2-(4-Hydroxyphenyl)benzothiazole dicarboxylate ester TACN chelators for ⁶⁴Cu PET imaging in Alzheimer's disease

Keyphrases

• Cu(II) 100%
• Binding Affinity 100%
• Esters 100%
• Dicarboxylate 100%
• Bifunctional Chelator 100%
• Chelator 100%
• P-hydroxyphenyl 100%
• Alzheimer's Disease 100%
• PET Imaging 100%
• Benzothiazole 100%
• High Affinity 50%
• Partition Coefficient 50%
• Stronger Binding 50%
• New Series 50%
• Form-stable 50%
• Lipophilicity 50%
• Amyloid Aggregates 50%
• Amyloid Plaques 50%
• In Vitro Autoradiography 50%
• Carboxylate Ester 50%
• Pendant Arm 50%
• Alkyl Carboxylates 50%
• Blood-brain Barrier Penetration 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Chelating Agent 100%
• Copper 64 100%
• Alzheimer's Disease 100%
• Dicarboxylic Acid 100%
• Benzothiazole 100%
• Polyethylene Terephthalate 100%
• Carboxylate 25%
• Autoradiography 25%
• Lipophilicity 25%
• Amyloid Protein 25%
• Amyloid Plaque 25%
• Blood-Brain Barrier 25%

Chemistry

• Benzothiazole 100%
• Chelating Agent 100%
• Kd 66%
• Logd 33%
• Autoradiography 33%
• Lipophilicity 33%
• Carboxylic Acid 33%
• Partition Coefficient 33%