Abstract

Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.

Original languageEnglish (US)
Article number49
JournalBiomedical microdevices
Volume18
Issue number3
DOIs
StatePublished - Jan 1 2016

Fingerprint

Orthogonal functions
Hydrogel
Bovine Serum Albumin
Hydrogels
Particles (particulate matter)
Printing
Magnetic resonance
Iron oxides
Nanoparticles
Polyethylene glycols
Magnetic Resonance Spectroscopy
Gels
Biomedical Engineering
Epitopes
Biomedical engineering
Diagnostic Imaging
Imaging techniques
Fabrication
Kinetics
Pharmaceutical Preparations

Keywords

  • 3D printing
  • Biomaterial
  • Hydrogel
  • Polyethylene glycol
  • Stereolithography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

Cite this

3D printing enables separation of orthogonal functions within a hydrogel particle. / Raman, Ritu; Clay, Nicholas E.; Sen, Sanjeet; Melhem, Molly; Qin, Ellen; Kong, Hyunjoon; Bashir, Rashid.

In: Biomedical microdevices, Vol. 18, No. 3, 49, 01.01.2016.

Research output: Contribution to journalArticle

Raman, Ritu ; Clay, Nicholas E. ; Sen, Sanjeet ; Melhem, Molly ; Qin, Ellen ; Kong, Hyunjoon ; Bashir, Rashid. / 3D printing enables separation of orthogonal functions within a hydrogel particle. In: Biomedical microdevices. 2016 ; Vol. 18, No. 3.
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