 5589-5592 4 p.

Research output: Contribution to journalArticle

Enzymes
Myoglobin
Reactive Oxygen Species
Oxidoreductases
Oxygen

A new ratiometric and colorimetric chemosensor for cyanide anion based on Coumarin-hemicyanine hybrid

Yang, Z., Liu, Z., Chen, Y., Wang, X., He, W. & Lu, Y., Jul 14 2012, In : Organic and Biomolecular Chemistry. 10, 26, p. 5073-5076 4 p.

Research output: Contribution to journalArticle

Cyanides
cyanides
Anions
anions
conjugation

Aptamer-based origami paper analytical device for electrochemical detection of adenosine

Liu, H., Xiang, Y., Lu, Y. & Crooks, R. M., Jul 9 2012, In : Angewandte Chemie - International Edition. 51, 28, p. 6925-6928 4 p.

Research output: Contribution to journalArticle

Fluidic devices
Fluidics
Biosensors
Adenosine
Enzymes

Biomimetic surface engineering of lanthanide-doped upconversion nanoparticles as versatile bioprobes

Li, L. L., Zhang, R., Yin, L., Zheng, K., Qin, W., Selvin, P. R. & Lu, Y., Jun 18 2012, In : Angewandte Chemie - International Edition. 51, 25, p. 6121-6125 5 p.

Research output: Contribution to journalArticle

Lanthanoid Series Elements
Biomimetics
Rare earth elements
Nanoparticles
Phospholipids

Catalysis of gold nanoparticles within lysozyme single crystals

Wei, H. & Lu, Y., Apr 1 2012, In : Chemistry - An Asian Journal. 7, 4, p. 680-683 4 p.

Research output: Contribution to journalArticle

Muramidase
Catalysis
Gold
Nanoparticles
Catalyst activity

Direct detection of adenosine in undiluted serum using a luminescent aptamer sensor attached to a terbium complex

Li, L. L., Ge, P., Selvin, P. R. & Lu, Y., Sep 18 2012, In : Analytical chemistry. 84, 18, p. 7852-7856 5 p.

Research output: Contribution to journalArticle

Terbium
Biosensors
Adenosine
Sensors
Nucleic Acids

Discovery of the DNA "genetic code" for abiological gold nanoparticle morphologies

Wang, Z., Tang, L., Tan, L. H., Li, J. & Lu, Y., Sep 3 2012, In : Angewandte Chemie - International Edition. 51, 36, p. 9078-9082 5 p.

Research output: Contribution to journalArticle

Gold
DNA
Oligonucleotides
Nanoparticles
Nucleotides

DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery

Xing, H., Wong, N. Y., Xiang, Y. & Lu, Y., Aug 1 2012, In : Current Opinion in Chemical Biology. 16, 3-4, p. 429-435 7 p.

Research output: Contribution to journalReview article

Nucleotide Aptamers
Molecular imaging
Drug Carriers
Drug delivery
Nanostructured materials

DNA-directed assembly of asymmetric nanoclusters using Janus nanoparticles

Xing, H., Wang, Z., Xu, Z., Wong, N. Y., Xiang, Y., Liu, G. L. & Lu, Y., Jan 24 2012, In : ACS Nano. 6, 1, p. 802-809 8 p.

Research output: Contribution to journalArticle

Janus
Nanoclusters
nanoclusters
DNA
deoxyribonucleic acid
Uracil-DNA Glycosidase
Catalytic DNA
Uracil
Assays
Chemical activation

Functional protein microarrays by electrohydrodynamic jet printing

Shigeta, K., He, Y., Sutanto, E., Kang, S., Le, A. P., Nuzzo, R. G., Alleyne, A. G., Ferreira, P. M., Lu, Y. & Rogers, J. A., Nov 20 2012, In : Analytical chemistry. 84, 22, p. 10012-10018 7 p.

Research output: Contribution to journalArticle

Electrohydrodynamics
Microarrays
Printing
Streptavidin
Substrates

In vitro selection of metal Ion-Selective DNAzymes

Ihms, H. E. & Lu, Y., Mar 19 2012, Ribozymes: Methods and Protocols. Hartig, J. (ed.). p. 297-316 20 p. (Methods in Molecular Biology; vol. 848).

Research output: Chapter in Book/Report/Conference proceedingChapter

Catalytic DNA
Metals
Ions
In Vitro Techniques
Nucleic Acids

Label-free catalytic and molecular beacon containing an abasic site for sensitive fluorescent detection of small inorganic and organic molecules

Song, P., Xiang, Y., Xing, H., Zhou, Z., Tong, A. & Lu, Y., Mar 20 2012, In : Analytical chemistry. 84, 6, p. 2916-2922 7 p.

Research output: Contribution to journalArticle

Labels
Molecules
Sensors
Nucleosides
Adenosine

Metal ion-dependent DNAzymes and their applications as biosensors

Lan, T. & Lu, Y., 2012, In : Metal Ions in Life Sciences. 10, p. 217-248 32 p.

Research output: Contribution to journalArticle

Catalytic DNA
Biosensing Techniques
Biosensors
Metal ions
Metals

Polyvalent mesoporous silica nanoparticle-aptamer bioconjugates target breast cancer cells

Li, L. L., Yin, Q., Cheng, J. & Lu, Y., Sep 1 2012, In : Advanced Healthcare Materials. 1, 5, p. 567-572 6 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Nanoparticles
Silica
Cells
Nucleotide Aptamers
Biomarkers
Glucose
Antibodies
Proteins
Assays

Redox tuning of two biological copper centers through non-covalent interactions: Same trend but different magnitude

New, S. Y., Marshall, N. M., Hor, T. S. A., Xue, F. & Lu, Y., May 4 2012, In : Chemical Communications. 48, 35, p. 4217-4219 3 p.

Research output: Contribution to journalArticle

Azurin
Copper
Tuning
Proteins
Scaffolds (biology)

Significant increase of oxidase activity through the genetic incorporation of a tyrosine-histidine cross-link in a myoglobin model of heme-copper oxidase

Liu, X., Yu, Y., Hu, C., Zhang, W., Lu, Y. & Wang, J., Apr 27 2012, In : Angewandte Chemie - International Edition. 51, 18, p. 4312-4316 5 p.

Research output: Contribution to journalArticle

Myoglobin
Heme
Histidine
Tyrosine
Oxidoreductases

Spectroscopic and DFT studies of second-sphere variants of the type 1 copper site in azurin: Covalent and nonlocal electrostatic contributions to reduction potentials

Hadt, R. G., Sun, N., Marshall, N. M., Hodgson, K. O., Hedman, B., Lu, Y. & Solomon, E. I., Oct 10 2012, In : Journal of the American Chemical Society. 134, 40, p. 16701-16716 16 p.

Research output: Contribution to journalArticle

Azurin
Static Electricity
Discrete Fourier transforms
Copper
Electrostatics

The importance of peripheral sequences in determining the metal selectivity of an in vitro-selected co 2+-Dependent DNAzyme

Nelson, K. E., Ihms, H. E., Mazumdar, D., Bruesehoff, P. J. & Lu, Y., Feb 13 2012, In : ChemBioChem. 13, 3, p. 381-391 11 p.

Research output: Contribution to journalArticle

Catalytic DNA
Metals
Clone Cells
Metal ions
Ions