7-amido-1,8-naphthyridines as hydrogen bonding units for the complexation of guanine derivatives: The role of 2-alkoxyl groups in decreasing binding affinity

Thomas J. Murray, Steven C Zimmerman

Research output: Contribution to journalArticle


The unusually low stability of a hydrogen bonded complex between a guanosine derivative and a 7-amido-2-alkoxy-1,8-naphthyridine, containing the DAA-ADD motif, can be explained by a conformational/steric effect.

Original languageEnglish (US)
Pages (from-to)7627-7630
Number of pages4
JournalTetrahedron Letters
Issue number42
StatePublished - Oct 16 1995


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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