Abstract
Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.
| Original language | English (US) |
|---|---|
| Article number | 49 |
| Journal | Biomedical microdevices |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- 3D printing
- Biomaterial
- Hydrogel
- Polyethylene glycol
- Stereolithography
ASJC Scopus subject areas
- Biomedical Engineering
- Molecular Biology
Cite this
3D printing enables separation of orthogonal functions within a hydrogel particle. / Raman, Ritu; Clay, Nicholas E.; Sen, Sanjeet; Melhem, Molly; Qin, Ellen; Kong, Hyunjoon; Bashir, Rashid.
In: Biomedical microdevices, Vol. 18, No. 3, 49, 01.01.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 3D printing enables separation of orthogonal functions within a hydrogel particle
AU - Raman, Ritu
AU - Clay, Nicholas E.
AU - Sen, Sanjeet
AU - Melhem, Molly
AU - Qin, Ellen
AU - Kong, Hyunjoon
AU - Bashir, Rashid
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.
AB - Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.
KW - 3D printing
KW - Biomaterial
KW - Hydrogel
KW - Polyethylene glycol
KW - Stereolithography
UR - http://www.scopus.com/inward/record.url?scp=84971343336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971343336&partnerID=8YFLogxK
U2 - 10.1007/s10544-016-0068-9
DO - 10.1007/s10544-016-0068-9
M3 - Article
C2 - 27215416
AN - SCOPUS:84971343336
VL - 18
JO - Biomedical Microdevices
JF - Biomedical Microdevices
SN - 1387-2176
IS - 3
M1 - 49
ER -