Abstract
The purpose of this study was to determine if α-tocopherol - a reactive oxygen species (ROS) scavenging agent - inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The LPS-induced increase in ROS and IL-6 was reduced by pretreatment of α-tocopherol. Intraperitoneal injection (i.p.) of LPS induced lipid peroxidation and IL-6 in brain. Importantly, three daily injections (20 mg) of α-tocopherol increased brain α-tocopherol and decreased LPS-induced lipid peroxidation and IL-6 in brain. Taken together, these data indicate that α-tocopherol can mitigate inflammatory cytokine production in the brain.
Original language | English (US) |
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Pages (from-to) | 101-109 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 149 |
Issue number | 1-2 |
DOIs | |
State | Published - Apr 2004 |
Keywords
- Brain
- Cytokines
- Lipopolysaccharide
- Mice
- Reactive oxygen species
- α-Tocopherol
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology