TY - JOUR
T1 - λ -Prophage induction modeled as a cooperative failure mode of lytic repression
AU - Chia, Nicholas
AU - Golding, Ido
AU - Goldenfeld, Nigel D
PY - 2009/9/1
Y1 - 2009/9/1
N2 - We analyze a system-level model for lytic repression of λ phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultraviolet radiation are in good agreement with experimental data.
AB - We analyze a system-level model for lytic repression of λ phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultraviolet radiation are in good agreement with experimental data.
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U2 - 10.1103/PhysRevE.80.030901
DO - 10.1103/PhysRevE.80.030901
M3 - Article
C2 - 19905052
AN - SCOPUS:70349519194
SN - 1539-3755
VL - 80
JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
IS - 3
M1 - 030901
ER -