3D laser optoacoustic ultrasonic imaging system for preclinical research

Sergey A. Ermilov, Andre Conjusteau, Travis Hernandez, Richard Su, Vyacheslav Nadvoretskiy, Dmitri Tsyboulski, Fatima Anis, Mark A. Anastasio, Alexander A. Oraevsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical or other type of biomedical research. The system (LOUIS-3DM) combines a multi-wavelength optoacoustic and ultrawide-band laser ultrasound tomographies to obtain coregistered maps of tissue optical absorption and acoustic properties, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distribution of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, etc.).

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2013
StatePublished - May 28 2013
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2013 - San Francisco, CA, United States
Duration: Feb 3 2013Feb 5 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotons Plus Ultrasound: Imaging and Sensing 2013
Country/TerritoryUnited States
CitySan Francisco, CA


  • laser ultrasound
  • Photoacoustic tomography
  • speed of sound tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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