7-amido-1,8-naphthyridines as hydrogen bonding units for the complexation of guanine derivatives: The role of 2-alkoxyl groups in decreasing binding affinity

Thomas J. Murray; Steven C. Zimmerman

doi:10.1016/0040-4039(95)01586-7

7-amido-1,8-naphthyridines as hydrogen bonding units for the complexation of guanine derivatives: The role of 2-alkoxyl groups in decreasing binding affinity

Thomas J. Murray
, Steven C. Zimmerman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The unusually low stability of a hydrogen bonded complex between a guanosine derivative and a 7-amido-2-alkoxy-1,8-naphthyridine, containing the DAA-ADD motif, can be explained by a conformational/steric effect.

Original language	English (US)
Pages (from-to)	7627-7630
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	42
DOIs	https://doi.org/10.1016/0040-4039(95)01586-7
State	Published - Oct 16 1995

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "7-amido-1,8-naphthyridines as hydrogen bonding units for the complexation of guanine derivatives: The role of 2-alkoxyl groups in decreasing binding affinity",

abstract = "The unusually low stability of a hydrogen bonded complex between a guanosine derivative and a 7-amido-2-alkoxy-1,8-naphthyridine, containing the DAA-ADD motif, can be explained by a conformational/steric effect.",

author = "Murray, \{Thomas J.\} and Zimmerman, \{Steven C.\}",

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AU - Zimmerman, Steven C.

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Y1 - 1995/10/16

N2 - The unusually low stability of a hydrogen bonded complex between a guanosine derivative and a 7-amido-2-alkoxy-1,8-naphthyridine, containing the DAA-ADD motif, can be explained by a conformational/steric effect.

AB - The unusually low stability of a hydrogen bonded complex between a guanosine derivative and a 7-amido-2-alkoxy-1,8-naphthyridine, containing the DAA-ADD motif, can be explained by a conformational/steric effect.

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UR - https://www.scopus.com/pages/publications/0028799223#tab=citedBy

U2 - 10.1016/0040-4039(95)01586-7

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JO - Tetrahedron Letters

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IS - 42

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7-amido-1,8-naphthyridines as hydrogen bonding units for the complexation of guanine derivatives: The role of 2-alkoxyl groups in decreasing binding affinity

Abstract

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