@article{02631fbb45a34a4288e6b54acbf44852,
title = "2-(4-Hydroxyphenyl)benzothiazole dicarboxylate ester TACN chelators for 64Cu PET imaging in Alzheimer's disease",
abstract = "Herein we report a new series of bifunctional chelators (BFCs) with high affinity for amyloid β aggregates, strong binding affinity towards Cu(ii), and favorable lipophilicity for potential blood–brain barrier (BBB) penetration. The alkyl carboxylate ester pendant arms show high binding affinity towards Cu(ii). The BFCs form stable 64Cu-radiolabeled complexes and exhibit favorable partition coefficient (log D) values of 0.75–0.95. Among the five compounds tested, 64Cu-YW-1 and 64Cu-YW-13 complexes exhibit significant staining of amyloid plaques in ex vivo autoradiography studies.",
author = "Yujue Wang and Huynh, {Truc T.} and Nilantha Bandara and Cho, {Hong Jun} and Rogers, {Buck E.} and Mirica, {Liviu M.}",
note = "Funding Information: This work was supported by research funding from the NIH (R01GM114588 to L. M. M.). We thank the small animal imaging facilities at Washington University School of Medicine for excellent technical assistance and the Isotope Production Group at Washington University for the production of 64Cu. Funding Information: This work was supported by research funding from the NIH (R01GM114588 to L. M. M.). We thank the small animal imaging facilities at Washington University School of Medicine for excellent technical assistance and the Isotope Production Group at Washington University for the production of 64Cu. Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry",
year = "2022",
month = jan,
day = "21",
doi = "10.1039/d1dt02767k",
language = "English (US)",
volume = "51",
pages = "1216--1224",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "3",
}