3D printing enables separation of orthogonal functions within a hydrogel particle

Ritu Raman; Nicholas E. Clay; Sanjeet Sen; Molly Melhem; Ellen Qin; Hyunjoon Kong; Rashid Bashir

doi:10.1007/s10544-016-0068-9

3D printing enables separation of orthogonal functions within a hydrogel particle

Ritu Raman, Nicholas E. Clay, Sanjeet Sen, Molly Melhem, Ellen Qin, Hyunjoon Kong, Rashid Bashir

Research output: Contribution to journal › Article › peer-review

Abstract

Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.

Original language	English (US)
Article number	49
Journal	Biomedical microdevices
Volume	18
Issue number	3
DOIs	https://doi.org/10.1007/s10544-016-0068-9
State	Published - Jun 2016

Keywords

3D printing
Biomaterial
Hydrogel
Polyethylene glycol
Stereolithography

ASJC Scopus subject areas

Biomedical Engineering
Molecular Biology

Access to Document

10.1007/s10544-016-0068-9

Cite this

@article{19ac61adc52344c79e4007ec72054b05,

title = "3D printing enables separation of orthogonal functions within a hydrogel particle",

abstract = "Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.",

keywords = "3D printing, Biomaterial, Hydrogel, Polyethylene glycol, Stereolithography",

author = "Ritu Raman and Clay, {Nicholas E.} and Sanjeet Sen and Molly Melhem and Ellen Qin and Hyunjoon Kong and Rashid Bashir",

note = "Funding Information: We acknowledge Boris Odintsov for his assistance in MR imaging. This work was funded by the National Science Foundation (NSF) Science and Technology Center EBICS (Grant CBET-0939511) and National Institute of Health (1R01 HL109192 to H.K). R.R was funded by an NSF Graduate Research Fellowship (Grant DGE-1144245) and NSF CMMB IGERT at UIUC (Grant 0965918). N.C. was funded by a Dow Graduate Fellowship. Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

year = "2016",

month = jun,

doi = "10.1007/s10544-016-0068-9",

language = "English (US)",

volume = "18",

journal = "Biomedical Microdevices",

issn = "1387-2176",

publisher = "Kluwer Academic Publishers",

number = "3",

}

TY - JOUR

T1 - 3D printing enables separation of orthogonal functions within a hydrogel particle

AU - Raman, Ritu

AU - Clay, Nicholas E.

AU - Sen, Sanjeet

AU - Melhem, Molly

AU - Qin, Ellen

AU - Kong, Hyunjoon

AU - Bashir, Rashid

N1 - Funding Information: We acknowledge Boris Odintsov for his assistance in MR imaging. This work was funded by the National Science Foundation (NSF) Science and Technology Center EBICS (Grant CBET-0939511) and National Institute of Health (1R01 HL109192 to H.K). R.R was funded by an NSF Graduate Research Fellowship (Grant DGE-1144245) and NSF CMMB IGERT at UIUC (Grant 0965918). N.C. was funded by a Dow Graduate Fellowship. Publisher Copyright: © 2016, Springer Science+Business Media New York.

PY - 2016/6

Y1 - 2016/6

N2 - Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.

AB - Multifunctional particles with distinct physiochemical phases are required by a variety of applications in biomedical engineering, such as diagnostic imaging and targeted drug delivery. This motivates the development of a repeatable, efficient, and customizable approach to manufacturing particles with spatially segregated bioactive moieties. This study demonstrates a stereolithographic 3D printing approach for designing and fabricating large arrays of biphasic poly (ethylene glycol) diacrylate (PEGDA) gel particles. The fabrication parameters governing the physical and biochemical properties of multi-layered particles are thoroughly investigated, yielding a readily tunable approach to manufacturing customizable arrays of multifunctional particles. The advantage in spatially organizing functional epitopes is examined by loading superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA) in separate layers of biphasic PEGDA gel particles and examining SPION-induced magnetic resonance (MR) contrast and BSA-release kinetics. Particles with spatial segregation of functional moieties have demonstrably higher MR contrast and BSA release. Overall, this study will contribute significant knowledge to the preparation of multifunctional particles for use as biomedical tools.

KW - 3D printing

KW - Biomaterial

KW - Hydrogel

KW - Polyethylene glycol

KW - Stereolithography

UR - http://www.scopus.com/inward/record.url?scp=84971343336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971343336&partnerID=8YFLogxK

U2 - 10.1007/s10544-016-0068-9

DO - 10.1007/s10544-016-0068-9

M3 - Article

C2 - 27215416

AN - SCOPUS:84971343336

VL - 18

JO - Biomedical Microdevices

JF - Biomedical Microdevices

SN - 1387-2176

IS - 3

M1 - 49

ER -

3D printing enables separation of orthogonal functions within a hydrogel particle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other links

Fingerprint

Cite this