Abstract
Estrogen receptors (ERs) mediate the actions of the steroidal estrogens, and are important for the regulation of several physiological and pathophysiological processes, including reproduction, bone physiology, cardiovascular physiology and breast cancer. The unique pharmacology of the ERs allows for certain ligands, such as tamoxifen, to elicit tissue- and context-specific responses, ligands now referred to as selective estrogen receptor modulators (SERMs). Recently, the cholesterol metabolite 27-hydroxychoelsterol (27HC) has been defined as an endogenous SERM, with activities in atherosclerosis, osteoporosis, breast and prostate cancers, and neural degenerative diseases. Since 27HC concentrations closely mirror those of cholesterol, it is possible that 27HC mediates many of the biological effects of cholesterol. This paper provides an overview of ER pharmacology and summarizes the work to date implicating 27HC in various diseases. Wherever possible, we highlight clinical data in support of a role for 27HC in the diseases discussed.
| Language | English (US) |
|---|---|
| Pages | 29-35 |
| Number of pages | 7 |
| Journal | Maturitas |
| Volume | 104 |
| DOIs | |
| State | Published - Oct 1 2017 |
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Keywords
- 27-hydroxycholesterol
- Cholesterol
- Estrogen
- Estrogen receptor
- Selective estrogen receptor modulator
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Obstetrics and Gynecology
Cite this
27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. / He, Sisi; Nelson, Erik R.
In: Maturitas, Vol. 104, 01.10.2017, p. 29-35.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator
AU - He,Sisi
AU - Nelson,Erik R.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Estrogen receptors (ERs) mediate the actions of the steroidal estrogens, and are important for the regulation of several physiological and pathophysiological processes, including reproduction, bone physiology, cardiovascular physiology and breast cancer. The unique pharmacology of the ERs allows for certain ligands, such as tamoxifen, to elicit tissue- and context-specific responses, ligands now referred to as selective estrogen receptor modulators (SERMs). Recently, the cholesterol metabolite 27-hydroxychoelsterol (27HC) has been defined as an endogenous SERM, with activities in atherosclerosis, osteoporosis, breast and prostate cancers, and neural degenerative diseases. Since 27HC concentrations closely mirror those of cholesterol, it is possible that 27HC mediates many of the biological effects of cholesterol. This paper provides an overview of ER pharmacology and summarizes the work to date implicating 27HC in various diseases. Wherever possible, we highlight clinical data in support of a role for 27HC in the diseases discussed.
AB - Estrogen receptors (ERs) mediate the actions of the steroidal estrogens, and are important for the regulation of several physiological and pathophysiological processes, including reproduction, bone physiology, cardiovascular physiology and breast cancer. The unique pharmacology of the ERs allows for certain ligands, such as tamoxifen, to elicit tissue- and context-specific responses, ligands now referred to as selective estrogen receptor modulators (SERMs). Recently, the cholesterol metabolite 27-hydroxychoelsterol (27HC) has been defined as an endogenous SERM, with activities in atherosclerosis, osteoporosis, breast and prostate cancers, and neural degenerative diseases. Since 27HC concentrations closely mirror those of cholesterol, it is possible that 27HC mediates many of the biological effects of cholesterol. This paper provides an overview of ER pharmacology and summarizes the work to date implicating 27HC in various diseases. Wherever possible, we highlight clinical data in support of a role for 27HC in the diseases discussed.
KW - 27-hydroxycholesterol
KW - Cholesterol
KW - Estrogen
KW - Estrogen receptor
KW - Selective estrogen receptor modulator
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UR - http://www.scopus.com/inward/citedby.url?scp=85027247881&partnerID=8YFLogxK
U2 - 10.1016/j.maturitas.2017.07.014
DO - 10.1016/j.maturitas.2017.07.014
M3 - Review article
VL - 104
SP - 29
EP - 35
JO - Maturitas
T2 - Maturitas
JF - Maturitas
SN - 0378-5122
ER -