2013 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis Polyphosphate: A Novel Modulator of Hemostasis and Thrombosis

Stephanie A. Smith, James H. Morrissey

Research output: Contribution to journalReview article

Abstract

Polyphosphate is a highly anionic, linear polymer of inorganic phosphates that is found throughout biology, including in many infectious microorganisms. Recently, polyphosphate was discovered to be stored in a subset of the secretory granules of human platelets and mast cells, and to be secreted on activation of these cells. Work from our laboratory and others has now shown that polyphosphate is a novel, potent modulator of the blood clotting and complement systems that likely plays roles in hemostasis, thrombosis, inflammation, and host responses to pathogens. Therapeutics targeting polyphosphate may have the potential to limit thrombosis with fewer hemorrhagic complications than conventional anticoagulant drugs that target essential proteases of the blood clotting cascade.

Original languageEnglish (US)
Pages (from-to)1298-1305
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume35
Issue number6
DOIs
StatePublished - Jun 27 2015

Keywords

  • blood coagulation
  • blood platelets
  • hemostasis
  • polyphosphates
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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