(2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester

Atli Thorarensen; Kevin A. Swiss; Scott E. Denmark

doi:10.1107/S0108270196005434

(2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester

Atli Thorarensen, Kevin A. Swiss, Scott E. Denmark

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The structure of the title compound, C₃₁H₃₉NO₇Si, was determined and found to be a fused tricyclic nitroso acetal. Remarkable features include a twist-boat conformation of the tetrahydro-1,2-oxazine ring and a highly pyramidalized N atom [Σ(angles) = 310.6(6)°]. Three of the contiguous stereocenters in the nitroso acetal are of the same correct relative and absolute configuration as is found in (+)-crotanecine.

Original language	English (US)
Pages (from-to)	[d]2558-2561
Journal	Acta Crystallographica, Section C: Crystal Structure Communications
Volume	52
Issue number	pt 10
DOIs	https://doi.org/10.1107/S0108270196005434
State	Published - 1996

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Biochemistry, Genetics and Molecular Biology(all)

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10.1107/S0108270196005434

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Thorarensen, A., Swiss, K. A., & Denmark, S. E. (1996). (2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester. Acta Crystallographica, Section C: Crystal Structure Communications, 52(pt 10), [d]2558-2561. https://doi.org/10.1107/S0108270196005434

(2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester. / Thorarensen, Atli; Swiss, Kevin A.; Denmark, Scott E.

In: Acta Crystallographica, Section C: Crystal Structure Communications, Vol. 52, No. pt 10, 1996, p. [d]2558-2561.

Research output: Contribution to journal › Article › peer-review

Thorarensen, A, Swiss, KA & Denmark, SE 1996, '(2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester', Acta Crystallographica, Section C: Crystal Structure Communications, vol. 52, no. pt 10, pp. [d]2558-2561. https://doi.org/10.1107/S0108270196005434

Thorarensen, Atli ; Swiss, Kevin A. ; Denmark, Scott E. / (2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester. In: Acta Crystallographica, Section C: Crystal Structure Communications. 1996 ; Vol. 52, No. pt 10. pp. [d]2558-2561.

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title = "(2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester",

abstract = "The structure of the title compound, C31H39NO7Si, was determined and found to be a fused tricyclic nitroso acetal. Remarkable features include a twist-boat conformation of the tetrahydro-1,2-oxazine ring and a highly pyramidalized N atom [Σ(angles) = 310.6(6)°]. Three of the contiguous stereocenters in the nitroso acetal are of the same correct relative and absolute configuration as is found in (+)-crotanecine.",

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T1 - (2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester

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AU - Swiss, Kevin A.

AU - Denmark, Scott E.

PY - 1996

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AB - The structure of the title compound, C31H39NO7Si, was determined and found to be a fused tricyclic nitroso acetal. Remarkable features include a twist-boat conformation of the tetrahydro-1,2-oxazine ring and a highly pyramidalized N atom [Σ(angles) = 310.6(6)°]. Three of the contiguous stereocenters in the nitroso acetal are of the same correct relative and absolute configuration as is found in (+)-crotanecine.

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(2aS,3S,6S,7S,7bR)-7-[(Dimethylphenyl) -silyl]-2-oxo-6- [(1R,2S)- 2-phenylcyclohexyloxy]-2a,3,6,7,7a,7b -hexahydro-2H-1,4,5- trioxa-4 a-azacyclopenta[cd]indene-3-carboxylic acid 1-methylethyl ester

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