5-HT and 5-HT-SO4, but not tryptophan or 5-HIAA levels in single feeding neurons track animal hunger state

N. G. Hatcher, X. Zhang, J. N. Stuart, L. L. Moroz, Jonathan V Sweedler, Rhanor Gillette

Research output: Contribution to journalArticle

Abstract

Serotonin (5-HT) is an intrinsic modulator of neural network excitation states in gastropod molluscs. 5-HT and related indole metabolites were measured in single, well-characterized serotonergic neurons of the feeding motor network of the predatory sea-slug Pleurobranchaea californica. Indole amounts were compared between paired hungry and satiated animals. Levels of 5-HT and its metabolite 5-HT-SO4 in the metacerebral giant neurons were observed in amounts approximately four-fold and two-fold, respectively, below unfed partners 24 h after a satiating meal. Intracellular levels of 5-hydroxyindole acetic acid and of free tryptophan did not differ significantly with hunger state. These data demonstrate that neurotransmitter levels and their metabolites can vary in goal-directed neural networks in a manner that follows internal state.

Original languageEnglish (US)
Pages (from-to)1358-1363
Number of pages6
JournalJournal of Neurochemistry
Volume104
Issue number5
DOIs
StatePublished - Mar 1 2008

Fingerprint

Hydroxyindoleacetic Acid
Hunger
Tryptophan
Neurons
Serotonin
Animals
Metabolites
Gastropoda
Pleurobranchaea
Molluscs
Neural networks
Serotonergic Neurons
Mollusca
Oceans and Seas
Acetic Acid
Modulators
Neurotransmitter Agents
Meals

Keywords

  • Appetite
  • Pleurobranchaea
  • Serotonin
  • Serotonin sulfate

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

5-HT and 5-HT-SO4, but not tryptophan or 5-HIAA levels in single feeding neurons track animal hunger state. / Hatcher, N. G.; Zhang, X.; Stuart, J. N.; Moroz, L. L.; Sweedler, Jonathan V; Gillette, Rhanor.

In: Journal of Neurochemistry, Vol. 104, No. 5, 01.03.2008, p. 1358-1363.

Research output: Contribution to journalArticle

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AU - Zhang, X.

AU - Stuart, J. N.

AU - Moroz, L. L.

AU - Sweedler, Jonathan V

AU - Gillette, Rhanor

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