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  • John E Cronan
2010

Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme A synthesis

Thomas, J. & Cronan, J. E., Mar 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 3, p. 1374-1377 4 p.

Research output: Contribution to journalArticle

Biotin synthesis begins by hijacking the fatty acid synthetic pathway

Lin, S., Hanson, R. E. & Cronan, J. E., Sep 2010, In : Nature chemical biology. 6, 9, p. 682-688 7 p.

Research output: Contribution to journalArticle

Expression of Vibrio harveyi Acyl-ACP synthetase allows efficient entry of exogenous fatty acids into the Escherichia coli fatty acid and lipid a synthetic pathways

Jiang, Y., Morgan-Kiss, R. M., Campbell, J. W., Chan, C. H. & Cronan, J. E., Feb 2 2010, In : Biochemistry. 49, 4, p. 718-726 9 p.

Research output: Contribution to journalArticle

Intein-mediated cyclization of bacterial acyl carrier protein stabilizes its folded conformation but does not abolish function

Volkmann, G., Murphy, P. W., Rowland, E. E., Cronan, J. E., Liu, X. Q., Blouin, C. & Byers, D. M., Mar 19 2010, In : Journal of Biological Chemistry. 285, 12, p. 8605-8614 10 p.

Research output: Contribution to journalArticle

Lipoic acid synthesis: A new family of octanoyltransferases generally annotated as lipoate protein ligases

Christensen, Q. H. & Cronan, J. E., Nov 23 2010, In : Biochemistry. 49, 46, p. 10024-10036 13 p.

Research output: Contribution to journalArticle

Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA

Feng, Y. & Cronan, J. E., Sep 1 2010, In : Journal of bacteriology. 192, 17, p. 4289-4299 11 p.

Research output: Contribution to journalArticle

Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis

Wier, A. M., Nyholm, S. V., Mandel, M. J., Massengo-Tiassé, R. P., Schaefer, A. L., Koroleva, I., Splinter-BonDurant, S., Brown, B., Manzella, L., Snir, E., Almabrazi, H., Scheetz, T. E., Bonaldo, M. D. F., Casavant, T. L., Soares, M. B., Cronan, J. E., Reed, J. L., Ruby, E. G. & McFall-Ngai, M. J., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2259-2264 6 p.

Research output: Contribution to journalArticle

Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase

Zhu, L., Lin, J., Ma, J., Cronan, J. E. & Wang, H., Feb 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 2, p. 689-698 10 p.

Research output: Contribution to journalArticle

2011

A complex lipoate utilization pathway in Listeria monocytogenes

Christensen, Q. H., Hagar, J. A., O'Riordan, M. X. D. & Cronan, J. E., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31447-31456 10 p.

Research output: Contribution to journalArticle

A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis

Christensen, Q. H., Martin, N., Mansilla, M. C., de Mendoza, D. & Cronan, J. E., Apr 1 2011, In : Molecular Microbiology. 80, 2, p. 350-363 14 p.

Research output: Contribution to journalArticle

A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis

Martin, N., Christensen, Q. H., Mansilla, M. C., Cronan, J. E. & de Mendoza, D., Apr 1 2011, In : Molecular Microbiology. 80, 2, p. 335-349 15 p.

Research output: Contribution to journalArticle

Closing in on complete pathways of biotin biosynthesis

Lin, S. & Cronan, J. E., Jun 1 2011, In : Molecular BioSystems. 7, 6, p. 1811-1821 11 p.

Research output: Contribution to journalReview article

Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters

Feng, Y. & Cronan, J. E., Apr 1 2011, In : Molecular Microbiology. 80, 1, p. 195-218 24 p.

Research output: Contribution to journalArticle

Probing protein dynamics in vivo using backbone cyclization: Bacterial acyl carrier protein as a case study

Volkmann, G., Murphy, P. W., Rowland, E. E., Cronan, J. E. & Byers, D. M., Dec 23 2011, Methods in Protein Biochemistry. Walter de Gruyter GmbH and Co. KG, p. 271-293 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism

Hassan, B. H. & Cronan, J. E., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8263-8276 14 p.

Research output: Contribution to journalArticle

Synthesis of the α,ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway

Cronan, J. E. & Lin, S., Jun 1 2011, In : Current Opinion in Chemical Biology. 15, 3, p. 407-413 7 p.

Research output: Contribution to journalReview article

The enzyme function initiative

Gerlt, J. A., Allen, K. N., Almo, S. C., Armstrong, R. N., Babbitt, P. C., Cronan, J. E., Dunaway-Mariano, D., Imker, H. J., Jacobson, M. P., Minor, W., Poulter, C. D., Raushel, F. M., Sali, A., Shoichet, B. K. & Sweedler, J. V., Nov 22 2011, In : Biochemistry. 50, 46, p. 9950-9962 13 p.

Research output: Contribution to journalReview article

2012

Altered regulation of escherichia coli biotin biosynthesis in bira superrepressor mutant strains

Chakravartty, V. & Cronan, J. E., Mar 1 2012, In : Journal of bacteriology. 194, 5, p. 1113-1126 14 p.

Research output: Contribution to journalArticle

Crosstalk of Escherichia coli FadR with Global Regulators in Expression of Fatty Acid Transport Genes

Feng, Y. & Cronan, J. E., Sep 28 2012, In : PloS one. 7, 9, e46275.

Research output: Contribution to journalArticle

Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity In vivo

Smith, A. C. & Cronan, J. E., Jan 1 2012, In : Journal of bacteriology. 194, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

Evolution of a new function in an esterase: Simple amino acid substitutions enable the activity present in the larger paralog, BioH

Flores, H., Lin, S., Contreras-Ferrat, G., Cronan, J. E. & Morett, E., Aug 1 2012, In : Protein Engineering, Design and Selection. 25, 8, p. 387-395 9 p.

