5-HT and 5-HT-SO4, but not tryptophan or 5-HIAA levels in single feeding neurons track animal hunger state

N. G. Hatcher, X. Zhang, J. N. Stuart, L. L. Moroz, J. V. Sweedler, R. Gillette

Research output: Contribution to journalArticle

Abstract

Serotonin (5-HT) is an intrinsic modulator of neural network excitation states in gastropod molluscs. 5-HT and related indole metabolites were measured in single, well-characterized serotonergic neurons of the feeding motor network of the predatory sea-slug Pleurobranchaea californica. Indole amounts were compared between paired hungry and satiated animals. Levels of 5-HT and its metabolite 5-HT-SO4 in the metacerebral giant neurons were observed in amounts approximately four-fold and two-fold, respectively, below unfed partners 24 h after a satiating meal. Intracellular levels of 5-hydroxyindole acetic acid and of free tryptophan did not differ significantly with hunger state. These data demonstrate that neurotransmitter levels and their metabolites can vary in goal-directed neural networks in a manner that follows internal state.

Original languageEnglish (US)
Pages (from-to)1358-1363
Number of pages6
JournalJournal of Neurochemistry
Volume104
Issue number5
DOIs
StatePublished - Mar 1 2008

Keywords

  • Appetite
  • Pleurobranchaea
  • Serotonin
  • Serotonin sulfate

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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