TY - JOUR
T1 - 2D Solid-State Nanopore Field-Effect Transistors
T2 - Comprehensive Computational Methodology for Biosensing Applications
AU - Athreya, Nagendra
AU - Sarathya, Aditya
AU - Xiong, Mingye
AU - Leburton, Jean Pierre
N1 - Funding Information:
The authors gratefully acknowledge supercomputing resources offered by an Extreme Science and Engineering Discov ery Environment grant (TG-MCB170052) and a Blue Waters grant (baxi).
Publisher Copyright:
© 2007-2011 IEEE.
PY - 2020/12
Y1 - 2020/12
N2 - State-of-the-Art technologies for the implementation of solid-state nanopores for molecular biosensing are reviewed in this article, with an emphasis on the use of 2D material membranes. Specific advantages of these 2D materials are their ability to read biomolecular information by electronic current variations along the nanoporous membranes. This review outlines a comprehensive computational approach combining molecular dynamics with semiconductor modeling and statistical signal processing to analyze the detailed interaction between biomolecules and solid-state nanopores. The technique is illustrated with three important biomedical applications, i.e., deoxyribonucleic acid (DNA) sequencing, epigenetic detection of DNA methylation, and identification of backbone breakage sites along double strand DNA (dsDNA).
AB - State-of-the-Art technologies for the implementation of solid-state nanopores for molecular biosensing are reviewed in this article, with an emphasis on the use of 2D material membranes. Specific advantages of these 2D materials are their ability to read biomolecular information by electronic current variations along the nanoporous membranes. This review outlines a comprehensive computational approach combining molecular dynamics with semiconductor modeling and statistical signal processing to analyze the detailed interaction between biomolecules and solid-state nanopores. The technique is illustrated with three important biomedical applications, i.e., deoxyribonucleic acid (DNA) sequencing, epigenetic detection of DNA methylation, and identification of backbone breakage sites along double strand DNA (dsDNA).
UR - http://www.scopus.com/inward/record.url?scp=85093683219&partnerID=8YFLogxK
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U2 - 10.1109/MNANO.2020.3024388
DO - 10.1109/MNANO.2020.3024388
M3 - Article
AN - SCOPUS:85093683219
SN - 1932-4510
VL - 14
SP - 42
EP - 51
JO - IEEE Nanotechnology Magazine
JF - IEEE Nanotechnology Magazine
IS - 6
M1 - 9229228
ER -