1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner; M. Christina White; Patrick Dolan; Thomas W. Kensler; Shigefumi Yukihiro; Sandra E. Guggino

doi:10.1016/S0960-894X(01)80840-4

1α,25-dihydroxyvitamin D₃ hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner, M. Christina White, Patrick Dolan, Thomas W. Kensler, Shigefumi Yukihiro, Sandra E. Guggino

Research output: Contribution to journal › Article › peer-review

Abstract

Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.

Original language	English (US)
Pages (from-to)	2919-2924
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(01)80840-4
State	Published - Dec 22 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Online availability

10.1016/S0960-894X(01)80840-4

Library availability

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Cite this

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title = "1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain",

abstract = "Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.",

author = "Posner, {Gary H.} and White, {M. Christina} and Patrick Dolan and Kensler, {Thomas W.} and Shigefumi Yukihiro and Guggino, {Sandra E.}",

year = "1994",

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AU - Posner, Gary H.

AU - White, M. Christina

AU - Dolan, Patrick

AU - Kensler, Thomas W.

AU - Yukihiro, Shigefumi

AU - Guggino, Sandra E.

PY - 1994/12/22

Y1 - 1994/12/22

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JF - Bioorganic and Medicinal Chemistry Letters

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