1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner, M Christina White, Patrick Dolan, Thomas W. Kensler, Shigefumi Yukihiro, Sandra E. Guggino

Research output: Contribution to journalArticle

Abstract

Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.

Original languageEnglish (US)
Pages (from-to)2919-2924
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number24
DOIs
StatePublished - Dec 22 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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