9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1

Kenneth L. Rinehart; Wayne W. Carmichael; Michio Namikoshi

9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1

Kenneth L. Rinehart (Inventor), Wayne W. Carmichael (Inventor), Michio Namikoshi (Inventor)

Chemistry

Research output: Patent

Abstract

The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products. ##STR1##

Original language	English (US)
U.S. patent number	5569757
Filing date	3/30/93
State	Published - Oct 29 1996

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title = "9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1",

abstract = "The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products. ##STR1##",

author = "Rinehart, {Kenneth L.} and Carmichael, {Wayne W.} and Michio Namikoshi",

note = "This invention was supported by funds from the National Institute of Allergy and Infectious Diseases, Grant No. Al 04769..sup.1 Thus the government of the United States of America has certain rights in this invention.; 5569757",

year = "1996",

month = oct,

day = "29",

language = "English (US)",

type = "Patent",

}

TY - PAT

T1 - 9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1

AU - Rinehart, Kenneth L.

AU - Carmichael, Wayne W.

AU - Namikoshi, Michio

N1 - This invention was supported by funds from the National Institute of Allergy and Infectious Diseases, Grant No. Al 04769..sup.1 Thus the government of the United States of America has certain rights in this invention.

PY - 1996/10/29

Y1 - 1996/10/29

N2 - The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products. ##STR1##

AB - The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products. ##STR1##

M3 - Patent

M1 - 5569757

Y2 - 1993/03/30

ER -

9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1

Abstract

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