3D biofabrication strategies for tissue engineering and regenerative medicine

Piyush Bajaj, Ryan M. Schweller, Ali Khademhosseini, Jennifer L. West, Rashid Bashir

Research output: Contribution to journalReview article

Abstract

Over the past several decades, there has been an ever-increasing demand for organ transplants. However, there is a severe shortage of donor organs, and as a result of the increasing demand, the gap between supply and demand continues to widen. A potential solution to this problem is to grow or fabricate organs using biomaterial scaffolds and a person's own cells. Although the realization of this solution has been limited, the development of new biofabrication approaches has made it more realistic. This review provides an overview of natural and synthetic biomaterials that have been used for organ/tissue development. It then discusses past and current biofabrication techniques, with a brief explanation of the state of the art. Finally, the review highlights the need for combining vascularization strategies with current biofabrication techniques. Given the multitude of applications of biofabrication technologies, from organ/tissue development to drug discovery/ screening to development of complex in vitro models of human diseases, these manufacturing technologies can have a significant impact on the future of medicine and health care.

Original languageEnglish (US)
Pages (from-to)247-276
Number of pages30
JournalAnnual Review of Biomedical Engineering
Volume16
DOIs
StatePublished - Jul 2014

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Regenerative Medicine
Biocompatible Materials
Tissue Engineering
Tissue engineering
Biomaterials
Tissue
Technology
Transplants
Preclinical Drug Evaluations
Drug Discovery
Health care
Scaffolds
Medicine
Screening
Tissue Donors
Delivery of Health Care
In Vitro Techniques

Keywords

  • bioprinting
  • hydrogels
  • photolithography
  • scaffolds
  • stem cells
  • vascularization

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

3D biofabrication strategies for tissue engineering and regenerative medicine. / Bajaj, Piyush; Schweller, Ryan M.; Khademhosseini, Ali; West, Jennifer L.; Bashir, Rashid.

In: Annual Review of Biomedical Engineering, Vol. 16, 07.2014, p. 247-276.

Research output: Contribution to journalReview article

Bajaj, Piyush ; Schweller, Ryan M. ; Khademhosseini, Ali ; West, Jennifer L. ; Bashir, Rashid. / 3D biofabrication strategies for tissue engineering and regenerative medicine. In: Annual Review of Biomedical Engineering. 2014 ; Vol. 16. pp. 247-276.
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