Research output: Contribution to journalArticle

Only one of the five Ralstonia solanacearum long-chain 3-ketoacyl-acyl carrier protein synthase homologues functions in fatty acid synthesis

Cheng, J., Ma, J., Lin, J., Fan, Z. C., Cronan, J. E. & Wang, H., Mar 1 2012, In : Applied and environmental microbiology. 78, 5, p. 1563-1573 11 p.

Research output: Contribution to journalArticle

Remarkable Diversity in the Enzymes Catalyzing the Last Step in Synthesis of the Pimelate Moiety of Biotin

Shapiro, M. M., Chakravartty, V. & Cronan, J. E., Nov 9 2012, In : PloS one. 7, 11, e49440.

Research output: Contribution to journalArticle

The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities

Bi, H., Christensen, Q. H., Feng, Y., Wang, H. & Cronan, J. E., Feb 1 2012, In : Molecular Microbiology. 83, 4, p. 840-855 16 p.

Research output: Contribution to journalArticle

2013

Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation

Goble, A. M., Feng, Y., Raushel, F. M. & Cronan, J. E., Dec 20 2013, In : ACS chemical biology. 8, 12, p. 2622-2629 8 p.

Research output: Contribution to journalArticle

Discovery of new enzymes and metabolic pathways by using structure and genome context

Zhao, S., Kumar, R., Sakai, A., Vetting, M. W., Wood, B. M. K., Brown, S., Bonanno, J. B., Hillerich, B. S., Seidel, R. D., Babbitt, P. C., Almo, S. C., Sweedler, J. V., Gerlt, J. A., Cronan, J. E. & Jacobson, M. P., Sep 24 2013, In : Nature. 502, 7473, p. 698-702 5 p.

Research output: Contribution to journalArticle

FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle

Bi, H., Wang, H. & Cronan, J. E., Sep 19 2013, In : Chemistry and Biology. 20, 9, p. 1157-1167 11 p.

Research output: Contribution to journalArticle

Profligate biotin synthesis in α-proteobacteria - a developing or degenerating regulatory system?

Feng, Y., Zhang, H. & Cronan, J. E., Apr 1 2013, In : Molecular Microbiology. 88, 1, p. 77-92 16 p.

Research output: Contribution to journalArticle

Proofreading of noncognate Acyl adenylates by an acyl-coenzyme a ligase

Manandhar, M. & Cronan, J. E., Dec 19 2013, In : Chemistry and Biology. 20, 12, p. 1441-1446 6 p.

Research output: Contribution to journalArticle

The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis

Hermes, F. A. & Cronan, J. E., Oct 1 2013, In : Yeast. 30, 10, p. 415-427 13 p.

Research output: Contribution to journalArticle

The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance

Zhu, L., Bi, H., Ma, J., Hu, Z., Zhang, W., Cronan, J. E. & Wang, H., Oct 1 2013, In : mBio. 4, 5, e00613-13.

Research output: Contribution to journalArticle

The wing of a winged helix-turn-helix transcription factor organizes the active site of BirA, a bifunctional repressor/ligase

Chakravartty, V. & Cronan, J. E., Dec 13 2013, In : Journal of Biological Chemistry. 288, 50, p. 36029-36039 11 p.

Research output: Contribution to journalArticle

2014

A Francisella virulence factor catalyses an essential reaction of biotin synthesis

Feng, Y., Napier, B. A., Manandhar, M., Henke, S. K., Weiss, D. S. & Cronan, J. E., Jan 1 2014, In : Molecular Microbiology. 91, 2, p. 300-314 15 p.

Research output: Contribution to journalArticle

Biotin and lipoic acid: Synthesis, attachment, and regulation

Cronan, J. E., Jan 1 2014, In : EcoSal Plus. 6, 1, p. 1-39 39 p.

Research output: Contribution to journalArticle

Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme a carboxylase

Smith, A. C. & Cronan, J. E., Jan 1 2014, In : Journal of bacteriology. 196, 21, p. 3768-3775 8 p.

Research output: Contribution to journalArticle

Inefficient translation renders the enterococcus faecalis fabk enoyl- acyl carrier protein reductase phenotypically cryptic

Bi, H., Zhu, L., Wang, H. & Cronan, J. E., Jan 1 2014, In : Journal of bacteriology. 196, 1, p. 170-179 10 p.

Research output: Contribution to journalArticle

PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis

Feng, Y. & Cronan, J. E., Jul 2014, In : Research in Microbiology. 165, 6, p. 429-438 10 p.

Research output: Contribution to journalArticle

Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine

Kumar, R., Zhao, S., Vetting, M. W., Wood, B. M. K., Sakai, A., Cho, K., Solbiati, J., Almo, S. C., Sweedler, J. V., Jacobson, M. P., Gerlt, J. A. & Cronan, J. E., Feb 11 2014, In : mBio. 5, 1, e00933-13.

Research output: Contribution to journalArticle

Roles of small laccases from streptomyces in lignin degradation

Majumdar, S., Lukk, T., Solbiati, J. O., Bauer, S., Nair, S. K., Cronan, J. E. & Gerlt, J. A., Jun 24 2014, In : Biochemistry. 53, 24, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

Successful conversion of the Bacillus subtilis BirA group II biotin protein ligase into a group I ligase

Henke, S. K. & Cronan, J. E., May 9 2014, In : PloS one. 9, 5, e96757.

Research output: Contribution to journalArticle

The chain-flipping mechanism of ACP (acyl carrier protein)-dependent enzymes appears universal

Cronan, J. E., Jun 1 2014, In : Biochemical Journal. 460, 2, p. 157-163 7 p.

Research output: Contribution to journalReview article