27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator

Research output: Contribution to journalReview article

Abstract

Estrogen receptors (ERs) mediate the actions of the steroidal estrogens, and are important for the regulation of several physiological and pathophysiological processes, including reproduction, bone physiology, cardiovascular physiology and breast cancer. The unique pharmacology of the ERs allows for certain ligands, such as tamoxifen, to elicit tissue- and context-specific responses, ligands now referred to as selective estrogen receptor modulators (SERMs). Recently, the cholesterol metabolite 27-hydroxychoelsterol (27HC) has been defined as an endogenous SERM, with activities in atherosclerosis, osteoporosis, breast and prostate cancers, and neural degenerative diseases. Since 27HC concentrations closely mirror those of cholesterol, it is possible that 27HC mediates many of the biological effects of cholesterol. This paper provides an overview of ER pharmacology and summarizes the work to date implicating 27HC in various diseases. Wherever possible, we highlight clinical data in support of a role for 27HC in the diseases discussed.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalMaturitas
Volume104
DOIs
StatePublished - Oct 1 2017

Fingerprint

Hydroxycholesterols
Selective Estrogen Receptor Modulators
Estrogen Receptors
Cholesterol
Supravalvular Aortic Stenosis
Pharmacology
Breast Neoplasms
Ligands
Biuret
Cardiovascular Physiological Phenomena
Tamoxifen
Osteoporosis
Reproduction
Prostatic Neoplasms
Atherosclerosis
Estrogens
Bone and Bones
Library Catalogs
MSH Release-Inhibiting Hormone
Bone

Keywords

  • 27-hydroxycholesterol
  • Cholesterol
  • Estrogen
  • Estrogen receptor
  • Selective estrogen receptor modulator

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

Cite this

27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. / He, Sisi; Nelson, Erik R.

In: Maturitas, Vol. 104, 01.10.2017, p. 29-35.

Research output: Contribution to journalReview article

He, Sisi; Nelson, Erik R. / 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator.

In: Maturitas, Vol. 104, 01.10.2017, p. 29-35.

Research output: Contribution to journalReview article

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