Abstract
In this work we introduce an improved prototype of three-dimensional imaging system that combines optoacoustic tomography (OAT) and laser ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SoS). The OAT scan is performed by a 360 degree rotation of a mouse with respect to an arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. A 532 nm wavelength output, being mostly absorbed within a narrow superficial layer of skin, is used to outline the visualized biological object. Broadband laser ultrasound emitters are arranged in another arc pattern and are positioned opposite and orthogonal to the array of transducers. This imaging geometry allows reconstruction of volumes that depict SoS distributions from the measured time of flight data. The reconstructed LUT images can subsequently be employed by an optoacoustic reconstruction algorithm to compensate for acoustic wavefield aberration and thereby improve accuracy of the reconstructed images of the absorbed optical energy. The coregistered OAT-LUT imaging is validated in a phantom and live mouse using a single-slice system prototype.
| Original language | English (US) |
|---|---|
| Title of host publication | Photons Plus Ultrasound |
| Subtitle of host publication | Imaging and Sensing 2014 |
| Publisher | SPIE |
| ISBN (Print) | 9780819498564 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
| Event | Photons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States Duration: Feb 2 2014 → Feb 5 2014 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 8943 |
| ISSN (Print) | 1605-7422 |
Other
| Other | Photons Plus Ultrasound: Imaging and Sensing 2014 |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 2/2/14 → 2/5/14 |
Fingerprint
Keywords
- Laser ultrasound
- Optical absorption
- Photoacoustic tomography
- Speed of sound tomography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
3D laser optoacoustic ultrasonic imaging system for research in mice (LOUIS-3DM). / Ermilov, Sergey A.; Su, Richard; Conjusteau, Andre; Ivanov, Vassili; Nadvoretskiy, Vyacheslav; Oruganti, Tanmayi; Talole, Pratik; Anis, Fatima; Anastasio, Mark A.; Oraevsky, Alexander A.
Photons Plus Ultrasound: Imaging and Sensing 2014. SPIE, 2014. 89430J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8943).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - 3D laser optoacoustic ultrasonic imaging system for research in mice (LOUIS-3DM)
AU - Ermilov, Sergey A.
AU - Su, Richard
AU - Conjusteau, Andre
AU - Ivanov, Vassili
AU - Nadvoretskiy, Vyacheslav
AU - Oruganti, Tanmayi
AU - Talole, Pratik
AU - Anis, Fatima
AU - Anastasio, Mark A.
AU - Oraevsky, Alexander A.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - In this work we introduce an improved prototype of three-dimensional imaging system that combines optoacoustic tomography (OAT) and laser ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SoS). The OAT scan is performed by a 360 degree rotation of a mouse with respect to an arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. A 532 nm wavelength output, being mostly absorbed within a narrow superficial layer of skin, is used to outline the visualized biological object. Broadband laser ultrasound emitters are arranged in another arc pattern and are positioned opposite and orthogonal to the array of transducers. This imaging geometry allows reconstruction of volumes that depict SoS distributions from the measured time of flight data. The reconstructed LUT images can subsequently be employed by an optoacoustic reconstruction algorithm to compensate for acoustic wavefield aberration and thereby improve accuracy of the reconstructed images of the absorbed optical energy. The coregistered OAT-LUT imaging is validated in a phantom and live mouse using a single-slice system prototype.
AB - In this work we introduce an improved prototype of three-dimensional imaging system that combines optoacoustic tomography (OAT) and laser ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SoS). The OAT scan is performed by a 360 degree rotation of a mouse with respect to an arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. A 532 nm wavelength output, being mostly absorbed within a narrow superficial layer of skin, is used to outline the visualized biological object. Broadband laser ultrasound emitters are arranged in another arc pattern and are positioned opposite and orthogonal to the array of transducers. This imaging geometry allows reconstruction of volumes that depict SoS distributions from the measured time of flight data. The reconstructed LUT images can subsequently be employed by an optoacoustic reconstruction algorithm to compensate for acoustic wavefield aberration and thereby improve accuracy of the reconstructed images of the absorbed optical energy. The coregistered OAT-LUT imaging is validated in a phantom and live mouse using a single-slice system prototype.
KW - Laser ultrasound
KW - Optical absorption
KW - Photoacoustic tomography
KW - Speed of sound tomography
UR - http://www.scopus.com/inward/record.url?scp=84902094572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902094572&partnerID=8YFLogxK
U2 - 10.1117/12.2044817
DO - 10.1117/12.2044817
M3 - Conference contribution
AN - SCOPUS:84902094572
SN - 9780819498564
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
PB - SPIE
ER -